Conserved Protein Domain Family
HORMA

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pfam02301: HORMA 
HORMA domain
The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognize chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.
Statistics
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PSSM-Id: 460526
Aligned: 114 rows
Threshold Bit Score: 60.3783
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFJ00812           18 SLEAVKTLVAAGLGCIAFLRDLLP--EDNFTKTSFsafddsfgmstdgrtptpassqkpggFKVMTITRNST-------- 87 
EME46196           35 SSKLVTEFFEFACNAILFQRGVYP--PEDFAPVKK--------------------------YGLNMM------------- 73 
EPE04486           22 SAKLVSEFFQYSIHSILFQRGVYP--AEDFTSVKK--------------------------YGLNMLGRSTEhhgttgsg 73 
EJT72915           32 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAIKK--------------------------YGLNML------------- 70 
EGS20224           23 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 61 
jgi:THITE_2039922  21 SAKLVAEFFQYSIHTILFQRGVYP--AEDFTAVKK--------------------------YGLNML------------- 59 
XP_001903599       30 SAKLVAEFFQYSIHTILFQRGVYP--AEDFSAVKK--------------------------YGLNML------------- 68 
EGY15545           22 SAKLVAEFFQYSIHTILFQRGVYP--AEDFSVVKK--------------------------YGLNMLa------------ 61 
XP_011107312       89 SAKMVSEFFEYSIHSILFQRGVYP--PDDFAPVKK--------------------------YGLNML------------- 127
XP_003668671        5 ITKWLKIYLKSYINLILYYRNVYPstTFDFTTYQT--------------------------FNLPQF------------- 45 
EFJ00812           88 --EEADR---LLNYVENGIFDALQ----KQYLESFIFGIY-LDKDKpndVVEAYTFNFEYhqvpgtd-vvipimaTIRKT 156
EME46196           74 ----VSIddqVKAYVKK-IMSQLSkwmqKSKISKLVIVVTnKETGE---HVERWQFDVNMflgeskkkratssgn----- 140
EPE04486           74 anKAVSAddqVRAYIKK-IMGQLDrwmaGGQISKLVLVITdKDTGD---HVERWQFDVQItaskkksktkgssaaATTAD 149
EJT72915           71 ----VSAddqVKAYIKK-IMGQLDrwmvKGKISKLVIVITdKDTGE---HVERWQFDVQIfggksksssksktaaAAAAA 142
EGS20224           62 ----VSSddqVRAYIKK-IMLQLDkwmlAGKVQKLVIVITdKDTGE---HVERWQFDVQIlqktskrskpsskssATPSA 133
jgi:THITE_2039922  60 ----VSSddqVRAYIKK-IMTQLDkwmvGGKVSKLVIVITdKDTGE---HVERWQFDVQIlakpkskssskskpsTTSGG 131
XP_001903599       69 ----VSSddqVRSYIRK-IMSQLDkwmlGGKISKLVIVITdKDTGE---HVERWQFDVQIfkkassssksktstpIGden 140
EGY15545           62 --AAVSSddqVRAYIKK-IMGQLDrwmkYGKISKLVIVITsKDTGE---HVERWQFDVQIfnqhksakskaak------- 128
XP_011107312      128 ----VNTddqVKAYIKK-IMSQLSkwmlGGKISKFILVISdKDSGE---KLERWQFDVQIlakskkkkgdaeadtVMGGT 199
XP_003668671       46 --TPINRhpqLQSYIEELILDLLSk---LNHIYHISLCIInKSNEI---CVEKYVLDFGEfkhittttnnarddgDDDe- 116
EFJ00812          157 LGNLSlgagddslqrarstgddplqqalnqGKAPTFGDVKARVKVRVVSIYARDIDLTVT---Pgsseashllydadgas 233
EME46196          141 ----------------kensepaadeapaaAVEKSESDVQAEIQALFRQITASVSFLPML---D---------------- 185
EPE04486          150 kenndgg-----------------saaappAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 193
EJT72915          143 VAGAGgqenaeaaga-----gaaaaaaaatAPEKTEAEIQAEIAAIFRQITASVTFLPQL---A---------------- 198
EGS20224          134 deneagss---------------staaassPPEKTEAEIQAEIAALFRQITASVTFLPQL---Q---------------- 179
jgi:THITE_2039922 132 ADqenapshadse------nsraaaappapAADKTEAEIQAEIAAIFRQITASVTFLPQLpggH---------------- 189
XP_001903599      141 tgee-------------------rptatekEKDKTEAEIQQEIAAIFRQITASVTFLPQL---S---------------- 182
EGY15545          129 ------------------adqenaapvtedAPDKTEKEIQDEIAAIFRQITASVTFLPQL---D---------------- 171
XP_011107312      200 Dkenaga-----------------gtsteaTMEKTEKEIQEEIQSIFRQITASVTFLPML---Dn--------------- 244
XP_003668671      117 -----------------------------dNQILSESEVFDEFRSSLNSLISHLEKLPKI---K---------------- 148
EFJ00812          234 aqyvdvallssqssrgtEkRYANFKVFYNAS------TPIDYeapgfkpgdvdkdrwyIMTHAIDEIPERYTMGKLDTGH 307
EME46196          186 -------------------GNCTFNVLVYADad--seVPLEWg---------------DSDAKEVKNAEKVMLRSFSTNS 229
EPE04486          194 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIVNGERVQLRGFSTSS 237
EJT72915          199 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIENGERVQLRGFSTAS 242
EGS20224          180 -------------------GDCTFNVLVYADas--seVPVEWg---------------DSDPKEIENGERVQLRSFSTSN 223
jgi:THITE_2039922 190 -------------------GGCTFNVLVYVDdaetveVPVEWg---------------DSDAKEIANGERVQLRGFSTHC 235
XP_001903599      183 -------------------GNCTFNVLVYADad--seVPVEWg---------------DSDAKEIKDAEKVQLRGFSTAN 226
EGY15545          172 -------------------GDCTFNVLVYADad--seVPVEWg---------------DSDAKEIENAERVQLRGFSTSN 215
XP_011107312      245 -------------------NHCTFNVLVYADgd--aeVPMEWg---------------DGEDLGIQDAEQVQLRSWSSSS 288
XP_003668671      149 -----------------D-NMVTFQIVINAV-------------------------------------------ELQLGH 167
EFJ00812          308 H 308
EME46196          230 H 230
EPE04486          238 H 238
EJT72915          243 H 243
EGS20224          224 H 224
jgi:THITE_2039922 236 H 236
XP_001903599      227 H 227
EGY15545          216 H 216
XP_011107312      289 H 289
XP_003668671      168 H 168
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