3J9M


Conserved Protein Domain Family
MRP-S23

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pfam10484: MRP-S23 
Mitochondrial ribosomal protein S23
MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.
Statistics
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PSSM-Id: 463108
Aligned: 27 rows
Threshold Bit Score: 136.62
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J9M_AS        2 AGSRLETVGSIFSRTRDLVRAGVLK--EKPLWFDVYDAFPPLREPVFQRPRV--RYgkaKAPIQDIWYHEDRIRAKFYsv 77 
Q7QD03         2 ANSRLEKIGTIITRTQGLLKSGAMKfdERPLWYDVVTAFPPHEEPRYDRPAP--RV-----PVRQIFYQEDTVRAKFHks 74  Anopheles gambi...
Q8IP62         2 AQSRLEKIGTIFTRVQGLLRGGAMKteDKPIWYDVYAAFPPKLEPRFDRPAP--EI-----PVRQIFYAEDVVRAKLHke 74  fruit fly
EFA07822       2 AQSRLERIGTIYTRAQGLIKSGGVRweDRPLWFDIYEAFPPKEEPNYDRPAP--NI-----PIKQIFYEEDKIRAIFHrn 74 
XP_003425757   2 AQSRLEKVGTIYSRLTSLIKSGGIPeeNKPIWLDLYKAFPPKYEPTFSRPAS-------GPPVRKIFYTEDLIRAQFHkh 74 
XP_011260048   2 AQSRLEKVGTIYTRVISLLKGKAMKeeDKPLWLAVYEAFPPKYEPRFDRQLP--KK-----NIKNIFYKEDLIRARFLkd 74 
EEB16657       2 A-SRLEKIGSIYARVSNLLSKRKPGsiEKPLWFDIYTKYPPIQEPLWNRPPL--DI-----KVKEIFYEEDKIRAKVHka 73 
XP_002641727   4 FITRAERSGNIFSRVTGLIRAGQLSwaDRPLWYDVYISSPPLSPPDWNVKLP--KF---DQPIRPIFYEEDVLRAKFYkt 78 
PDM67811       4 FVTRSERAGNIFFRITALIRSGQLQwaDRPAWYDVYVAHPPLTPHDWNVQLP--KY---NEPVKKIFYEEDIVRAQFYkn 78 
XP_002108327   2 A-SRNFKVGTVYTRVLGLLKSGAIK--QKPLWFDIVETFPPILPTMHNRAPVpgRA-------RKLQYWEDEVREKFYke 71 
3J9M_AS       78 ygsGQRAFDLFNPNFKST-CQRFVEKYTELQK-L--GETDEEKLFVETGKALLAEGV 130
Q7QD03        75 -gkATFAVNLLDHNNRTP-TQQFIELYQSLST-Q--GALDEEQVFATAIDLHEDKMR 126 Anopheles gambiae str. PEST
Q8IP62        75 -nkPQETISLFDHRRSTQ-SQQFVQIYQDLKG-Q--GALDEQRIYETALDLLAEQRQ 126 fruit fly
EFA07822      75 -nkKIGATHLLDTKYKTL-TQKFIESYTTIQA-QygESATEEQIYKEAIDLLKKSHQ 128
XP_003425757  75 -hrRYSNVNLLDNKSVSR-TESFILIYRQLEK----DGVPQDEIYNKAIEEFLEKFK 125
XP_011260048  75 -qdFIPAINLANESVPSA-TQNFLSIYKTIKE-Q--EKLSGNETYKKAMQQYTSEVK 126
EEB16657      74 lknKLTPFNLADNRNNNE-SELPIKLYQDYVS----QGLTEDEAIQKLTEDFNKDKQ 125
XP_002641727  79 yrsTAGIQ--VDSSRTSV-SQQFINEYKLVKSeN--ASATPEELFELTTKRLNENGI 130
PDM67811      79 hrnVGHVS--MDKEGDSI-SQQFINEYQALSKeE--PNLPMEEMFAKTEKRLEDVGL 130
XP_002108327  72 -fkFIEPVNLYETDNKPTiCDRFIMHYEQFSQ----EETDGDVAFAKSKEALEQEGV 123
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