1JJ2,1C04,1NKW,1VVJ,2J28,2X7N,3J6B,3J7Y,4V4N,4V61,4WCE,5AN9,5V7Q,6V39,7AIH,7JIL,7OOD,8A22


Conserved Protein Domain Family
Ribosomal_uL14
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cd00337: Ribosomal_uL14 
Ribosomal protein uL14
Ribosomal protein uL14 (L14 in bacteria and mitochondria, L23 in eukaryotes, L38 in fungal mitochondria) is part of the large ribosomal subunit, located between the centers of activity for peptidyl transferase and GTPase. uL14 has an "all beta" fold that binds 23S rRNA. Ribosomal proteins, which are components of ribosomal subunits, are RNA-binding proteins that might have multiple extra ribosomal functions and may be involved in tumorigenesis in mammals.
Links
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Statistics
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PSSM-Id: 466774
Aligned: 386 rows
Threshold Bit Score: 67.4811
Created: 6-Mar-2002
Updated: 19-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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L14 - 23S rRNA
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:L14 - 23S rRNA interaction site [nucleic acid binding site]
Evidence:
  • Structure:1JJ2: Haloarcula marismortui RPL14 binds 23S rRNA, contacts at 4A
  • Comment:The elongating polypeptide at ribosome passes through the GTPase center which includes L14. L14 contact 23S RNA in this region.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## ##            # #####         #       # #                          #        #
1JJ2_J        13 EKGSLITCADNTgareLKVISVHGysgtknrhpKAGLGDKITVSVTKgtpe---------------mrrQVLEAVVVRQR 77  Haloarcula mari...
8A22_Ai        3 PNYSFLKVVDNSgaklVKIIGFYGhp-----gkAVGVGEVVKVAIKEakgek-------------vsagEMKKAVIVEQK 64  Polytomella magna
AAG23665       3 YPETNVFIVDNSnvkeVRCVHVYNqss----nnFGSTGSFIIGVITKlkknnlk---------stqkrgDLVKVLIVFTR 69  Thraustochytriu...
Q5DUY3         3 QKFTNLYVTDNSgaiaVRVFQTYPgn-----rkIVPVGSIVRHSVKKihrilpwgkqlrgrrkriicrsQCGRSWIVQTS 77  Nyctotherus ovalis
XP_001694002   3 PKYSFLKIVDNSgaklAQVIGFYGhq-----ggYASVGDVVKVVVKEargek-------------ttagVMRKAVVVEQK 64  Chlamydomonas r...
ADV41820       3 KKETKMTVADNSdarlVLCIHANTkra---rykKTSLANFVKVTIKRkvsrr------------nnikkRVNWCLIGATP 67  Bigelowiella na...
AEV66700       3 FKESWLSVSDNTnvrwLQCFQLYKgfh----rkSTKVGFFIKGAAKIvepprieykg---fkfkfnkkgDICRGLIIRTK 75  Oxytricha trifa...
ETO10781       3 RLKSKVGCFDNTgaklLEVIAPVKqha----lnNVYLGRAFIGFVKRaslgk------------svqrkQIIKGLLICTR 66  Reticulomyxa fi...
XP_013905825   3 PKGAFLRVVDNSg---ARVGQVIWtr-----fsAAKLGSIVKVAIKEakggk-------------vaagQMKKAVVVETK 61  Monoraphidium n...
YP_009240004   3 QKESLLWVGDNSdalkALCIHTNKkkn---thrKTSLANFVKATIKKrvsrr------------knikrRVNWFLVGSTA 67  Lotharella sp. ...

Feature 1        #        ####### #                                   #               
1JJ2_J        78 KPirr--pdGTRVKFEDNAAVIVDENEDp-----------------rGTELKGPIare-vaQRFGSVAS 126 Haloarcula marismortui
8A22_Ai       65 FPvfr--pnGSHFRHLRNSCVLLSEKGQp-----------------lGNKVRALLtyefikPRWSKLRT 114 Polytomella magna
AAG23665      70 KEknnikgsGIFVKAPKNFGILFDKKIAv------------------GSRCKGVLp----iKIKPLVPS 116 Thraustochytrium aureum
Q5DUY3        78 YQipy--idGATLRFSKNRVLLVKRKRGiri--------------yrGRRIYGLTtr---aVNNERTIN 127 Nyctotherus ovalis
XP_001694002  65 YPfhr--qnGSHVQYLRNAAVLLSEKGQp-----------------iGNKVRSMLgvefnkPRWAKLKS 114 Chlamydomonas reinhardtii
ADV41820      68 RRiar--lsGESIRFSKTKALLVDDKKKks----------------mGSLIKGVLpr---eVRAADASE 115 Bigelowiella natans
AEV66700      76 FRank--ldGCYSIFNSNSIILLKKKQDl-----------------kSKYLYGPVphqikrKKFLNLFK 125 Oxytricha trifallax
ETO10781      67 KKhrr--pdGSFIQFNQNRAILLKKATKeqlastkaakrwatkteplGTAITSAIplelrqKRLKKLVL 133 Reticulomyxa filosa
XP_013905825  62 YPtrr--pnGAHFQFLRNSCVLLNEKGAp-----------------iGSRMRSLLtyefgkPRWKRLSM 111 Monoraphidium neglectum
YP_009240004  68 KRiar--ksGDGIRFARTKVVLVDEKQKkt----------------lGTRIKGVLp-----REVSAAGA 113 Lotharella sp. CCMP622

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