3P24


Conserved Protein Domain Family
fragilysin
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TIGR03935: fragilysin 
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fragilysin
Members of this family are fragilysin, the Bacteroides fragilis enterotoxin. This enzyme is a Zn metalloprotease. Three distinct subtypes included in this family all are produced by enterotoxigenic (by definition) strains of Bacteroides fragilis. [Cellular processes, Pathogenesis]
Links
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Statistics
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PSSM-Id: 188450
Aligned: 4 rows
Threshold Bit Score: 514.896
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3P24_A        6 LLLMLGTAALLAACSNEADS-----LTTSIDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKR 80  Bacteroides frag...
P54355       14 LLLMLGTAALLAACSNEADS-----LTTSIDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKR 88  Bacteroides frag...
ZP_05280161   6 IVNFLLGVVLVSSCTNEQFTdppsmVSQTETPDIVLNVNEAVEDFDSFVSKLRSAG----TIKLVTPDFTRIVRNNGADS 81  Bacteroides frag...
AAC38327      6 YYLFFAATALFTACADDLLH-----VEETASPQLEHVLNLRSMDYEDLAGVLSKISNTEHTIMLQEGSELWTTSIKAIHG 80  Bacteroides frag...

3P24_A       81 TKIQLDNENVRLFNGRDKDSTNFILGDEFAVLRFYRNGESISYIAYKEAQMMNEIAEFYAAPFKKTRAINEKEAFECIYD 160 Bacteroides frag...
P54355       89 TKIQLDNENVRLFNGRDKDSTSFILGDEFAVLRFYRNGESISYIAYKEAQMMNEIAEFYAAPFKKTRAINEKEAFECIYD 168 Bacteroides frag...
ZP_05280161  82 CFQAEGSERLLLSN----DSISMILTDQYIVF----TSDLITEQNYK-----ATTTQYYLVHKSKEYVAEYNKILTSEVN 148 Bacteroides frag...
AAC38327     81 VEIEESNRPVYLFEGQDKDSINAILSQSYATIRLQRGGDLIDYIVYKDKERMAEIANYYQNHYLSASSDTSDKIVVCNTG 160 Bacteroides frag...

3P24_A      161 S--RTRSAGKYPVSVKINVDKA---KKILNLPECDYINDYIKTPQVp----HGITESQTRAvpSEPK-TVYVICLRENGS 230 Bacteroides frag...
P54355      169 S--RTRSAGKDIVSVKINIDKA---KKILNLPECDYINDYIKTPQVp----HGITESQTRAvpSEPK-TVYVICLRENGS 238 Bacteroides frag...
ZP_05280161 149 QlvKTRGLDEDSPKVVLHSNNAisiNQALHLSETILEQPQMKN-EVpfsglSGMPETRSSRigHRPKdVLRIWLIRHKGY 227 Bacteroides frag...
AAC38327    161 E--DTRSGKSDIKNIRIDITKAignNPFKGLPIKDYPTEKLSTIDK-----NSILSLSSRA--TYPA-TLEFMLIKEKDG 230 Bacteroides frag...

3P24_A      231 TVYPNEVSAQMQDAANSvyavhgLKRYVNLHFVL--YTTEYACPSGNAD--E--GLDGFTASLKANPKAEGY------DD 298 Bacteroides frag...
P54355      239 TIYPNEVSAQMQDAANSvyavhgLKRYVNFHFVL--YTTEYSCPSGDAK--E--GLEGFTASLKSNPKAEGY------DD 306 Bacteroides frag...
ZP_05280161 228 SGFQHEVTWQQNDTRAM------IKDLNPN--VKveFYTRYSNFTAGSD--AskTLDEFRKWVK-DSKSKGYdwsdriDK 296 Bacteroides frag...
AAC38327    231 GSLEHDITSQIQAVTTS------LKFLIDSGFITvkYTIKDSSHKGGASdyEvsALESFQNYLRSWDEVKGQ------DK 298 Bacteroides frag...

3P24_A      299 QIYFLIRWGTWDNN-----ILGISWLNSYnvNTASDFKASGMST-TQLMYPGVMAHELGHILGANHADDPKDLMYSKYTG 372 Bacteroides frag...
P54355      307 QIYFLIRWGTWDNK-----ILGMSWFNSYnvNTASDFEASGMST-TQLMYPGVMAHELGHILGAEHTDNSKDLMYATFTG 380 Bacteroides frag...
ZP_05280161 297 DIFILISYGGYNEN-----IVGLGALDTYklDRESNPRAFGLSAmNPITAPKTLAHELGHILGAVHTD------YTWWEG 365 Bacteroides frag...
AAC38327    299 KPYILLRDGTWDSGktfgyASGIGVIHLN--NPRGNFEVAAIST-TSSSHPYTLAHEIGHLLGAEHVDNEQDLMYTWYSP 375 Bacteroides frag...

3P24_A      373 Y-----------------LFHLSEKNMDIIAKN 388 Bacteroides fragilis
P54355      381 Y-----------------LSHLSEKNMDIIAKN 396 Bacteroides fragilis
ZP_05280161 366 WwifqipqydvmsyrefrRNLIRDPNNVRIVRN 398 Bacteroides fragilis 3_1_12
AAC38327    376 Qv---------------tPNHLSADNWVRMLEC 393 Bacteroides fragilis
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