Conserved Protein Domain Family
Tmpp129

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pfam10272: Tmpp129 
Putative transmembrane protein precursor
This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.
Statistics
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PSSM-Id: 463039
Aligned: 34 rows
Threshold Bit Score: 366.98
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD80066      36 FCIMAPTTEFISA-GVTLENLFNRFLGNESQYFVQYHLKRTVMVRLFSSSLVF---LYF---MFMQFLSKnvavsapnis 108
XP_001607904  17 aCIIYPPNEFVSA-GLTVKSIFAELLGSESETFVQYHIRRSIATLLIHSVIPF---GYL---LGLVMTGNvdavev-iig 88 
2_pfamImport   1 -CFILRTKEFVSA-GVVIESLFDWLLIKEHEDFIHYHIRRTSLTIFVHSLLPL---GYI---FGLSLVMEdlsii---ts 69 
XP_001951476  19 aCFVLRTTEFVSN-GLTVESLFDMVIDKEYNNFILHHIKRTSYSIIVHSSLPF---VYL---LGTLIVNDnek------a 85 
KJE90682      16 gCLVFPPPALVSE-QLTLDALLASFGPREDRSYIHHHMHMTTLTLAAHALLLL---GFVagtAGLLHDDPswna----tp 87 
EGT59395      46 cVMAYPPEGVLDElGVTLFDFFSVIYVRQRYNFIEYSSKRIIFFKTFLAMWPSaisFYFvhgylrwksvh--gsrfpell 123
1_pfamImport   1 FALVFPPEELLDGlGITLFDLFSILKDPEQYGFIEYVCKRQTFFKTFVALYPAafsGYFvhgnmfmrkef-gisrfpell 79 
XP_002644008  46 FALAFPPEELLDGlGLTLYDLFSIIYDQRNYSYIDYAAKRVLFFHVFVASYPAlisGYFvhgqlfttain--trrfpelf 123
EFO89927      46 FALVFPPEELLDGlGLTLFDLFTIIYNSRHYGFVEYAAKRVAFFHAFVAAYPCvisLYFvhgnlfmtavd--trrfpepl 123
CDS41676      27 FALVAPPNVLLSA-GLTIENLFHRLLGSEELFFTAYHLRRTAILKALSFFIPL---GYF---ITLRTFGNpem------g 93 
CCD80066     109 fpFTIWDVILWIGIgGLSIIGSHTYlVWYGSGTWYGHPTILSLKQTImESlpdsQSSSSttassslsngafgvalkaLIS 188
XP_001607904  89 neNPWWMVLIACSL-VGPLFALYKV-LQWSSNDWETHPIARSLAVYCnNN----TTWLS------------------AAS 144
2_pfamImport  70 ldGLWWSTLVLFSH-ILPFTSSFFI-LLWAYDGWSSHPIARTLSLFCpEG----TSWKQ------------------LAS 125
XP_001951476  86 fvSAYFYELILLS--LLPIMYSVSVvFKWKSNNWANHPLSIILSRYNs------VDWTL------------------VAQ 139
KJE90682      88 elLQYAAMLLAVAAvVLAFTMLAHA-FRWSLLDGEYHPSARNLSAYS-------PTWRH------------------LAR 141
EGT59395     124 dfPLIWYGAFVVSV-------IGAIaYYMRIKDYEQWPIYQYFVENPe-----------------------------VAN 167
1_pfamImport  80 dnPIFWNTFFVISI-------FSALvYNYHISDYKKWPFYQYFIDNPe-----------------------------CLN 123
XP_002644008 124 dhPWLWLLVFVTSV-------IGLVtYYYKIREYTQWSAFQYFMDHPe-----------------------------TLD 167
EFO89927     124 dhPYMWFTAFVISV-------IGAAlYCNRIKDYKQWPVYRYYNEHPd-----------------------------ALE 167
CDS41676      94 flNAVGNVGLALSIaQVAIASFYIYlEWYAHGKWTGHPGMQEMRKIAeSIssssFS-TSptssneleflrshpspegVAS 172
CCD80066     189 SINSEYQRSDKFVAGQGsls-tnwSgRRFVITDSWILTSRFTEFKIVKQSSENMLAVVVSAFSVL---DPSSltqdgqp- 263
XP_001607904 145 DINIEFRRIDKIVIDTN-------SiTKIVATDNWIIKVSPYKLYFAHQSDTALVLNRSDTHAFSq--STRT-------- 207
2_pfamImport 126 TINADYRGIDKICLEPS-------SmTKVVVTDTWIIKISPYNVNLAHQSDSTLEVCSADTHHISv--DGEG-------- 188
XP_001951476 140 NISTEYQCLQKLTLAYG-------TiNRTVVTENWIISIKPYMVYVSKKSESSFLVYSSDNHNSTp-dGTPG-------- 203
KJE90682     142 QIDMECRRMDCVVVNSH-------E-AQLVITSDWILQRTWYNLHIANHNDVDMSILGSETIPIAarpAAEAmhanpqla 213
EGT59395     168 DVELVLGNAEAFRVSCS-------QrTLVVVTAEYFIYSSNWRYVAVKNADVRFVADHARPPAVLimdDGEE-------- 232
1_pfamImport 124 QVEELVSEPDTFKIRFC-------AhTFLYCNRNFFAYVSNWRLVAVKQADLRLLVDNTRMPMIPn-mDDEE-------- 187
XP_002644008 168 GVETVINDPETFRIRLS-------QrTHVYVTRNFFIYSSNWRFVAVRIIDVRLQVDNTRMPMIMnihDEEE-------- 232
EFO89927     168 EAQDVISSPDTFRVKLS-------QrTFLFVTRSFFVYSSNWRFVAVKIADLRLQVDNTRMPLLPnnqDEEE-------- 232
CDS41676     173 SIDKEFRRMEKFVAFAGrgltsswSgRRIVVTPSWILFSHRTTFLPICQLLGHLGAVVVGTRCITnqiASLGedeeqer- 251
CCD80066     264 -------dgeslgVQTIVTVRFIRTDTGVCLLSFGFPASNLDELRSKLRFPLIQAQGVQLEPTIIQRFIEAFTQVVDENQ 336
XP_001607904 208 -------------EVQYVNIAVIPTRAGAQPFNIRLNALDFKDLQDKVSRPIKVLDSVVFHRTLLDRFIDTFKEQIAQNP 274
2_pfamImport 189 -------------TVQYVTIEVKTIRPGLPSFFIRCNALDFNDLKNKIRRPIRILDGITFHKTRTDHFLEVFRETVEKNP 255
XP_001951476 204 -------------SIQFINIQVIPIRSQIKWFIVRIRSEDFKTLEEHIGHPIQIADNVKLQRSRTERFIEVFRDQVSQNP 270
KJE90682     214 alayttggvasdhTVQMIRIHVTAATPGVQPFDIRLNSTDFSAIQDKLTTIIRNAQSIVIAQTLSDRFVTAFLETVSQNP 293
EGT59395     233 -------------RLRSIYIRGNFTPNYIPSLPLALRLDHFRAINETLPVPIFIPAGLKIPLTVMDEMLQDFALRITKNS 299
1_pfamImport 188 -------------RLRHIFVIVSFRQPYLPVFTISLRHDLYRQLNEVLAVPIIVPAHITIPLTIMEELKEDFIERVAQND 254
XP_002644008 233 -------------RLRAMFIKVNFNVPYLAPFTMTLRQDYYHQLNEILEIPIFVPPHITVPMTIMEELKEDFVHRIRNNS 299
EFO89927     233 -------------RIRYIFVKVRFRPEYLQSFTITLRQDYYRMLNEVLEVPIFVPPHINVPMTIMEELKEDFIDRIETNS 299
CDS41676     252 ------adpmlgsGVVMATIRIADMDSGACILSFDLPASELENFRLYLCCPLVYAQGVSLEPSIIQRFLEAFSAVVQENE 325
CCD80066     337 PVNLP---SGyELGQ-CIGCMV--QQVNVTLNRQCessltssssslanNSnqsLNNNQCGICYCRPLWCLECLARWFASR 410
XP_001607904 275 EYE-----TAqELEQ-CVGCMQ--AFSNVKLNKLCa------------LPddlLQPNPCVVCYCRPMWCVDCMAKWFASR 334
2_pfamImport 256 TYALQ---ANqELDT-CIGCML--MEPQVKLVKSC-------------------TNSQCTICYCRPLWCLDCMAKWYASR 310
XP_001951476 271 VYNGYs-sAElEDDV-CAGCLV--NPPDIKLTKCCed---------------sNDIVNCTSCQCRPMWCVDCMAKWYESR 331
KJE90682     294 VYPHPassSHvATDDmCVGCMA--HPPRAKIVQRC------------------QTPTACTPCYCRPMWCLECLGKWFASK 353
EGT59395     300 RVTYQq--KRsDKRA-CFGCANnyEDKMVVLRKTCtgtep---rtgfhELgl-rLQPPCDGCLCEPLWCVSCAGRIFVMK 372
1_pfamImport 255 RHIHHa--KAsDKEP-CFACGT--EENIIKIVKTCadnne---rwqwsREgqrVYTDQCQVCVCRPLWCNRCIAQIFIGK 326
XP_002644008 300 RHTHRv--KRsEQDP-CFACGS--EENIIKISKSCtgeeq---rllfhDVvl-nPTPNCENCTCRPLWCCGCIAQIFITR 370
EFO89927     300 RYLHRv--KRsDLDP-CFACGT--EENIVKIEKTCtgqep---rvlfhDTgl-rFTPPCENCTCRPLWCRNCIAQIFITK 370
CDS41676     326 PIEIP---PSmELER-CIGCLS--NQTSVAIRRSC--------------------AGECGSCRCRPMWCEMCVGRWFASR 379
CCD80066     411 QTNMHrpTTQWLSGRVPCPTCRTYFCARDVS 441
XP_001607904 335 QDESA--PETWLSSKCTCPVCRAKFCVRDVC 363
2_pfamImport 311 QDQDR--PETWLSSTCTCPVCRSVFCVLDVY 339
XP_001951476 332 QPQND--TTIWLSSKCTCPLCRQLFCILDVC 360
KJE90682     354 QNPAA--TSNWLNGTAQCPTCRATFCLLDVR 382
EGT59395     373 QTSDNvhRDEYHLGSCPCPFCRKSFCIHDVH 403
1_pfamImport 327 QNIDAvyRHDYWRGTAQCPTCRKAFCIRDVH 357
XP_002644008 371 QKIDNvnRYEYHRGSGKCPTCRKTFCIRDVH 401
EFO89927     371 QNVDNiyRYEYFRGSAQCPTCRKNFCIRDVH 401
CDS41676     380 LAQSHvpTSEWVASRVPCPTCRSPFCIRDVL 410
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