Conserved Protein Domain Family
DCAF17

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pfam15802: DCAF17 
DDB1- and CUL4-associated factor 17
DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes. It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.
Statistics
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PSSM-Id: 464881
Aligned: 13 rows
Threshold Bit Score: 560.441
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007253568  51 GNLRILRNLILQDG---TEFTKVWTKSSKSLISYESGRIY---FENYRNCY--SSLTAEPQVLYELPRRSKAEKIEDSLL 122
3_pfamImport   1 KNLKILKHLVCQDT---TSLRNVWMKQSKSPVVYERGRIY---FDNYQCCF--SCANSSPKLLYKMPKCSKMEKIEDALL 72 
A8WHR0        44 SNLKILRNIILKDD---TEFVKVWSKTSKSLISYESGRIY---FDNYRCCY--SSLLPEPELLYELPRTPKTEKIEDALL 115 zebrafish
XP_006636656  54 KNMRMLRHILLQDT---TNFTNVWRKHSKGPIDYEHGKIY---FENYRSCY--SSIPPKPQCLYELPNCSKSQKIEDALI 125
XP_001640777  24 KDLKLLRLLVEKRS---TKFKNVWSKKSKDPIGFDCGHLF---LDKFRTSF--ST-NGKPKELYRMQPLRSSEKVESAVV 94 
XP_009031969  24 QNMKLLKFLLSKHDiheEVFSSECTIESKYKLFYDNLIVFnnkLQKYSNIFskTCMKGI-KIKFKSISSSKYGKIEDCLF 102
OCA23644      54 TNLDIIRKLVCQKN---TVFRRVWTKHSKLAINYAKGRIY---FDNFRCCF--NSATPVPQQMYEMPRCSKLEKIEDALL 125
XP_515899     31 TNLGILRALVCQES---TKFKNVWTTHSRSPIAYERGRIY---FDNYRRCV--SSVASEPRKLYEMPKCSKSEKIEDALL 102
XP_008117078  47 KNMGILRKLICQES---TTFRNVWTKHSTSPITYQSGKIY---LENYRYCL--SSITPEPRIIYQMPACPKSEKIEDVLL 118
XP_011488071  32 HCLNVLRGVLLQEN---RNFQKIWSKISKSTITYESGKVY---FENYQNCY--SCIQAEPHSLYKMPKRSKHEKIQDALL 103
XP_005799456  32 FCLKILRSITLHEN---RSFIKVWSKTSKTAIMYDSGRIY---FDNYQNCY--SCVHDQPQNLYKFPKKSKQQKIEDALL 103
XP_005452992  43 lirhnlkilrgillqenrtftkvwsktskstvMYENCKLY---FENYQHCY--SCVHAEPQILYKLPTRSKQEKIEDTLM 117 Nile tilapia
XP_011608106  32 HNMKVFRNLLFQDN---RSFIKVWSRSSKSTIMYESGKIY---FENYLNCY--SCVHSVPQVLYKLPQRSKLEKFEDALL 103 torafugu
XP_007253568 123 CQCPLEK----VLSQASQQKPFLLALTANNWLYCLSADTGETLQKVYLSSHFKF-RSLDWDISQETFYVKSVHRKQTAIA 197
3_pfamImport  73 SECPVGE----LLPSLLDYKSSLITVTANNWLFRVSVNTGEVLEKVFLSSLYRF-RYVTWDVPQESLVVKSAQNRQRAMV 147
A8WHR0       116 CQCPLEN----VLPNASEQKSCLLTLTANNWLYLLSADTGETLQRVYLSSRFKFsRSLGWDSSQETFYVKSVQCKQTALE 191 zebrafish
XP_006636656 126 CQCPLDR----TLPSPSDRNPCLLALNASNWLYCYSAMTGEQLEKVYLSPRYKF-RYLCWDVPQETLCIKSVQNKQTSIA 200
XP_001640777  95 FESPLDQqsfvSTVETKGFKSCVIGVTANGFLFRQDVDTGKRLQTVFLSRTIKF-KNIFWESDLTRLVIKSVHSK--PLP 171
XP_009031969 103 SQCPVED----VSYLESLEQPHFYVISQNNWFLRINCHTCTVDKELYMTDLCKF-KLIMWDVQEERLYLSATISEGg--- 174
OCA23644     126 CECPLGE----SLPHPSDYTPSLLAVTGQNWLLRISADTGEILEKIYLGSYRKF-RYINWDVPQETLVLKSIQTKSATVS 200
XP_515899    103 WECPVGD----ILPNSSDYKSSLIALTAHNWLLRISATTGKILEKIYLAAYCKF-RYLSWDTPQEVIAVKSAQNRGSAVA 177
XP_008117078 119 LECPVGE----VLPNPSDYKPSLVVLTAHNWLLRLSATTGEILEKVYLAAHCKF-RYLSWDTPQDVMVVKSIQQKHPGAA 193
XP_011488071 104 CQSPLDT----TLPSASDHTPSLLALTANNWLYRISSNTGKELQRVYLSPRFQF-RYLGWDVSQETFYIKSLQKKETPLE 178
XP_005799456 104 CQSPLDK----TLSSPSEHKPCLLALTADNWLCRISAETGKELQRIYLSPKYKY-RYLAWNVPQETFYIKSVQNKETPLA 178
XP_005452992 118 CHSPVEK----SLSSPSDHKPSLLALTANNWLIRLSAETGEELQRVYLSPNYKF-RYLGWDVSQETFYVKSVQNKETPLA 192 Nile tilapia
XP_011608106 104 CQSPLGD----VLSNPSDHKPSLLALTANGWLYRLSAETGEELQKVYLSPNIKF-RYLGWDVSQETVYIKSVQNKETSLE 178 torafugu
XP_007253568 198 RQ-AGTD----NVLMHLAIFTVF----PLQVVGLLEISKKVFGKSVVDVLLSQGVLAVSHSSKCVKLYSLEYIVKK---- 264
3_pfamImport 148 AQeVNIKq---TISVYYLILNYLlknnPYALIGYIETNEKVFGNHVIDATISHGILIVMYRMGLVRLYNFQWITET---- 220
A8WHR0       192 RQ-AGVDn---NILMRVAAFQVF----PLQLVGMLEINKKVFGKTAVDVLLSQGVLAVSHSSKLVRLYSFEYIVNK---- 259 zebrafish
XP_006636656 201 RQ-TGPGq---DTLMCLAVFRVL----PLELLGMLEISRRVFGNNVVDVMLSQGILAISHSTGMVKLYSFENIVEK---- 268
XP_001640777 172 RViSGNNphvnNVLLHLALFDVA----PLKFVALIPIERSLFGSTITDATSSMGILFVMHRSGLIQLYSTQEIIDK---- 243
XP_009031969 175 -----------KKTFVFALFSVW----PLRFQGVFSLSSKSFGFDMKEALLSENMLLVTSSDAMVRIF------------ 227
OCA23644     201 QEdEGNTr---AVLFYLAVFSVF----PLSLVGILEITKHIFGSTVTDAMISHGMLIVMHSVGLVRLYSFERITEQ---- 269
XP_515899    178 RQ-AGIQq---HVLLYLAVFRVL----PFSLVGILEINKKIFGN-VTDATLSHGILIVMYSSGLVRLYSFQTIAEQ---- 244
XP_008117078 194 RQ-AGVQq---SVLFVLAVFRVL----PLSFIGMLELDKKFFGNSMTDASMSDSMLIVTHSTGLVRLYSFQTISEQ---- 261
XP_011488071 179 RQ-AGISq---STVMHLAVFHVF----PLQIVGILEINKKVFGSGVTDVVLSQGVLAVSHSNKSVRLYSFVHIIQK---- 246
XP_005799456 179 RQ-AGISq---NVVMHMAIFHVF----PLQIVGILEINKKGFGSGVTDVVLSQGVLAVSYSNKSVKLYSFEHVVQR---- 246
XP_005452992 193 RQ-AGITq---NTVMHIAIFHVF----PLDVIGIMEINKKVFGNGVIGADLVQGVLALYYSNKSVKMYSFEHIVQRylte 264 Nile tilapia
XP_011608106 179 RQ-AGITq---NTVMHLAIFHVF----PLQIVGILEINKRVFGNGVTDVVVSQGAIVVSYSNKSVKLYSFEHILQRh--- 247 torafugu
XP_007253568 265 FRTTELVLGQQCDLY----------------GAKGTVGEVPY-GIPVNIQIKECPPVLFEMSYLDNGIQIGGHPWHYIYT 327
3_pfamImport 221 YTSKKVMLGQKCQWN----------------GTTGIVGDTPF-GIPCNITVTDTPPLLFEVPCLENAFQIGGYPWHYIIT 283
A8WHR0       260 FRTEELILGQQCELN----------------NARGIVGDAPY-GVPVNICIHECPPVLFEMTYFENGVQIGGHPWHYIYT 322 zebrafish
XP_006636656 269 FMIKKLTLGEKCEWN----------------GIQGSVGESPL-GIPFNIQITDSPTLMFEVSCLESGFQIGGHPWHYIYT 331
XP_001640777 244 Y-SQITDLGKPYTINtsacsnptseyhanniDGTGIVGSHPF-GIPVNVHMVSKPTLLLEVSSHQHSLSFGGFPWHFVVS 321
XP_009031969 228 --------GLDCEFY------------------SKPVNNLKFeSLPVIPSIENYCRLLFEVPAPWDFFTVGGMPWHYIVF 281
OCA23644     270 FMKQKHVVGQVCSWK----------------GETGTIGDFPF-GIPCNIKPTESLPFLFEVSCLENAFQVGGHPWHYIIT 332
XP_515899    245 FMQQKLDLGCACRWG----------------GTTGTVGEAPF-GIPCNIKITDMPPLLFEVSSLENAFQIGGHPWHYIIT 307
XP_008117078 262 FMLQRVDLGQEYNWN----------------GKIGIVGKYPF-GIPYNIKITGAPDLLFEVSSLESTFQIGGFPWHYIIT 324
XP_011488071 247 YLTEKLTLGQQSALL----------------EGK-TVGDAPF-GIPVNIQIPDCPPVLFEVSCSNNGVQIGGFPWHYIYT 308
XP_005799456 247 CLIEELTLGQQSPLL----------------GHR-TVGDVPF-GIPVNIQITEPPPLLFEAF-SHNGIQIGGFPWHYIYT 307
XP_005452992 265 K----VTLGKQSPLL----------------GGK-TVGDAPF-GIPLNIQITDCPPVLFKVSCAENSVQIGGNPWHYIYT 322 Nile tilapia
XP_011608106 248 L-TERLILGKQSSLL----------------EGK-TVGDFPF-GIPRNIHITDCPPLLFEVLCSNNSVQIGGYPWHFIYT 308 torafugu
XP_007253568 328 PNHKKHKGTHHICSIRDGTLAKNGVQDMKCDSLEADWIFFHPDDSGRIIHAGPSTINVLKIIEGKEVDTNYEVIHD---- 403
3_pfamImport 284 PNKKKQKGTYHICSLENNTLAENGIQDMKCCSLECDWIYFHPDDSGRVVHVGPNQINVLRLKETPETDHQHQVTED---- 359
A8WHR0       323 PNHKRHRGTHHVCSITDGALAKNGVQDMKCDSLEVDWIFFHPDDSGRIIHAGPSTINILKIMAETGCDWKYEIITD---- 398 zebrafish
XP_006636656 332 PRSKKHKGTYHICSLKDGQLAKNGIQDMNCCSLESDWIYFHPGDSGRIIHVGPSKVNVLKIAETQENLLQFEVIQE---- 407
XP_001640777 322 PP--RQSSVFHVYSIKEKELVGNGIIKSDVLSVEPDQAYFHADHSGRLLHICPHSIRFLKLKTLGDLGVGQLVLDTc--- 396
XP_009031969 282 SS--FSQSQFSVQCLRTRTVAKDGKLNIKNALLDPDKCFFYPDSSGKIVKVSNDSVELYNLKSD-----GYDKFNNptcs 354
OCA23644     333 PNKKKEKGTYHIRSLDDHSLAKNGIRDMSCCSLEPDWIHFHPDASERIIHVGPDQIRVLRLKELQNDSYRHQVCED---- 408
XP_515899    308 PNKKKQKGVFHICALKDNSLAKNGIQEMDCCSLESDWIYFHPDASGRIIHVGPNQVKVLKLTEIENNSSQHQISED---- 383
XP_008117078 325 PNKKSQKGIFHVCSLKDHTLAKNGVQEMKCCSLEPDWITFHPDSSGRILHVGPNLIKVLKLKEVEGNTELQKVTED---- 400
XP_011488071 309 PPHKTHRGTHHICSLQDHSMAINGIQNMNCCALESDGIFFHPDDSGRIIHVGPTTIKVLKILGEINSSLPSEVVED---- 384
XP_005799456 308 PPHKKHRGTHYISALKDSTLAKNGIQNMNCCSLESDVIFFHPADSGRVIHIGPNTINVLKVISELNSPLPSEVLED---- 383
XP_005452992 323 PPRKKDEGTYHICSLKDGTMATNGVQEMDSYSLENDGIFFHPDDSGRIIHVGPvtinvlkilgelnsal----------- 391 Nile tilapia
XP_011608106 309 PPQKNHRGTHHVCSLKDCSLAINGVQSMSCNSLESDAMSFHPDDSGRMIHVGPTIINVLKLVSDLNNDMQSRVVKD---- 384 torafugu
XP_007253568 404 ----FSIIT--SRDRSAT-SKVTVTSSGRTVKRRFQQLD---DDPEQETFKMAKYEDELDLLAIVdVSpTAEDVGQASVR 473
3_pfamImport 360 ----FVILA--KREAKLL-HSVTVTASGRVVKKRFEQLD---DEPEQETFKIVDYEDELDLLAVVaVT-QTESEGRAHID 428
A8WHR0       399 ----FSITA--ARDSNA--SQVIVTSSGRTVKRRFQMLD---DDPAQETFRMVKYEDELDLLAVVdIT-HAEDEGQARLR 466 zebrafish
XP_006636656 408 ----YSIEA--HRENKAD-SLVTVTASGRTVRRRLHQLD---DDPEQETFQCVEYEDELDLLAVVsVT-QTESEGKAHVG 476
XP_001640777 397 ----FSISTrdNQSNRSTkGQTSYTSSGRLVKCVSSDGY---HDPEYDSIQDLDYEDELDLVAVL----SSRDCSSGYIG 465
XP_009031969 355 vellYMLDY--SEEKRPV---VTHTSSGRAIKKR--TFPgaiSENFHSKVQLVICEIDMDIIGV--VTlSRCSSNVAAIT 425
OCA23644     409 ----FAILA--TRDKEVN-KPVTVTASGRLVKKRFAQLD---DDPEQETFKIVVYEDELDLLTVVaVT-QTEAEGKAHVA 477
XP_515899    384 ----FVILA--NRENNKNeNVLTVTASGRVVKKSFNLLD---DDPEQETFKIVDYEDELDLLSVVaVT-QIDAEGKAHLD 453
XP_008117078 401 ----FIIQA--SRENNIE-NSITVTSSGRIVKNRFNSLD---DDPEKETFQIVDYEDELNLLSIAaVT-QIGSDGSARLD 469
XP_011488071 385 ----FSMAT--HR-NAPT-PEVTVTSSGRTVKRRFHQLD---DDPGQEAFRMVEYEDELDLLAVV-MTdGVEEEGRAHVL 452
XP_005799456 384 ----YSLTT--HR-SHPS-PRVTVTSSGRTVRSRFQQLD---DDPMQETFRLLEYEDELDLLAIA-VTnGEGEEGRAHVQ 451
XP_005452992 392 pskvvedfslkthrnnPI-SQVTVTSSGRTVKRRFQQLD---DDPSQKTFRMVEYEDELDLLAIV-VTnGEEGEGRACIQ 466 Nile tilapia
XP_011608106 385 ----FSMAT--HRssnp-tqqVTVTSSGRTVKRRFHQLD---DDPDQETFRMVEYEDELDLLAAV-VTdGNEGEGRAHIQ 453 torafugu
XP_007253568 474 LYDNKSGGLMKRITLNEPWDVTYSHEVYLDRDTVIHIEQERNNSFCCHVYKM 525
3_pfamImport 429 LYNNQTGTLVKTVPLVEYWDVTYSHRIFFDRETVVHIEQKPNRIFCCYVYKM 480
A8WHR0       467 LHDNKTGALMKRVPLEEPWDVTYSHEVYFDRDTIIHTVQEKNNSFCCHVYKM 518 zebrafish
XP_006636656 477 IYDNWSGVLMKSVPLVESWDVTYGHQFFFDCDTIIHIEQEKNHKFCCHVYKM 528
XP_001640777 466 LYDNQTGVLVKEITL-DNWDDESEHSIMMERDLIVHICRTPFKKFSCTLYRL 516
XP_009031969 426 FYEIDTGNYITKLEFAEAWDVNAEHDVKLDLDILYHYIK-TNSKHVLIVYRL 476
OCA23644     478 LHCNDTGKLLKNIVLLESWDVTHSHAVFFDRDTLIHIEERPNRNFSCYVYKM 529
XP_515899    454 FHCNEYGTLLKSIPLVESWDVTYSHEVYFDRDLVLHIEQKPNRVFSCYVYQM 505
XP_008117078 470 LRCNERGTRLKSIPFVESWDVTYSHEVYFDRNVVLHIEQKPNRTFSCYVYHM 521
XP_011488071 453 LHDNQTGRLLRKIDLVESWDETYQHQLFFDKDTIVHIEQ-KNSNFCCHVYKL 503
XP_005799456 452 LHDNQTGRLQRKIDLDEPWDETYPHELFFDRDTIVHIEQ-KGSQFCCYVYKL 502
XP_005452992 467 LHDNQTGQLLRTIDLIETWDETNKNEVFFDKDTIVHIEQ-KNAKFCchvykl 517 Nile tilapia
XP_011608106 454 LYDNQSGQLLRNVALSESWDE------------Tfphelfldkdtivhieqk 493 torafugu
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