5B3G,5B3G,6KPD


Conserved Protein Domain Family
GRAS
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pfam03514: GRAS 
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GRAS domain family
Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.
Links
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Statistics
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PSSM-Id: 397536
Aligned: 30 rows
Threshold Bit Score: 338.486
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5B3G_B  87 ADSVLLEAARAFSDKDTA--RAQQILWTLNEL-SSPYG-DTEQKLASYFLQALFNRMTG-SGERCYRTM-VTAAATektc 160 thale cress
O80933 344 LRSLLIHCAQAVAADDRR--CAGQLLKQIRLH-STPFG-DGNQRLAHCFANGLEARLAG-TGSQIYKGI-VSKPRS---- 413 thale cress
Q9LTI5 224 LRSLLTQCAQAVASFDQR--RATDKLKEIRAH-SSSNG-DGTQRLAFYFAEALEARITGnISPPVSNPF-PSSTTS---- 294 thale cress
Q9SNB8 209 MRNLLMQCAQAVASFDQR--RAFEKLKEIREH-SSRHG-DATQRLGYHFAEALEARITGtMTTPISA---TSSRTS---- 277 thale cress
Q9LRW3 145 AEKLLNPCALAITASNSS--RVQHYLCVLSEL-ASSSG-DANRRLAAFGLRALQHHLSS---SSVSSSFwPVFTFA---- 213 thale cress
Q9SN22  27 MEQLLLHCATAIDSNDAA--LTHQILWVLNNI-APPDG-DSTQRLTSAFLRALLSRAVS-KTPTLSSTI-SFLPQAdelh 100 thale cress
Q9SUF5 104 LVHLLVAAADASTGANKSreLTRVILARLKDL-VSPGDrTNMERLAAHFTNGLSKLLER-------DSV-LCPQQHrddv 174 thale cress
O23210 122 FIEDLIRVVDCVESDELQ--LAQVVLSRLNQRlRSPAG-RPLQRAAFYFKEALGSFLTG------SNRN-PIRLSSws-- 189 thale cress
Q9FYW2 174 YVDELIRFAECFETNAFQ--LAHVILARLNQRlRSAAG-KPLQRAAFYFKEALQAQLAG-------SAR-QTRSSSss-- 240 tomato
O81316 205 ITEQLVKAAEVIES-DTC--LAQGILARLNQQlSSPVG-KPLERAAFYFKEALNNLLHN-----------VSQTLNpy-- 267 thale cress

5B3G_B 161 sfESTR----KTvlkFQEVSSWATFGHVAANGAILEAVDGE---AKI--HIVDISSTFCTQWPTLLEALAtr----sDDT 227 thale cress
O80933 414 --AAAVlkahQL---FLACCPFRKLSYFITNKTIRDLVGNS---QRV--HVIDFGILYGFQWPTLIHRFSm------YGS 477 thale cress
Q9LTI5 295 --MVDIlkayKL---FVHTCPIYVTDYFAANKSIYELAMKA---TKL--HIVDFGVLYGFQWPCLLRALSkr----pGGP 360 thale cress
Q9SNB8 278 --MVDIlkayKG---FVQACPTLIMCYFTANRTINELASKA---TTL--HIIDFGILYGFQWPCLIQALSkr----dIGP 343 thale cress
Q9LRW3 214 --SAEVkmfqKTllkFYEVSPWFALPNNMANSAILQILAQDp-kDKKdlHIIDIGVSHGMQWPTLLEALScr---leGPP 287 thale cress
Q9SN22 101 rfSVVEla------aFVDLTPWHRFGFIAANAAILTAVEGY---STV--HIVDLSLTHCMQIPTLIDAMAsr---lnKPP 166 thale cress
Q9SUF5 175 ydQADVisafEL---LQNMSPYVNFGYLTATQAILEAVKYE---RRI--HIVDYDINEGVQWASLMQALVsr---ntGPS 243 thale cress
O23210 190 -eIVQRiraiKE---YSGISPIPLFSHFTANQAILDSLSSQsssPFV--HVVDFEIGFGGQYASLMREITek----sVSG 259 thale cress
Q9FYW2 241 -dVIQTiksyKI---LSNISPIPMFSSFTANQAVLEAVDGS---MLV--HVIDFDIGLGGHWASFMKELAdkaecrkANA 311 tomato
O81316 268 -sLIFKiaayKS---FSEISPVLQFANFTSNQALLESFHGF---HRL--HIIDFDIGYGGQWASLMQELVlr----dNAA 334 thale cress

5B3G_B 228 P-HLRLTTVVVankfvndqtaSHRMMKEIGNRMEKFARLMGVPFKFNIi---HHVgDLSEFDLNELDVKP---DEVLAIN 300 thale cress
O80933 478 P-KVRITGIEFpqp----gfrPAQRVEETGQRLAAYAKLFGVPFEYKA----IAK-KWDAIQLEDLDIDR---DEITVVN 544 thale cress
Q9LTI5 361 P-MLRVTGIELpqa----gfrPSDRVEETGRRLKRFCDQFNVPFEFNF----IAK-KWETITLDELMINP---GETTVVN 427 thale cress
Q9SNB8 344 P-LLRVTGIELpqs----gfrPSERVEETGRRLKRFCDKFNVPFEYSF----IAK-NWENITLDDLVINS---GETTVVN 410 thale cress
Q9LRW3 288 P-RVRITVISDltad--ipfsVGPPGYNYGSQLLGFARSLKINLQISVl-----------DKLQLIDTSP---HENLIVC 350 thale cress
Q9SN22 167 P-LLKLTVVSSsdhf---ppfINISYEELGSKLVNFATTRNITMEFTIvpstYSD-GFSSL-LQQLRIYPssfNEALVVN 240 thale cress
Q9SUF5 244 AqHLRITALSRatn----gkkSVAAVQETGRRLTAFADSIGQPFSYQ-----HCKlDTNAFSTSSLKLVR---GEAVVIN 311 thale cress
O23210 260 G-FLRVTAVVAe--------eCAVETRLVKENLTQFAAEMKIRFQIEFv---LMK-TFEMLSFKAIRFVE---GERTVVL 323 thale cress
Q9FYW2 312 P-ILRITALVPe--------eYAVESRLIRENLTQFARELNIGFEIDFv---LIR-TFELLSFKAIKFME---GEKTAVL 375 tomato
O81316 335 PlSLKITVFASpa------nhDQLELGFTQDNLKHFASEINISLDIQVl-------SLDLL--GSISWPNsseKEAVAVN 399 thale cress

5B3G_B 301 CVGAMHGI----ASRGSpr--dAVISSFRRLRPRIVTVVEEE--ADLvGEEeggfddEFLRGFGECLRWFRVCFESW-EE 371 thale cress
O80933 545 CLYRAENLhdesVKVEScr--dTVLNLIGKINPDLFVFGIVN--GAY-NAP------FFVTRFREALFHFSSIFDML-ET 612 thale cress
Q9LTI5 428 CIHRLQYTpdetVSLDSpr--dTVLKLFRDINPDLFVFAEIN--GMY-NSP------FFMTRFREALFHYSSLFDMF-DT 495 thale cress
Q9SNB8 411 CILRLQYTpdetVSLNSpr--dTALKLFRDINPDLFVFAEIN--GTY-NSP------FFLTRFREALFHCSSLFDMY-ET 478 thale cress
Q9LRW3 351 AQFRLHHLk---HSINDer--gETLKAVRSLRPKGVVLCENN--GECsSSA------DFAAGFSKKLEYVWKFLDST-SS 416 thale cress
Q9SN22 241 CHMMLRYIpeepLTSSSsslrtVFLKQLRSLNPRIVTLIEED--VDL-TSE------NLVNRLKSAFNYFWIPFDTT-DT 310 thale cress
Q9SUF5 312 CMLHLPRFshqtPSSVI-----SFLSEAKTLNPKLVTLVHEE--VGLmGNQ------GFLYRFMDLLHQFSAIFDSL-EA 377 thale cress
O23210 324 ISPAIFRRl-------Sgi--tDFVNNLRRVSPKVVVFVDSEgwTEIaGSG------SFRREFVSALEFYTMVLESL-DA 387 thale cress
Q9FYW2 376 LSPAIFRRvg-----------sGFVNELRRISPNVVVHVDSEglMGY-GAM------SFRQTVIDGLEFYSTLLESLeAA 437 tomato
O81316 400 ISAASFSHl------------pLVLRFVKHLSPTIIVCSDRG--CER-TDL------PFSQQLAHSLHSHTALFESLdAV 458 thale cress

5B3G_B 372 SFPRTS--NERLMLERA-AGRAIVDLVACEPSDSTERRETARKWSRRMRNSGFGAVGYSDEVADDVRALLRRYK--Egvw 446 thale cress
O80933 613 IVPRED--EERMFLEMEvFGREALNVIACEGWERVERPETYKQWHVRAMRSGLVQVPFDPSIMKTSLHKVHTFYhkD--- 687 thale cress
Q9LTI5 496 TIHAEDeyKNRSLLERElLVRDAMSVISCEGAERFARPETYKQWRVRILRAGFKPATISKQIMKEAKEIVRKRYhrD--- 572 thale cress
Q9SNB8 479 TLSEDD--NCRTLVERElIIRDAMSVIACEGSERFARPETYKQWQVRILRAGFRPAKLSKQIVKDGKEIVKERYhkD--- 553 thale cress
Q9LRW3 417 GF------KEENSEERKlMEGEATKVLMNAGDM----NEGKEKWYERMREAGFFVEAFEEDAVDGAKSLLRKYD------ 480 thale cress
Q9SN22 311 FM---S--EQRRWYEAE-ISWKIENVVAKEGAERVERTETKRRWIERMREAEFGGVRVKEDAVADVKAMLEEHAvgWg-- 382 thale cress
Q9SUF5 378 GLSIAN--PARGFVERVfIGPWVANWLTRITAN-DAEVESFASWPQWLETNGFKPLEVSFTNRCQAKLLLSLFN--Dg-- 450 thale cress
O23210 388 AAPPGD--LVKKIVEAFvLRPKISAAVETAADR---RHTGEMTWREAFCAAGMRPIQLSQFADFQAECLLEKAQv-Rg-- 459 thale cress
Q9FYW2 438 NIGGGNcgDWMRKIENFvLFPKIVDMIGAVGRR-----GGGGSWRDAMVDAGFRPVGLSQFADFQADCLLGRVQv-Rg-- 509 tomato
O81316 459 N----AnlDAMQKIERFlIQPEIEKLVLDRSRP---IERPMMTWQAMFLQMGFSPVTHSNFTESQAECLVQRTPv-Rg-- 528 thale cress

5B3G_B 447 SMVQ---CP-DAAGIfLCWRDQPVVWASAWR 473 thale cress
O80933 688 FVID---QD-NRWLL-QGWKGRTVMALSVWK 713 thale cress
Q9LTI5 573 FVID---SD-NNWML-QGWKGRVIYAFSCWK 598 thale cress
Q9SNB8 554 FVID---ND-NHWMF-QGWKGRVLYAVSCWK 579 thale cress
Q9LRW3 481 NNWEirmED-GDTFAgLMWKGEAVSFCSLWK 510 thale cress
Q9SN22 383 MKKE---DD-DESLV-LTWKGHSVVFATVWV 408 thale cress
Q9SUF5 451 FRVE---ELgQNGLV-LGWKSRRLVSASFWA 477 thale cress
O23210 460 FHVA---KR-QGELV-LCWHGRALVATSAWR 485 thale cress
Q9FYW2 510 FHVA---KR-QAEML-LCWHDRALVATSAWR 535 tomato
O81316 529 FHVE---KK-HNSLL-LCWQRTELVGVSAWR 554 thale cress
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