Conserved Protein Domain Family
Nop53

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pfam07767: Nop53 
Nop53 (60S ribosomal biogenesis)
This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.
Statistics
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PSSM-Id: 462259
Aligned: 129 rows
Threshold Bit Score: 154.76
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH60085       4 TAKGKRAWRKNIQLGeadYVDKKREDAR-----TGGAVDELPDDALFFTDTDGGGGia--------nAAvltrkEKARNK 70 
1_pfamImport   1 NKNKKKSWNKHSDIN---DVDAFLEDVRlqertTGGLLSEKSDESLFFLDAGPPKDqrvsqpaee-----qkrskgkaWR 72 
XP_005454351  38 NKNKKKNWNKYSDVQ---DVEEFLEDVRhqertTGGLLSEKSDDSLFFLDVGQPKKveekeaaepv---kgkkrkgksSR 111
XP_011607051  38 NKNKKKNWTKYSDIN---DVEDFLEDVRhqertTGGLISEKPDDSLFFLDVGQPSTaestvpepg----egkkrkgktSR 110
XP_007492014  75 PRNKKRGWRRLAEEPlgqEVDTFLEDVRlqeraTGGLLSETPDENLFFVDKGRGEEdski--------------kqdLKK 140
6_pfamImport   1 PRNKKRVWWRLAQEPlglEVDPFLEDLRlqehtSSGWVSEPPHGKLFFMDSGPKDSergrkrt-------kqkrplLLQK 73 
Q8BK35        41 PRNKKRGWRRLAEEPlglEVDQFLEDVRlqertTGGLLAEAPNEKLFFVDTGFKRKeprkkrt------lvqkksQRLQK 114 house mouse
XP_017823461  41 PRNKKRGWRRLAQEPlglEVDQFLEDVRlqertSGGLLSEAPNEKLFFVDTGPKEKgltkkrtkvqkKS------LLLRK 114
XP_003464661  40 PRNKKRGWRRLAEEPlglEVDQFLEDVRlqertIGGLLSEAPDDKLFFVDTGSKEKeqsrk--rtkvQK-----KSLLQK 112
KAE8585751    35 NKNKKKNWLRHSDVK---DVEEFLDDVRfqqrtAGGLLQDKADESLFFVDTGKPEKga--------kLK-------KKDA 96  tropical clawed...
EEH60085      71 TLRVDSILtktrTSC---PYpVPVPRGAKGPptasratkgAETTSDRslreaSSFskAVAKAGGATREKINGaalykpnr 147
1_pfamImport  73 PLRIDLILqr-dSLVpipKD-VLAYQ-KPNA---------KKLRRI------AEKaaQLSAKGVVTRRQKRLlnrppvke 134
XP_005454351 112 PLRIDLILqh-dSRVappKD-VLAYQ-KPNA---------KKLRRA------AERaeKLAAKGVVPRSKKRLlnrpvvdr 173
XP_011607051 111 PLRIDLILqr-dSLVpppID-VLAYQ-QPNA---------KKLRRK------AQRaeQLAAKGVVTRRQKQLlnrrpvdr 172
XP_007492014 141 SFWIDRVLes-nSKVpspKN-ILAHQ-VPNG---------KKLKRK------QRLweHLAQQGKQPREVRKAqarllqpp 202
6_pfamImport  74 PLRVDLMLen-tSKIpapKD-ILSHQ-VPNA---------KKLKRK------EQLweRLAKQGELPREVRRAqaplhspp 135
Q8BK35       115 PLRVDLALen-hSKIpapKD-ILAHQ-VPNA---------KKLRRK------EELweKLAKQGELPRDVRKAqarllspp 176 house mouse
XP_017823461 115 PLRVDLILen-tSKVpapKN-VLAHQ-VPNA---------KKLRRK------EQLweKLAKQGELPREVRRAqarllnpp 176
XP_003464661 113 PLRVDLILen-tSKIpapKD-VLAHQ-VPNA---------KKLRRK------EQLweRLAKQGELPREVRKAqarllnpp 174
KAE8585751    97 PLHIDLILqs-dSKVlppKD-ISSHQVPNGR---------KLKRKQElqaklEKRg-ILSRSEKLLQARLNKrdskakae 164 tropical clawed...
EEH60085     148 rftlddvladdpdapkkqktYDIWDGGLArdaardatrekhkattkagakhaEAASYSKHRLGDAPGSSSARgnkkkaya 227
1_pfamImport 135 rtkka---vteannnpnrdyYDMWreepkdts------------------dpwflqqtGKKRVPRPERMNEKpsv----- 188
XP_005454351 174 tskkt---eteannnperdfYDIWgqetkdlg------------------epwylqqtRKKLVKRPEKLNEKpsv----- 227
XP_011607051 173 aakks---lteannnpgrdfYDIWgqeskpvg------------------dlwylqqtGKQLVKRPERLNEQpsv----- 226
XP_007492014 203 tpk------tppsdpadrpfYDLWAQ--Dnpldrplvg-----------qdtffleqtKKKGVKRPRRLQTKpsq----- 258
6_pfamImport 136 gakarpgpralrsspsttstTD--NPlerplagq----------------dpffleqtKKKGVERPLRLHTTpfq----- 192
Q8BK35       177 tpka----kpgpqdiierpfYDLWNP--Dnpldtplig-----------qdaffleqtKKKGVRRPQRLHIKpsq----- 234 house mouse
XP_017823461 177 avka----kpspqdtverpfYDLWAPDNPldrpl-------------vgqdeFFLEQTKKKGVKRPPRLHTKpsr----- 234
XP_003464661 175 tpkr----kpgpqdaverpfYDLWAPDNPldral-------------lgqdtFFLEQTKKKGVRRPQRLHRKpss----- 232
KAE8585751   165 a-----------snnsgrsfYDIWGNDNPldfeh-------------qgkdsWYLEQTKKSRVKHPDRLRVKpse----- 215 tropical clawed...
EEH60085     228 pkngvgaVEVDAAGSSYNPPEDARQEVI--AYEVGKElRKKLKKQLDPVRApvSNNEANQKLAEElyyaqenlyedasdd 305
1_pfamImport 189 ----lpaVEVIAAGGSYNPEFFSHQALLqeAHNVELK-RQKEEDRIAKQLA----VNKEHFATEEtvmkeqveglaas-- 257
XP_005454351 228 ----lpaVEVIAPGGSYNPDFFSHQELLreAHEVEVK-KKKVEDKIERQLA----YNKEDTATEEtilreqveglveese 298
XP_011607051 227 ----lpaVEVIGPGGSYNPDFFSHQALLqeAHDVEVK-KHKAEEKIERQLA----FDKDDTATEEtvfkeqveglveedd 297
XP_007492014 259 ----apaVEVIPSGGSYNPSFQAHQALLqeAHEVELQ-RQKVEEKLSRQLA--FPTVDKAPTQESafkelceglleesde 331
6_pfamImport 193 ----vpaVEVTPSGASYNPSFEDHQTLLweAHEVKLQ-LQREEEKLELQLA--LPHAEQAATQEStfeemcqelleesdg 265
Q8BK35       235 ----vpaVEVIPAGASYNPTFEDHQALLreAHEVELQ-REKEAEKLERQLA--LPTSEQAATQESvfremceglleesdg 307 house mouse
XP_017823461 235 ----vpaVEVVPAGASYNPSFEDHQTLLsaAHEVELQ-RQKEAEKLERQLA--LPAAEQAATQEStfqelceglleesdg 307
XP_003464661 233 ----apaVEVMPAGASYNPTFEDHQALLlvAHEVELQ-RQKEAEKLERQLA--LPSPEQVATQETmfqemceglleesdg 305
KAE8585751   216 ----vpaIELVSSGSSYNPSFQSHQMLLlqAHEVELK-KLKEEEKIEKQLK--FPTAADAPTEESrfqelceglveesev 288 tropical clawed...
EEH60085     306 eagg-----------gdggggasknknpatsrdGKMTKAQRNKQLRRREQEAEEEANRLAKRHRRDLSNLKHLDARLDAE 374
1_pfamImport 258 ---------------------eedvavgaivmaEKKTERQRRKERVEKLKVQRRQANRAKSDKRQQLFQLNSIKKTIKER 316
XP_005454351 299 eeeek---------edapkedgeevavgaiavaDKKTERQRKREKAEKMKEQQRLAERRQTEQQQQLFQLRSIKTSIKQQ 369
XP_011607051 298 daea-----------aeaaneqdhvavgaitlsEKKTERQRKKEKAEKLKDQRRLAERQQTGQQQQLYQLRSIKSSIRQQ 366
XP_007492014 332 etp------------aepgdgdadgpaprppgpEKKTEQQRRREKEARKLKAQQAAERAARKRRQEVFQLRGIRLQVAQR 399
6_pfamImport 266 egepg--------earddefggakattparlaaVEKTEQQRRREKAAEMLRVQPATVRAARLQKQELFRLRGIKAHVAQQ 337
Q8BK35       308 edeheagragqpeagdgtteisptgaagpekrmEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVARR 387 house mouse
XP_017823461 308 egepgqgq--gqgkepeagdadvcptparlaatEKKTEQQRRREKAARRLRAQQAVLRAARLRHQELFRLRGIKAQVALR 385
XP_003464661 306 egelgqd-----aasevggaqaapqpalpatamEKKTEQQRRREKAARTLRVQQAMLRAARLRRQELFRLRGIKAQVAQR 380
KAE8585751   289 pa--------------aaeerseeqgtgsclqrERKTERQRKKEKEAKILRAKLHADKIKKQRIQSLFQLRSIQAALAKR 354 tropical clawed...
EEH60085     375 AAEEEAKrerrkVAREERKA----AQPDRLGKHRFVEEHTPVMLKDELTGSLRTLAGTHTLLRDRLKSL 439
1_pfamImport 317 ETNTKVK-----QEQRKSNQeaekAQPRRLGKLKFQPQDMEVQLSNELAGSLRRLKPEGSVLKDRFKSL 380
XP_005454351 370 EEKTQVR-----QKRRKAKEeaqkAQPRRLGKLKFQPQDMEVQLSDELAGSLRQLKPEGSVLMDRFKSL 433
XP_011607051 367 EEKTKAR-----RNERKAKQeaqkSQPRRLGRLKFQAPDLEIKLSDELAGSLRQLKPEGSVLSDRFKSL 430
XP_007492014 400 LTELARR-----RERRRLKRlaedEKPRRLGRLKYQAPDIDVQLSTELADSLRKLKPEGSILRDRFKSF 463
6_pfamImport 338 la--------------------eaDKPRRLGQLKYQAPDINM----DLANSLPTLKPEGNILCDRFKSS 382
Q8BK35       388 LAELARR-----REQRRIRRlaeaDKPRRLGRLKYQAPDIDVQLSSELSGSLRTLKPEGHILRDRFKSF 451 house mouse
XP_017823461 386 LAELARR-----RRQRQARReaeaDKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 449
XP_003464661 381 LAELARR-----REQRRLKRlaedDKPCRLGRLKYQAPDIDVQLSSERSDSLRALKPEGNILQDRFKSF 444
KAE8585751   355 EGEMARR-----KALKAEKRkkeaLQPRRLGRLKYKDPEIDVLLSDELPESLRKLKPEGNIATDRFKSF 418 tropical clawed frog
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