Conserved Protein Domain Family
bHLH_TS_OLIG2
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cd18940: bHLH_TS_OLIG2 
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins
Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is a bHLH transcription factor that is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube.
Links
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Statistics
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PSSM-Id: 381510
Aligned: 6 rows
Threshold Bit Score: 146.324
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #   # ### #    #                   ####                          
Q13516        95 KKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVS 174 human
Q90XB3        93 KKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVS 172 chicken
XP_006009120  68 KKDKKQMSEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVS 147 coelacanth
XP_004912201  78 KKDKKQMNECELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLNNSLEEMKRLVS 157 western clawed ...
NP_835201     69 KKDRKLLSENELQSMRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLSNSLEEMKRLVS 148 zebrafish
OCT93825     154 KKDKKQMNESELQHLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVS 233 African clawed ...

Feature 1             
Q13516       175 EIYGG 179 human
Q90XB3       173 EIYGG 177 chicken
XP_006009120 148 EIYGG 152 coelacanth
XP_004912201 158 EIYGG 162 western clawed frog
NP_835201    149 EIYGG 153 zebrafish
OCT93825     234 EIYGG 238 African clawed frog

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