Conserved Protein Domain Family
DDE_Tnp_4

?
pfam13359: DDE_Tnp_4 
DDE superfamily endonuclease
This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Statistics
?
PSSM-Id: 463855
Aligned: 44 rows
Threshold Bit Score: 105.437
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EDO37985       98 IDGFEGKCQIPQlagAIKavrfkIKAPSLVTHKMKYyndnlkchSMTLQAVTDSSGKFLD-VSTGYPGGITNTEALAMS- 175
XP_001868759  118 LDGKHITIQAPP---N--------SGSTFFNYKKTF--------SVVLLALVDANCNFIA-VDVGAYGRNSDGGIFASS- 176
XP_001889281  217 MDGLNLPVQTSP---DQE-----IENTTFNGWLHDH--------FVSSVFAFSAKGEIIT-CNLNAPGSWHDSRVARPIy 279
Q54RV8         99 LDTTVFPIRT-------------MDDQFYSIKHSKR--------CLKYEAIVTLDKGTCChLTGPHVGSELDLVVYIKE- 156 Dictyostelium ...
CAR21568      127 IDGTHVKIARPHgnaR-------LECVAYSGHKKTH--------TLKYQAVTTPDGICID-LAGPFAGSQHDSFLFTNS- 189
Q9R319        109 LDGTVIRTDRVA---APGp---nGADLRWSGKHKHH--------GGNVQVIATPDGWPIW-VSPVRPGREHDTTCARHH- 172 Streptomyces c...
jgi:Gobs_0696 100 VDGTLIRTDGCR---TKNpd--tGHDLWFSGKHKAH--------GGNVQIVSDPDGHPVV-VSEVEPGSVHDLAAARAT- 164
EAY22388       15 VDSTTIPFNIPS---VKE-----ERLYSWDEKNHCN--------GIKLQVLVSPDGKAIH-QNVEFMAAVHDKKIFDLS- 76 
tgen:AM1_2372  57 VDTFEQARERPI---DND-----EQRSYFSGKKQQH--------TFKSQIVTLPGGKDIVdAIAGKKGPTSDISVFREH- 119
Q10YK6          7 VDSSEQSRERPK---ESE-----KPEKYYSGKKKNN--------TFKNQIITTPKGTEIVdVIIGERGPLSDINLLNKQ- 69  Trichodesmium ...
EDO37985      176 DIYKNVKqgvilnsps--atveglqvkPIIATDASYK--LRKw----cI-CPYP----------DNNMLSPSQ--ERFNS 234
XP_001868759  177 VLGKALAgnrlnvpeaaplpgtntltpHVIVGDEAFP--LKPy----lM-RPY-----------PGDNLDNAK--RIFNY 236
XP_001889281  280 EKLRAqtp-----------------egYYLVTDTAFPrgTDQiag-riR-APMKdgarlplnrlERERL------LQEDR 334
Q54RV8        157 VAHLDll------------------pgEKIFADEDFC--CNEfss-klI-RPIKk--------tHETMLTNEE--HCFNN 204 Dictyostelium ...
CAR21568      190 GLYRRlkpalk-----------vggiqYRIFGDPAYR--SSD------LlTVGY----------KGQNLTNGQ--KEYNT 238
Q9R319        173 GLVEALNriaa-------------eldMPTLVDFGYE--NAGdg---fR-HPFKk--------pAGSELTEEQ--QTYNK 223 Streptomyces c...
jgi:Gobs_0696 165 GFLGALHaaaallg-------lpalaaLAALADKGYH--GAGig---vL-TPTK-----------GRGLHSNN--LIRNR 218
EAY22388       77 KVSDFltvkrg-----------fddyqYPVLADRGYI--GIQkyhltaV-VMKR---------------SHEEadVERNN 127
tgen:AM1_2372 120 QSQFAPGqg--------------------fdGDKAYV--GAQn----vQ-TPHKk--------pRGKELTPKQ--KAQNK 162
Q10YK6         70 RENFKDNqy--------------------fqGDKADQ--GAEr----tS-TPKKk--------pRKKEMPEEI--KEKNQ 112 Trichodesmium ...
EDO37985      235 ELG-SAVHIAEDALARLRgRWNTLa--GSCLDEN-VEKIPETVLICCVLHN 281
XP_001868759  237 RLS-RIRRASENTFGIYMqMFRIF---NRPIQAK-PENVDKIIMAAIVLYQ 282
XP_001889281  335 QLL-SYRQTAEWGMRTIQgTFGCL---HVPLQIAyHEIRGDLLETCARLFN 381
Q54RV8        205 WVS-SNGIIVKNFFKDLK-KFEILkdwRSS-----IDKHMKMVYFLTWVVN 248 Dictyostelium discoideum AX4
CAR21568      239 ILS-GSRVSIEWFFGEVKnNFQIFn-iLGRLKVGgVRFCGAYFTIAVFLTN 287
Q9R319        224 VIR-GIHGVCERANSLLKtTFKAL---R-RVSLD-PSRITKIAAAALVLLQ 268 Streptomyces coelicolor
jgi:Gobs_0696 219 LIG-CLRAPGERGIALLKtRWKAL---G-RIRLC-PQRIGAIAKAALVLTN 263
EAY22388      128 AIA-QDRQIVERFFARFKsCWSCM---KNGFRGE-RTSLPLIISGLVGLTN 173
tgen:AM1_2372 163 KFSsTRRIFVEHTIRLVR-IFRVA---QERFRLR-HDTYEQVILTVCGLVR 208
Q10YK6        113 QKA-QKRIFVEHVIRLLK-IFGIA---RERFRLK-EKSYEKVIMVVCGLVK 157 Trichodesmium erythraeum IMS101
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap