Conserved Protein Domain Family
bHLH_TS_ASCL1_Mash1
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cd19742: bHLH_TS_ASCL1_Mash1 
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins
ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system.
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Statistics
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PSSM-Id: 381585
Aligned: 6 rows
Threshold Bit Score: 120.244
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #   # ### #    #                 ####                             
P50553       115 QQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQ 185 human
Q06234        78 QQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQ 148 African clawed frog
AAA03722      97 QQQPAAVARNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQ 167 chicken
XP_014348999 195 QQPAAVARRNERERNRVKLVNMGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQ 265 coelacanth
XP_007903037 111 QQPAAVARRNERERNRVKLVNMGFQTLRQHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFP 181 elephant shark
Q90260        63 QQPMAVARRNERERNRVKQVNMGFQTLRQHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAVLQ 133 zebrafish

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