1YGP,1AHP,1FA9,1NOI,2C4M,6GPB,4BQE,4L22


Conserved Protein Domain Family
GT35_Glycogen_Phosphorylase

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cd04300: GT35_Glycogen_Phosphorylase 
Click on image for an interactive view with Cn3D
glycogen phosphorylase and similar proteins
This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Statistics
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PSSM-Id: 340853
Aligned: 56 rows
Threshold Bit Score: 1076.77
Created: 23-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitehomodimer
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:active site pocket [active site]
Evidence:
  • Structure:6GPB: Oryctolagus cuniculus Glycogen phosphorylase B binds heptulose 2-phosphate (a potent inhibitor), cofactor pyridoxal phosphate, and AMP. Contacts at 3.5A.
  • Citation:PMID 1900534
  • Citation:PMID 2106586
  • Comment:Each of N- and C-terminal domains binds one AMP molecule.
  • Structure:1YGP: S. cerevisiae Glycogen phosphorylase binds cofactor pyridoxal phosphate. Contacts at 3.5A.
  • Citation:PMID 8703213
  • Structure:1AHP: E.coli Maltodextrin phosphorylase binds maltose (a natural substrate), pyridoxamine phosphate, sulfate ion, and glycerol. Contacts at 3.5A.
  • Citation:PMID 9145112

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                     # #                 
1YGP_A         45 QDRFIDHVETTlarslyncddmVAYEAASMSIRDNLVidwnktqqkfttrdpkRVYYLSlEFLMGRALDNALINmkiedp 124  baker's yeast
1AHP_B         12 QEALSRQWQRYglns----aaeMTPRQWWLAVSEALAemlraqpfakpvanqrHVNYISmEFLIGRLTGNNLLNlg---- 83   Escherichia coli
6GPB_A         28 KKNFNRHLHFTlvkdrnvatprDYYFALAHTVRDHLVgrwirtqqhyyekdpkRIYYLSlEFYMGRTLQNTMVNla---- 103 
4BQE_A         64 AGNIVYHAKYSphfsplkfgpeQALYATAESLRDRLIqlwnetyvhfnkvdpkQTYYLSmEYLQGRALTNAIGNln---- 139  thale cress
NP_232414      15 QENVKRHLTATyattvehasarAWYLAMGRALAEFTTfdlleteqderilnskSLNYLSlEFLIGRLTGNNLISmg---- 90   Vibrio choler...
AAO86575       70 QISFVNHIEYTcarsrfnfdkfSAYLACSYSVRDRLIelfndtqeyfiaqkakHVYYVSiEFLVGRFLRNALQNle---- 145  Tritrichomona...
XP_668342      67 QRSIVNHVEYTlartrfnfddnAAYRATAYSIRDRLIenlndtneyfnerdckRCYYLSlEFLLGRAMQNALVNld---- 142  Cryptosporidi...
ABB88567      194 QEDIVNHVEYTlarsrvnfdnfEAYQATSFSLRDRLIerwndtqtwfkekdpkRVYYLSmEFLMGRSLLNTLYNld---- 269  Chlamydomonas...
ABB88569       58 TTDITSKLKYLfgrng-dytnaDAYQGTAWSVREKLIdsfnkthehwkkedpkFIYYLSaEFLMGRSLTNTVYNlg---- 132  Chlamydomonas...
XP_001449904   13 QQSIVHHVEYTlartrfdfskfHSYQALSHSVRDRLIeafndtnlhfhqmdakRIYYLSlEFLIGRCLQNALVNld---- 88   Paramecium te...
Feature 1                                                ###                                      
1YGP_A        125 edpaaskgkpREMIKGALDElgfkLEDVLDqepDAGLGNGGLGRLAACFVDSMATegiPAWGYGLRYEYGIFAQKIid-g 203  baker's yeast
1AHP_B         84 ---------wYQDVQDSLKAydinLTDLLEeeiDPALGAGGLGRLAACFLDSMATvgqSATGYGLNYQYGLFRQSFvd-g 153  Escherichia coli
6GPB_A        104 ---------lENACDEATYQlgldMEELEEieeDAGLGNGGLGRLAACFLDSMATlglAAYGYGIRYEFGIFNQKIcg-g 173 
4BQE_A        140 ---------lQGPYADALRTlgyeLEEIAEqekDAALGNGGLGRLASCFLDSMATlnlPAWGYGLRYRHGLFKQIItk-k 209  thale cress
NP_232414      91 ---------vYEAVGQAMEElgqnLSDLLEeerDPSLGNGGLGRLAACFMDSCAAqeyPTVGYGLHYEYGLFKQSFee-g 160  Vibrio choler...
AAO86575      146 ---------lEDLYRESLNEldisLDQLFNeeyDPGLGNGGLGRLAACFMDSLATlnlPAWGYGLMYSFGMFKQTIgpdg 216  Tritrichomona...
XP_668342     143 ---------iEENYRKSLFDlgynLEALYDnehDAALGNGGLGRLAACFLDSLATknyAGWGYGIRYTYGIFEQKIvq-g 212  Cryptosporidi...
ABB88567      270 ---------iKESYQEALAElgydLETLADlerDAALGNGGLGRLAACFLDSMATlnlPAWGYGIRYQYGMFRQTIqn-g 339  Chlamydomonas...
ABB88569      133 ---------lEGEYGNALREmgyhMEKVADaerDAALGNGGLGRLAACFLDSMATldlPGWGYGIRYKYGMFKQGLkd-g 202  Chlamydomonas...
XP_001449904   89 ---------lEEDYREALMDlgykLEELYDeevDPALGNGGLGRLAACFLDSLATlnyPSFGYGIRYTYGIFKQLIkd-g 158  Paramecium te...
Feature 1                                                                                         
1YGP_A        204 YQVETPDYwl-nSGNPWEIERnevQIPVTFygyvdrpeggkttlsasqwiggERVLAVAYDFPVpgfktsNVNNLRLWQA 282  baker's yeast
1AHP_B        154 KQVEAPDDwh-rSNYPWFRHNealDVQVGIggavtkd---------grwepeFTITGQAWDLPVvgyrngVAQPLRLWQA 223  Escherichia coli
6GPB_A        174 WQMEEADDwl-rYGNPWEKARpefTLPVHFygrvehts------qgakwvdtQVVLAMPYDTPVpgyrnnVVNTMRLWSA 246 
4BQE_A        210 GQEEIPEDwl-eKFSPWEIVRhdvVFPVRFfgkvqvnpd-----gsrkwvdgDVVQALAYDVPIpgygtkNTISLRLWEA 283  thale cress
NP_232414     161 RQKEAPDAwcgvEGYPWEVARpelKQEIGFyghvevvnen--gkerrrwvpgMLVQAMPWDLPIvgyqsdTVYPLRLWEC 238  Vibrio choler...
AAO86575      217 SQMEIPDYwl-nYGDPWRVQKptvSYPVNFfgyvdqn---------gkwvpsQTIIAMANDFLIpgfatdNTLGLRLWSS 286  Tritrichomona...
XP_668342     213 RQFEHPDYwl-vQSNPWEIERqdvTYGVRFyghvrefeeh--grkkfrwvdgEVIQAVAYDNPIpgfdtyNCINLRLWKA 289  Cryptosporidi...
ABB88567      340 FQHEQPDYwl-tFGNPWEIERlivSYPIKFyghvsvvned--grqlfrwnagETVTAVAYDNPIpgfgtrNCINLRLWAA 416  Chlamydomonas...
ABB88569      203 YQVEMPDIwl-tKGNPWEVRRddvKFEVGFggrverkkvn--gkemtvwtpsEKVIAQAYDNPIpgyatpTTSNLRLWDA 279  Chlamydomonas...
XP_001449904  159 YQVESPDFwl-nHGNPWEIERldvQYQIRFygfvkkvwdh--gversvweggETIMARAYDTPIpgyntqNTIALRLWKS 235  Paramecium te...
Feature 1                                           #  # #      #                                 
1YGP_A        283 Rpttefdln-kfnngdykNSVAQQQRAEsitavlYPNDNFAQGKELRLKQQYFWCAASLHDILRRFKkskrpw------- 354  baker's yeast
1AHP_B        224 Thahpfdlt-kfndgdflRAEQQGINAEkltkvlYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHlagrel------- 295  Escherichia coli
6GPB_A        247 Kapndfnlk-dfnvggyiQAVLDRNLAEnisrvlYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKsskfgcrdpvrtn 325 
4BQE_A        284 KaraedldlfqfnegeyeLAAQLHSRAQqictvlYPGDATENGKLLRLKQQFFLCSASLQDIISRFHersttegsr---k 360  thale cress
NP_232414     239 Raiapfsle-sfnngnyfEAQHALIDAGnitkvlYPNDNHEKGKTLRLMQQYFHSAASVRDILRRHEaaghal------- 310  Vibrio choler...
AAO86575      287 Kpsaeldee-kfrygdyyDAIAQKQRAEnltsvlYPNDNTNEGKEMRLMQEFFMSSATLQDIIRRLKtvqkadv------ 359  Tritrichomona...
XP_668342     290 Tpsrefdfn-afnegkyvDAVCARQRAEyitsvlYPNDNTEQGKELRLKQQYFFVCATIQDILRRFKksgkvdw------ 362  Cryptosporidi...
ABB88567      417 Kpskefdle-afntgdyvAAILSKQRAEtlssvlYPDDRTYEGKELRLKQQHFFVSATIQDCVRRYRdahpndw------ 489  Chlamydomonas...
ABB88569      280 Vpvhefdls-afnagdydRAMLERERAEgisavlYPNDSTPEGKELRLKQQYFFVCASLQDVMSRFRavhganw------ 352  Chlamydomonas...
XP_001449904  236 Hpasefdfs-sfntgdyfKALEQRQKAEyitsvlYPNDSTDAGKELRLKQQYLLVSASMQDIVRRFKrrkvldw------ 308  Paramecium te...
Feature 1                      # #                                   ##   #                       
1YGP_A        355 -tefpdqVAIQLNDTHptLAIVELQRVLVDleklDWHEAWDIVTkTFAYTNHTVmQEALEKWPRRLFGHLLPRHLEIIYD 433  baker's yeast
1AHP_B        296 -heladyEVIQLNDTHptIAIPELLRVLIDehqmSWDDAWAITSkTFAYTNHTLmPEALERWDVKLVKGLLPRHMQIINE 374  Escherichia coli
6GPB_A        326 fdafpdkVAIQLNDTHpsLAIPELMRVLVDlerlDWDKAWEVTVkTCAYTNHTViPEALERWPVHLLETLLPRHLQIIYE 405 
4BQE_A        361 wsefpskVAVQMNDTHptLAIPELMRLLMDdnglGWDEAWDVTSkTVAYTNHTVlPEALEKWSQSLMWKLLPRHMEIIEE 440  thale cress
NP_232414     311 -adlpkyETIQLNDTHptIAIPELMRILIDeklmSWEAAWAICShTFAYTNHTLlPEALETWSESLIQRLLPRHMEIIYE 389  Vibrio choler...
AAO86575      360 -relpryAAIQLNDTHptVMVAELLRILVDeeniPFDEAYDICTkVFSYTCHTLmPEALEKWGVPMFENVLPRHLQLIYQ 438  Tritrichomona...
XP_668342     363 -selpkkVSCQLNDTHptIAVAEMMRILIDveelDWDFAWNITSeCFNYTNHTVlPEALEKWSSSLFSKLLPRHLMIINE 441  Cryptosporidi...
ABB88567      490 -eqfpekVAFQLNDTHptIAVAELMRVLMDdhklGWTKSWDICNkVFAFTNHTVlPEALERWPVALIEKLLPRHMQIIYD 568  Chlamydomonas...
ABB88569      353 -ealpekACFQLNDTHptIAVAELMRLLVDveglEWDAAWTITTkCLNYTNHTVmPEALEKWPVKVMAKMLPRHMEIIEV 431  Chlamydomonas...
XP_001449904  309 -nafpqkVAVQLNDTHpaLAIVELLRILIDieqlDNMSAWQIVTkSFNYTNHTVlPEALEKWGVPLIEKLLPRHLEIIYL 387  Paramecium te...
Feature 1                                                                                         
1YGP_A        434 INWFFLEDVAkkfpkDVDLLSRis-----iIEEns---peRQIRMAFLAIVGSHKVNGVVELHSELIKTti----fKDFI 501  baker's yeast
1AHP_B        375 INTRFKTLVEktwpgDEKVWAKl------aVVHd------KQVHMANLCVVGGFAVNGVAALHSDLVVKd-----lFPEY 437  Escherichia coli
6GPB_A        406 INQRFLNRVAaafpgDVDRLRRms-----lVEEga----vKRINMAHLCIAGSHAVNGVARIHSEILKKt-----iFKDF 471 
4BQE_A        441 IDKRFVQTIRdtrvdLEDKISSls-----iLDNnp---qkPVVRMANLCVVSSHTVNGVAQLHSDILKAe-----lFADY 507  thale cress
NP_232414     390 INHRFLQQVRakwpgDVAKQQKls-----iIEEgf----hRMVRMANLCVVGSYAVNGVAALHSELVKRd-----lFPEF 455  Vibrio choler...
AAO86575      439 LNQLFIDQLRynyhaDDEMIRDls-----iIEEgc----eKKVRMANLAVIGSHKVNGVAAIHSELMKQy-----vFKNF 504  Tritrichomona...
XP_668342     442 INYRFLNDVRavlgdGPWISKMs------iYEEgw----dKKIRMANLAVIGCRKVNGVAVIHSEIVKKdlfsdfvEYYR 511  Cryptosporidi...
ABB88567      569 INWRFLQTVRnkfgdDWERISRms-----vIEEqpn--geKMVRMAFMAVVASHTVNGVAAIHSEIIKEt-----iFKDF 636  Chlamydomonas...
ABB88569      432 INEGWTKWLGvhlkdLKSEERAkkiaamsiIHAnpwnadeMLVNMAYLAVVGSSAVNGVAAIHSNIVKDe-----iLNDF 506  Chlamydomonas...
XP_001449904  388 INFLFLEKVQqkypnNWGKLSAls-----iVEEeg----tKKVRMANLSIVGSKFVNGVAKIHTELLKTt-----iFKEF 453  Paramecium te...
Feature 1                     #      #                                                            
1YGP_A        502 KFYGPSKFVNVTNGITPRRWlkqaNPSLAKLISETlndpteeylldmAKLTQLEKyvedkEFLKKWNQVKLNNKIRLVDL 581  baker's yeast
1AHP_B        438 HQLWPNKFHNVTNGITPRRWikqcNPALAALLDKSlqkew---andlDQLINLVKladdaKFRDLYRVIKQANKVRLAEF 514  Escherichia coli
6GPB_A        472 YELEPHKFQNKTNGITPRRWlvlcNPGLAEIIAERigeey---isdlDQLRKLLSyvddeAFIRDVAKVKQENKLKFAAY 548 
4BQE_A        508 VSIWPNKFQNKTNGITPRRWlrfcSPELSDIITKWlktdk--witdlDLLTGLRQfadneELQSEWASAKTANKKRLAQY 585  thale cress
NP_232414     456 VELYPGKIQNVTNGITPRRWlkfcNPGLSALISEKighew---paklDQLTKVAQyaedaAFQKRFMEVKKANKARLADW 532  Vibrio choler...
AAO86575      505 NRIWPDKFCNKTNGVTVRRWlhhcNPELSNLITQVvgden--waihpGGLTKLMTkiddpNFVSEWAAVKNANKLRFANW 582  Tritrichomona...
XP_668342     512 RKGIKDKFINVTNGVTPRRWvncaNPKLSHLISNWlgsds--wltnfDMIRSLQNniddlSLQKEWAEVKLSNKERLAKW 589  Cryptosporidi...
ABB88567      637 YELWPNKFQNKTNGVTQRRWlafcNPPLRQLITKKlgndd--wtlhlDNLRELRKyandpEFQTEWRGVKSEAKKKAAAL 714  Chlamydomonas...
ABB88569      507 YEIFPSKFQNKTNGVTPRRWlawcNPELAQLITEAlgsse--windtEKLAGLRAfasdpAFQAKWAAVKKAKKAKLAEL 584  Chlamydomonas...
XP_001449904  454 FEMHPNKFQNKTNGVTPRRWvrcaNPALAALYDRVlgsdk--wvldmEQLKQLEShvsdpQFVREFQMIKIENKERFVHW 531  Paramecium te...
Feature 1                                  ## ####                                          #    #
1YGP_A        582 IKkendgvdiinreylddtLFDMQVKRIHEYKRQQLNVFGIIYRYLAMknmlkngasieevarkyprKVSIFGGKSAPGY 661  baker's yeast
1AHP_B        515 VKvrtgid------inpqaIFDIQIKRLHEYKRQHLNLLRILALYKEIrenpq---------adrvpRVFLFGAKAAPGY 579  Escherichia coli
6GPB_A        549 LEreykvh------inpnsLFDVQVKRIHEYKRQLLNCLHVITLYNRIkkepn---------kfvvpRTVMIGGKAAPGY 613 
4BQE_A        586 IErvtgvs------idptsLFDIQVKRIHEYKRQLMNILGVVYRFKKLkemkpee------rkktvpRTVMIGGKAFATY 653  thale cress
NP_232414     533 VKdhmgie------ldtnaIFDVQIKRLHEYKRQHLNMLHILSLYHRLindps---------fdmhpRVVFFAAKAAPGY 597  Vibrio choler...
AAO86575      583 VSenmgve-----lnpnvqLFDVQVKRIHEYKRQTLNILSVIYRYLRIlsgdt---------qgmqpRAIFIGGKAAPGY 648  Tritrichomona...
XP_668342     590 VEintgyk------vstsmLFDIQVKRIHEYKRQLLNLFYIIHRYLTLkhispee------rkkfvpRCCFFGGKAAPGY 657  Cryptosporidi...
ABB88567      715 IHrltgvr------vstdaMFDIQIKRIHEYKRQLLNVLGIIYRYDQIkkmtpqq------rksvvpRVCVIGGKAAPGY 782  Chlamydomonas...
ABB88569      585 IKkihgdd------vnqnaLFDIQIKRIHEYKRQYLNVLSIIWRYKQLkkmtpeq-----rkasavpRVCVIGGKAASAY 653  Chlamydomonas...
XP_001449904  532 IRktcqvd------lnvdsLFDIQVKRIHEYKRQLMNILYVIYRYLIIkestpee------rkrivpRSVCFGGKAAPGY 599  Paramecium te...
Feature 1          #                                 ##                     # ####  #             
1YGP_A        662 YMAKLIIKLINCVADIVNNDESIEHLLKVVFVadyNVSKAEIIIPaSDLSEHIStaGTEASGTSNMKFVMnGGLIIGTVD 741  baker's yeast
1AHP_B        580 YLAKNIIFAINKVADVINNDPLVGDKLKVVFLpdyCVSAAEKLIPaADISEQIStaGKEASGTGNMKLALnGALTVGTLD 659  Escherichia coli
6GPB_A        614 HMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLenyRVSLAEKVIPaADLSEQIStaGTEASGTGNMKFMLnGALTIGTMD 693 
4BQE_A        654 TNAKRIVKLVNDVGDVVNSDPEVNEYLKVVFVpnyNVTVAEMLIPgSELSQHIStaGMEASGTSNMKFALnGCLIIGTLD 733  thale cress
NP_232414     598 HLAKEIIYAINMIAQKVNNDPRVGNKLKVVFIpdyRVSMAEIIIPaADVSEQIStaGKEASGTGNMKMALnGALTIGTMD 677  Vibrio choler...
AAO86575      649 FFAKKLIKLINNVSRVINNDPRVGDLLKLLYIpnyNVSLAEVIIPgSDINEQIStaGTEASGTSNMKFAFnSSLIVGTWD 728  Tritrichomona...
XP_668342     658 ATAKTAIKMMNNLSVIINNDPDTKDYLMCVFLpnyNVSNAQIIIPaSDISQHIStaGTEASGTSNMKFVMnGGLIIGTLD 737  Cryptosporidi...
ABB88567      783 EMAKRIIKLICAVGDKINQDPDMGDLLKLVFLpdyNVSSAEVIIPaTELSQHIStaGTEASGTSNMKFTMnGSLIIGTLD 862  Chlamydomonas...
ABB88569      654 DMAKRIIRLVTAVGEVINKDPETKDYLRLYFLpdyNVTLAETIIPaAELSQHIStaGTEASGTSNMKFQMnGCLIMGTWD 733  Chlamydomonas...
XP_001449904  600 VNAKRVIKLINSVADVINNDHQIGDLLKVVFMpnyNVSNAQIIIPaAELSQHIStaGTEASGTSNMKFIMnGCLILGTLD 679  Paramecium te...
Feature 1                                                                                         
1YGP_A        742 GANVEITREiGEDNVFLFGnLSENVEELRYNhqyh--pqdLPSSLDSVLSYIEsgqfsp---enpneFKPLVDSIKyh-- 814  baker's yeast
1AHP_B        660 GANVEIAEKvGEENIFIFGhTVKQVKAILAKgydpvkwrkKDKVLDAVLKELEsgkysd---gdkhaFDQMLHSIGkq-- 734  Escherichia coli
6GPB_A        694 GANVEMAEEaGEENFFIFGmRVEDVDRLDQRgynaqeyydRIPELRQIIEQLSsgffsp---kqpdlFKDIVNMLMh--- 767 
4BQE_A        734 GANVEIREEvGEENFFLFGaTADQVPRLRKEredg--lfkPDPRFEEAKQFVKsgvf------gsydYGPLLDSLEgntg 805  thale cress
NP_232414     678 GANVEIREEvGDDNIYIFGlEVDGVEALKARgynpydfyhADPLLKASLDLLVgeeftp---gapgkLRATYDSLLdg-- 752  Vibrio choler...
AAO86575      729 GANIEIGDAiGNENVFFFGtKVENVDRIRAGdgr----hiSEKLTRVFDAIRNgmfg-------dneYQCVIDSIYn--- 794  Tritrichomona...
XP_668342     738 GANVEIREEcGNETMFIFGaLEQEVEHIRNRareg--nypIDQRLHDVFNFIRtggimlgdgkaqgeFCEIVNKICsngd 815  Cryptosporidi...
ABB88567      863 GANVEIAEEiGDENIFIFGaKAHEVARLRAErrn----lhVDERFNHVVNMIRtghfg-----wedyFGPVVDAITtg-- 931  Chlamydomonas...
ABB88569      734 GANIEIAEEtGVENVFVFGvRAEEINQLRKDrkn----fkTDPRWDELMKDIEggmfg-----dkdyFKPLVDSVNnmk- 803  Chlamydomonas...
XP_001449904  680 GANVEIDEAvGRENIFIFGtQVEDVDNMKEKmrntdpheyFPQELLKVFTEIDngrfg-----hneeLKWIVDSIRyk-- 752  Paramecium te...
Feature 1                                                                         
1YGP_A        815 ---gDYYLVSDDFESYLATHELVDQEFHNqRSEWLKKSVLSlANVGFFSSDRCIEEYSDTIWNV 875  baker's yeast
1AHP_B        735 --ggDPYLVMADFAAYVEAQKQVDVLYRD-QEAWTRAAILNtARCGMFSSDRSIRDYQARIWQA 795  Escherichia coli
6GPB_A        768 ---hDRFKVFADYEEYVKCQERVSALYKN-PREWTRMVIRNiATSGKFSSDRTIAQYAREIWGV 827 
4BQE_A        806 fgrgDYFLVGYDFPSYMDAQAKVDEAYKD-RKGWLKMSILStAGSGKFSSDRTIAQYAKEIWNI 868  thale cress
NP_232414     753 ---gDPYLVLADFASYVKAHEAIDKQYRD-QAGWAKKAILNtALVGKFSSDRSIRDYVNNIWKL 812  Vibrio cholerae O1 biovar elt...
AAO86575      795 ---gDHYLCGQDFDMFVEIQDKVDRAYQD-KEKWTKMGITStANMAFFSSDRTIDEYAKQIWDV 854  Tritrichomonas foetus
XP_668342     816 gqigDFYLVCHDFPLYCDAQMRVDQAYRD-QTTWVKTCIKAaSSMGKFSTDRTIEEYATAIWEL 878  Cryptosporidium hominis TU502
ABB88567      932 ---gDYYLVANDFPGYLETQFRADEVYKN-QTEWTRMSIMAtAGGGKFSTDRTIAEYARDIWHA 991  Chlamydomonas reinhardtii
ABB88569      804 -vgnDWFLLANDFAGYLAAQEEVDATYKD-QAEWLRRSIMYtAGSGKFSSDRTIREYAEDIWHV 865  Chlamydomonas reinhardtii
XP_001449904  753 ---nDNYLVGQDFKDYIKAQQQVDDLYRQ-PNEWAKKSIYNaIRSYKFSSDRTIYEYAEDIWQL 812  Paramecium tetraurelia

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