4DCK,3HBW


Conserved Protein Domain Family
beta-trefoil_FGF13

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cd23329: beta-trefoil_FGF13 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 13 (FGF13) and similar proteins
FGF13, also called fibroblast growth factor homologous factor 2 (FHF2), is a microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, it may participate in the refinement of axons by negatively regulating axonal and leading processes branching. FGF13 plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. It may regulate voltage-gated sodium channels transport and function. It may also play a role in MAPK signaling. It is required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. FGF13 interacts with SCN1A, SCN5A, and SCN8A. It may also interact with SCN2A and SCN11A. FGF-13 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 467015
Aligned: 8 rows
Threshold Bit Score: 311.2
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:the C-terminus of voltage-gated sodium channel in complex with FGF13 and calmodulin
  • Structure:4DCK; Homo sapiens FGF13 interacts with SCN5A, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # ###                                  # # ### #                               #
4DCK_C        12 QLKGIVTKLYSRQGYHLQLQaDGTIDGTKDEdstYTLFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSELfTPECKFK 91  human
3HBW_A        13 QLKGIVTKLYSRQGYHLQLQaDGTIDGTKDEdstYTLFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSELfTPECKFK 92  human
2494461       65 QLKGIVTKLYSRQGYHLQLQaDGTIDGTKDEdstYTLFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSELfTPECKFK 144 human
NP_991265     13 QLKGIVTKLYSRQGFHLQLQaDGTIDGTKEEdnsFAIFNLIPVGLRVVAIQGVqTKLYLAMNNEGYLYTSEHfTPECKFK 92  zebrafish
NP_001007400  13 QLKGIVTKLYSRQGFHLQLQaDGTIDGTKEEdsgFTMFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSEHfTPECKFK 92  zebrafish
A6P7H6        65 QLKGIVTKLYSRQGYHLQLQpDGTIDGAKEEessATVFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSEHfTPECKFK 144 African clawed ...
XP_005990392  19 QLKGIVTKLYSRQGYHLQLQaDGTIDGTKEEdsaYTLFNLIPVGLRVVAIQGVqTKLYLAMNSEGYLYTSEHfTPECKFK 98  coelacanth
XP_007891007  19 QLKGIVTKLYSRQGYHLQLQpDGTIDGTKEEgssYTLFNLIPVGLRVVAIQGVkTGLYMAMNNEGYLYTSEHfTPECKFK 98  elephant shark
Feature 1        # # #####                                         ##    #           
4DCK_C        92 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPLKVAMYKEPSLHDL 159 human
3HBW_A        93 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPLKVAMYKEPSLHDL 160 human
2494461      145 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPLKVAMYKEPSLHDL 212 human
NP_991265     93 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGQIMKGNHVKKtKPAAHFIPKPLKVAMYREPSLHDL 160 zebrafish
NP_001007400  93 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPLKVAMYREPSLHDL 160 zebrafish
A6P7H6       145 ESVFENYYVTYSSMIYRQQHSGRSWFLGLNKEGEIMKGNHVKKnKPAAHFLPKPLKVAMYKEPSLHDL 212 African clawed frog
XP_005990392  99 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPIKVVMYREPSLHDL 166 coelacanth
XP_007891007  99 ESVFENYYVTYSSMLYRQQQSGRGWYLGLNKEGEIMKGNHVKKnKPAAHFLPKPLEVALYREPSLHEL 166 elephant shark

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