Conserved Protein Domain Family
MTTB

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pfam06253: MTTB 
Trimethylamine methyltransferase (MTTB)
This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.
Statistics
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PSSM-Id: 428852
Aligned: 23 rows
Threshold Bit Score: 571.91
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013045417               20 GGRAANTARRGDTLFKQspWRLPVNHDRPIEPLSEDGVIAIHNGAMHILEEIGIEFLNEEAQQLFKDAGCKV--DGTNVK 97  Ca...
dbos:SAR116_0785           13 GGRSSRREKRKLHVPSM--LPTLESRLPLTEPMDEDQIARIDDASMSILEDVGVVFRDPVALDDWRSAGARV--EGDLVK 88 
vbi:Arad_3336              26 GGRGAERSRKPSGSK----YLNLVNNLARTELLSPETLDDIHEASLTILEEIGMDIILPEARERMKAAGADVtpGTERVR 101
DSMZRoselon:roselon_00032  13 GGRRTGTSRAAGPAIAQtpWRIPLNTDRPTEPLDEAGIAALHSGAMRILSEIGIEFLNDEALGHLRAAGCRI--EGQTAR 90 
Q1GEL3                     12 GGRAGAAARRGAATLEQmpWKPPVNIDRPVEPLTAEGIAAIHDGAMRILEEIGVEFLNDEALEIFKEAGLKV--DGALVR 89  Ru...
WP_012179478               13 GGRAANARRIRAHAIEQlpFHVPRNPDAPTEPLAPEGVAAIHDTAMRVLEEIGIAFLNAEALEIFREAGCHV--TGELVR 90  Di...
Q92YQ8                      7 GGRRSR-AIRGGDGISQlpWQEVVNTYAPMQLLDEERIEALHRNSMRILSEIGIRVMSEKAMALFEKAGAIVdrENLMIR 85  Si...
Q5LVY0                      6 RGRRARTEAPASARKVD--YRNLRNPFPPMAAFSEDRIEALHEASLSVLEELGIKVLHPGARDLYRQGGARI--DGEMVH 81  Ru...
Q16AK7                     11 RTRRDGGPKAAPERNVN--YRNLRNPFPPMEVFSSDQIAAMHETSLRTLEELGIKVLLPEAVEVLRKGGARV--VDQMVY 86  Ro...
Q28SB5                      3 NRRRNRNAPRASARVTQ--YGQLRNPFPPMNVFPADRIEAMHDAGLDILERLGIKVLLPEARAIFATAGAMV--KDDMVY 78  Ja...
WP_013045417               98 MGRDWVMDMIAKVPRQFTITPRNPDHEITIGGNHILFGNVSSPPNYYDLDLGhKIAGTREQCANLLKLSQYFNCIHFVGG 177 Ca...
dbos:SAR116_0785           89 FDRAHIRSLISSIPETITLHARNPENTIGLGGRKSMFIPMTGAPYLRDLDDD-RRLPTLNDLGMFHKLAHMSPALHSSAH 167
vbi:Arad_3336             102 FDRGMIMELITSVPSTFTLHARNPLRNVEIGGNNLIFAQVASAPFVADREGG-RRAGNREDFRKLIKLAQSYDVIHTTGG 180
DSMZRoselon:roselon_00032  91 FDPDFVMDMVGKAPAQFTITPRNPDRSVTIGGRHMTFVNVSSPPNAWDLERG-KRPGDFATFREFMKLTQYFNCIHIAGG 169
Q1GEL3                     90 MDREFVMEMVGKVPSEFTLTPRNPERAIRIGGNSIVFGNVSSPPNYWDMDLNkKVPGTREHCQNLLKLTQYFNCIHFAGG 169 Ru...
WP_012179478               91 MDRHFVLEMLSRAPAQFTLTPRNPDREITIGGQHMVFVNVSSPPNYWDMETG-KTPGTRAQCRNLLKLCQYFNCIHVVGG 169 Di...
Q92YQ8                     86 IDESIVEAALATTPSSFTLTSRNPEKRLTIGGNTIAFGLVAGPPNVHDRVNG-RRQGNLADYQNFTRLAHHFNAIHILGN 164 Si...
Q5LVY0                     82 IGREMVEAALASAPKSIRMRGAVPDRDVVLELGRMAFQPGAGCPHATDLARG-RRPGTIADFRELVQITQSFDVLHMVP- 159 Ru...
Q16AK7                     87 LGRDMIDAALATAPRSITGRAGARDRDILLELGSLVFQPGAGAPHATDLARG-RRPGSARDFREYTTLCHHFDVFQMMS- 164 Ro...
Q28SB5                     79 IGRDIVEASLASAPRRIEGRAGAPERDVVLELGSLVFQPGAGAPHATDEVRG-RRPGCARDFKELIQLTNHFDVFHMLP- 156 Ja...
WP_013045417              178 YPVEPVDIHASIRHLDVIYDKLTLTDKVAHAYALGKERIEDVMEMVKIAAGLSEAAfqSKPHMFTNINSTSPLKHDHPMI 257 Ca...
dbos:SAR116_0785          168 HIVEPMDHPVPHRHLQITYSSMKYSDKTFMGMTTSGKNGEDVMDMCDILFGAGYLE--DHAVVVGNINGNSPLVWDETML 245
vbi:Arad_3336             181 YPVEPIDIHASVRHLDCLSDIVKLTDKAFHCYSLGKQRNLDSIEIARIGRGISMEQmeREPSLFTIINSSSPLRLDGPML 260
DSMZRoselon:roselon_00032 170 YPVEPIDVHASVRHLDCLFEKLTLTDKVAHAYSLGPERVEDVMEMVRIAGGLTHDEfdAAPRMYTNINSVSPLKHDWPML 249
Q1GEL3                    170 YPVEPVDLHASIRHLDVLYDKLTLTDKVMHAYSLGKERVEDVMEMVRIAGGLSHEEfdSQPHMYTNINSTSPLKHDEPMI 249 Ru...
WP_012179478              170 YPVEPVDVHASVRHLDVLFDKLTLTDKVAHAYSLGKERVEDVMEMVRIAGGLTEAEfaARPHMYTNINSTSPLKHDQPMI 249 Di...
Q92YQ8                    165 QVCAPMELPANSRHLDTYKANLALSDLCFHCTAIGRGRAVDGINMMAIARGISVEEmsQSPGVITIISVNSPRLFDDAMA 244 Si...
Q5LVY0                    160 PLVEAQDVPMHLRHMAMTEVELTQSDKVPFLYSRGTPQVMDGFEMIRDFRGLSDAEfrAQSWCYTIINTNSPRTIDMPMA 239 Ru...
Q16AK7                    165 PSVEPQDVPTHLRHYFTTEVQLTRTDKFPFVFARGTPQAMDCFEMLRDFRGLSDAEfaDSPHCYTIINTNSPRTLDIPMA 244 Ro...
Q28SB5                    157 PLVEPQDIATNIRHYFTLECQLTESNKFPFIFSRGTPQVTESFEMLRDFRGLSDAEfeAEPRCYTIINTNSPRTLDVPMA 236 Ja...
WP_013045417              258 DGSLRMIRRGQAVVVTPFTLAGAMAPVTMTGAVTLSIAEALSAIALFQYVKPGCPCVIGTFTSNVDMKSGAPAFGTAEYM 337 Ca...
dbos:SAR116_0785          246 GAMRAFVRRNQPVLCSPFVLGGANTPASTVPAVAQLNAEALSALAYTQVVRKGAPAIYGHYLSTVSMRSGAPMAGTPEIS 325
vbi:Arad_3336             261 QGIIEMSSRGQVVVITPFTLAGAMAPVTIAGALVQQNAEALCGIAFSQMVRKGAPVMYGGFTSNVDMKTGAPAFGTPEYM 340
DSMZRoselon:roselon_00032 250 DGAMRLARRGQPVVVTPFTLAGAMAPVTLAGAVALSLAEGLAAIALLQWIAPGCPVAIGTFTSNVDMKSGAPAFGTPEYM 329
Q1GEL3                    250 DGALRLVRRGQPVIVSPFTLAGAMAPVTMAGAVAQSLAEALCAIALFQYVRPGTPCAIGTFTSNVDMKSGAPAFGTPEYM 329 Ru...
WP_012179478              250 DGALRCIRRGQALIVTPFTLAGAMAPVTLAGAVAQSVAEALAAIALAQYVRPGCPVALGTFTSNVDMKSGAPAFGTPEYM 329 Di...
Q92YQ8                    245 DGLIAMAEHGQPVTITPFTLMGAMTPVTLAAALCQQNAEALFGVTLAQLVNPGTPVMYGAFTSNVDMRSGAPAFGTPENA 324 Si...
Q5LVY0                    240 QGLIDFARHGQMAIITPFTLMGAMAPVTVAGAMTLSHAEALAAITLSQLAQPGAPVCYGTFTSNVDMKSGAPAFGTPEHF 319 Ru...
Q16AK7                    245 QGLIDFARNGQLSIVTPFTLMGAMAPITVAGAITLSHAEALAAITLTQLVKPGAPVCYGTFTSNVDMKSGAPAFGTSAHF 324 Ro...
Q28SB5                    237 QGLIDFARMGQISIVTPFTLMGAMAPITVAGAITLSHAEALAAITLTQLTNPGAPVCYGTFTSNVDMKSGAPAFGTPSHF 316 Ja...
WP_013045417              338 RATQITGQMARYYDMPMRASGV-CAANIPDGQSIWETSNSLWSAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEMLQII 416 Ca...
dbos:SAR116_0785          326 LMNFMIGQMARFYGVPWRTSNTlGGAKTLDAQAGYESATTLMAVLMAGANYIWHSAGWNEAGMHCSVAKFMVDAEQCAMG 405
vbi:Arad_3336             341 KAVIAGGQLARRYGIPYRTSNT-NASNTLDAQAAYESALSLWALTQGGGNFVLHAAGWSEGGLTACFEKFILDVDMLQMV 419
DSMZRoselon:roselon_00032 330 RATQMTGQMARHYGLPMRASGV-CAANVPDGQAMWETGNSLWAAVQSGANMVYHAAGWLEGGLIASPEKFVMDCELLQQI 408
Q1GEL3                    330 RATQMTGQMARFYGLPMRSSGV-CAANVPDGQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQMI 408 Ru...
WP_012179478              330 RATQMTGQMARFYGLPMRASGV-CAANVPDGQAMWETSNSLWSAVQSGANMVYHAAGWLEGGLIASPEKFIMDCEMLQQI 408 Di...
Q92YQ8                    325 KANIIAGQLARRYKLPYRTSNA-NASNAVDLQAAYETEMATWGAVLGGANLIYHAAGWLEGGLTASYEKLVLDVEILQNM 403 Si...
Q5LVY0                    320 TASLVAGQLARRIGLPWRCAGG-SAANINDAQAANETQFGLWGCLLAGATVTIHAAGWLEGGLTVSYEKIITDLEVLQMV 398 Ru...
Q16AK7                    325 QASLAAGQLARFTGLPWRSAAG-SASNINDVQAANENQMGLWGSLMGGATVIIHAAGWLEGGLSVSYEKIITDFEVLNMI 403 Ro...
Q28SB5                    317 QASLAAGQLARHIGLPWRSAAG-SAANLNDVQAANENQFGLWGCLMAGATVVIHSAGWLEGGLSISYEKLITDAEVLNMV 395 Ja...
WP_013045417              417 QRYMEPdiWDAQPDAIAID-AIREVGASGHYFGIQHTQDRYQSAFHEPFVSDWRNFEAWEAAGAIRTPERANKLFKDIIA 495 Ca...
dbos:SAR116_0785          406 YRMAEG--LRWDDFDEALS-AIRDIGPGGHYLGHAHTLENFERAFFMPSLFDNNSFEQWQAEGAQDVTARALSMARQMLN 482
vbi:Arad_3336             420 AEFLTP--LDVSQDALALD-AVRDVGPGGHYFGTAHTLARYETAFYSPILSDWRNYETWTEAGRPTTYDHANRIFKETLA 496
DSMZRoselon:roselon_00032 409 QRYFEPalTATAEDDLAID-AIAEVGPGGHFFGCAHTQARYQNAFYQPFASDWRNFEAWAGDGGVWTVERAHRIYKRILA 487
Q1GEL3                    409 QRYMDPviNATGPEEIALD-AIREVGNDGHFFGIQHTQDRYATAFYQPFLSDWHNYEAWEAAGGTWTAQRANGLFKQIIN 487 Ru...
WP_012179478              409 ARYFSPdlTATTPDDLAFD-AMAEVGTSGHFFGIQHTQDRYETAFYQPFLSDWRNFEAWERDGATWTVARAHRIYKEILT 487 Di...
Q92YQ8                    404 MGFLEP--MPFSEDDLGFD-AIRSVPAGGHFFGSEHTMARYETAFYQPMLSNWQNYGSWQEAGGRDALERATDIWQQALR 480 Si...
Q5LVY0                    399 AELCAG--TPATDADIALD-ALREVPPMGHFFGAAHTMARYQTQFYEPLVGDWSNFGQWSERGAVDANHRATGIWRGIVD 475 Ru...
Q16AK7                    404 AELCAG--KQAGIDEIGFDtALSAVEPSGHFFAAPQTMARYNTEFYEPIVHDYANFGTWTERGAQDANQRATRVWQDILA 481 Ro...
Q28SB5                    396 AELCAG--AQASDAEIGLD-AIEDTAPSGHFFATAQTMARYQTEFYEPIIHDYANFGTWTERGSKDASTRARDVWQGILA 472 Ja...
WP_013045417              496 TFQAPPMPADRHEELLAFVDRRKAEG 521 Candidatus Puniceispirillum marinum
dbos:SAR116_0785          483 EYEEPKLDVAINDALLDYIARREREI 508
vbi:Arad_3336             497 RYERPPLDSAIEEELDAFVARRKEEG 522
DSMZRoselon:roselon_00032 488 EFEAPPMDAEIRDELADFVARRKAQG 513
Q1GEL3                    488 EFEAPTLDEGIREELQAFVARRKEEG 513 Ruegeria sp. TM1040
WP_012179478              488 EFTPPPMDPAIREELSDFVARRKAEG 513 Dinoroseobacter shibae
Q92YQ8                    481 EYEEPVLDPAIREELDAYTIKRRAEI 506 Sinorhizobium meliloti
Q5LVY0                    476 NFEPPPMDPDRVAALQDFIARRTAEG 501 Ruegeria pomeroyi
Q16AK7                    482 ADKRPEVDGKRLENLQDFIAKRTAEG 507 Roseobacter denitrificans OCh 114
Q28SB5                    473 DPKSPTVNGDRLSALQDDIARRTQAG 498 Jannaschia sp. CCS1
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