Conserved Protein Domain Family
bHLH_TS_ATOH8
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cd11421: bHLH_TS_ATOH8 
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins
ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins.
Links
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Statistics
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PSSM-Id: 381427
Aligned: 16 rows
Threshold Bit Score: 119.076
Created: 9-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #   # ### #    #                 ####                       
Q96SQ7       224 IKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYS 291 human
CBY16106     183 YKNMSRERRLIANARERTRVHTISTAFDALRQAIPTYSYNQKLSKLAILRIASTYIKSLSALTGDTEQ 250 Oikopleura dioica
XP_002596072 129 YKTLTRDKRIVANARERSRVHTISAAFESLRRAVPSYSYNQKLSKLAILRVACSYITALACLNGQDYS 196 Florida lancelet
XP_002412927 208 YKGMTRQRRIEANARERSRVHTISAAFEALRRAVPAYADNQKLSKLAILRIAAAYIVALARLNDQDYS 275 black-legged tick
AAK14073     267 YKNMTRERRIEANARERTRVHTISAAYETLRQAVPAYASTQKLSKLSVLRVACSYILTLSRMAGEDYS 334 fruit fly
XP_002737163 129 YKSLSRARRIVANARERNRVHTISAAFEGLRKAVPSYSHNQKLSKLAILRIACSYILALARLADLDYT 196 Saccoglossus kowalevskii
OWF51843     224 YKNMTRERRVEANARERTRVHTISAAFDSLRRAVPSYSYNQKLSKLAILRIASSYINALGSLADHDYS 291 Yesso scallop
PIK49490     277 HKGLNRSRRIVANARERNRVHTISAAFEGLRRAVPCYSHNQKLSKLAILRIACSYILALANLADLDYS 344 Japanese sea cucumber
ESN91010      22 YKSMTKQRRIEANARERSRVHTISAAFDNLRRAVPTYTQNQRLSKLAILRIACSYILALAKLAEIDTQ 89  Helobdella robusta
XP_013416000 230 YKNMTRERRVEANARERTRVHTISAAFERLRRAVPSYSNNQKLSKLAILRIACSYILSLARLADMDYS 297 Lingula anatina

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