1BBC,6Q42


Conserved Protein Domain Family
Phospholip_A2_1
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pfam00068: Phospholip_A2_1 
Phospholipase A2
Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.
Links
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Statistics
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PSSM-Id: 459659
Aligned: 111 rows
Threshold Bit Score: 71.4838
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BBC_A         2 LVNFHRMIKLTT-G--Ke----AALSYGFYGCHCGV--GGRGSPKDATDRCCVTHDCCYKRLek-rGC-----GTKFLSY 66  human
XP_003445625  26 MWHFGSMIQCAQpG--V-----NPLRYNNYGCYCGF--GGGGTPRDGVDACCQVHDKCYADSrkipGCgdvdnLPYIIDF 96 
3_pfamImport   1 LWQFGKMISCIQpG--V-----NPLIYNEYGCWCGF--GGRGSPVDELDMCCKVHDKCYEASrsipGCtavvdLPHIQVY 71 
XP_030852832  51 FLQFAAMIQCTT-K--K-----NPIQYQGYGCHCGFlnGGSAKPVDATDQCCMDHDRCLKELettgVCt---kHAFITTY 119
XP_001631251   4 ALDFYMLSQCIT-G--R-----DPADFNGYGCYCGL--GGEGFALDDLDRCCVKHDNCYGIIqdsgICgl-sfNVYTLPY 72 
EDO40720       6 LVQFGLMIKCTT-G--R-----SAFDYNGYGCWCGK--GGSGRAVDATDRCCLIHDRCYDAVirdrVCpw-giNVYTTVY 74 
EDO40990      17 VWRFASMIAKAT-G--R-----GAWQYTHYGCWCGL--GGKGNPVDAVDRCCVCHDVCYNKLidrgICnk--sRIYLVNY 84 
EKC17483      23 LTQFGHMIYSST-G--R-----DPFEFIDYGNWCGL--GGNGSVIDAIDECCFHHDNCYAVIigipACg----SVYTTKY 88 
XP_002127054  40 IWQFGVMVQCAE-GldHqfpmwTMENYNDYGCHCGM--GGKGDPLDVIDECCMEHDSCYKETrlrhk--vwkwQIYFTHY 114
XP_001632805   3 LDNFRKMIGCHT-G--N-----SAFDYIDYGCWCGL--GGNGSPLDETDECCYIHDKCYDDIiarsTCgy-sfQVYFRDY 71 

1BBC_A        67 KF---SN--------SGSR-ITCa----------------KqDS-CRSQLCECDKAAATCFARnkTTYNKKYQ 110 human
XP_003445625  97 DF---TC--------NNQR-VTCs---------------aAnNT-CQAAVCECDRAAAHCFAQ--NTYNPENK 139
3_pfamImport  72 DY---TC--------SNKQ-VTCp---------------aTnDK-CQAATCKCDRDAAYCFAN--AEYKPENK 114
XP_030852832 120 AVemkGCg------kKKAAnITCkpqadyspleatfafgkVd---CAESLCRCDRDAAVCFSQ--NPFQNRYK 181
XP_001631251  73 TY-------------SADC-KTCdepsv--------ywfyGk---CRHALCLCDLIAAKCFKE--TAYNEKYR 118
EDO40720      75 FR------------------KGCnif------------gkTnNP-CQYRICQCDSAAVRCFKR--SYYNNRYK 114
EDO40990      85 YF---TGkktsgfwrWKKT-VNVs--------------------rCGYEKCKCDAAAVVCFRR--NRFNKKYR 131
EKC17483      89 NF---NI--------SKGE-IECh---------------dE-RP-CERALCNCDRRASLCFHAnrKAYNSTNK 132
XP_002127054 115 NY---QC--------HGKR-ITCyn----------------gSS-WKQDLCQCDVKAAGCFATnrAKYNRAYK 158
XP_001632805  72 KH---SC-------------TRCeplss--------ypsdDyYReCRVDLCKCDSEAAKCFKQ--ARFNPDLE 118
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