Conserved Protein Domain Family
mit_SMPDase

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pfam14724: mit_SMPDase 
Mitochondrial-associated sphingomyelin phosphodiesterase
The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyze the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.
Statistics
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PSSM-Id: 464282
Aligned: 7 rows
Threshold Bit Score: 1339.09
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015221715   1 MAVPQLQ-QPSFLLANLKADCMNKSLLQQCQELVKIIDEYPAKELHFIFPWLVETVFGSLDGVLVGWNLRYLQAKAN--E 77 
Q9NXE4        40 MAFPHLQ-QPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNpvE 118 human
XP_415236     22 MAGPYLQ-QPSFLLATLKADCVNKPFAQRCHDLETVIEEFPAKELHGIFPWLVESIFGSLDGTIVGWNLRCLQGRTNptE 100
XP_008121782  12 MAAP----QHSYLLASLRADCLNKPFAQRCLDLQTVIQDFPAKELHAIFPWLVESIFGSLDGVLVGWSLRTLQGRTNptE 87  green anole
XP_016288249 104 MALPHVQ-PPSFLLASLKADCVNKPFTQRCHDLVKVIDDFPAKELHYIFPWLVESIFGSLDGILVGWNLRCLQGRMNpiE 182 gray short-tail...
XP_014344765   1 MAGPPIQqQANFLLASLKADFENKSLSQRCHDLAKVIEDYPVKELSSIFPWLIESAFGSLDGSIIGWNLRGLQSRMNpiE 80  coelacanth
XP_019212335   1 MANPTLQ-QPSFLLANLKADATTKPLLQRCQDLVKIIDEYPAKELHLIFPWLVESVFGSLDGVIAGWNLRFLHSRSN--E 77  Nile tilapia
XP_015221715  78 YNIVLEFLNPSGPMMKLVYKLQAEEYKYEFSVSYLPGPVRASIQGGVLPDCPLFHNKLQSPLSGL-LSLSLSLNPFEYYM 156
Q9NXE4       119 YSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGG-LGLNLALNPFEYYI 197 human
XP_415236    101 YSVALDFLDPSGPMMKLVYKLQAEEYRYDFPVSYLPGPVKASIQEQVLPECSLYHNKVQFPSSGG-LGLNLALNPFEYYM 179
XP_008121782  88 YNLALEFLDPGGPMMELVYKLQAEEYRYDFPVSYLPAPVKASIQERILPECSLYHNKVQFPPSGGvLGLSLALNPYEYYM 167 green anole
XP_016288249 183 YSIAMEFLDPSGPMMKLVYKLQAEDYKYDFPVSYLPEPVRACIQERVLPECPLYHNKIQFPPAGG-QGLHLalnpfeYYM 261 gray short-tail...
XP_014344765  81 YSTVVEFLDPSGPMMKLVYKLQAEEYKYEFPVSFLPDPVRASILEGVLPDCPLYHSKIQIPSLGG-LSLSISLNPFECFL 159 coelacanth
XP_019212335  78 YNIVMDFLNPSGPMMKLVYKLQAEEYKYEIPINYLPGPVKACIQEGVLPDCPLFHNKLQFPLSGL-LTLNIAFNPFEFFM 156 Nile tilapia
XP_015221715 157 FCFASSLITPK------------NYPVGQHVNASDSAYFVLVDNYLKYFLPTEGNVPPSPFS-DVRGTVSPPAPRSPTVP 223
Q9NXE4       198 FFFALSLITQK------------PLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSS-SPGGTSPSPPPRTPAIP 264 human
XP_415236    180 FYFAISLITQK------------NSPITHHISPSNSAYFILVDTYLKCFLPTEGSVLPPPSS-NPGGAIPSPTPRSPAVP 246
XP_008121782 168 FYFAISLITQK------------NVHPTYHVSMSNSAYFVLVDRYLKWFLPTEGNVIPPRSS-DPGGPAPSPAPRSPVMP 234 green anole
XP_016288249 262 FFFALSLVTQR------------P------------------------------------------------TPRTPAVP 281 gray short-tail...
XP_014344765 160 FYFAANLLTQRartflserqhpkSYLVGQPVSTSDSAYFVLVDRYLKYFLPTEGNLPPPPMSlNPGGTVSPPVPRSPAIQ 239 coelacanth
XP_019212335 157 FNFAYCLITPK------------NYPPGQYGSSTDSAYFVLVDTYLKYFLPTEGSVPPSPFS-DSRGSVSAPSPRSSSVS 223 Nile tilapia
XP_015221715 224 FAGYGVHYSSLLKRHISHQPSVNADPAAQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPQVK----------LEVLQYR 293
Q9NXE4       265 FASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAK----------LEVLHYR 334 human
XP_415236    247 FTSYGMHHTSLLKRHIAHQPSVNADPASQEIWRSETLLQIFVEMWLHHYSLEMYQKMQSPHIK----------LEVLHYR 316
XP_008121782 235 FTSYGMHPTSLLKRHIAHQTSANADPASQEIWRSETMLQVFVEMWLHHYPLDIYQKIQSPHIK----------LETFHYH 304 green anole
XP_016288249 282 FSSYGLHHTSLLKRHISHQPSVNADPASQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAK----------LEVLHYR 351 gray short-tail...
XP_014344765 240 FASYGIHHSSLLKRHISHQPSVNADPAAQEIWRSETVLQVFVEMWLHHYSLDLYQKLQSPHMKavcdhkgsikLEILQYR 319 coelacanth
XP_019212335 224 FASYGIHSPSLLKHHIFHQPSVNADPAAQEIWRSETLLQMFVEIWLHHYSLEMYQKLQSPQ------------LALLQYR 291 Nile tilapia
XP_015221715 294 LG---ISSLHCsTPTPPGYGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QIssSPSTHSHT--SPLEEFKR 366
Q9NXE4       335 LS---VSSALY-SPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFAN-SLKPE-QA--SPSAHSHAt-SPLEEFKR 405 human
XP_415236    317 LS---ISSKHHgSPAQSSYQALHAYQESFKPTEEHVLVVRLLVKHLHAFSN-SLKPE-PL--SPSAHSHTa-SPLEEFKR 388
XP_008121782 305 LPsiySPSSSFaFPIQSSYRSYYTYQESFKPSEEQVLVIRLLVKHLHAFSNsSLRAEaPAspSPSGHSHSp-GPLEEFKR 383 green anole
XP_016288249 352 LS---VSSSLHsSPAQPSYQALHAYQESFKPTEEHVLVVRLLLKHLHAFSN-SLKPE-QL--SPSTHSHTa-SPLEEFKR 423 gray short-tail...
XP_014344765 320 LG---VSNVHYgTSLQPGYGTLRAYQEPFNPSEEHVLVVRLLIKHLHAFSN-SLRPE-QI--SPLAHSHTa-SPLEEFKR 391 coelacanth
XP_019212335 292 LS---MSSMPCqPHAPPGSGTLHTYQEPFSPTEEHVLVVRLLVKHLHAFSN-SLKPE-QLssSPSAHSHThtSPLEEFKR 366 Nile tilapia
XP_015221715 367 VVIPRFVQQKLYVFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTTDKQSPQADNQNRSVPDKW------ASFVQENL 438
Q9NXE4       406 AAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPDKQAPGSDSQPRCVSEKW------APFVQENL 477 human
XP_415236    389 VVIPRFVQQKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPEKPPQTAELLPRSVSEKW------AAFIQENL 460
XP_008121782 384 IVIPRFLQQKLYVFLHHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPERATLGAEQAPRIMSEKW------APFVQENL 455 green anole
XP_016288249 424 VVIPRFVQQKLYIFLQHCFGHWPLDASFRAVLEMWLSYLQPWR--YAPEKPFLATDPQPRSIPEKW------APFVQENL 495 gray short-tail...
XP_014344765 392 VVIPRFVQQKLYVFLQHCFGHWPLDASFRVV-------LETWLsyLQPWRYPPEKWLHAFQENQERsvpdkwAAFVQENL 464 coelacanth
XP_019212335 367 VVVQRFVQQKLYLFLQHCFGHWPLDASFRAVLETWLSYIQPWR--YTGEKANPQPD-QNRTVPEKW------ESFVHENL 437 Nile tilapia
XP_015221715 439 LMYTKLFQGFLNRAVRTDLVNAKNALMLFRVSKVFAQPNLSEMIQKGEQLFLEPEHVLHHRQHRLFMTPGHGGSFLSSRQ 518
Q9NXE4       478 LMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWP 557 human
XP_415236    461 LMYTKLFVGFLNRTLRTDLVSPKNALMVFRVAKVFAQPNLAEMILKGEQLFLEPELVIPHRQHRLFMTPTLGGSFLSSWP 540
XP_008121782 456 LMFTELFVAFLTRALRTDLVSPKNALMLFRATKVFAQPSLAPVIQKAEQLFLEMDLAINAASSPASLGAG-SSPLLRSQP 534 green anole
XP_016288249 496 LLYTRLFIGFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVMPHRQHRVFMTPNFPGNLLSSWP 575 gray short-tail...
XP_014344765 465 LLYTKLFQGFLNRALRTDLVSPKNALMVFRVAKVFTQPNLAEMIQKGEQLFLEPEHVLHHRQQRIFMTPSLGGSFLSLRQ 544 coelacanth
XP_019212335 438 LMYTKLFQVFLNRAVRTDLVNAKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPEHVLHHRQPRGYLTPGQGGSYLSSRQ 517 Nile tilapia
XP_015221715 519 PVI-----------TDSVFKVKSHVYSLEGQDCQYKQMFGAEVRNSVLKLVQLIAQARQTAKSISAHTAEA-------AA 580
Q9NXE4       558 PAV-----------TDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAES-------PA 619 human
XP_415236    541 PAI-----------TDASFKVKSHVYSLEGQDFQYKQMFGTEVRNLVLKLAQLICQAQQTAKSISDHSAET-------TA 602
XP_008121782 535 RLLlslrgasslsdSASAFKIKSRLYGLQGQEAQYRPLFGPEVRGMVLRLVQLIVQAQQRLKSLDPSSWDAsptgplpSS 614 green anole
XP_016288249 576 PTI-----------TDASFKVKSHVYSLEGQEGQYKQMFGPEVRALVLRLAQMIAQAKQTANSLSDYSNEM-------SA 637 gray short-tail...
XP_014344765 545 PAI-----------TDASFKVKNHVYSLEGQECQYRPMFGTEVRNMVLKLAQQIAQAKQTAKSISDHSVEA-------AS 606 coelacanth
XP_019212335 518 RVV-----------TDMVFKVKSHVYGLEGQDCQYKQMFGTELRGAVMKLIQIIAQARQTAKRISDHSSEV-------AA 579 Nile tilapia
XP_015221715 581 NQSFLSWLGFGSSDPNASYT----GSDVDDMGL-ESIKKTDEYLDRVLDYLRQIFRLNTGQLSQIMVNYVSTQDDFGSKQ 655
Q9NXE4       620 GHSFLSWLGFSSMDTNGSYT----ANDLDEMGQ-DSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQ 694 human
XP_415236    603 SHSFFSWFKFTPSEMNGSYT----GNDLDEIGQ-DSIKKTDEYLEKALEYLCQIFKLNEAQLTQMMMKCGTAQDENGKKQ 677
XP_008121782 615 SPSFLSWLRFGISDPNGSSSssaaGSDLDEAGHlDGGRRTEEYLEKALEFLCLIFRLNEAQLSRVMLTLGAAPDESGVKQ 694 green anole
XP_016288249 638 NRSFFSWLGFRHVDVNGTFS----ANDLDELGQ-DSIKKTDEYLEKALEYLGQIFRISEAQLTQVMVNVGATPDENGKKQ 712 gray short-tail...
XP_014344765 607 SRSFLSWFKFDSPDFSSSYM----GNDLDELGP-SNIKKTDEYLDKALENLCHVFRLNALQLSQMAANFTTAQNDGGKKQ 681 coelacanth
XP_019212335 580 NKSFLSWFGLGASDLNNSFP----GAEPEETG--EYLKKTHEFLDRALENLCQIFKLNQGQLNQLISNLGSLEDDGNSKQ 653 Nile tilapia
XP_015221715 656 LPDCIRGENGLILTDLGRMQIINGLRRFEIDYQGDPELQPIRSYESAVLVRLLFRLSSLINE------------------ 717
Q9NXE4       695 LPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINH------------------ 756 human
XP_415236    678 LPDCIESENGLILTPLGRYQMINGLRRFDVQYQGDTELQPIRSYENATLVRLLYRLSSALNE------------------ 739
XP_008121782 695 RPDCAETDAGLVLTPLGRYQIINGLRRFEISYQGDPELQPIRSYENPTLVRSLFRLSSTINEwglsfslslsllfsalwp 774 green anole
XP_016288249 713 LPDCIMSDEGLVLTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEAAPLVRLLFRVSSALNR------------------ 774 gray short-tail...
XP_014344765 682 LPDCIEGETGLILTPLGRYQIINGLRRFDIVYQGDPELQPIRSYESAVLVRLLFRLSSAVNE------------------ 743 coelacanth
XP_019212335 654 LPDCVQSENGLILTDLGRRQIINGLRRFDIHYQGDPELQPIRSYENALLVRLFYRISSLINE------------------ 715 Nile tilapia
XP_015221715 718 --RFAG-EMASLCSRRDFLGRLSRYYLT-RPPVPGKSTRSPATRHS-PEWQTRPRLSLRGLGSYRTLCALPLLYLLASVV 792
Q9NXE4       757 --RFAG-QMAALCSRDDFLGSFCRYHLT-EPGLASRHLLSPVGRRQvAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLF 832 human
XP_415236    740 --RLAD-QMDVLCSREDFVGRFCRYHLT-NPHLVHKIRYSPVLKDR-TSQNWGPRISLRFLASYRTLISLLMLYFIASWF 814
XP_008121782 775 caQWVGaDVRGPAPGGDFLGSLARFHLL-EPAWSGGLG----GRQS-WEWAERPRLSLRFLASYRLLFSLALSYALTAWI 848 green anole
XP_016288249 775 --RFAG-QMAALCSREDFLGAFCRYHLM-DLVQAQRTRLSPVAPHR-AGRPHGPRISLRFLGSYRTLVSLLTIFFVASLF 849 gray short-tail...
XP_014344765 744 --RFAG-DMEALCARDNFLGRLSCYYLMpPPPLVERFRHSPVTRRD-LAPMQHPRVSLRFLASYRTLLSVLLLFFLASLF 819 coelacanth
XP_019212335 716 --RFGR-HMNALCSRPDFLGRLSRHYLT-NLDSTTKLKHSPMSRRM-LERSQRPRLSLRPLASYRTILLLLLFYVFGSLL 790 Nile tilapia
XP_015221715 793 CsMGPLSFAFCVLLACCLYGVFMT 816
Q9NXE4       833 C-VGPLPCTLLLTLGYVLYASAMT 855 human
XP_415236    815 H-IGPVGCTFIILFSYFLYAVIMA 837
XP_008121782 849 C-FGPAATSGLFLLGYLLYASAMA 871 green anole
XP_016288249 850 C-VGPLSCIVLILVTYLLYAITMT 872 gray short-tailed opossum
XP_014344765 820 S-IGPLACAFLILVVVALHGIVMT 842 coelacanth
XP_019212335 791 S-LGPISSTVLLLAGGFLYGLLMT 813 Nile tilapia
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