Conserved Protein Domain Family
BNIP3
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pfam06553: BNIP3 
BNIP3
This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.
Links
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Statistics
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PSSM-Id: 461945
Aligned: 18 rows
Threshold Bit Score: 203.457
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003435820  36 PEE-LGESWIELSSNTNTGATsGlvgagttaavvgggssnnfvptgttmlagavgTKSPDRTTPLAFAS-VEEYIRLLRE 113
Q5VK49        13 EEPgLNGSWVELEMNGNTQHQsPslpsllgngnqgepq---tsqaleavqeeeevLTGGLEHVPSSSSIhNGDMEKILLD 89  zebrafish
XP_006625864  22 EEPgLNGSWVELEMNGNTGVAhPpsssngn-------------------egedehNGGGLEHVPSSSSIhNGDMEKILLD 82 
NP_991134     12 GEPgLNGSWVELEMNRNAA---Slsssiasvppp-----------laqvveeddgMVGGLEHVPSSSSIhNGDMEKILLD 77 
XP_003978419  13 GDAgLNGSWVELEMNRGAAGSvQststtgpaavl----------lplpqveeeeaMVGGLEHVPSSSSIhNGDMEKILLD 82 
XP_005991949  13 EETgLNGSWVELQINNNGNGNdNgn-----------------------------gRNGGLEHVPSSSSIhNGDMEKILLD 63 
XP_393165     10 SDEsLGESWVELN-------------------------------------------PVPDRITPLPFSSgGEEYLRLLRE 46 
EEB14955      12 TDEiLGDSWVELNTTGNG--------------------------------------STPDRVTPLPFTS-GEEYLRLLRE 52 
XP_002048105   8 TEDlLGESWIELSTTAAMAGI-----------------------------------KSPDRITPLPFSN-GEEYLRLLRE 51 
Q175B2        21 SEDlLGESWIELSSSTNTCP------------------------------------KSPDRTTPLPFTS-VEEYLRLLRE 63  yellow fever mo...

XP_003435820 114 AQRdESKESsrvaSLTSTrkNSPRgsPKSPp------------------nSPNTELAATEEDlrnvyinyvnkdGDIV-- 173
Q5VK49        90 AQH-ESSPS----SSSCN--SPPR--PHSPdqdegqimf--dvempserdCQSEDDSMEKDK------------EDDIlm 146 zebrafish
XP_006625864  83 AQH-ESSQS----SSSCD--SPPR--PHSPqdegqitfdvemhsgrdngsTQSEEEGLEKER------------EDDIlm 141
NP_991134     78 AQH-ESSRS----NSSCD--SPPR--PHSPqdegqiif-------dvdtrrdSQEEVMEKIR------------DDDIl- 128
XP_003978419  83 AQH-ESSRS----NSSCD--SPPR--PHSPqdegqlifh---vdvagrrdSQSEEEVVDKER------------DMDIl- 137
XP_005991949  64 AQH-ESGQSssqsSSNSD--SPSR--PPSPqdgqitfdv--emhaskdssSQFEEDGSGRDK------------ETDIa- 123
XP_393165     47 AQR-DSLPSsarhSLASSrrGTPRdsPKSPp------------------nSPNTEL-STEDElkgvyinyccnkESEFl- 105
EEB14955      53 AQR-ESNQSsarvSLASSrrDSPRdsPKSPp------------------nSPNTEL-NTEDEfrgvyinylckdGV-Lnl 111
XP_002048105  52 AQR-ESNQSsrvvSLASSrrDTPRdsPKSPp------------------nSPQSEL-CPDDElrnvyinywtknGDKQnt 111
Q175B2        64 AQR-ESKESsrvaSLTSSrrDSPRgsPKSPp------------------nSPNTELATTEEElrgvyinylnreGAATsa 124 yellow fever mo...

XP_003435820 174 -KDTDWVWDWSSRPDQQPPKDWKFEHPNqtqeernKpiHAGYSIRQVRVGKNS-LFSREFLYSIVLTNVLSLLLGAGIGA 251
Q5VK49       147 nKGESWVADWSSRPENVPPKEFHFRHPK-------RsgSVSLSMRKSGAMKKGgVFSAEFLKVFMPSLLLTHILALGIGV 219 zebrafish
XP_006625864 142 kKSADWVADWSSRPENIPPKEFHFRHPK-------R--SVTLSMRKTGAMKKGgVFSAEFLKVFIPSLLLSHILALGLGV 212
NP_991134    129 mKDSDRMADWSSRPENIPPKEFHFRHPR-------R--SVTLSMRKTGAMKKGgIFSAEFLKVFIPSLLLSHILVLGLGV 199
XP_003978419 138 mKDADWVADWSSRPENIPPKEFNFRHPR-------R--SVMLSMRKTGAMKKGgIFSAEFLKVFIPSLVLSHILALGLGV 208
XP_005991949 124 mKTSDWVSSFSSRPENNPPKEFQFKHPK-------R--SVNLSMRKTGAMKKGgIFSPEFLKVFIPSLLISHILALGLGI 194
XP_393165    106 eKNTDWIYEWSSRPDQAPPKDWKFKHPQg------MnkRKSYSIRTTKVGKIG-LFSKEVLYTLVITNILSVLVGAGLGV 178
EEB14955     112 dSNSDWIWDWSSRPEQAPPKDWKFKHPK----------RKTYSIRNAKVGRNS-LFSKEVLYTLFITNFISLLLGTGVGL 180
XP_002048105 112 -dNGDWLQNWNRGADEQPPKDWKFERSNdde--eeKkkSSGYSIRLKRLGANS-LFSREILYSLLVTNVLSLLLGAGFGL 187
Q175B2       125 qKDTDWVWEWSSRPDQLPPKDWKFEHPKqd----vRrmQQGYSMRLTRVGKNS-LFSREVLYSLVLTNVLSLLLGAGIGA 199 yellow fever mo...

XP_003435820 252 WLQKRGLLLTRVS 264
Q5VK49       220 YIGKRLSTPPSST 232 zebrafish
XP_006625864 213 YIGKRLTSPSASS 225
NP_991134    200 YIGKRLTTPPASS 212
XP_003978419 209 YIGKRLTTPPASS 221
XP_005991949 195 YIGKRLTNPSAST 207
XP_393165    179 WLSRRGSITTSVT 191
EEB14955     181 WLSRRGLIIPKIN 193
XP_002048105 188 WLSKRGILLTRVV 200
Q175B2       200 WLHKRGLLFTRIS 212 yellow fever mosquito
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