3M63


Conserved Protein Domain Family
Ufd2P_core

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pfam10408: Ufd2P_core 
Ubiquitin elongating factor core
This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, pfam04564, which has ligase activity.
Statistics
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PSSM-Id: 463080
Aligned: 153 rows
Threshold Bit Score: 300.643
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3M63_A        224 LGPILSLSPIEa--------------aVAIRNYg---dNLLRSkqQTAM---IHESLQAEHKVVIDRLFFIVDKLVRGSl 283  baker's yeast
Q23QU7        291 LGPFLRISTVDflivhed--drksvqeMRNKVFlefnnIRSNQ--QYNLqikYYSELNQNYTKLLVELF----KMLLKKt 362  Tetrahymena t...
A0DHJ7        238 LGPLFTISLLQdnryvrerahqslkvkMTKRQFe-----------------lLLKQYQQTNQNHVENLVSLIKLCLSR-- 298  Paramecium te...
A0BFS9        467 FGSILCLSTFPrd------------fpEVNKIFc-----------SDQGlpiLIECYRRPIYEIINQMADIFLRIIRRGk 523  Paramecium te...
A0BR25        373 IGKILSGSCFYtd-------------sMIVNKFt----------gDYSSmtiLRDRYRTRIFNLNDDVCNLFTRILKHKs 429  Paramecium te...
A0DLL3        312 vGILLSLSSFPtd------------ghLWKSHFs----------dDRKQmmeQMSSLRTRMFTIIDDLCMLFEKILNSNe 369  Paramecium te...
XP_001566746  275 LGVLFGLGPKPmaaara----pngnwlEVLELFpyqkkDEHQQ---------TVYTMQQEVKALAKMNVQLLQSLLRVN- 340 
Q4DG09        271 LGALLGVSTQIrshrllppysmsseraQLMSMFs----------tEVDDhskQISDLQFQMQASCAGNKRIILALLQAK- 339  Trypanosoma c...
Q584R0        275 LGAILGVGVFSrasrplppllrmvewrGYMDMFp----------tESEDhsqKISDLQSSMETACDANKRIVLVLLQNK- 343  Trypanosoma b...
XP_002141583  248 fGGFISPNPIDkslqsk-----dnlnpIIQKYF------SGILmkTQTQitqCKLSIKNELSLIHEQSLILFRNILKSNi 316 
3M63_A        284 ---NSRTDMISYFAHIANKNHLRRADH-----------------PPFK---------ELSSNGFMSNITLLLVRFSQPFl 334  baker's yeast
Q23QU7        363 gnyNYANETLRFVAACIIGNKDRAKLYrr--------------lEQQNkq------pITSSDAFMANILDVMLEIAKIIf 422  Tetrahymena t...
A0DHJ7        299 ---NTFQQTIQFFNHVCFCNKFKTKEG-----------------YQQNrmmn--lkqNVSSDGFLLNIYDTLLLLSNKIs 356  Paramecium te...
A0BFS9        524 ---KSQLELFTYLVKLIEINLDIEKVTeke------------------------kfdKCCYQGMMFNLQQVLLEIFNPFi 576  Paramecium te...
A0BR25        430 --nVLKMNFYNFISTIITLNLNLEKQFnqg------------------------lqqQCSSPGMVFNLHYVLLKMFNPWi 483  Paramecium te...
A0DLL3        370 ---ILRYKFFEFLSNIIKLNLNLEKQLniq------------------------lqkLSSSPGLVNHLFYILTYLFNKFa 422  Paramecium te...
XP_001566746  341 ---MTRNATLRYLGQALQLNEDYLKTM-----------------HHDS---------PISSRYFMIQLQSVLIELALPIf 391 
Q4DG09        340 ---VSREPTLRYIGTALRLNAGYTKTV-----------------HHNL---------PLSSRYFMTQLNDVLLEAALPLf 390  Trypanosoma c...
Q584R0        344 ---LSRFHTLRFMGSALRLNAGYTRTM-----------------HHDL---------PLSSRFFMCQLNDVLMEAALPVf 394  Trypanosoma b...
XP_002141583  317 ---NNRRKVLKWIGLVCCSNEGRTKLFnaisslsslrnnsntrsLQSSiqslilrtsGQTTNGFSLNVLELILKLLEPV- 392 
3M63_A        335 d-----iSYKK-----IDKIDANYFnn------------pSLFI-DL-SGETRLNs----------DFKEADA-----FY 375  baker's yeast
Q23QU7        423 n-----kNDNK-----WEKIRPEFFs-------------qSQRLtYL-KEEPFYSkeki---sdsvMQEEISE-----F- 469  Tetrahymena t...
A0DHJ7        357 grt----------ddtYTKIDKQFWyt-----------------iPFeKEQMLLSssi------plSKQNIQI------- 396  Paramecium te...
A0BFS9        577 yntnqanAK-------LSKINKDLLaqiknq---pllakiYSNVkQMaPLKTELIqldk--------------------- 625  Paramecium te...
A0BR25        484 dtqdkinSR-------IKNIQTQMIivlkeh---plfstlYQNIdLLaPDLTPLQelqel-------------------- 533  Paramecium te...
A0DLL3        423 dsqttinLF-------IKKIDLNLLsyckkh---plfqplYQNVdLLaSELTPFVepkef-------------------- 472  Paramecium te...
XP_001566746  392 qartnkeDMSSgcsydYRQIPAHYLldrl--------ygpHGVVvSFgSDVERVAhydndnplplvPSNRGAY------- 456 
Q4DG09        391 ek-----------aydPTTIPPFYVled----------naDNTVvDFgEDVERIVhydeshplppfPALSEPF------- 442  Trypanosoma c...
Q584R0        395 tk-----------gcdASSIPPAYLled----------pgEETVvDFgESVERIThydenrplpsfPSLQEPF------- 446  Trypanosoma b...
XP_002141583  393 -------KIEK-----VLDLDYFYIlwgkldengdignevKSILgDLiNEATLG------------DKEKIKQwtdiiEA 448 
3M63_A        376 ---DKNRKtad--skpNFISDCFFLTLTYLHY--------GLGGTLSFEE-KMGSEIKALKeeiekvkkiaanhdvfarf 441  baker's yeast
Q23QU7        470 ----------------GTITEYFFLCQQLAHY--------SIIPMFADFK-ENAEQLQRTEkevkrmpqshpl------- 517  Tetrahymena t...
A0DHJ7        397 ----------------GNVSYLFFYTLKFVQI--------GIIPVIQRMK-DLLKLMQEKKdllelmkdhpqegll---- 447  Paramecium te...
A0BFS9        626 ------------tpeiDPMTFLYLLIQKINSLqqhmiidyVISYVILQYDkRHFGSSSKLTqqs---------------- 677  Paramecium te...
A0BR25        534 ------------etrmDPMTIMFLLSQRINHIvatnidqfYYNRVLSKLR-DIAQQYGQESpqfr--------------- 585  Paramecium te...
A0DLL3        473 ------------ktiiDPMTALYLLTQRLSHIvatclqqfYISTIMREMK-DLPQEAFQTQvfd---------------- 523  Paramecium te...
XP_001566746  457 ----------------KPFIHLFFLAARAVTL--------CAAVLIDEHD-RDERQATHPQasqqq-------------- 497 
Q4DG09        443 ----------------KPSVHLFFLVARSIML--------SAGVMIETHQ-RVEQDLAHPQlppeq-------------- 483  Trypanosoma c...
Q584R0        447 ----------------KPTVHLFFLAARSMML--------SVSVLIELHE-RVEHESSRPNtstqq-------------- 487  Trypanosoma b...
XP_002141583  449 kkiDIENKkleyndiiRFPTQIFWLSCKAIIV--------FMHPILSEYE-NKIHELNEYRnnstsmgllr--------- 510 
3M63_A        442 itaqlskmekalktteSLRFALQGFFAHRSLQLEVFDFICGASTFLIR----VV-----------DPEHE-FPfkqikLP 505  baker's yeast
Q23QU7        518 ----ykmaeqkvnemkAYYFQYNAFLQMDSRLYVQRDMYDLLFFLLPRwlrlDI------------------------SK 569  Tetrahymena t...
A0DHJ7        448 --------kdeiealdeevhqlELVIFNPSRIKDTVQLFDTFIFLF---------------------------------- 485  Paramecium te...
A0BFS9        678 ---------------eidKAKYDVLLLNPRSVQNTIQFLSFQSKVA---------------------------------- 708  Paramecium te...
A0BR25        586 -------------dilKLKMSFDAQILHPKTITNTMQFLSFSSQLA---------------------------------- 618  Paramecium te...
A0DLL3        524 -------------illKRKISFDLQILHPKGIKYITQFLSFANQLA---------------------------------- 556  Paramecium te...
XP_001566746  498 -----------rdfftAEKLLVEGLLGSNELSASRLEFLNHLAHWLLT----VMqvddq--------------------- 541 
Q4DG09        484 -----------ravyvAEKSLIEGLIGSENLGRKRVQVLNGIAAWLVR----LMnvspg--------------------- 527  Trypanosoma c...
Q584R0        488 -----------ralciVEKSLVEGLIGSHSLGQKRVRLLNGIAGWLVK----VMgtled--------------------- 531  Trypanosoma b...
XP_002141583  511 -------qdteferltAELLLYDCTLFHTNIMTTYWHFLSIFCHFIIR----SIynfdeygnkikEWDDLiHSkqgklln 579 
3M63_A        506 L-----IpdqigvenvdnadflrAHAPv-----------------PFKYYPEFVVEGPVNYSLYISKYqtspIFRn---- 559  baker's yeast
Q23QU7        570 LhnniiP----------------DYKPc----------------sLLNSLPENMITDVFDYHFFYTNFrrdyVKTs---l 614  Tetrahymena t...
A0DHJ7        486 -------------------------KSwlnlnkmvdgqtqwqqpdILNYIPEFLINDIIDYVDFYMQN----FEGft--e 534  Paramecium te...
A0BFS9        709 -------------------------QSllden--------ykpkyPYGLLSNQFMNDIFHYCFIY-------NSNnlald 748  Paramecium te...
A0BR25        619 -------------------------LSmvden--------dkpkyPYGLLPSSFVYDTHSFFVVY-------NYNdeilk 658  Paramecium te...
A0DLL3        557 -------------------------LSlidtd--------lkpiyPYGLLSATFLIDTQTFVSIY-------AYNdeiin 596  Paramecium te...
XP_001566746  542 -------------------gvlpAEPPa-----------------EWGYLPQCLVNCVI-------------RATsmapl 572 
Q4DG09        528 -------------------gvlsKEPPe-----------------EWKYLPQQLVDLVI-------------LGVkmapl 558  Trypanosoma c...
Q584R0        532 -------------------gtllPEPPe-----------------TWKYLPQQLVEVVI-------------RGMqlapl 562  Trypanosoma b...
XP_002141583  580 amr-------------nfgqpssslSP------------------QFSVLPSRIVDDIMTTTELILR-----IKGndesi 623 
3M63_A        560 PRL--GSFVEFTTMVLRCPEL--VSNPHLKGKLVQL----LSVGAmpltd-----nspgfMMDIFEHDELVNKNLLYALL 626  baker's yeast
Q23QU7        615 TEQyiNSFLEMTVLFLSNCQI--SSNPYLKAKLVEI----LYFFYhsd---------kskVHSILSKNLYAKRNITASLM 679  Tetrahymena t...
A0DHJ7        535 NYFnhQKFIALAELGMYFIHLpiATNKYLAGKFIEVilffTKVTKks-----------lnLSYIFVQNELIRDNLLLGLM 603  Paramecium te...
A0BFS9        749 YLDevISICEFTIITMKYQEL--IEDTHLRVLGMHLfyifNDYVIqqqhg-----kasdkAFKIFSENKVIKEFLIEGLI 821  Paramecium te...
A0BR25        659 HSNelGKCCEFAIFAMNTRN---MTNPHLRIKGIELfhifDQGRMnrrgi-----vqpqsYDFIFRYNEIIEKHMIGGIL 730  Paramecium te...
A0DLL3        597 YVIelQKCCEFAAISMN-KKL--LPNPHLRIRSINIfqiiDETKGsflqkytrqnwrqsqELNILFDSKFLRTCLVDGLI 673  Paramecium te...
XP_001566746  573 DGLysDGMISLMLVLMGNTKY--FPKPHTHALFPAYllrlQENYT---------------TRKVLEQHPWFSTHIVRACM 635 
Q4DG09        559 EYFdlEHIVSLMLVLMGNTTY--FPKPHTHALFPSFltrlLQNEE---------------TKRALTSHRWFTQHIVRSCV 621  Trypanosoma c...
Q584R0        563 DYPdvENVISLMLVLMGNTVY--FPKPHTHALFPDFllrlLRNED---------------TQQALMAHRWFSQNIVRSCV 625  Trypanosoma b...
XP_002141583  624 IGFdfDSYISLCISLISFGNY--FNNPHSRCQKGVGsihyLLQLPq--------------YRQKIETNEDCIEFILPNLI 687 
3M63_A        627 DFY--VivektgsSSQFYDKFNSRYSISIILEELYyKIPs-YKNQLIWQSQNNAD------FFVRFVARMLNDLTFLLDE 697  baker's yeast
Q23QU7        680 KFY--IdieftgdSHQFYSKFNYRHYVNYLYTKLW-VEEt-YQNEMKKLINEP--------LFERFINMLINDATYCTDE 747  Tetrahymena t...
A0DHJ7        604 TQY--SavgetgaNNQFYAKFQYRFYINDILFQLM-LLQi-YQTQLKKYVKCE--------LGQRLIKLMISDMNYGFEE 671  Paramecium te...
A0BFS9        822 KAY--Vdqd-kvkVTNIIPTFRFKQAVSQLFSYILtTHSniYNKKFVDYVQSNTD------TYSNFALAYINDIKELLDQ 892  Paramecium te...
A0BR25        731 KVF--IdcertgeGNQFYEKFNFRYQFCKLIRFLLeKHRdrYNSLLTQTVEKEKE------MFLAFANYYLNDMIFLLDE 802  Paramecium te...
A0DLL3        674 QSF--IdtekvaeGNQYFQKLNIRVKICLIIRYLLqVHKslYQESLFHGFKNDQE------QQLHFSNYFLNDFIYVIEE 745  Paramecium te...
XP_001566746  636 ECY--Iave-----kssYERVEVRYELSYAIKTFL------KSNLLCDPVREEMEsqanntMLERFSHMAVAEVNEAVDQ 702 
Q4DG09        622 LCY--Iave-----kstYEKVSVRYMLSYCTKSFL------MFDSLCQPVREEFEvd--gtILERFSHMVTADVNEAVDQ 686  Trypanosoma c...
Q584R0        626 LCY--Iave-----kstYEKVSVRYTLSRCTKSFL------LHESLCQPVRAEFEag--gtLLERFSHMVTAEVNDAVDQ 690  Trypanosoma b...
XP_002141583  688 SLFndVq------KSPYFDRFSLRLPIIILLENLI-GIEs-HRNRLYSFVKDRDE------AFTKFIHLLVSDLNYLLEE 753 
3M63_A        698 G-LSNLAEVHNIQNELDnrarGAP------------------------------------------PTR-EEe------D 727  baker's yeast
Q23QU7        748 G-ISNMQKILDTRSKQDvn----------------------------------------------tLSP-QE-------Y 772  Tetrahymena t...
A0DHJ7        672 IwTNYLETYKKKQLDVPntfeQ---------------------------------------------------------K 694  Paramecium te...
A0BFS9        893 C-LSTTQKLKQEEDSAQtvqv-----------------------------------------rnptLQErKE-------K 923  Paramecium te...
A0BR25        803 C-LTRMKRMKNLESNQQe-------------------------------------------------------------F 820  Paramecium te...
A0DLL3        746 C-LLSLKNIKKLQVEQQ--------------------------------------------------------------S 762  Paramecium te...
XP_001566746  703 V-IDTLTRMNEMVKAGAdlseNAVtssssqntadglhgqqq---------pqvrhqrnnanrseeaVSSeDDgeedeveN 772 
Q4DG09        687 L-VETLTQMNRMVKEGAdlsvSARaslsnngenirrgnaqrrqegmatsnsnnnnnqnnnfrsadgNVNeEEaeadgddG 765  Trypanosoma c...
Q584R0        691 L-IGTLTQMNRLVREGAdlseNPNphrgdgggndgtag----------------raatvnrgthrnteNeEEse---deT 750  Trypanosoma b...
XP_002141583  754 G-MSMLAEIKKREISNNanrdNLQtnnniyndsnnni----------------nitnqssnqnnedLEHeSAyqnsdiqS 816 
3M63_A        728 KELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAAFVT-PEIVYRLASMLNYNLESLVGPK----CGELKV-KDPQS 801  baker's yeast
Q23QU7        773 QLYDRMIGSSSHFNKQ----SRETIGLISNLSIWAPQPFLS-DTFLDVITGMLNNFLQKMMDPT----LNQYTT--D-KE 840  Tetrahymena t...
A0DHJ7        695 YNKKRELDLIKSQIQSNLQNMKSNLKLLVEFSNHIPKDLMN-EFFQEMILKMINYYLDNFLNERs---KEKLDSlKKIAE 770  Paramecium te...
A0BFS9        924 ILKQLFLEIAEKKCLGDWKGFEELFKNIVLFTKIEPKAFLI-EESRQTFTENLNYVVVKLNGPEn---NNCLTS-KFFTK 998  Paramecium te...
A0BR25        821 MDNKQEYLKIQQELKTYTIFLQEYYKNIQVFSEVQPEAFLT-DEIRDKLANNLNYTLEQLNGKQ----AIQYKI-QSLES 894  Paramecium te...
A0DLL3        763 FFQNHQLHKLQKELTIKSQFFYEYLRSLEVITSIQPEIFLI-DEIREKLAIHLNYILEQINGKSsediAQNIDV-QN--- 837  Paramecium te...
XP_001566746  773 TDRSQTYHERGMSLRSHLMLFTASMDMFIELSLQFPKGVSQ-NMVAGQISEMLARSLMAFAGPN----SRNLKI-QNADL 846 
Q4DG09        766 E-APLTYHQLGLGLRERILLFEASMNLFIQLAISFSKGVAQ-NMVAQQISQMLARSLVSFAGAE----SKNLKI-EYPER 838  Trypanosoma c...
Q584R0        751 EGSPQSYHQLGLGLKQRILLFEGSVDLFIQLASSFPKGVAQ-NMVAQQISQMLARSLTSFVGAD----SKKLKI-EHPER 824  Trypanosoma b...
XP_002141583  817 SIEEMPLERLNQSCKGYMQLSHTSASLLQKITQYYPEEIIDsPLILPQIVTCLNSTLDRLVGPK----CLELKV-SNFES 891 
3M63_A        802 YS--FNPKDLLKALTTVYINLse--------------------qSEFISAVAKDERSFNRNLFVRAVDILGRKtgLASPE 859  baker's yeast
Q23QU7        841 FD--FNSSVIVKDLIIIYSSLgh--------------------dKSFRQKVTADSRSFDQKLFETALKRVRKEq-QIGQQ 897  Tetrahymena t...
A0DHJ7        771 KD--FKLAVFLQQIGIFFTNIcd--------------------eKKVVSILVKDDRSYHIENFQKLEQIFRNNi-AGQQD 827  Paramecium te...
A0BFS9        999 YDvkIEPRHLSNYIVDIFINIkn--------------------qQEFWDELAMNNSTLQLEILHQLVNQMGYLk-LKTQY 1057 Paramecium te...
A0BR25        895 VN--FDPKLIMGNVIELYINFsq--------------------nEKFLMQVVKDDRCFSIELFQVTINLLDKHh-IIPYE 951  Paramecium te...
A0DLL3        838 ----FDKMFVVEILINVYTNLrk--------------------nQQFILEVVKDERSFSVELFKKTQNETKQYinYEKYS 893  Paramecium te...
XP_001566746  847 YN--FRPREVLMRLVDCFTHFrr--------------------sKSFLRCLCHCSIPLSD--ISSVMRTIVDRq-LISED 901 
Q4DG09        839 YN--FRPREILNRLVDCLSQFrr--------------------fQNFMRSLCNCGVPLRE--ILQAIETVTERg-LVGEH 893  Trypanosoma c...
Q584R0        825 YG--FRPREILGRIVECLVQFvr--------------------lENFLRCLCNCGVPQKD--ILQAMKVISERg-LVGEH 879  Trypanosoma b...
XP_002141583  892 YN--FNPRQLLANICLTYIKLsfknistmtnsvnlstnseqeicSQLISEIIEEQRFFKVATFAKAYHIVRREg-LLNLV 968 
3M63_A        860 FIEKLLNFANKA 871  baker's yeast
Q23QU7        898 IIEKFQDFLNNL 909  Tetrahymena thermophila SB210
A0DHJ7        828 KVEKLSRFIQSL 839  Paramecium tetraurelia
A0BFS9       1058 QLQEFLQIINSL 1069 Paramecium tetraurelia
A0BR25        952 RIQQFRDLIFKL 963  Paramecium tetraurelia
A0DLL3        894 L--QFEEFINQV 903  Paramecium tetraurelia
XP_001566746  902 LIWKVSEMKSAV 913 
Q4DG09        894 LIWKLREIASTL 905  Trypanosoma cruzi
Q584R0        880 LVWKLNEIASSL 891  Trypanosoma brucei
XP_002141583  969 QLKQFGQLVKII 980 
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