Conserved Protein Domain Family
LPLAT_LCLAT1-like
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cd07990: LPLAT_LCLAT1-like 
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.
Links
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Statistics
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PSSM-Id: 153252
Aligned: 72 rows
Threshold Bit Score: 84.2123
Created: 5-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative acyl-acceptor binding pocket
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 #  # #                 
Q6NYV8        55 VALLElv--------lgVKVVVTGdgfi-------------------pgeRSVIIMNHRTRLDWMFLWCCLLRysylrqE 107 zebrafish
XP_636516    169 CYLLGi----------dVQIEVAGdvnssfiahyydkgfkkrladslgigPKIIFSRHASFADTLVPQGIFSLfy---hM 235 Dictyostelium d...
ZP_01906199  110 GALFElatt-----lfgLRWTVEGaela-------------------ppaPALYLTRHASIIDTLVPNVFVTAans-ipL 164 Plesiocystis pa...
YP_002432343 116 FFIFS------------VKLKTEGaeca-------------------fpgPMVLMIRHASTADTVLASVLVAKsfk-mrL 163 Desulfatibacill...
ZP_03888682   94 RLLLDvlmrva-qrlfaLRLVTDGeswspldd-----------gtpgstnAMVVLSRHAGPGDSFLLVHTLMNrdhlrqP 161 Geodermatophilu...
EEQ81437      51 CKILNil--------sdRIFEFEGenli------------------npreNYLVISNHVNEYDFLVLSNLFNNsenlsnV 104 Nosema ceranae ...
YP_889975     87 RRILD------------VEVLLDTgsvepg--------------evprdePVIVFSRHCGPGDSLLIAWLLTFhyr-lrT 139 Mycobacterium s...
XP_002121380  62 LYVLYmssagswgdlagHTFLLTGddvsv-----------------iageESLLLLNHQTPVDIAVLMRCLHAtpnaaaS 124 Ciona intestinalis
NP_001026220  63 KWLLAmvasw--gwwagYTVVEWGddvka-----------------vsedEAVVLVNHQATGDVCTLMMCLQDkgtvvrQ 123 chicken
CAH69078      63 RWLLAmvasw--gwcagYTVTEWGddvsp-----------------mtedEAMVIVNHQATGDVCTLMMCLQDkgtvvrK 123 zebrafish

Feature 1           ####                                                                         
Q6NYV8       108 KICLKAALKsvPGFGWAMQVAs-FIFIQRrw-----edDRTHMSNMLQYFcrir----------------epvQLLLFPE 165 zebrafish
XP_636516    236 RYIVKKELLwdPALDVSGSRTp-NFFLFRdagtdgmevEIEAIKSMVSDFkpt-----------------epdVTCIWPE 297 Dictyostelium d...
ZP_01906199  165 RCVVKRELLnePCLDIAGQYIp-NHFVDRdpsd--sehELAAIEALAAGLdp-------------------geGLLIYPE 222 Plesiocystis pa...
YP_002432343 164 RFVLKQELLwdPCLDVVGNRIp-NVFVQRdgkt--tdrELAAIKDLSKDLss-------------------rdGILIYPE 221 Desulfatibacill...
ZP_03888682  162 RIVLKDLLQldPLIDVYLNRLp-NHFVSAdpav--gygSEEAIADLARNLge-------------------edALLIFPE 219 Geodermatophilu...
EEQ81437     105 KYVMKSEMRnyYGIFQILDLLn-FLTIERdi-----kkDEKTIKNYCSRInkae----------------saiHLVLFPE 162 Nosema ceranae ...
YP_889975    140 RIVLKGLLRcePVLDLAGDLGc-LCFLSR---------GGKRARAQVRELaasl---------------aggdALLLFPE 194 Mycobacterium s...
XP_002121380 125 TMWVSDWLIq-FIPYGWMAKChnDFFLLQs-------vDAKRLKMFFKNSetsnelvrlqksivdnfrsrnrkWVIVFPE 196 Ciona intestinalis
NP_001026220 124 MMWLMDHIFk-YTNFGIVSLIhgDFFIRQgkah--rdqQLVLLKEHLEKYyrsr----------------nrkWIVLFPE 184 chicken
CAH69078     124 MMWLMDHVFk-YTNFGVVSLIhgDFFIRQgkah--rekQLVYLKDHLDKFyysr----------------drkWIVLFPE 184 zebrafish

Feature 1        ###                                                                             
Q6NYV8       166 GTDLTEntrarsd-------efaeknGLQKYEYVLHPRtTGFTFIVDTLRGgdnl------------------------- 213 zebrafish
XP_636516    298 GTRFSKskrekvlesfkkkndtknyeLASNLKHTLLPRvGGVLSLLEANPCg---------------------------- 349 Dictyostelium d...
ZP_01906199  223 GTRFTEgkrcrviarl-eqkqpelaeRAVALEHTLLPRpGGTLALMRGAPQa---------------------------- 273 Plesiocystis pa...
YP_002432343 222 GTRFQQhklekiqkrfkeqetpvissMAAKFTHVLPPRiGGFSAITEAAPDa---------------------------- 273 Desulfatibacill...
ZP_03888682  220 GANFTPqrrtraiqrlrdrgllaavrRAEAMRHLLPPRpGGVVAALQSAPHa---------------------------- 271 Geodermatophilu...
EEQ81437     163 GTLITEntinksk-------efrkskNLEPLDYVLSPRyKGFKVIAEGLKDsnik------------------------- 210 Nosema ceranae ...
YP_889975    195 GGNFSWarwheaisrlrssgrlrearRAWRQSYTLPPRtGGAAAAMAGAPHa---------------------------- 246 Mycobacterium s...
XP_002121380 197 GGFLSKrrsgsq--------rfarknDLPILEHVALPRsGAVQCILDTLGVdgkypgkngscdnsagftalgpttnrnss 268 Ciona intestinalis
NP_001026220 185 GGFLRKrretsq--------afakknNLPFLQHVTLPRlGATQVILKTLVApqengtpaggdav------------ikes 244 chicken
CAH69078     185 GGFLRKrretsq--------sfakknDLPYLTHVTLPRlGATQIILKNLGPqqengilgtdgspp-----------gqsn 245 zebrafish

Feature 1                                                    
Q6NYV8       214 -----davhDITVAYPqnipqterh----llagvfprEIHFHVQ 248 zebrafish
XP_636516    350 ---------DILFCSHfgmeassdfg-qmmngelcnrVVKIKFE 383 Dictyostelium discoideum AX4
ZP_01906199  274 ---------DVVIVGHeglggfatva-dlwsgeiigrEVHVRFW 307 Plesiocystis pacifica SIR-1
YP_002432343 274 ---------DIVVCVHtgfegsanfs-efwqgaligkTVKVAFW 307 Desulfatibacillum alkenivorans AK-01
ZP_03888682  272 ---------DVVLVAHtglehlstvr-dlwrslpmdkTLHLRWW 305 Geodermatophilus obscurus DSM 43160
EEQ81437     211 ------kvlDITFTYPecvqptlssilfsnqkykikyTMNIHEL 248 Nosema ceranae BRL01
YP_889975    247 --------sVLVLTHSgfsadgrar---pwwrlpvhrRLVVHVS 279 Mycobacterium smegmatis str. MC2 155
XP_002121380 269 dscpikwiiDVTIGYKqtmscsef-----iighrgrqTIHVHYR 307 Ciona intestinalis
NP_001026220 245 kskglqwviDATIAYPkgepidiqt---wilgyrqptVTHVHYR 285 chicken
CAH69078     246 kpkglqwviDMTIAYPnarpmdiqt---wifgyrdptVTHVHYR 286 zebrafish

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