4AEZ


Conserved Protein Domain Family
Mad3_BUB1_I

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pfam08311: Mad3_BUB1_I 
Mad3/BUB1 homology region 1
Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.
Statistics
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PSSM-Id: 462420
Aligned: 144 rows
Threshold Bit Score: 91.0522
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AEZ_I         53 KERMGHERKIETses-----ldDPLQVWIDYIKWTLDNFPQg-eTK-TSGLVTLLERCTREFVRNPLYKDDVRYLRIWMQ 125  fission yeast
O02053         53 TARLKLDQLLEElqnlecseesEELQKILDFCSWFEEKLAI----GfHKVYYELLWKIISRHGFLEKYKEDERMLKIWEK 128  Caenorhabditi...
Q6FSY2         44 RIRASFESSLLVkie----dhdDPLVLYLDYIDWINHAFPQg-gSSrSSGMLDVIERCITYFKDSERYRDDERYVKIWLW 118  [Candida] gla...
CCK70631       32 ERKLQFEQKLLDele----emdDPLELFIDYINWLLSLNSG---EGgNDQLQSLLERCLLYIMNIDTYYNDPRFLKVWLH 104 
CCF60444       51 DIRLIFEKRLLTdle----dmdDPLELFLDYISWIHEANEN------FDFLIDIMERCLSYIKSFETYHNDPRFLKIWLL 120 
CCD24528       42 DVKLHFERKLLNele----dmdDPLELFLDYLGALSQLIPEn-----NQFLIELIERSLLYLRDIDTYQNDPRYLQLWHK 112 
XP_003673647   46 EIKLFFEEKLLNvle----dldDPLELFMEYIASIVELVPEn-----DPFLMNMIERCLLYIIEVDTYLNDPRYLSVWLR 116 
Q6FQ60         19 DVRKHYENLLYEdle----nldDPLQLYLEYIKHLKHCQNEgqgIScSQVLQDVMERCLLYFLDLEIFKNDPRLLRVWIS 94   [Candida] gla...
P41695         38 QTKIAYEQRLLNdle----dmdDPLDLFLDYMIWISTSYIEvdsESgQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIW 113  Saccharomyces...
EDQ89237       51 LRIKSASQRMTElqt-----dgNPLEGWWSFLNLQLDSL-----KGpCQHLLRFYKTGIERI-DQERYRDQELYVQLWLE 119 
4AEZ_I        126 YVN-YI---------DEPVELFSFLAHHHIGQESSIFYEEYANYFESRGLFQKADEVYQKGK 177  fission yeast
O02053        129 MADnSA---------GHAHDIYQFAISRKSLVKCAALYARWSQSVELAGAYVEARRVLILAR 181  Caenorhabditis elegans
Q6FSY2        119 YME-LFsdk----ykSDCKDLFIFMLRNRIGSKVPLMYEELSSLLYELKEYKYAISVINLGL 175  [Candida] glabrata
CCK70631      105 YIN-AYvvq---hdlEECERHFVFMWRRHIGSKLALFYEEFAQLLFQLGKVDECYLILRVGL 162 
CCF60444      121 YMD-FIkse----nlNDYLTIFNFMYSNNIGSKLSLFYEEYSKLLWKANLNLESLYILNVGI 177 
CCD24528      113 YID-FLdrqqsvdnlEEIFNVLKYMFSLHIGYKLALFYEYFSTYLFQVDRFIEAHYILEVGI 173 
XP_003673647  117 YIQ-LLegrglmktePEVLAIFQYMFNMKIGSRLALFYEAFSQRLARMNRFIEAHYIMELGI 177 
Q6FQ60         95 YMN-MVyke----fiDEKINILCYLYHKKIAVRLALFYEQLAECLASINKGEESVAILRLGK 151  [Candida] glabrata
P41695        114 YIN-LFlsn----nfHESENTFKYMFNKGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGA 170  Saccharomyces cerevisiae S288C
EDQ89237      120 YAR-LAmac---gdaEEAGFTFQQMQQDSIGRGFRHFHTIWAEFEESQGHTGRSLEILRKGR 177 
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