Conserved Protein Domain Family
52

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PHA02592: 52 
DNA topisomerase II medium subunit; Provisional
Statistics
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PSSM-Id: 222896
Aligned: 21 rows
Threshold Bit Score: 586.253
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
37651722  111 HNRSLQSIINHEALEFAMYTVEERAIPSLIDGLKPVQRFFMYRALeyaKQNRSKFNKVAALAGGVSEA-GYHHGEGSAAG 189
34419516    1 MQRTLSSIVNDEALEYAMYTIENRALANGIDGLKPVQRFVLYNVI---KDASTSFDKVAALGSSVSKI-GYNHGETSAQD 76 
66391455    1 MERSIKDVVQVEGLTFALYTIYSRAIPHLVDGFKPVHRFFVHSAA----KGGSGFQKVASIAGGVAIY-GYHHGETSVEE 75 
66392041  111 HNRSLQSIINHEALEFAMYTVEERAIPSLIDGLKPVQRFFMYRALeyaKQNRSKFNKVAALAGGVSEA-GYHHGEGSAAG 189
38640269    4 IKRGISSLVNNEAKEFAMYTIEERALPSMVDGLKPVQRYILFSVL---KNAGREFKKNAAVAGVISEY-GYNHGEMAAMD 79 
109290217 101 HNRHLQSIINNEALEFAMYTVEERAIPSIIDGFKPVQRFFMYRALeyaKQNKTKFNKVAALAGGVSEA-GYHHGEGSAAG 179
157311570   6 TYRSLESIVHNEAKEYAIYSAEERGIPQLVDGLKPVQRFVMECALqksKGDRKKFRKMADIGSGVAEL-GYHHGETNAVE 84 
238695150  12 TYRSLESIVHNEAKEYAIYSAEERGIPQLVDGLKPVQRFVMECALqksKGDRKKFRKMADIGSGVAEL-GYHHGETNAVE 90 
282599156   2 KEISISQHIQGDHKAYATYD-NQRNIPHIADGLKPSLRKIIHTAIetmRGKEEV--KVAALGSRASDLtEYGHGEDSIID 78 
294661428   1 MERSIKDVVQVEGLTFALYTIYSRAIPHLVDGFKPVHRFFIHSAM----QGGTGFQKVASIAGGVAMY-GYHHGETSVEE 75 
37651722  190 AGQLIANTW--NNNIPILEGDGNFGSRMVQQAAAPRYVFCRVHQNFWDIYRDIE---LAPVHPEPEHLPPRYYLPVIPMV 264
34419516   77 ALALMAAEW--QNNVPIVQGRGNFGSRMVKESASARYVYAKLHDNFDLYFKDIH---LSPEHKDLEHVPPQFYVPVLPMI 151
66391455   76 ALSLMAAHW--CNNIPLFDRDGFFGSRLVKKPGAPRYIYCKLSPLFKAIYMDED---LTIPHEDPEHLPPAYYLPIIPMV 150
66392041  190 AGQLIANTW--NNNIPILEGDGNFGSRMVQQAAAPRYVFCRVHQNFWDIYRDIE---LAPVHPEPEHLPPRYYLPVIPMV 264
38640269   80 AACLMASTW--NNNFPVIQGRGNFGCRAVQEGAAARYIFCSKHERFESMFKDME---LLEESTADGSILPRYYLPILPTV 154
109290217 180 AGQLIANTW--NNNIPVLEGDGNFGSRLVQQAAAPRYVFCRVHQNFWDIYKDIS---LSPVHPDPEHLPPRFYLPVIPMV 254
157311570  85 AGSLMANTW--SNNTPLLDGQGNFGSRLVQKAGAARYIFARVHENFFKIYKDMN---CAPKHEDLEHIPPAFYLPVVPMV 159
238695150  91 AGSLMANTW--SNNTPLLDGQGNFGSRLVQKAGAARYIFARVHENFFKIYKDMN---CAPKHEDLEHIPPAFYLPVVPMV 165
282599156  79 AVVTLGRNYrgTNNLPLLQKQGQFGTMVDNDASEPRYIHVSRHANLSHCFKEEDraiLDFQVSEGKTIEPVFFLPPLPLV 158
294661428  76 ALSLMAAHW--CNNIPLFDRDGFFGSRLVKKPGAPRYIKCKLSPIFKAIYMDGD---LTPVHEDPEHVPPAYYLPIIPMV 150
37651722  265 LANGVKGIATGYATNIFPHSYKSLIKCTKAAIEGKPIPR--LEVQFPEFSGVIRRVS--AKTIEVEGLYELS--GQTKLt 338
34419516  152 LMNGVQGIATGFACNILPHDPEWVKKAVLEYLAGKEISE--PVVKFPEFYGKIEKLE--HNKYAQIGTVEIS--GLTAV- 224
66391455  151 LVNGFRGIAKGYATNIPPHDPVSVLNGCVSYLNGKDFT---LDLKYPQFKGDIVDGT-------MYGKYELQ--GKTKLv 218
66392041  265 LANGVKGIATGYATNIFPHSYKSLIKCTKAAIEGKPIPR--LEVQFPEFSGVIRRVS--DKTIEVEGLYELS--GQTKLt 338
38640269  155 LLNGVSGIATGFATKIMPHSVQSVAKCVEQVLKSGKCDE--PEIQFPKFFGKILSIEgeTQSWKVEGDYELS--GKTKLi 230
109290217 255 LANGVKGIATGYATTIFPHSYESLVKCTLAAVKGEEIPE--PEVQFPCFKGIVRRIN--SKSIEIEGLYELV--GQTKLi 328
157311570 160 LANGISGIATGYKTDILPHSLESLIECTELALAGKLDKE--PSVQFPKFTGKVIPRDd-RDGVILEGTYELN--GKTTLt 234
238695150 166 LANGISGIATGYKTDILPHSLESLIECTELALAGKLDKE--PSVQFPKFTGKVIPRDd-RDGVILEGTYELN--GKTKLt 240
282599156 159 LINASSGVGNGYSSKILPRSPQALIEMSKAILNETPINPewSLPHFPGFKGRVKATG--PCSYEIHGAIQLNpkAKTEFt 236
294661428 151 LVNGFSGIAKAYATNIPPHDPKSVVNGCIAYLNDKDFT---LDLKYPYFKGEITDGT-------IYGTYELQ--GKTKLv 218
37651722  339 ITELP--VKFDRLSYVI-LLDKLKDQGKIVSYKE--QHKNGFRFDVTLKRQdkfgeqlqnnPEATHEKIIKMFGLRQVLT 413
34419516  225 VTEIP--TGFDHAKYII-ELDKLVEKGKISSYVD--ETSETFQFRVRFKRG----------AKMTEESVIKTLKLQSTFT 289
66391455  219 ITEIP--VKYDRVKYIA-ILDKLEEKGCIVSYKD--LSKEDFRYEITLKREy--------aNGLTHEKILKDFGLIENSN 285
66392041  339 ITELP--VKFDRLSYVI-LLDKLKDQGKIVSYKE--QHKNGFRFDVTLKRQdkfgeqlqnnPEATHEKIIKMFGLRQVLT 413
38640269  231 INELP--PKYDRLKYVT-HLNKLVETDKIVGYDEskMKDREFCFKVTLKRD----------FDVSHENIIKVFKLSQNVS 297
109290217 329 ITEVP--VRYDRLEYVS-ILDKLEEQGKIVGYKE--QTSDGFRFEVTLKRQdkfgelmeknPEVAHERIIKMFNLRQNLS 403
157311570 235 ISEVP--YKFDREEYVA-VLDALEEKDLIVSYNDr-CSKDGFRFEVTLKRDyfk----sedESARHEKIMKDFKLTQLVA 306
238695150 241 ISEVP--YKFDREEYVA-VLDALEEKDLIVSYNDr-CSKDGFRFEVTLKRDyfk----sedESARHEQIMKDFKLTQLVA 312
282599156 237 IIDLPpdSKYQYEQFKErELLPLLDSKTIKNFESd-STEQAWSIKVQSTRE-----------FAQHPELVKRMGMILRVT 304
294661428 219 ITEIP--VKYDRVKYIA-ILDKLEEKGVIVSYKD--LSKEDFRYEVTLKREy--------aNGLTREKILKDFGLIENSN 285
37651722  414 QNITVLNPEGKLAEYECAEDVIRDFVEHRRKFTAERVEYERQKSEHARDLAWAKFKFIN----MVIDDKITIKGKQKAEL 489
34419516  290 QNINVIDENYQIRHFDDVRELVKWFVDFRMSFLPKRIQDSTERTEKRASLAIAKVEFIK----RVVSGTIILFGKKRAEV 365
66391455  286 PNINVI-FNGKLHSYERPETLLKDFVDIRMTVYQQRIEKRIQEAKEALARALAKVEFID----QMIESPDSLKGLSRSEA 360
66392041  414 QNITVLNPEGKLAEYECAEDVIRDFVEHRRKFTAERVEYERQKSEHARDLAWAKFKFIN----MVIDDEITIKGKQKAEL 489
38640269  298 QYIRVIDQNGNLKPYDNASDLIVDFVNFRFNVLQKRIDNAIIATREKLDFAQAKVDFIK----LVLADKIVFNRQTRKQV 373
109290217 404 QNITVLDENGKLAEYECAADLIRDFVEHRKKYTNQRVIFEKEKAEYSRDLAWAKFAFVN----EVIEEKIVLRGKSKAQL 479
157311570 307 QNIVVVNERGLVEVFEKASDLIRRFVEIRLGYVDKRIELMQAETLEAYNYAMAKAEFID----RVIKGEIELQGKKKAEV 382
238695150 313 QNIVVVNERGLVEVFEKASDLIRRFVEIRLGYVDKRIELMQAETLEAYNYAMAKAEFID----RVIKGEIELQGKKKAEV 388
282599156 305 ENLTVWTWDGQLKRYPTAEALLRDWLVGREYYMEKRRQSEIARSTKEMNWLLVKVEFLKwwnaNHNQAVRMSNDEIKSSF 384
294661428 286 PNINVI-FEGKLYSYERPETLLKDFVDIRMNVYQQRINKRIQETKEALDKALAKVAFIA----QMVESPDSLRGLSRSEA 360
37651722  490 VKEIASNPDFKGFENELVGMSIYRMTEDETYKLQDEAIKQGKLFDYWLGTTPEAEYINDLNSL 552
34419516  366 AAELKADEAFSEHVTELLNMSVDKMTDDEIARLEKDATVAQKELSYWQKTTAQKEFIKDIKAI 428
66391455  361 VQFVSTWKGCENHAEILVAMNILSSNY------------------------------------ 387
66392041  490 VQEIASNPDFKGFENELVGMSIYRMTEDETYKLQDEAIKQGKLYDYWVNTTPEAEYINDLKSL 552
38640269  374 IEQINAFDELKTYADQLVQMNLYHMTEDEVAKLEKQVAELQKEHDFWKTTTPRKQYQSDIKEF 436
109290217 480 IAEVKSKPNMAGFENELVGMSIYRLTEDETHKLQEEALKQTKEYDYWSNTTPENEYVKDLETL 542
157311570 383 MQSINGHEKLRPYADKLVSMPLYSVTQEEYDRLVKDAEKHHSEYEYWTKTTAMKEYKKDLKEL 445
238695150 389 MQSINGHEKLRPYADKLVSMPLYSVTQEEYDRLVKDADKHHSEYEYWTKTTAMKEYKKDLKEL 451
282599156 385 TSTLGDLKFDDEMLSKLLALPVSSLKMSGIEALQNAHDEVESYVRFMESTTAKAMIITDMEEY 447
294661428 361 VKFVSTWIGCENHAEMLVAMNIYHLTTDERKKLEDEAEELRKQLKYWEETTPKIEYLNDLKEL 423
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