Conserved Protein Domain Family
GPCR_chapero_1

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pfam11904: GPCR_chapero_1 
GPCR-chaperone
This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.
Statistics
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PSSM-Id: 463391
Aligned: 88 rows
Threshold Bit Score: 146.242
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006854269        189 RADMTLAGFDGLRIQRSDQSVL--FLGDG--SedgrapPGTLCMVSHKDKEVTnaLDGAGIRATDAE------------- 251
EDV22628            162 RVDTTLLSLDENIGKTGNRSII--FKAAD--N------GAEIIEVDHEKRKAC----------SETIsldeigr---rlg 218
XP_001640192          6 RVDTTLLGFDQNEWQRGNRTYV--FKADD--K------GGTFLEIDHERRRVW----------TETLslryysqrwqkda 65 
CUT99623            103 RLDTTLLDFKNRSWVRGQLSII--VDGNKpfE-------SRTCLIDHEHRSYQilDGTMARENSDEW------------- 160
XP_002016389        231 RLDTTLVDFNDMKWERGDISFL--FRGEAppR-------EALVLLDNEQACYQ----RLRHEEAD--------------- 282
WGS:AAPU:GI20952-PA 226 RLDTTLVDFNDMRWDRGDISFL--FRGEAapN-------ESLVLLDNEQQCYQ----RLRYEESD--------------- 277
Q7Q159              146 RLDTTLVDFSDMRWERGDISFI--FKGDNppK-------DSLTALDNECRCYQ----HVRHEETEME------------- 199 Anophele...
2_pfamImport          1 RLDTTLVDFTDMRWERGDISFI--FRGDKnpT-------ESLTVLDNEYKCFQ----RIRHEESENE------------- 54 
XP_004226058        171 RMDSTLEDFSERRWIRGDISIIidFAADGepD---------VLLLDNKNKIYQh-MKQTTVQEREAS------------- 227 vase tun...
CAG08519            148 RVDATLLGFENMTWIRGRRSYI--FRGDD--S------CAELMEVNHDNEVVD----------TERFnisqemedvtles 207 spotted ...
XP_006854269        252 ---VAQEVAAMSQTNMFRPGIDVTQAVLLPQL----TW-RRQERSETVG-QWKAKVYDMHHVVVSVKSRkvpgamsddef 322
EDV22628            219 sepSSELVFERLRMPVTSTIINIDNIEFSRQKsgiwGW--RTDRTEAVN-NYEAKVYNVSNVVVIARTR----------- 284
XP_001640192         66 asrMFYCVRTLIFAIIISVQI-SNYICY-RHKtm-wGW--GGDKTETVD-DYECKVYTASGVEVVTKTR----------- 128
CUT99623            161 ---LNETVQTSLHMPLIRMHMDFTRLSCKKETsk-lPW-LKDNVPEKIG-PYNTQNYSINHVKISVKKR----------- 223
XP_002016389        283 ---MEDEVDGLMSTDIMATQMSTKTINFARAQs---GWiFRANRKELIGgQYQCELYTIQGLIIKQRKR----------- 345
WGS:AAPU:GI20952-PA 278 ---MEDEVDVLMSTDILATQMSTKTIQFARAQr---GWlFRANRKELIGgQYQCEIYTIQGLVLKQRKR----------- 340
Q7Q159              200 ---IEDEVDILMSSDILAAQMSTKGISFTKAQs---GWiFREDRRETVAgQYDSDLYTINGLTLEQRKR----------- 262 Anophele...
2_pfamImport         55 ---IEDEVDVLMSSDILAAQMSTKKINFSRAQt---GWfFRADRKELVAgQYNSDLFTINGLVLKSRKR----------- 117
XP_004226058        228 ---IEEEVDISMSTDIVDAAMKTKESVIESVNs---GWiFTHHKAEKIG-QFNADFYRISNLMLVTRKR----------- 289 vase tun...
CAG08519            208 mqpAEQEVAKRLTTPIVNTYLDTKEIAFERNKsgiwGW--RTEKTEVVN-GFEAKVFSVNNVNVVIRTR----------- 273 spotted ...
XP_006854269        323 fntcnendtesegyEDVLTEEEKKQ------------------LEMALkmgspengddgfsd--mvvshrhscyeqrdVF 382
EDV22628            285 --------------YEHLSEEDKER------------------NKT---------------------------------- 298
XP_001640192        129 --------------VEHLADEDRKQ------------------TQ----------------------------------- 141
CUT99623            224 --------------SEHLTKEDVRF------------------LSTLH-------------------------------- 239
XP_002016389        346 --------------REHLSHEDLQKnraiiesmrssvvqpdgrRSSLNsqttdtttdsnnpaapngitlpelprrsslQA 411
WGS:AAPU:GI20952-PA 341 --------------REHLSHEDLQKnraive-------titkgGNHTDsnaattpngsnl-------tlpelprrsslPP 392
Q7Q159              263 --------------REHLSRDDLQKnkalme-------sltkgGQGQQggidqnge---------------iyrreslQP 306 Anophele...
2_pfamImport        118 --------------REHLSSDDLQKnkmlve-------sftkgSNSSSgsltpngslkn--------epyevsrrsslIP 168
XP_004226058        290 --------------REHLSEEDIKKnkm------------lrdAISKGedagkildece--------dssdperrqslPA 335 vase tun...
CAG08519            274 --------------TEHLTDEEKAR------------------IK----------------------------------- 286 spotted ...
XP_006854269        383 IEG----------------------GEHSDGVSCEVKQEKKGWFGhwgKrgvksneghpkkfapprssvcmdekvsdllg 440
EDV22628            299 --E----------------------GRSFFHSLMGAIEQHSNEKD---K------------------------------- 320
XP_001640192        142 --S----------------------KSTMIASFLGIEEENQlnpaehvfatlvgrlnsfqs------------------- 178
CUT99623            240 SHI----------------------KQGTVNSAVKLVQDRA--------------------------------------- 258
XP_002016389        412 PPA----------------------SSVTWDQYLEAAVGRCprl------------------------------------ 433
WGS:AAPU:GI20952-PA 393 PPT----------------------TTVTWSQYIEAPVGKCpql------------------------------------ 414
Q7Q159              307 PPN----------------------CEVTWQDYVSAEPGQYpnl------------------------------------ 328 Anophele...
2_pfamImport        169 PPE----------------------TNVTWEDYINAEVGEMpsi------------------------------------ 190
XP_004226058        336 PEP----------------------SKITWKQYNNHRNSDpcl------------------------------------- 356 vase tun...
CAG08519            287 --SrsrvvftvlcgsserlislcsgERNILESLLGTVEQHISAQG---D------------------------------- 330 spotted ...
XP_006854269        441 dstiqsrpgrhsvevgvrgdEf-------Rr--vRETKDGkkfastses--------------shkrvkdgNRESEYKKG 497
EDV22628            321 --------------------TdavpetiqQdkreDSSEIEqadlkslssqdyfy----pteetkkqdigrpKEMSVKEQR 376
XP_001640192        179 ----------------------------------------------------nsmfppslwltdqndvgklKEMSVKKQK 206
CUT99623            259 -----------------------------Sa--vNEETADgvklprltprvtwrtyrswklqdndlyigrkPVLKLQTNE 307
XP_002016389        434 --------------------------------------------------------------------grpLVNKQSSKT 445
WGS:AAPU:GI20952-PA 415 --------------------------------------------------------------------graPVNKQSNKT 426
Q7Q159              329 --------------------------------------------------------------------greLVYKESSKN 340 Anophele...
2_pfamImport        191 --------------------------------------------------------------------grkMVYKESSKH 202
XP_004226058        357 --------------------------------------------------------------------grhRKEKLNTKR 368 vase tun...
CAG08519            331 --------------------M--------Tm---EYATAtnptaitpeeyfd------pdfelgnrdigrpIEMSVRTQK 373 spotted ...
XP_006854269        498 LRPVLWLSPNFPLST-EELLPLLDILANKVKAIRRLRELLTT------KLPPGtFPVKVAIPVVPTIRVIV-TFTKFEEL 569
EDV22628            377 LKASLWLCDDYYLSLqEQVLPIINLMAISNPHFQKLRDFISM------QLPSG-FPIKIEIPLYHILNARI-TFANLNGE 448
XP_001640192        207 FRATISMADPYPLSLqEQVLPIIKLLAISNAHFAKLRDFIAL------HLPSG-FPVKIEIPLFHVLNAKI-TFANINAL 278
CUT99623            308 MKLNVAMTNEIDFNI----TYLLDMF----KCFSPLRKFTKLdetilsSLPPG-FPVRIDVPVSPGITGRV-TFKSVELC 377
XP_002016389        446 LRATVAMSTDFPLSV-EMLLDVLEVV-APLKHINKLRNFVTL------KLPTG-FPVKIEIPVLHTVTAKV-TFQKFEFT 515
WGS:AAPU:GI20952-PA 427 LRATVAMSTDFPLSV-DMLLDVLEVV-APLKHINKLREFVTL------KLPTG-FPVKIEIPVLHTVTAKV-TFQKFEFR 496
Q7Q159              341 FKATVAMSKDFPLSV-DMLLNVLEVI-APFKHFSKLREFVTL------KLPSG-FPVKIDIPILPTVSAKI-TFQKFEFR 410 Anophele...
2_pfamImport        203 FKATVSMSTDFPLSI-EMLLNVLEVI-APFKQFTKLREFITL------KLPSG-FPVKIEIPILRTVSAKI-TFQRFDFQ 272
XP_004226058        369 FEASLGMSAEFPVRL-ENLLPIFAALGTKAKLFSKLKDFVTL------RLPSG-FPVRIDIPVFPTVKA-ViTFPQFEFR 439 vase tun...
CAG08519            374 FKGTLWMSEDHPLSLvEQVTPIIDLMARTSSHFARLRDFVTL------KFPPG-FPVKIEIPLFHVLNARI-TFGSVNKC 445 spotted ...
XP_006854269        570 Q-PLEEFCTPpssplpgrlvgrespsisanysngswfqwIKVPYRQgssgin---spssrVEDIQDPFAIPSDYT 640
EDV22628            449 NeAVQGLSPL-----------------------------EAKLDTtddv-------kqknYLIDDSCFDIPSSYS 487
XP_001640192        279 EsDVTGVNVAr---------------------------ePIMSEQPeegvasshnpltakCKIEEMCFEVPTGYR 326
CUT99623            378 EgDKmtn---------------------------------------------------sgFVLRDELFKIPMGYI 401
XP_002016389        516 Ns------------------------------------------------------------IPDKLFEIPSNYW 530
WGS:AAPU:GI20952-PA 497 Dn------------------------------------------------------------IPAKLFEIPAHYW 511
Q7Q159              411 Dd------------------------------------------------------------ISPDLFVIPEDYK 425 Anopheles gam...
2_pfamImport        273 Dn------------------------------------------------------------ISEELFEVPSDYV 287
XP_004226058        440 Ss------------------------------------------------------------IPSSMFTVPSTYK 454 vase tunicate
CAG08519            446 ----STDAELktt-----------------------pagTPTPTAEdeeaa-----dlspFQVCPSVFEVPPSYH 488 spotted green...
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