6W17


Conserved Protein Domain Family
SPIN90_LRD
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pfam09431: SPIN90_LRD 
SPIN90/Ldb17, leucine-rich domain
This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts. Ldb17 is involved in the regulation of endocytosis in yeast. SPIN90 is an F-actin binding protein that regulates actin polymerization and endocytosis. It associates with and activates the Arp2/3 complex, without requiring a preformed actin filament. This LRD, within the C-terminal armadillo repeat (ARM) domain of SPIN90, is important for activation of Arp2/3 complex.
Links
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Statistics
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PSSM-Id: 462796
Aligned: 83 rows
Threshold Bit Score: 91.3824
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6W17_H       190 DSFGMCVLTL-LSINEQFMLVRlaskgsfeiANGIMDLLSsSKVDNGIYSEGLVFTLNREKDPRSR----------M--- 255 Schizosaccharom...
EKC40342     575 DQCTDPLVNLlLAYNLHFPFQE---------SNDIMSVLA-KKGTVKVFTEKLLEIFNKGEDPVKM----------Fehq 634
ESN94574     176 peISELCIKLlLAFNLHLEVLK---------DNICMKSVA-KKKSCKYLTEHLLLLFNRGDDPVKL----------Pdik 235
XP_002597336 253 EQVPDLFLNLiLAFNLHFSDPK---------DNLVMKAIA-NSSNVRAFSEKMMLLVNRGDDPVHM----------Fdhe 312
XP_026695884 514 EDLDDVMIRViLSINLHHVSPD---------ANPTLNVIA-ARGGSTRLSEKLMLLFNRGHDPVNEgcdpvneghdPtsc 583
Q9ESJ4       540 EQLPDLCMNLlLALNLHLTAPE---------QNVIMAALS-RHTNVKIFSEKLLLLLNRGDDPVRI----------Frhe 599 house mouse
XP_009080856  51 DQLPDLFINVlLAFNLHIPVPE---------HSVIMTTIS-KHSNVKTFTEKLLLLLNRGDDPVCI----------Fkhq 110
XP_015203564 586 EQLPDLCINLlLAFNLHLAVPA---------SNLIMQTLV-KRHNVKILTEKILLLLNRGDDPVCV----------Frhd 645
XP_023181439 563 EQLPDIFLNLlLAFNLHHTVPS---------NNAIMQEL--KQKNVKVLTEKVLLLLNRGEDPVCM----------Fkht 621
XP_017208746 590 EQLPDLFINVlLAFNLHLSVPD---------SNIVMQTLM-KRDNAKILSEKLLLLLNRGEDPVCV----------Fsha 649

6W17_H       256 -----LILKQLFLLFTTPATYE-IFYTNDLNVLIDIFIREINNIpdELSDLRYAYLQVLIPLLENTQVRHPpHYKTKCI 328 Schizosaccharomy...
EKC40342     635 sypvqSQVKFMIDMFSHPGTAS-LLYVNDAKVLIDILIRNLTDLq-PGDKMRSSILILVKLLLQNSDYFEH-QHRMTEL 710
ESN94574     236 svptnSVIKFISDIFSDTVTSN-IFYTNDAKVLVDIVLRQLTDLs-PGDFMRTEHLSLMQLVLLNSGYFEQ-QHRLQEL 311
XP_002597336 313 prppnSLLKFLADVFSSEVTSG-IFYTNDMMVLIDIIVRQVSDLp-PGDEIRTEHLSLFHSIVKNTSYREH-RHRRDDL 388
XP_026695884 584 dqppnSVLKFFQDIFARRDTGDcFLYTNDLMVLIDIIVRNIADLs-SGSKGRTEYLDLLLKVAGTSSFIET-RHRCRDL 660
Q9ESJ4       600 pqpphSVLKFLQDVFSSSATAA-IFYHTDMMALIDITVRQIADLs-PGDKLRMEYLSLMHAVVRSTPYLQH-RHRLSDL 675 house mouse
XP_009080856 111 pqpphSVLKFLQDIFASKDTAS-IFYHTDMMVLIDILVRQIADLs-PGDKLRMEYLSLMHAIIRSTPYLQH-QHRLTDL 186
XP_015203564 646 ppaphSVLKFLQDVFASPDTAH-IFYRTDMMVMIDIAVRQISDLs-PGDKLRMEFLSLMHAIVRTTDYLEH-RHRLPDL 721
XP_023181439 622 ppaphSVLKFLQDVFASRETAD-IFYRTDMMVMIDIAVRQISDLs-PGDKLRMEYLSLMHSIMRSTDYLEH-QHRLSDL 697
XP_017208746 650 paaphAVVKFLQDVFSSADSAQ-IFYRSDLMVLIDITVRQISDLe-PGDRMRAQYLSLMLSVMRCSEYQEH-RHRLADL 725
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