1NBF,1VJV,1NB8


Conserved Protein Domain Family
Peptidase_C19

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cd02257: Peptidase_C19 
Click on image for an interactive view with Cn3D
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Statistics
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PSSM-Id: 239072
Aligned: 308 rows
Threshold Bit Score: 42.8555
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Active Site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Active Site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #     #                                                                      
1NBF_A          8 GLKNQGA-TCYMNSLLQTLFFtnqlrkavymmptegddssksvplalqrvfyelqhsdkpvgtkkltksfgwetldsfMQ 86   human
EAL41393      337 LEANLPNaYCNAMLQVLYFIIplrk-------------------------------------------------ailaHC 367  Anopheles gam...
NP_001012972  519 LEPHIPNaYCNCMIQVLYFLEpvrc--------------------------------------------------lvqNH 548  chicken
BAA31685      524 LEPHIPNaYCNCMIQVLYFLEpvrc-------------------------------------------------liqnHL 554  human
Q09798        502 LETDITNsYCNSVLQLLSYVPsfskaa----------------------------------------------ishslGP 535  fission yeast
XP_324149     824 LENNITNsYANSLLQVMHYTPllrnma----------------------------------------------lqhaaTA 857  Neurospora cr...
EAL21450      512 LETDILNsYTNSLLQALHYTLplraia----------------------------------------------tahicVD 545  Cryptococcus ...
CAG80154      364 LSGLETNpFNPLLQLFRFCSPvfnf-------------------------------------------------alrsVA 394  Yarrowia lipo...
CAG59857      495 LDNDVDNpFTNALIQLYRFIPeisnf-----------------------------------------------listlKH 527  Candida glabr...
CAG84443      516 LENHLDNsYINSLLQLYKYSPvfqnfiikhllk---------------------------------ewlpndlttiiqNG 562  Debaryomyces ...
Feature 1                                                                                         
1NBF_A         87 HDVQELCRVLLDNVEnkmkg------------------------------------------------------------ 106  human
EAL41393      368 CAKEFCLSCELGFLFhmlnvgsssspcqasnflrsfrtvpeaaalgl------------------------ilssnsanv 423  Anopheles gam...
NP_001012972  549 LCQKEFCLGCELGLLfhmldlsrgdpcqgsnflrafrtipeasalgliladsdeatgkvnlgrliqswnrfiltqlhqet 628  chicken
BAA31685      555 CQKEFCLACELGFLFhmldlsrgdpcqgnnflrafrtipeasalgliladsdeasgkg--nlarliqrwnrfiltqlhqd 632  human
Q09798        536 CDLMECLLCELGFLFamlkestgrncqatnflrafsn------------------------------------------- 572  fission yeast
XP_324149     858 CLADPCLLCELGYVFdmlqkgegpschatnmlraln-------------------------------------------- 893  Neurospora cr...
EAL21450      546 CKKEHCLLCEAGFLFrmled------------------------------------------------------------ 565  Cryptococcus ...
CAG80154      395 RGTPNRLLNEVGLLFdmmhkarghvcrasnlm------------------------------------------------ 426  Yarrowia lipo...
CAG59857      528 EHFESPLLTDMAYLF----------------------------------------------------------------- 542  Candida glabr...
CAG84443      563 NPQGSSILNELGYIFdmmnkshgkncktsnfsnvlsqn------------------------------------------ 600  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        107 ------------------tcveGTIPKLFRGKMVSYiqckevd-------------------------------yrsdrr 137  human
EAL41393      424 nlisliqnwnrfvlhqihsellEALKKNETMHFYEQqpsqqqhtpeqdst------------------thrcnkcnttrv 485  Anopheles gam...
NP_001012972  629 qeqegpqayrgagsstfgssgdSVIGQLFSCEVENCsmcrcgk--------------------------------etvrv 676  chicken
BAA31685      633 mqeleipqayrgaggsfcssgdSVIGQLFSCEMENCslcrcgs--------------------------------etvra 680  human
Q09798        573 -ssfaqslgivfddysdgtfpdSFVIQKFTKFMLTEisriadyedkkdgtsfpvsfllksfcipemqtyrcgicgitsqk 651  fission yeast
XP_324149     894 --htsnasvsgvlediakdknpSTLVKNLTMFLFDKisqdykgtp---------------------------pisteler 944  Neurospora cr...
EAL21450      566 ------------------akgrNCQASNFSRAFSATsqayalglm----------------------------dentnsk 599  Cryptococcus ...
CAG80154      427 ------hcydgiaqtrslapedATNIVLFCRFLLEQigfeqrqtpalfdsfrqll--------gatvitvntfscgkmaq 492  Yarrowia lipo...
CAG59857      543 ----------------------DMMRNTIDGICRTTnyqm-------------------------------------sln 563  Candida glabr...
CAG84443      601 qvaqmqelinkddcknlnafeiRAIIGKFNKFLLSTcnndllnqfntslseit-----------nigyeieiksngcnin 669  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        138 eDYYDIQLSIKgk--------------------------------------------------kNIFESFVDYVAVEQld 167  human
EAL41393      486 kDNVLLVCSLLyptatt------------------------------------------nnvegTFGTILKHSLGVEKtt 523  Anopheles gam...
NP_001012972  677 sSTLLFTLSYPesaek-------------------------------------------pvkdyEFAQILKRSICLEQnt 713  chicken
BAA31685      681 sSTLLFTLSYPdgsksd-----------------------------------------ktgknyDFAQVLKRSICLDQnt 719  human
Q09798        652 iKSSLYIIDLHypsqq-------------------------------------------lesilSFEWLFKMSLDRRVdl 688  fission yeast
XP_324149     945 tLFKLNQPPNPldlvkrlletdaryqikcmhcqhvsprtattfvnklcypaakpnirgmkaqriTFSQVLKAGLENEAvn 1024 Neurospora cr...
EAL21450      600 sTAPYGSLIQN-----------------------------------------------------FNRWLLSTFSTESIvd 626  Cryptococcus ...
CAG80154      493 aESVWYTLELAlg--------------------------------------------------sTFYECLERTLDKELht 522  Yarrowia lipo...
CAG59857      564 dVLEKNNLSLHtis------------------------------------------------esNMLQKINSLSLNDDgg 595  Candida glabr...
CAG84443      670 nVNYNSQLTVDlmsppinklsili----------------------------sanstsatkknlNILNYLDYSMNQFKti 721  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        168 gdnkydagehglqeaekgvkFLTLPp------------------------------------------------------ 193  human
EAL41393      524 pawcetcn--kftptnqksrVTGLPailsincgl---------------------------------------------- 555  Anopheles gam...
NP_001012972  714 qawcence--kyqptvqtrnIRCLPd------------------------------------------------------ 737  chicken
BAA31685      720 qawcdtce--kyqptiqtrnIRHLPdilvincevnsskeadfwrmqaevafkmavkkhggeisknkefaladwkelgspe 797  human
Q09798        689 ppgwceycl-ahqpfllrsfIRSLPdclfintqvkhhe------------------------------------------ 725  fission yeast
XP_324149    1025 kg--------------yctkCQRYQnld---------------------------------------------------- 1038 Neurospora cr...
EAL21450      627 ge---------------tfhLRPFPqktsgldglsm-------------------------------------------- 647  Cryptococcus ...
CAG80154      523 rawcdkcr--kyqslhvskhVESLP------------------------------------------------------- 545  Yarrowia lipo...
CAG59857      596 kk---------------qlsIQELNdfl---------------------------------------------------- 608  Candida glabr...
CAG84443      722 kcqqcnns--fphlleirqsLVHLPp------------------------------------------------------ 745  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        194 ----------------vLHLQLMRFmydpq---------------------------------------------tdqni 212  human
EAL41393      556 ---------dnekeleyLKRQMSRSagahssps----------------------------------------sqlpagg 586  Anopheles gam...
NP_001012972  738 ----------------vLVINCEVNsskeadfwktqaeyafqralmkrggfeitkgkeislgdwkelgnpevghsypsve 801  chicken
BAA31685      798 gvlvcpsieelknvwlpFSIRMKMTknkgldv-----------------------------------------cnwtdgd 836  human
Q09798        726 -----hwklwarknwlpKKLHLRRVn------------------------------------------------------ 746  fission yeast
XP_324149    1039 --------------qrkIIFNIPAVlalcteittaehrkl--------------------------wstpgwlpeeigii 1078 Neurospora cr...
EAL21450      648 -------ndgpsaidqvLGVKIKTTntcrhcgfvssrd------------------------------stlhvvdlvypk 690  Cryptococcus ...
CAG80154      546 -----------------QVLTLSVAdgnvdv--------------------------------------------aksfl 564  Yarrowia lipo...
CAG59857      609 --------------lseLCEEEVKF------------------------------------------------------- 619  Candida glabr...
CAG84443      746 ----------------vILINVNFTgqefnliqnfp----------------------------------nwlvpefyty 775  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        213 KINDRFEFPEQLpldefl-------------------------------------------------------------- 230  human
EAL41393      587 NGGTEDPPPAQK-------------------------------------------------------------------- 598  Anopheles gam...
NP_001012972  802 ELKNIWIPHAIKmrltknkeldvcnw------------------------------------------------------ 827  chicken
BAA31685      837 EMQWGPARAEEEh------------------------------------------------------------------- 849  human
Q09798        747 DTMQCVSQKISNldk----------------------------------------------------------------- 761  fission yeast
XP_324149    1079 VDQGHVYCYEGDdlklhl-------------------------------------------------------------- 1096 Neurospora cr...
EAL21450      691 KMNPRLSFSDILrsslirdsttkaicssckafapldsrrslspssghplppvlsvna----------------------- 747  Cryptococcus ...
CAG80154      565 VLDGKVSPAAET-------------------------------------------------------------------- 576  Yarrowia lipo...
CAG59857      620 IDQNFVLQHCYCcefavktkgcmtygqtsgslykpsitigpnactqkngkvsyphsilgyiehglknsivlnkkceqcgi 699  Candida glabr...
CAG84443      776 GMNNKVSFKLHSnd------------------------------------------------------------------ 789  Debaryomyces ...
Feature 1                                                                                         
1NBF_A        231 ----------------------------------------------------------qktdpkDPANYILHAVLVHSGd 252  human
EAL41393      599 ----------------------------------------------------------------VTKTYNLSAVVCYINd 614  Anopheles gam...
NP_001012972  828 ---------------------------------------------------sesdelspnddpeSVYVYDLMATVVHILd 856  chicken
BAA31685      850 ----------------------------------------------------------------GVYVYDLMATVVHILd 865  human
Q09798        762 -------------------------------------------------------------dqqSLSVYVLRGIIYEIRq 780  fission yeast
XP_324149    1097 -----------------------------------------------------------nrgihNITVYSLVGTVVNVEt 1117 Neurospora cr...
EAL21450      748 --------------------mvtnsdvygfwkdkkdvkekdgvrrflpkrvtirevgklengqeEGVKYSIRSMVVQIQe 807  Cryptococcus ...
CAG80154      577 ----------------------------------------------------------------DNDAYKLVGFICQIQg 592  Yarrowia lipo...
CAG59857      700 kenleedisiqelppilslslefddnamklakttknwlpkefyasimknkplvrgsvndirtntMIYKYELHGYIARISd 779  Candida glabr...
CAG84443      790 ---------------------------------------------------------------nLSNKYELLGYVCEINv 806  Debaryomyces ...
Feature 1                  #                               #                                      
1NBF_A        253 n-----hGGHYVVYLNpkg--------------dgkWCKFDDDVVSRCTKeeaiehnyggh------------------- 294  human
EAL41393      615 ------gSQHNLVSLIhvpsyyqqpkpgdaastagsWYIFNDFSISPVPVqeavwf------------------------ 664  Anopheles gam...
NP_001012972  857 srtggslVGHIKVGETyhqrke--------gvthqqWYLFNDFLIEPVDKceavqf------------------------ 904  chicken
BAA31685      866 s-----rTGGSLVAHIkvgetyhqr---kegvthqqWYLFNDFLIEPIDKheavqfdmnwkvpailyyvkrnlnsrynln 937  human
Q09798        781 n----geEPHFVSTIRvsdntss------dnpddnrWYIFNDFLVKEVTEeealtvhgpwkipiiv-------------- 836  fission yeast
XP_324149    1118 ks---pqKSHLVATVNvgraepe-------skdqdrWHLFNDFSVRGISKvealtfnaawkmpvvvmfqvkaanhrfnmd 1187 Neurospora cr...
EAL21450      808 sp---daVAHLVSFVKmpskd-----------gssaWIMFNDFLVRPVSEdevlsfpdqwkvpaviilerenaeellnle 873  Cryptococcus ...
CAG80154      593 ------nGQVAFIRVGd------------------eWYLFNDFLVTKVSEkeafmktpwkrtvmmvyavgaderfdydsw 648  Yarrowia lipo...
CAG59857      780 p----drGDHYVTFSRiynee----------skmfrWYLFNDYLVTEVDEsivydlgkhwlkpevviygdaeelrkpfny 845  Candida glabr...
CAG84443      807 gse-flkGKHNLVSYIkie---------------skWYLFNDFLVMPIPEsevfdlsyhwkkpiivmyqlanhadfgsfq 870  Debaryomyces ...
Feature 1                                                                                         
1NBF_A            --------------------------------------------------------------------------------      human
EAL41393          --------------------------------------------------------------------------------      Anopheles gam...
NP_001012972      --------------------------------------------------------------------------------      chicken
BAA31685      938 iknpieasvllaeaslarkqrkthttfiplmlnempqigdlvgldaefvtlneeeaelrsdgtkstikp----------- 1006 human
Q09798            --------------------------------------------------------------------------------      fission yeast
XP_324149    1188 wktrldtsvlfrdnnphalktyelldreteipgpdtviaidtefirlkereihidedgksktirpishaiarasvvr--- 1264 Neurospora cr...
EAL21450      874 vlpkeldreilfkdvsiawnrkqdmikhkilqreempkrgtlvaidaefvalqqeemefrsdgtknilrpshmslarvs- 952  Cryptococcus ...
CAG80154      649 kndmdvsalfeerlvngnnvsrettdygyelikevpppktlcaidaefvvlkneeteirsdgtkvvlaprnlclarvtll 728  Yarrowia lipo...
CAG59857      846 lkdveiddsilykdyfsaairesiqkeyellt------------------------------------------------ 877  Candida glabr...
CAG84443      871 qqsfaqlpdlndsilyrdhfaggirdsikreyelltkdeapnagtliaidaefvalnpeelevhyggvrnlikprnlsla 950  Debaryomyces ...
Feature 1                                                                                         
1NBF_A            --------------------------------------------------------------------------------      human
EAL41393          --------------------------------------------------------------------------------      Anopheles gam...
NP_001012972      --------------------------------------------------------------------------------      chicken
BAA31685     1007 --------------------------sqmsvaritcvrgqgpnegipfiddyistqeqvvdyltqysgikpgdldakiss 1060 human
Q09798            --------------------------------------------------------------------------------      fission yeast
XP_324149    1265 -------------------gqgsregvafiddyihiketivdyltewsgitptdldpinsqrnlvspktaykklwvlvnl 1325 Neurospora cr...
EAL21450      953 ----------------vlrgegemegkpfiddyihtseavvdyltefsgikagdldpnnsphtlvplkvaykklrllvdl 1016 Cryptococcus ...
CAG80154      729 nedghpfindyiainehivdyltafsgiepgdldpsisrkplvslptsyrrlwlllnlgcvfvghglandfrtinmqvpp 808  Yarrowia lipo...
CAG59857      878 ----------------------------------------------------------------rneaprpgsliaidae 893  Candida glabr...
CAG84443      951 ri------------svlrgdngpkqgvpfiddyiihtcfiddyltsfsgiepgdldpssstktlttlqtsyrklwlllnl 1018 Debaryomyces ...
Feature 1                                                              
1NBF_A        295 -----------------------------------dddlsvrhctNAYMLVYI 312  human
EAL41393      665 ----------------------------------------tldwkVPCVLFYT 677  Anopheles gambiae str. PEST
NP_001012972  905 ----------------------------------------dmswkVPAILYYA 917  chicken
BAA31685     1061 khlttlkstylklrflidigvkfvghglqkdfrvinlmvpkdqvlDTVYLFHM 1113 human
Q09798        837 ------------------------------yyekldtkipqwdevSDYTLLYQ 859  fission yeast
XP_324149    1326 gckflghglsqdfrviniqvprnqvidtsiifmkppsqrkislafLAWYLLKE 1378 Neurospora crassa
EAL21450     1017 gcifvghglskdfrtinifvppeqvmdtvliytlpgsqrklslrfLAWYLLHQ 1069 Cryptococcus neoformans var. neoformans ...
CAG80154      809 eqvidtvdlyyipserrklslrflawcvlgkkvqsgnhdstedshTALLLYKK 861  Yarrowia lipolytica CLIB99
CAG59857      894 fvtlknekydidcrgaktvvqskvsalarisvvrgneeqfgvpfiDDYIIIEK 946  Candida glabrata CBS138
CAG84443     1019 gcifvghglqndfrcinlhvpknqirdtadffylpelkrklslkfLAYILLKE 1071 Debaryomyces hansenii CBS767

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