Conserved Protein Domain Family
PGAP4-like

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cl04660: PGAP4-like Superfamily 
Post-GPI attachment to proteins factor 4 and similar proteins
This family includes post-GPI attachment to proteins factor 4 (PGAP4), also known as post-GPI attachment to proteins GalNAc transferase 4 or transmembrane protein 246 (TMEM246). PGAP4 has been shown to be a Golgi-resident GPI-GalNAc transferase. Many eukaryotic proteins are anchored to the cell surface through glycolipid glycosylphosphatidylinositol (GPI). GPIs have a conserved core but exhibit diverse N-acetylgalactosamine (GalNAc) modifications. PGAP4 knockout cells lose GPI-GalNAc structures. PGAP4 is most likely involved in the initial steps of GPI-GalNAc biosynthesis. In contrast to other Golgi glycotransferases, it contains three transmembrane domains. This family also includes uncharacterized fungal proteins with similarity to PGAP4.
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Statistics
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Accession: cl04660
PSSM Id: 471077
Name: PGAP4-like
Created: 8-Feb-2008
Updated: 4-Oct-2023
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