Conserved Protein Domain Family
DOCK_C-D_N
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pfam11878: DOCK_C-D_N 
Dedicator of cytokinesis C/D, N terminal
This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8) and DOCK-D subfamily (DOCK 9, 10, 11). DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases, required during several cellular processes, such as cell motility and phagocytosis. DOCK proteins are categorized into four subfamilies based on their sequence homology: DOCK-A (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11).
Links
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Statistics
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PSSM-Id: 463380
Aligned: 40 rows
Threshold Bit Score: 126.615
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_015793400   36 PFIVEPLDYEELINKMRTILQNDPQRELVLFPMDDFEAKNITRAMRTIRPVpyndheimIPSkliDTnILPVSLhVRQCI 115 
EEN62902       50 TDVVEPLDFEDFVSQHQNALEKEQLREFLDFPVDDLEIGVVPREIRTLEPC--------VPQ---NG-YEQDPH-VNDCI 116 
XP_006789865   55 YDAVEPLDLEEFFMSQLKSGDSALMQEFGDFPDDDLKVEQVEKECRTIRHS--------VPE---DG-VELDPH-VRDCI 121 
XP_006626930   57 YEAVEPVDLEEFLMTQLSSADSELMQELGDFPEDDLAVEFFPRECRTVQHS--------VPE---DG-EELDPH-VRDCV 123 
XP_022062318   50 TEAVEPVDFEEYLITHPPIVESGPLRDLIEFPPDDIEVIYTPRECRTVVQA--------VPE---EG--DTDPH-VRDCV 115 
XP_027318667   52 TEAVEPVDLEEYLSAHPMPVESGPLRDLFEFPSDDIEVVYXPRECRTLVSA--------VPE---ES--EMDPH-VRDCV 117 
XP_017948180   54 SDVVEPLDFEEYLSSHPPDAECEAIRDLYDVPPDDIEILYEPRECRTIEPA--------APE---EG--KLDAR-VREAL 119 
KTG38608       85 TEVVEPVDYEEYVSSHPPGAEPGPLRQLLEFPSDDLELLLQERECTTIEPP--------VP----EE-DSLDPR-VRDAL 150 
EHB12949       38 TEVIEPLDFEDVLLSWPPDAEPGPLRDLVEFPADDLELLLQPRESRTTKPG--------VP----ED--GMDAQ-ARAAV 102 
XP_026535379   49 TEVVEPVDFEKYLSTHLPDAEPGPLGDLIEFPKDDLEVSHEPRDCRTLEPG--------VP----ED-GKQDAR-VRDAV 114  mainland tige...

XP_015793400  116 DGFLRDWSVIEFKYEKYSGSWTELP-KLprLNEEANLQDQVYEID 159 
EEN62902      117 RVYTQDWNEVIRRYQQYGSGFMRDSe-LsrRSNTTGMVKQVFEVD 160 
XP_006789865  122 KSYTQPWLVVSRRCQGDGWSVYSERtGL-----HKLLRKQTFESD 161 
XP_006626930  124 QSYTQPWLTVSRRFQGDG-----WSiYSerTGLHKRLQKQTFESD 163 
XP_022062318  116 RSYTEDWAVVNRKYHKLGTGFNPNTlDKq-KERQKGLPKQVFEAD 159 
XP_027318667  118 RSYTEDWAIVNRKYHKLGTGFNPNTlDKq-KERQKGLPKQVFESD 161 
XP_017948180  120 KVYMHDWVLVQRRSQELSTAYSPITlERq-RQLQRGLSRHLYEVD 163 
KTG38608      151 GVYTDDWLIIQRKYQRYSTTQTPHNs-ErqREKQKGLVKQTFELD 194 
EHB12949      103 EMYTEDWVIVHRRYQHLSPAYSPTTa-DtqRERQKGLARQVFEQD 146 
XP_026535379  115 QVYTEDWVIVKKKYQKLSTMYNAITa-ErqRERQKGLSRQVFELD 158  mainland tiger snake
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