Conserved Protein Domain Family
YdjM
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pfam04307: YdjM 
LexA-binding, inner membrane-associated putative hydrolase
YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.
Links
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Statistics
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PSSM-Id: 427854
Aligned: 91 rows
Threshold Bit Score: 48.586
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5V568   1 M--FvGHaLLAFALGALAAWWLgls-------------reRAVQLGVIAglfAAVPD-VD--------IVYAPFGLLVGA 56  Haloarcula marismortui
Q97K38   1 MtgK-THiSIGLMSSAAVLSVNnptp----------eniaVGLAVGVLG---ALMPD-ID--------TSRSKVSYNLRK 57  Clostridium acetobuty...
Q186I4   1 MikE-THeRGGYIFALLILPFInnlylvkydiaykivliiIYIYFAYLG---SLFPD-ID--------MRGSYISKKFML 67  Clostridioides diffic...
Q18EP1  17 MspL-EHaLVALIPVTIYILLRhrrl-----------pskTMLSVVCFG---SVFPDlVD---------KPVSYANLTPW 72  Haloquadratum walsbyi...
Q5V391   1 MvlPsEHfIIALLPVAVYALLRdrhl-----------pslQLVAVTFFG---SQFPDlID-----------KPLAYELHL 55  Haloarcula marismortui
Q7MS32   1 MlaR-THlAFALGIATLPLYALslvdkat----lqgvevsLYLSGVALG---SLLPD-ID--------EPNSTLGRQLPL 63  Wolinella succinogenes
Q8TQH1   1 MvnTlSHlGIGFLIALALGLRGk-----------------KLKVVAFL----SVLPD-LDvipyslflAVSSSLTHESRN 58  Methanosarcina acetiv...
Q0W4H6   1 MlfF-GHiGLTLLVVFLVALALki---------------gVDYRLVIVG---SLLPDiIDk------pLGEYIFHSVFNN 55  uncultured methanogen...
Q12UG8   1 MfiI-GHlGLTLAIFLVISLLVpsi------------rnmIDYRFVAVG---ALLPDlIDk------pIGRLFFEEIFAN 58  Methanococcoides burt...
Q8TP13   1 MllF-GHlGVTLGIFFGLGIFIprl------------rtiIDPRYLAIG---AILPDlIDk------pIGEIIFASTFSS 58  Methanosarcina acetiv...

Q5V568  57 AENLtadgfw---------------------------------------------------etanvvHRGPTHSLLLgAA 85  Haloarcula marismortui
Q97K38  58 IVVYaalvivgayilmanfypevektnlflknmgvyklkdyipynlklsnaglliivgciifskftkHRSFSHSILG-LI 136 Clostridium acetobuty...
Q186I4  68 IYKLfgs---------------------------------------------------------rfrHRGFTHSLIAlLL 90  Clostridioides diffic...
Q18EP1  73 -------------------------------------------------------------------GRVFMHSLPF-AI 84  Haloquadratum walsbyi...
Q5V391  56 IPS----------------------------------------------------------------GRVFMHSLPF-AI 70  Haloarcula marismortui
Q7MS32  64 LSSLfhr---------------------------------------------------------lfgHRGATHSFLF-PF 85  Wolinella succinogenes
Q8TQH1  59 QLFYlf------------------------------------------------------------gHREFTHSILF-IA 77  Methanosarcina acetiv...
Q0W4H6  56 -------------------------------------------------------------------GRIFSHTLLF-IA 67  uncultured methanogen...
Q12UG8  59 -------------------------------------------------------------------GRIFAHTFLF-VL 70  Methanococcoides burt...
Q8TP13  59 -------------------------------------------------------------------GRIIGHTLLF-SL 70  Methanosarcina acetiv...

Q5V568  86 LAAAAGLWASNSRATRigslsigavltvltgavsgpiaglvmlvfvlavlgvatvaqsrdvspRTVTGL--ALLG---LL 160 Haloarcula marismortui
Q97K38 137 LFTVGVKLLLGNIFIY-------------------------------------------------------FAVG---FI 158 Clostridium acetobuty...
Q186I4  91 IYSFFKSLTIFTNNNI-----------------------------------------------VFSCLSsgFIIG---YL 120 Clostridioides diffic...
Q18EP1  85 PIVLVVLGYALITNRL------------------------------------------------HLGTG--FSVG---YL 111 Haloquadratum walsbyi...
Q5V391  71 PLSIVVIAYAVRTDRT------------------------------------------------RLGTA--FAFA---HL 97  Haloarcula marismortui
Q7MS32  86 GVALPGWGIASSQGIA-----------------------------------------------LEAVIG--LWLG---VW 113 Wolinella succinogenes
Q8TQH1  78 LVTLFIWVKTRDWIF--------------------------------------------------------TYGGfqsIF 101 Methanosarcina acetiv...
Q0W4H6  68 VLAIIALLVARKYR-------------------------------------------------YWGVGV--LTVS---AA 93  uncultured methanogen...
Q12UG8  71 VLFAMGAIIHKYHKEN-----------------------------------------------GTGMII--LSIA---SF 98  Methanococcoides burt...
Q8TP13  71 LLFMIGLYIYQRNR-------------------------------------------------DIRGLS--LTAG---SF 96  Methanosarcina acetiv...

Q5V568 161 THPFGDLFTG------GPPPFFYPF-----------DVTLVAERVMLHPDPTTHLLAafaielatvwlavwtyvhlrgyt 223 Haloarcula marismortui
Q97K38 159 SHMVADTFTN------SGIEVFYPI-----------KKKISLKLVHTGS------------------------------- 190 Clostridium acetobuty...
Q186I4 121 SHLCLDLITK------EGIELFYPI-----------TINISLLPIKTNS------------------------------- 152 Clostridioides diffic...
Q18EP1 112 LHLPGDWHTRlln-geIPPDLLWPLt----------SIPAHPGPAHWWGPHNI--------------------------- 153 Haloquadratum walsbyi...
Q5V391  98 SHLVADNQQLlppnlyVSSDLLWPL-----------QPPVARSPVPQWVGEGA--------------------------- 139 Haloarcula marismortui
Q7MS32 114 LHLIGDMLTK------SGIPLWLPWs----------ERPIALLPLSYRFKTGGII------------------------- 152 Wolinella succinogenes
Q8TQH1 102 LHVYLDYVTT------WKMRPLYPFs---------tDPSIIGSVYFYDPLLNLLPLLplffiilgslrrr---------- 156 Methanosarcina acetiv...
Q0W4H6  94 FHQVEDQMWN------AAGTWFWPLfgwgfpeyergDYILYLLNNLISRPDVFL-------------------------- 141 uncultured methanogen...
Q12UG8  99 MHLLQDRMWT------VPQTFLWPImgwefphgttyGGFSHYLSVVTANSFAPEVSN----------------------- 149 Methanococcoides burt...
Q8TP13  97 LHLFEDQMWF------DPQTFLWPLfgwsfpresrdYIGLEHLLDMFEASFHLDFLQ----------------------- 147 Methanosarcina acetiv...

Q5V568 224 ltglvrpraalglgyaaailfMPAPTLEQS-AHFVFSVLA-LGVVGAPTRPF 273 Haloarcula marismortui
Q97K38 191 ---------------------------MLDhFTGGLAF---IVFLAIILKIK 212 Clostridium acetobutylicum
Q186I4 153 ---------------------------KTEkFISKLLNFIvIFLIGYQFYIL 177 Clostridioides difficile 630
Q18EP1 154 ---------------------------NII-WWSAFSIIT-LS--IVAIRMG 174 Haloquadratum walsbyi DSM 16790
Q5V391 140 --------------------------VNLH-LWTGFSVLV-LT--LVAYVLV 161 Haloarcula marismortui
Q7MS32 153 -----------------------DLALGGI-FGALFAYLG-LN----LWGSS 175 Wolinella succinogenes
Q8TQH1 157 ---------gklngrfnnfyvYICKNSDKLyASLILVLFIwLAFTPVSKAFL 199 Methanosarcina acetivorans
Q0W4H6 142 ------------------------PEIAGL-LALGWFVLR-FKLY--KPENA 165 uncultured methanogenic archaeon
Q12UG8 150 ---------------------TYMFELAGL-SVFIIVVYW-QL----FRIIV 174 Methanococcoides burtonii DSM 6242
Q8TP13 148 ---------------------SHVIEILGL-AIGFVLAYY-LS----KKLIG 172 Methanosarcina acetivorans
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