1HLO,1AN2,1NLW,1R05,5EYO,1NKP


Conserved Protein Domain Family
bHLHzip_Max
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cd11406: bHLHzip_Max 
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basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins
Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.
Links
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Statistics
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PSSM-Id: 381412
Aligned: 31 rows
Threshold Bit Score: 103.585
Created: 14-Jun-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingdimer interface
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1NLW; Homo sapiens Max-Mad basic region binds the DNA, contacts at 4A
  • Structure:1NKP; Homo sapiens Myc-Max basic region binds the DNA, contacts at 4A.
  • Structure:1HLO; Homo sapiens Max forms a homodimer in complex with DNA, contacts at 4A.
  • Citation:PMID 9115440
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ### ### ##   #                     ##                                
1HLO_A        12 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKa---SRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQN 80  human
1NLW_B         1 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKa---SRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQN 69  human
NP_510223     48 RRAHHNELERRRRDHIKDHFTILKDAIPLLDGEKs---SRALILKRAVEFIHVMQTKLSSQGKAIEDLTRKN 116 Caenorhabditis elegans
XP_001746778  38 KRAHHNALERKRRDHIKDSFTMLRDTIPSINGEKqvqvSRAQILNKATDYIQYMRKRNQAHQAEMEELRRQN 109 Monosiga brevicollis MX1
BAE06551      22 KRSHHNALERKRRDHIKESFNGLRDSVPSLQGEKt---SRAQILNKATEYIQDVSRKNNADRQDIDELKKQN 90  Ciona intestinalis
XP_002735472  28 KRAHHNALERKRRDHIKDSFNGLKESVPTLQGEKq--aSRAQILNKATEYIQFMRRKNNAHQLDIDDLKRQN 97  Saccoglossus kowalevskii
KJE90474      30 KRAHHNALERKRRDHIKEKFNELRDTVPSIAGDKa---SRSLILNRATEFIVTMKQRNTAHEAEIDAIRKQN 98  Capsaspora owczarzaki A...
P91664        40 KRAHHNALERRRRDHIKESFTNLREAVPTLKGEKa---SRAQILKKTTECIQTMRRKISENQKDIEEIKRQN 108 fruit fly
XP_792474     29 KRAHHNALERKRRDHIKDSFSMLRDSVPNLQGEKa---SRAQILNKATDYIQFMRRKNNSHQTDIDDLKKQN 97  purple sea urchin
XP_019849704  36 KRAHHNALERKRRDHIKDSFTNLRDCIPSLSGEKv---SRAHVLNKATEYIRQMQRNSSVRTVEIDELRKKN 104 Amphimedon queenslandica

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