Conserved Protein Domain Family
MRNIP

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pfam15749: MRNIP 
MRN-interacting protein
This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP.
Statistics
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PSSM-Id: 464843
Aligned: 28 rows
Threshold Bit Score: 83.5301
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBN74166                  10 ALRCFSCQCF-QVNQRTK-SGKWKCRMCGEGQSIVKVWGrGGHAKDVRGLVMALNAAAGGGEDLNNvlrnnvggfgpqsq 87 
XP_004994640               8 YVFC--CRLFpRLHQTKK----WKCKLCGEAQSVRKIFF-KGTGKDCRTRVQALNLRRGEMESISAetame-------rd 73 
XP_002986378               6 ALRCYACKMF-QVKPRKKsSSKWCCSVCNEKQSVTKVYGsSGAAKKIRELVQTLNYSPLAQEQDHFepndvgdlttqeng 84 
Q9M9H0                     8 ALQCYECSTM-QVKQKKKsSNKWVCVICNQKQSVKKVFAqGYKAKELRFFVQSFNMSRKVADEEAHavgdsfpevyvege 86  tha...
WGS:AAFB:cds.EHI_076270A   7 LLQCFSCKMF-QVHIKKK-TKKFECKVCGAKQSYKHIFGiSKQAKDLRQICGEYNEKRIIEEEQHIekqvk------qkq 78 
EGG18937                   6 LLQCYSCHTF-QINQKTK-VSKFQCKICNEKQSVKKIYAiSNQPKDLRPLVQKYNLEGGLKREEADkhkveqfeinqqqd 83 
EFA83305                   6 LIQCFSCSMF-QVKQKAK-VNTFKCVICSEKQSIKKIFGiSYQAKDLRELVKKYNLEAGQRKERqeq------------q 71 
EGC40330                   1 --------MY-QVHQLNK-KKAFNCKICNEKQSYQKIYGqSYQAKDLTQLVKKYNMEKHNKPKPISiqd----------d 60 
Q55D89                     6 LVQCYSCTMF-QVSQKKK-KKDFQCKICNEKQSIRKVYGiSFMGKDLTTLVKKYNIEKKSNPPKPIkhnefeddededed 83  Dic...
XP_011431177               7 VLQCYSCFTF-QVHQVKKsSNKWNCKLCGEKQSIKKVYS-RGSGADCRRHVQNLNSLRQEADKIQTlsvch-------yd 77 
CBN74166                  88 srRHKQDGRNSSDRIGNQDGDraystvdraalqhtvgpaqpgLYGRNSSW 137
XP_004994640              74 ytEYEAEEGDAMDSWHAEYGDsidnpsp-------tthapefQTPKQSKW 116
XP_002986378              85 qsEVGEKNvh-------------------------------gYETKPSKW 103
Q9M9H0                    87 vnEEVN------------------------------------GTKKRSDW 100 thale cress
WGS:AAFB:cds.EHI_076270A  79 kqKEEDKVLDIKEEEKINKGE-------------------------ESIW 103
EGG18937                  84 dqHQHQQQANYFDDDDSEQNHqdefeqlqqq-qqtergsmkrKQQPQSSW 132
EFA83305                  72 qqDDYDDNFDFNLENESNNHSdslninnn------nstkstpQPQPPPSW 115
EGC40330                  61 hdNNNNNNNNNNNNNNNNNNNnnnnnnn--------sqslkqNTKPRTNW 102
Q55D89                    84 evNNNNNNNNNEDDNENDKNNnnennrnq------qqqqqqqQSSQPNKW 127 Dictyostelium discoideum AX4
XP_011431177              78 npELENKEQGLTTVPENQNRL---------------------PTYTESRW 106
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