Conserved Protein Domain Family
TB2_DP1_HVA22

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pfam03134: TB2_DP1_HVA22 
TB2/DP1, HVA22 family
This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.
Statistics
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PSSM-Id: 460820
Aligned: 313 rows
Threshold Bit Score: 38.2564
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008189637  73 PAVATISLtV-----SPpMSRkyervsaatEAlNeKFTYWMTFTAILILESLCrPVLR----LLPLYQMCRTWFFIWCFA 143
4_pfamImport   1 PILQAFKI-Lk----KPtNKK---------LT-Q-SVHYWSVYGSFLIIDWFLtTFFIt--cFIPFYDFFVLVFTIGMAV 62 
CAP36833      17 PVIHSFKV-Lk----KPtKPK---------LI-Q-CLHFWTIYGSFLITDWFLtTFFIs--cFIPFYDFFCLSFVVLLSA 78 
EPR79181      59 PLRESLMV-Ln----TVnPKI---------NElKhLLVFWMIFSLMVIFESAF-GFVIr---YIPLYYLIKLVFLWYIGP 120
EEQ82753      58 PLRETLLV-Lk----QVnPNK---------EEiRhLLIFWLVFGILTSLDAYS-RFIVs---FIPMFYTLKFFLLLYIGP 119
Q8STK5        58 PLQETLVI-Lr----QVnPKK---------DEaKhMLVFWMVFGILTSLDAYS-GAIIs---FIPLWYTMKFFFLLWAGP 119 Encephalitozoon...
A0CDJ7        14 PLIQSFKV-L-----KNkDKE---------GQqT-LLKYWCINWMISLLDIVL-EIVLn--dLL--VDIVLVSLAIGLIY 72  Paramecium tetr...
Q5KIV5       144 AAYLSAQV-LdssesSAnDEKv-----------KsLLSFFVVLGCIQTLESLMaGFLEk---rIPQYYTVKLLFLAYLLH 208 Cryptococcus ne...
XP_002903661 422 PAYVTIGV-L-----GE-KRT---------RRyEwWIAY---FSVAVTVDYLI-TAIGreigWIPLFYHVKLLVMMWLQF 481
XP_001009348  16 PAYYSLKF-L-----KKrNQQ---------QIsN-ILKFWCVNSVWTIFEVLV-PLVVd--qWF--FFVTNVIFYVALTF 74  Tetrahymena the...
XP_008189637 144 PIrDNGSAYIYDAII-R---PQ 161
4_pfamImport  63 PQ-LGVAPMLYTKFL-A---PA 79 
CAP36833      79 PH-LGFASMLYTKFL-A---PF 95 
EPR79181     121 LK-FNGAYTIYELTLsKipsEC 141
EEQ82753     120 FR-FKGTKIIYDSLIsKvpeKW 140
Q8STK5       120 LK-FRGGIIIYDNILaRipeKW 140 Encephalitozoon cuniculi GB-M1
A0CDJ7        73 NN-FKFSAAIFNNSI-Q---PF 89  Paramecium tetraurelia
Q5KIV5       209 PK-TQGAKKIHESVF-R---PL 225 Cryptococcus neoformans
XP_002903661 482 PY-FQGAERIFNACF-S---SV 498
XP_001009348  75 PE-YKRAGQIFDLTI-S---KL 91  Tetrahymena thermophila SB210
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