2Y9A


Conserved Protein Domain Family
Sm_G

?
cd01719: Sm_G 
Click on image for an interactive view with Cn3D
Sm protein G
The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit G binds subunits E and F to form a trimer which then assembles onto snRNA along with the D1/D2 and D3/B heterodimers forming a seven-membered ring structure.
Statistics
?
PSSM-Id: 212466
Aligned: 44 rows
Threshold Bit Score: 96.8169
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:heptamer interface [polypeptide binding site]
Evidence:
  • Structure:2Y9A; Human spliceosomal U4 snRNP core domain hetero-heptamer, contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1           #   #       #    #            #                                      # ## #  
2Y9A_G         5 HPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMAts-----------------gQQNNIG-MVVIRGNS 66  human
EAL44755       4 PKPELKHYLEKRILVKIHGKRSIIGVLSGYDEYMNLVLDEAYDASnpd---------------tdKHIPIG-MIMIRGNS 67  Entamoeba histo...
EAL18583       5 SQPELKKFMDRRLFLHLQGGRQISGVLRGYDMFLNLVVDSAFEELgg-----------------gQRKPCG-MVVIRGNS 66  Cryptococcus ne...
AAX30638       5 HQPELKKYLDKRLRLKLNANREVVGILRGFDAFMNIVVSDAYEVTkd-----------------gTQIKID-MAVVRGNS 66  Schistosoma jap...
XP_002490815   4 STPELKKYLHHRISVKINAGRQIEGLLTGYDVFLNLTLDDCVQVNpsn---------------raEDTPVG-SCVLRGNS 67  Pichia pastoris...
EGR32114      14 YGPDLQKYNGKRLLVYLNGKRRVQGVVKGHDNYMNIVLENAQELIgk-----------------dKVNNIG-KAVVRGNS 75  Ichthyophthiriu...
CBQ71737       5 SQPELKRFLDKRIAVNIQGGRKIQGTLRGFDMFLNLVVDDAVEQVrpeagn---------tnawhDGDRCG-TVVVRGNS 74  Sporisorium rei...
XP_002683442   6 QYPELKVYMNKRLSVKMNGKRHVEGTMIGFDPFMNITLENAYDLTgfskg----------eantnEKTHLG-TVVVRGNS 74  Naegleria grube...
XP_453405      2 TSPDLRKYMDKKLILQLNGNRKIIGILRGYDAFLNLVLDNPIQIFe------------------eGEVQMGpQTVVRGNS 63  Kluyveromyces l...
XP_001444103  14 YQADLNKYFGKRLKIKLNAKRTIIGTVIGFDIFMNLVLDHCKELIpgqgaenkdnlypgfsnvtdQLVDIG-QAIVRGNS 92  Paramecium tetr...
Feature 1        ##### # 
2Y9A_G        67 IIMLEALE 74  human
EAL44755      68 ILSVETID 75  Entamoeba histolytica HM-1:IMSS
EAL18583      67 VSAMELLD 74  Cryptococcus neoformans var. neoformans B-3501A
AAX30638      67 INIVEGVD 74  Schistosoma japonicum
XP_002490815  68 VISIEALE 75  Pichia pastoris GS115
EGR32114      76 IIRWDCLD 83  Ichthyophthirius multifiliis
CBQ71737      75 VTSLEALE 82  Sporisorium reilianum SRZ2
XP_002683442  75 IEMMECLD 82  Naegleria gruberi strain NEG-M
XP_453405     64 IVSIEPLD 71  Kluyveromyces lactis NRRL Y-1140
XP_001444103  93 IIMWECLD 100 Paramecium tetraurelia strain d4-2

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap