Conserved Protein Domain Family
Toxin_YhaV
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pfam11663: Toxin_YhaV 
Toxin with endonuclease activity, of toxin-antitoxin system
YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.
Links
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Statistics
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PSSM-Id: 431989
Aligned: 28 rows
Threshold Bit Score: 185.548
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q89TU0         13 VYAHPLFLDQFETMIAAVEKARKKDP-KGYKKKRAAKLLSAVLKVAFDDIPSDPTRDVYRQGGTLGD-EYKHWFRAKLLQ 90  Bradyrhizobium...
P64594         12 LYAHPCFQETYDALVAEVETLKGKDP-ENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSgKNKDWSRVKFGA 90  Escherichia co...
jgi:Xaut_4954  16 LFRARAFSEALDGLEAELVRLAAERP-DDASSHPKAKLLARILNLILDEIPRDPNAATYQLGNTLGP-SHRHWRRAKFLQ 93 
WP_012568630   10 LLEYPALTASLDRLADSVRRLRAADP-VDYVHHPNAKLLGRLLTIMLVEVPADPNRADYRLKGPLSP-----WRRVATG- 82  Rhodospirillum...
WP_015220445   11 IYFHPLFYQQWLELVNRVKYLKQRSApENFVTHPDVKLLKALDQGIKDKIPKDPFASYFALKKPLQ--KYSRLKKMGLPS 88  Cyanobacterium...
WP_015192019   11 IFFHPLFNAPWISLVAKVKQLKTKLEpKDFVTHPDTKLLKAIDLGIKDKIPSNPFASYFALQKPLH--KYGRLKKMGLPN 88  Stanieria cyan...
WP_015079922   15 IFFDPLFNTQWIELRDKVKKLKDELPkEEFIKHPDAKLLKALNIGIKEKITQDPFASYFILQKPLQ--KYGRLKKMGLPE 92  Anabaena sp. 90
WP_012167212    9 yfLKRLFGQQRLALRTEVKRLKATLPpEDYVRHPQVKLYAATMQAIKAKIPADPFASHFALTGPLK--KFGRVKKMGIPN 86  Acaryochloris ...
WP_015197878   12 YFHPQLFGTQYQELFDRVSELRKKLPeSEFKTHATVKLFAAITIAIETKIPSDPLASHFALTGALK--RYGRVKKMGLPE 89  Calothrix sp. ...
WP_015158542   12 YFHRQLFGEQRRQLRERVKQLKAELPeADYLTHPDVKLLAAVMVGIKEKIVLDPLATQFALTGPLR--RYGRMKGMGLPQ 89  Chamaesiphon m...

Q89TU0         91 -QFRLFFRYQqsADAKIIVLAWVNDDSTLRAYESANDAYAVFRKMLDRGNPPDSWNELVAAAS 152 Bradyrhizobium japonicum
P64594         91 gRYRLFFRYS--EKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETE 151 Escherichia coli K-12
jgi:Xaut_4954  94 -RFRLFFRFD--SASRIIIYAWVNDENTLRKAGSRSDPYAVFLRRLNDGNPPDRWDDLLADAK 153
WP_012568630   83 -RWRLFFRFD--SSSRIIAYCWLNGADGLRKDGDAGDPYAVFGRMVARGTPPEDWPALLRACR 142 Rhodospirillum centenum
WP_015220445   89 -RYRLFFRVFk--EANTIIILWLG---FPRKERDKKDCYKVFSKMVINGNFPEDIASFLDLAN 145 Cyanobacterium aponinum
WP_015192019   89 -HYRLFFRAF--KEKKVIIILWLG---FPRKEGDQKDCYQVFSKKILKGEFPNSLDDFLREYQ 145 Stanieria cyanosphaera
WP_015079922   93 -RYRLFFRVF--KEQKIIIILWLG---FPRKEGDKKDCYQVFTKKVENGDFPENVDQFMIeym 149 Anabaena sp. 90
WP_012167212   87 -RYRLFFRAFkvPESQSIFVLWLG---YPRKEGDKKDCYRAFRKMVERGDFPDSLDDLMVESE 145 Acaryochloris marina
WP_015197878   90 -RYRLFFRAFdtPKLKSIVILWLG---FPRKEGAKDDCYQVFTKMVARGTFPDSLDELIKEpg 148 Calothrix sp. PCC 6303
WP_015158542   90 -RYRLFFRAFtsEERQVLIVLWLG---YPRKAGDKQDCYEVFTKMVGNGDFPDNLPELLMATd 148 Chamaesiphon minutus
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