6H02


Conserved Protein Domain Family
Med23

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pfam11573: Med23 
Mediator complex subunit 23
Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.
Statistics
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PSSM-Id: 463299
Aligned: 15 rows
Threshold Bit Score: 1596.63
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6H02_A          6 QSIFEEVVKTEVIEEAFPGMFMDTPEdektKLISCLGAFRQFWGGL-SQESHEQCIQWIVKfIHGQHSPKRISFLY---- 80  
XP_970233       6 TNVLTDILKVEGIEEAFSCFLVHRPSaekeKVAVWQQELNTALRSI-PQEQLDTALRQYLN-TAVLCSQSKLQLLM---- 79  
EEB17621        9 TNIVNEILKVEGMEEAFSCFLVHRPDfeneKMEQFRSELQIALNNV-VPEQQEAGVRQFLLlAANMTNPSRLQFLL---- 83  
EFX89531        9 QALVSEALKVDAIEEAFNDFLIQRKDeg-iKYSALEKDLIAMMNDS-QAESQDAILPQFIAvISGVSSDSHSKILF---- 82  
Q5EB59          6 QSIFEEVVKTEIIEEAFPGMFMDTPEdektKLISCLAAFRQFWNGL-SQESHEQCVQWIVKfIHGQHSPKRISFLY---- 80   Norway rat
Q60UZ5         32 KSQIKSLIENNTTLRFFKPLTSNLGD----VTAILRISFNNMMSKM-EEKEKQSLVKELIKlVHHVAEKNTQDKVFiaas 106  Caenorhabditi...
Q10669         30 KSQIKSLVEENHTRKFFRPLTSNIGD----ETAILRIQFNNMMSKM-EEKEKQSLVKELIKmVHHVAEKNSPDRVFvgtn 104  Caenorhabditi...
XP_015787237   15 HNFIDSILRTEELEAIFTGYIVESSVneecKIKNYEEQMTALIKSCdTPEKIELMLRDYLNgAGSIPNVNKVRLLL---- 90   two-spotted s...
XP_018667177    8 eAVFGKALNTDIIVEVFTGFVSLANLdhtkRLKTCIKDFRTLYNSQ-STEEHVTSITLLIKfIHKQQHPRRISFMF---- 82   vase tunicate
XP_001951332   13 NQILNEIAKVDELVEAFNGYIQKDSLnnceQIEKLFMMLTNIVIRL-NDEQLSMSIKIILKtASTQTVSVRQKVFL---- 87   pea aphid
6H02_A         81 ------DCLAMAVETG--LLPPRLVCESLINSDTLEWERTqLWALTFKLVRKIIGGVDYKGVRDLLKVILE-KILTIPNT 151 
XP_970233      80 ------ELLESVVRNG--TIGARIVCEVVMNFDKLQHTNArFWIECFKLVRKIIDLVEYKGVREIMKGCCE-KAKSLPWR 150 
EEB17621       84 ------QLLEGAVQSN--IVSARLVCECILSCDKLSLNNQdFWVQCFQLMRKIIVGVDYKGVREIMKGCRE-KAAVIPAK 154 
EFX89531       83 ------KLLESVVNTN--IATSRKVCDSLLGNEKLTPANPlLWQGSFSLIRKIVCHVDYKGVREIMKTCLE-KAQLLPSR 153 
Q5EB59         81 ------DCLAMAVETG--LLPPRMVCESLINSDTLEWERTqLWALTFKLVRKIIGGVDYKGVRDLLKVILE-KILTIPNT 151  Norway rat
Q60UZ5        107 yervvdELLRYANQKE--VISTTLCVEGLIMTSDFRMCSR-IDQEKWKFIKECIPKIDYKGIRTIIRYILEsQLRRLPYQ 183  Caenorhabditi...
Q10669        105 yervvdQLLRYAHQKG--AISTNLCAEGLIMTSDFRLCSR-ICQEKWKFINDCIPKIDYKGIRNILRYILEsQLRRLPYS 181  Caenorhabditi...
XP_015787237   91 ------SM--LEHAinnhllSAKSVCEAILNCEHLHINKQiFFCQSFELIHRVISQVDYKGVRDIIRFMIE-KIHTIPIE 161  two-spotted s...
XP_018667177   83 ------DFLETCIQDG--FLLPRPVLDQLQGAE-LVHTNRlHWCRTYEVIRKFVHMVDYKGCRNLLHSMVL-KMTQIPQS 152  vase tunicate
XP_001951332   88 ------NMLQKLVQKH--GVSSRLMCECIINSEYLVHTNSeFWIECFHIIKSILDTVDYKGVREILKGCFD-KVVAMPKA 158  pea aphid
6H02_A        152 VSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKL-YPEg-kLPhwLLGNLVSDFVDTFRPTARINSICGRCSLLP 229 
XP_970233     151 LNAGLQPQTQALLSVAERIMDRNACLLPGYLLVNELQKA-YPD---CPhwRLAALFSDYVGSFRACAQMVAIVGQAEMRP 226 
EEB17621      155 LNAAQMPQITALESVMEFIFDRNACLLPAYFIVNEIQKA-YPEnknWPhwKLANLLSGFVESFRPCAQMVSIVGHSKLLP 233 
EFX89531      154 FSTSEYPNVTALEHTLKHILDRQVCLLPAYFIVNEIRKM-YPEnkdWPhwKLAGLLSEVVDSFRPLVQMLSPIGRPLMFP 232 
Q5EB59        152 VSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKL-YPEg-kLPhwLLGNLVSDFVDTFRPTARINSICGRCSLLP 229  Norway rat
Q60UZ5        184 LSPEKVNELRRVEDVLLKIVDRDLNLMPPLITLSEVMRGtPKQahmFP--RLTEKLANLSSHFRPIADLTHVCGRPFIYP 261  Caenorhabditi...
Q10669        182 LSPEQVNEIRIVENVILHIVDRDSNLMPPLITLSEIMRGmPKQalmLP--RLTEKLASLSVHFRPIADLSHVCGRGFVYP 259  Caenorhabditi...
XP_015787237  162 ANIAMLPQLDVMRKVLDYALNRNSSLLPAYLAFDEIKKKsd----kWMhwKFADLFSAFVESFRPVAQMVSIINRSKLLP 237  two-spotted s...
XP_018667177  153 VWIEEKQQVDAICSTIQLLLDPEACLLPGYLAVNEIRQN-MQDdllDApwPLLGKLTEFIDRFRATATMVSTTARWMLLP 231  vase tunicate
XP_001951332  159 LPASILPQFLALEEVIRYIFDRESCLLPGYFVINEILKV-YSEnkgWPhwKLGCLVSNFVESFRGAAQMTSMIGHSSMLP 237  pea aphid
6H02_A        230 VVNNSG---AICNSWK---LDPATLRFPLKGLLPYDKDLF-EPQTALLRYVLEQPYSRDmvcnmlGLNKQHKQRCPVLED 302 
XP_970233     227 VVEHSGcpeHLVNPWK---LDPCTLRFSLKGTLPYAPELL-EKQTGLLRYVLEQPYSRDmvcgmlGLQKQHKRHCAALEE 302 
EEB17621      234 VVEHSGyadHL-SPWK---LDPTTLKFTLKGILPYDRELS-EPQTGLLRYVLEQPYSRDmvccmlGLVKQHKQRCVALEE 308 
EFX89531      233 VVDPSAhgvH--HSWK---LEQGTLKLALKGNLPYEKEYT-EPQTRLIRYVLEQPYSREvlcgmlGLQKQHKQRHAVLEE 306 
Q5EB59        230 VVNNSG---AICNSWK---LDPATLRFPLKGLLPYDKDLF-EPQTALLRYVLEQPYSRDmvcnmlGLNKQHKQRCPVLED 302  Norway rat
Q60UZ5        262 IPFHPAf-hPPTSYWEdfgMNAQSPYTQSHHMLPYRPQHKaASCLYTFYMILRQPLGKD------SLNPTNRNKTKSHWE 334  Caenorhabditi...
Q10669        260 IPLHPSf-yPLTSCWEehgLNASNTIVQPHHTLPYRPEHT-STYLYTLYMILRQPLGKD------SLHPPSKTKTKTNWE 331  Caenorhabditi...
XP_015787237  238 IV---GyssTLNQSWQ---LNAATAAFDLKGLLPYNNELT-RPQIGLLRYVLEQPYSREmiyfmlSLTNKAKSRCPILEE 310  two-spotted s...
XP_018667177  232 VVDHAFy--QLPSTWK---LEADTLRFQLKKQLPYRPEMY-QRQHRLLNYILDQTYSRDmvlqvlGMQKHQKQRCEALEM 305  vase tunicate
XP_001951332  238 VVEHSGyadHLITPWK---LDPNTLKLTLKGNIPYPKQLL-QPQTKLLRYVLEQPYSRDmvcsmlGLQKMNKQRCIVLEE 313  pea aphid
6H02_A        303 QLVDLVVY-AMERSEtee-----kfDDGGTSQLLWQHLSSQLIFFV---LFQFASFPHMVLSLHQKLAgr------gLIK 367 
XP_970233     303 QLVELVIL-ALERTEn--------eGDESATQGLWLHLSSQLIYFV---LFQFASFPNIVISLHSRLQgr------dLRR 364 
EEB17621      309 QLVALVVV-AMERSEt---------ETGDSSHWLWLHLSSQLIYFV---LFQFASFPNIVMALHDKLSgr------dLKK 369 
EFX89531      307 QLVELLVQ-AMERAEiapeqdsdaaDELGVSHWLWHHLSSQIIYFV---LFQFASFSHLVTLLHEKLAer------kLRK 376 
Q5EB59        303 QLVDLVVY-AMERSEtee-----kfDDGGTSQLLWQHLSSQLIFFV---LFQFASFPHMVLSLHQKLAgr------gLIK 367  Norway rat
Q60UZ5        335 PLLSVMIVeAMAETEal-------pEGKQIPRYQWDNITNLVMYGMshlLVNPKNFFHYLKGLINQCK---------YTR 398  Caenorhabditi...
Q10669        332 MLISVMICeSMAEAEsl-------pETEPIPRYQWDNIVNIVIYGItqhLLVPKTFFNVLKNLIKRCK---------YTR 395  Caenorhabditi...
XP_015787237  311 QLVALIVL-AMEKSEnetn--nqedTDYSQTQCLWQILSGHLITFI---ILNHISFPQLVRSLHESLAar------nSKK 378  two-spotted s...
XP_018667177  306 GLVDLMFS-TVKKCStf-------eDKSNIQHLMWQHVACQVIYFV---LYQLASFPHIVEDLHTKLAaseelrdqcIQG 374  vase tunicate
XP_001951332  314 QLVELIIR-SMEKSDkev----tegADPEENHWLWLHISSQLIYFI---LFQFAVFPNVVNALHEKLLkk------dLHR 379  pea aphid
6H02_A        368 GRDHLMWVLLQFISGSIQKNALADFLP-VMKLFDLLYPEKE-YIPVPDiNKPQSTHAFAMTCIWIHLNRKAQ-------- 437 
XP_970233     365 GRDQLMWVLLQFISGSIQKNPLSNFLP-VLRLYELLFPEQEpPLPVPDfNQPQCTRQMAMTCIWIHLTKKAQ-------- 435 
EEB17621      370 GRDHLMWVLLQFISGSIQRNPLSNFLP-VLKLYDLLYPEKE-PLPVPDvNKAVCTHQMAMTCIWIHLLKKAQ-------- 439 
EFX89531      377 GRDQLMWVLLQYISGSIQKNPLAEFLP-LLRLYDLLYPERE-PLPVPDyTRPICVHQMAVACIWIHIVKKAQ-------- 446 
Q5EB59        368 GRDHLMWVLLQFISGSIQKNALADFLP-VMKLFDLLYPEKE-CIPVPDiNKPQSTHAFAMTCIWIHLNRKAQ-------- 437  Norway rat
Q60UZ5        399 ARDEVMWIVFQVVSSLHKMIKIEDAVQeIVDLYNELFDGEFsWHGASD-HPARMARFLAAASTWMLLEKNKA-------- 469  Caenorhabditi...
Q10669        396 ARDEVMWIVFQVVGSLSNLTRLDDAVTeIVELYNELFDGDVvWMGASD-HPALFARFLAAAGTWMILEKDFA-------- 466  Caenorhabditi...
XP_015787237  379 GRDHLMWMLLQYISGSIQKTPLTDFLP-FFKLHDLLYPEKD-PLPVPDiTKPICTHTFAISSIWIHLLKKAE-------- 448  two-spotted s...
XP_018667177  375 GRDYIMWVLLQFISGSIQKNPLSDFLS-VIKLVNLLYPEKQ-PLELPEmKSHSCTISFAAVCNLVHLNRKAQakppsdgn 452  vase tunicate
XP_001951332  380 SRDRLMWVLLQYISGSIQRNSLENILP-VLKLYDLLYPEKE-PLPVPDtSNALCTHQMAITCIWIHLLRKAL-------- 449  pea aphid
6H02_A        438 -NDnsklQIPIPHSLRLHHEFLQQ-SLRNKS--LQMnd-ykIALLCNAYSTNSECFTLPMGALVETIYGNGImriplpg- 511 
XP_970233     436 -AEmtnlTWPIPAKLRNHHDFLQQlVPPNNTv-LAMgndyrIALLCNAYSTNPDYYSKPMAALVETIQGSPKst------ 507 
EEB17621      440 -ADhlniQRPIPLTLKIHHEFLQHlVQPNNSlgLCMgadyrIALLCNAYSTNQEYFTRPMAALVETILGAQKsssl---- 514 
EFX89531      447 -TEqqklQRHFPQALKNHQEFLQHnALNPPS--SAPsgdyrVALLCNAFSTTLDCLARPMGSLMESLHGNLSqkgsgnag 523 
Q5EB59        438 -NDnsklQIPIPHSLKLHHEFLQQ-SLRNKS--LQMnd-ykIALLCNAYSTNSECFTLPMGALVETIYGNGImrvplpg- 511  Norway rat
Q60UZ5        470 -HKqn------tDTIKSHIKVIHEaALNFDPknMGM-----LAVLANAFKSDTRIGAQIVPAMSEALNTPPD-------- 529  Caenorhabditi...
Q10669        467 -DK----MPPANETIKSHIKFIQDgVDNFDSsnTAM-----LAVLSNIYRTDTKMGKLIVPTLQQMLESIDD-------- 528  Caenorhabditi...
XP_015787237  449 -NEpqkmIRPIPNCLRLHVEFLHQtFMSSDLp-ASLtvdskIPLICNAYSTNSDYYNRILTILCDTIKCNSRsgstg--- 523  two-spotted s...
XP_018667177  453 qDRnqqwN--IPVALHNQHECIKQ-CLKTTSinLkd---sqVALISNACSSNTEMFNMAVSVLVESVFGDTSstspmpg- 525  vase tunicate
XP_001951332  450 -MDnikfHRPIPLALKAHHEYLQMlVQPSNSa-LCMgtdyrVPLLCNAFSTNNECLSRPMAALVDAVLGSSSnrgisgvt 527  pea aphid
6H02_A        512 ---------------------------------------tncmasgSITPL----------------PMNLLDSLTVHAK 536 
XP_970233     508 --------------------------------------------apPTAPL----------------SMAVLDSLTVHSK 527 
EEB17621      515 -------------------------------------------ppgPTTPL----------------SMAILDSLTVHSK 535 
EFX89531      524 g------------------------------------saggmpntgPISPI----------------PLAFLDALTVHAK 551 
Q5EB59        512 ---------------------------------------tsclasaSVTPL----------------PMNLLDSLTVHAK 536  Norway rat
Q60UZ5        530 ----------------------------------------------PSQPTfdlsyqrkavnqfdafPKEFLDALTSRAK 563  Caenorhabditi...
Q10669        529 -----------------------------------------------TKSLfelsykrmavncfsafPVEFMEALTFRSK 561  Caenorhabditi...
XP_015787237  524 -----------------------------------------gntngAIIPL----------------SVSLLDSVTLHTK 546  two-spotted s...
XP_018667177  526 ---------------------------------------nncvafnKTVPC----------------SMDLLDTLTVHTK 550  vase tunicate
XP_001951332  528 sntqqstqspvitpavggtspvasvpgsggttspisgnasssnamgPTTPL----------------SMAVLDSLTIHAK 591  pea aphid
6H02_A        537 MSLIHSIATRVIKLAHAKSsvaLAPALVETYSRL-------LVYMEIESLGIKGF-----ISQLLPTVFKSHAWGILHTL 604 
XP_970233     528 MSLIHSIVTHVIKLAQAKLgmpLSPALVETYSRL-------LVYTEIESLGIKGF-----ISQLLPTVYKSHAWGTLYTL 595 
EEB17621      536 MSLIHSIVTHVVKQAQSKSilaLAPALVETYSRL-------LVYTEIESLGIKGF-----ISHLLPTVFKHHAWGILYTL 603 
EFX89531      552 MSLIHSIVTHVIKCAQTKMnvpLAPALVETYSRL-------LVYTEIESLGIKGF-----ITQVMTSVSKSQAWGIFHTL 619 
Q5EB59        537 MSLIHSIATRVIKLAHTKSsvaLAPALVETYSRL-------LVYMEIESLGIKGF-----ISQLLPTVFKSHAWGILHTL 604  Norway rat
Q60UZ5        564 RSLLGQILSVFRSFGTDKL---PSPAAFETLARIcqsedyeMAVKDLESLASRSLhi-stQERAADIATNNQAKDQCHFL 639  Caenorhabditi...
Q10669        562 KTLLIQCFQPLRSFSTVRL---PSPAVFETVAKIcesedyeMAVKDMEHLAQRSLhvataADRSSGEHQNVQAKDQCYFL 638  Caenorhabditi...
XP_015787237  547 MSLISNIVAQINKSSSKDGt-iISPALAETYSRL-------LIYIELETLGIKNF-----IQQVIPNAIRTQSWGTLNIL 613  two-spotted s...
XP_018667177  551 MSMLHSISTKIQKFAQAKSsvgLAPALVETYSRL-------LIYYEIETLGIKIL-----VSQVVPKVYEYRAWGILNTL 618  vase tunicate
XP_001951332  592 MSLIHSIVTHVLKLAQSKSnlaLAPALAETYSRL-------LVYTEIESLGIKGF-----ISQVLPTVFKSHAWGILYTL 659  pea aphid
6H02_A        605 LEMFSYRMHHIQPHYRvqLLSHLHTL---------AAVAQTNqnQLHLCVESTALRLI-------------TALGSSEVQ 662 
XP_970233     596 LEMFSYRMHHIHPHYRvqLLSHLHSL---------AAVPQANqtQLHLCVESTALRLI-------------TGLGSGEVQ 653 
EEB17621      604 LEMFSYRMHHIQPHYRvqLLSHLHSL---------AAVPQTNqtQLHLCVESTALRLI-------------TGLGSAEVQ 661 
EFX89531      620 VEMFTFRVHHMQPQYRiqLLTLLHSC---------A-VPQQHqtQLILCVENAALRLI-------------GLLGAAEMQ 676 
Q5EB59        605 LEMFSHRMHHIQPHYRvqLLSHLHTL---------AAVAQTNqnQLHLCVESTALRLI-------------TALGSSEVQ 662  Norway rat
Q60UZ5        640 FDFLAYRLPHVHSYGK--YTSTTGSLllyftasvaPNTPQNH--QVYRLLEQALLRRMywrtfhesvinhsQLFGSSYKE 715  Caenorhabditi...
Q10669        639 FDFLVYRLPHLHAYSK--YSSTVNALsyft--qhiPNNPQNH--QIYRLMEQFLMRRWcwagfhgcitahtQMFGTSYKD 712  Caenorhabditi...
XP_015787237  614 FEMFIHRLHHIPAPYRvqFLNQLHYL---------ANSPHSNqiQLHSCMESTALKLI-------------TGFTSEQVL 671  two-spotted s...
XP_018667177  619 LELMSYRMHHIQPNYRiqLLTHLHTL---------ANSPHANqrQLHLRLESTALKLI-------------MGFDNFGIK 676  vase tunicate
XP_001951332  660 LEMFSYRMHHIQPHYRvqLLSHLHSL---------AAVPQTNqtQLHLCVESTALRLI-------------TGLGSNEVQ 717  pea aphid
6H02_A        663 --PQ---FTRFLSDPKTv--L-SAESEELN----RALILTLARATHVTDfftgsdsiqgtwckdiLQTIMSFTPH----- 725 
XP_970233     654 --PE---LSRFLAEPKT---LiSAESEELN----RALVLTLARATHVTGadgsw-------chelLATIAQSTPH----- 709 
EEB17621      662 --PQ---LSRFLNEPKT---LvSAESEELN----RALVLTLARSMHVTGtgsdsis--gtwckelLSTIMQNTPH----- 722 
EFX89531      677 --PC---YSRSAADIKP---LfSSDSEELN----RALILTLARVISVAGcetqhs----swykdlLTLIQQQTPH----- 735 
Q5EB59        663 --PQ---FTRFLNDPKT---VlSAESEELN----RALILTLARATHVTDfftgsdsiqgtwckdiLQTIMTFTPH----- 725  Norway rat
Q60UZ5        716 --NSnnvMLRHLKNPKTfstPvDQWQFPLNpeifKMTIYAFMRALKITG----------------QEIPLDGTMHpihva 777  Caenorhabditi...
Q10669        713 --NT---MMRHMAYPKTfsvP-DQYPFAINpeifKMAIYSFLRAVKITA----------------QDIAIEKTMFptiin 770  Caenorhabditi...
XP_015787237  672 liTQ---LNRYQNEPKI---RiSHDSEELN----KVLILTLARAIHVTGcdtlie-----wckelLSNIMNSTPL----- 731  two-spotted s...
XP_018667177  677 --PQ---LVRMFNEQKQs--IvSQKSEELN----RVLVLTLARSIHITgaesisg----swctdiLKAVMSATPH----- 736  vase tunicate
XP_001951332  718 --PQ---LSRFLSEPKT---LvSAECEELN----RALVLTLARSMHITGtsasqeg---swckelLTTIMANTPH----- 777  pea aphid
6H02_A        726 --NWASHTLSCFPGPLQAFFKQ--NNVPQE--SRFNLKKNVEEEYR--------------KWKSMSn-ENDIITHFSMQ- 783 
XP_970233     710 --AWAPHTLECFPRALAEFFTQ--HAVPKE--NKQQLKKAVEEEYR--------------KWSSMNn-ENDMMAHFGVA- 767 
EEB17621      723 --SWANHTLQCFPLALHDFFQH--SPVQKE--NKPQLKKAVEEEYR--------------NWASMNn-ENDIIAHFSVA- 780 
EFX89531      736 --SWSSNTRDCFPPPLAEFFGQaaNQPVKE--SKQQLKQNIEEEHR--------------KVLTMn--PDDWPAHFAPQs 795 
Q5EB59        726 --NWASHTLSCFPAPLQAFFKQ--NNVPQE--SRFNLKKNVEEEYR--------------KWKSMTd-ENEIITQFSMQ- 783  Norway rat
Q60UZ5        778 gyGWPEKSTTFFPKWALEEIKK--TDVKKLapNYAEILSTTDEAFR--------------MNTLLT--GGQYVIRYADD- 838  Caenorhabditi...
Q10669        771 gfGWPEKSTSYFPKWALDAIKA--SDTSNAv-NTEEILSDVRNTAR--------------MHTSLT--PNQFVIRYGED- 830  Caenorhabditi...
XP_015787237  732 --AWSSCTLKCFPPAITEYYQN--FNTVTE--NKAQLKQSVEEEYR--------------KWITMSn-ENDIIAHFSIQ- 789  two-spotted s...
XP_018667177  737 --RWPQQTLACFPQSIQDFFNH--SNV--EplNKKQLKTNVEQEYIkwapllsadgmdssSSSGSSltEADALNHFSQP- 809  vase tunicate
XP_001951332  778 --TWAPHTLQCFPPALADFFVH--NPITKE--NKQQLKKAVEEEYR--------------NWASMTn-ENDIIAHFSVP- 835  pea aphid
6H02_A        784 GSPPLFLCLL-------WKMLLET--DHINQIGYRVLERIGARALVAHVRTFADFLVYEF--STSAGGQQLNKCIEILND 852 
XP_970233     768 GAPPLFLCLL-------WKMLLET--DHITPIAYKILERIGARALSAHLRKFCDCLVFEF--SNSPGGQHVNKCVDTIND 836 
EEB17621      781 GTPPLFICLL-------WKMILET--DRITSIAYKILERIGARALSAHLRKFCDYLVFEF--ANSRGEQHVNKCVDALND 849 
EFX89531      796 NNPPFFLCLL-------WKQLLET--ERINPVAYKCIERIGARGLGSHLRTFCDFLVYEF--ANSGKGQHVNKCIDVLNE 864 
Q5EB59        784 GFPPLFLCLL-------WKMLLET--DHISQIGYKVLERIGARALVAHVRTFADFLVYEF--STSAGGQQLNKCIEILND 852  Norway rat
Q60UZ5        839 PNPITYHCMLav----iFKQLCSKpeQDLTSEYYQVMEKKSPKDIVVMGNYLVDFIIADVknNQDCNEQTFKTIAKTAAL 914  Caenorhabditi...
Q10669        831 RDPATSHCMLavlfhfaYNSVDST--YNITSEFYEVMEKKTPKEIVVMGNYLVDYIIADAk-TQDCNEKTFKNIAKAAAL 907  Caenorhabditi...
XP_015787237  790 GTPPLFLCLL-------WKMILEN--DRINPIAYKILDRIGAKALSSHLRILVDYLVNEF--TNLCGTQNVTKYIDKLND 858  two-spotted s...
XP_018667177  810 GTPPYYLCLL-------WKVLFEE--KKLSSTSYKVLERIGASQLSQHVRKFSDFLVYEF--SVLEGGSDVKICANVLQD 878  vase tunicate
XP_001951332  836 TAHPLFLCLL-------WKMIIET--DRINPIAYKILERIGARALSAHLRKFCDYLVFKF--AVSEEGQHVNKCVDAINS 904  pea aphid
6H02_A        853 MVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLkPNDFRNRVSDFVKe-NSPEHWLQNDWHTKHMN-YHKKYPE 930 
XP_970233     837 MIWKYNIVTIDRLVLCLALRTQEGSEAQVCSFIIQLVLLkATEFRNRVQDFVKd-NSPDHWNQTNWHEKHLE-FHRKYPE 914 
EEB17621      850 MIWKYNIVTIDRLVLCLALRTQEGSEAQVCFFIIQLLLLkAAELRNRVQDFVKe-NSPEHWKQSNWHEKHLA-FHRKYPE 927 
EFX89531      865 MVWQYNVVTIERLVLCLALRPLEGNEAQVCCFIIQLLLLkTPQFRSRVQDFVKd-NSSEHWRQNNWHEKHLA-FQRKFPE 942 
Q5EB59        853 MVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLkPNDFRNRVSDFVKe-NSPEHWLQSDWHTKHMS-YHKKYPE 930  Norway rat
Q60UZ5        915 MCFHFNIHRADRFLLSLIMHPSTDEDAQICIQIANEFLL-TPKFQERIKWFYEn-DVPRKEKDPYEYIKAIVkYHDAFPE 992  Caenorhabditi...
Q10669        908 LVFQFQVLRADRLLLSLIMHPATDEDALICIQIANEFIL-TPEFQERIRWYHQ--NVPKKDHFPTEYIKAIVkYHDAFPE 984  Caenorhabditi...
XP_015787237  859 LIWKSHVITLDRLLLCLTLRAYEGNEAQVSLFIIQMLLLkTTDFSNRVADFVRe-MSPEHWKQSNWHEKHHA-LHRKYPE 936  two-spotted s...
XP_018667177  879 MVWKYNIVFLDRLILCLALRSSEANDVQVAFFIIQYLLIkPDDFLNRVRSFDHdvENLDHWMQDDWHAKHMA-YHQKFPE 957  vase tunicate
XP_001951332  905 MIWKYNIVTIDRLVLCLALRTQEGSEAQVCFFIIQLLLFkGAEFRARVCEFVKe-NSPEHWKQSNWHEKHLA-FHRKYPE 982  pea aphid
6H02_A        931 KLY-FEgla-----------eqvDPpvqiQSPYLPiYFGNVCLRFLPVFDIVIHRFLEllPVSKS--LETLLDHLGGLYK 996 
XP_970233     915 KFA-PE-----------------EQ----SSGYHP-YFGNVCLRFLPVFDIVVHRFLEipQVTKS--LEILLEHLGCLYK 969 
EEB17621      928 KFA-PEgileq--------sggaSS----PYHSLPvYFGNVCLRFLPVFDIVIHRYLElpPVTKS--LETLLEHLGCLYK 992 
EFX89531      943 RFGpPEsvle---------sigqGG----SYQSLPtYFGNVCLRFLPVFDITIHRFTEipPVTKS--LETILEHLGCLYK 1007
Q5EB59        931 KLY-FEglaeq-------vdppvPI----QSPYLPiYFGNVCLRFLPVFDIVIHRFLEllPVSKS--LETLLDHLGGLYK 996  Norway rat
Q60UZ5        993 FEA-CQlvpk----------nddTG----TNVHMPtYYGCLIERLLPILDQYVYVALEq-QGYKM--SNALLQLVSMFYR 1054 Caenorhabditi...
Q10669        985 FEA-CElvr-----------sydSS----SNVHMPtYYGCLIERLLPIMDQYLHVALEq-QGYKL--NPQILQSVSMLYK 1045 Caenorhabditi...
XP_015787237  937 KFY-FEglad---------isgqNM----QHSYLPtYFSNICLRFIPVLDLIIHRYLElpPGSPSplIDSLLEKYGCLYK 1002 two-spotted s...
XP_018667177  958 HYF-FEglvahcsspeqpnatgeKP----QPTYLPtYFCNITLRFLPVLDIVIHRCLElpPSSKS--LETLLEHLGLLYK 1030 vase tunicate
XP_001951332  983 KFA-PEgi-------------ldPA----SYQPLPvYFGNVCLRFLPVFDIVIHRYLElpPVTKS--LETLLDHLGCLYK 1042 pea aphid
6H02_A        997 FHDRPVTYLYNTLhYYEMHLRDRAFLKrKLVHAIIGSLKDnrpqgwcLSDTYLKC------------AMNAREEnpWvpd 1064
XP_970233     970 FHDRPVTYLYNTLhYYETRLRDRPPLKrRLVAAVLGTLKDs------LSEPYQLY------------LGRAADE--Mwtp 1029
EEB17621      993 FHDRPVTYLYNTLhYYDRNLRDRPVLKrRLVAAILGALKDirppgwsLSEAYINY------------MSGSGDEv-Swlp 1059
EFX89531     1008 FHDRPVTYLYTTLhYYERKLRDRPLLKrKLVSSIMGSLKDvrppgwaLSESYLNY------------STRQADDl-Nwlp 1074
Q5EB59        997 FHDRPVTYLYNTLhYYEMCLRNRDHLKrKLVHAIIGSLKDnrpqgwcLSDTYLKH------------AMNAREDnpwvp- 1063 Norway rat
Q60UZ5       1055 YHPMPIHFMYSVL-FVSHGKMAGPDAK-SFVSAFASQIEEc-----hLTEEFEKYn-----------HQKSSCEelI--- 1113 Caenorhabditi...
Q10669       1046 FHAMPIHFMYSVL-FTSHGLMSGPDAK-SFVLAFATQIEEc-----hLTEAFEKFn-----------HQKSSREqlI--- 1104 Caenorhabditi...
XP_015787237 1003 FHDRPLTYLYETLhYYEHKMRERPALRrKLVSIIIGAFKDikpanwaVTDAYLNY------------MKRPVEDl-Awnp 1069 two-spotted s...
XP_018667177 1031 FHDQPVTYLFNTLhYYESKLRGRHLLKkKLVSTIIGAITKnkppgwiLSETFMDY------------LQQPNDQqwqpd- 1097 vase tunicate
XP_001951332 1043 FHDRPVTYLYNTLhYYESKLRDRPSLKrKLVYAVLGSLCEtrg-cwtLSESYQRYniqtptstisnsMGTSTDVtvTpsa 1121 pea aphid
6H02_A       1065 d------tyyCRLIGRLVDTMAGK-SpgPFPNCDWRFNEFPnPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLV 1137
XP_970233    1030 e-----ldyyIQVVKRVVDILGGA-T--ANSVIDWRFNEFPnAGAHILYTSCVELMALSAGPVAVANGLLDVVAKGYVTI 1101
EEB17621     1060 d-----ldyyIKLIRRIVETMNGSkA--HFPSTDWRFNEFPnPAAHALYVTCVELMAVPVSPSVVANNLLDVVTKGYSVI 1132
EFX89531     1075 e-----ldyyVKLVGRLVDTTAGR-SpfPFPAMDWRFNEFPnASCHALYVTAVELLALPASPAIVANALMDVVLQGYNLL 1148
Q5EB59       1064 -----edsyyCKLIGRLVDTMAGK-SpgPFPNCDWRFNEFPnPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLV 1137 Norway rat
Q60UZ5       1114 ----------MELLDRMAASLDFVlTppTFVAKDWRTAEMS-PGAQALYLACIELMASPHSPEKLVNAMINVMQMRPHLR 1182 Caenorhabditi...
Q10669       1105 ----------MELIDRMSASLDFIlTppPFVAKDWKIAELS-PGAQTLYLACIELMASPHSPETLVAAMINVMQMKPHAR 1173 Caenorhabditi...
XP_015787237 1070 e-----ldyyFKLISRVVDTFQGK-S--PFPHVDWRFNEFAnAGVHALHITCIELMALPVAANVVANNLIDLVVVGHKYI 1141 two-spotted s...
XP_018667177 1098 ------svyyCQLIQRLANT-VGGkMtsSFSSRDWRFNEFPnASSHALHVTCVEALALPLPGEQVGQALMDVVLKTQSFV 1170 vase tunicate
XP_001951332 1122 piwvpdleyyVMLVKRITDTMNGN-V--KFPNIDWRFNEFPnPAVYALYMTCAELMALPLTPASVANSLLDVVMQRYTEI 1198 pea aphid
6H02_A       1138 PRENit---awMNAIGLIITALPEPYWIVLHDRIVSVISspSLTSEtew-vgyPFRLFDFTACHQSY---SEMSCSYTLA 1210
XP_970233    1102 PSSDih---qwVNAVGLILAALPVSYWSVLHDRLVATLN--ELETWnfd--csPFRLFDFKETHAGL---LHNNFSYMLA 1171
EEB17621     1133 PWDQih---lwINSIGLVLAALPESYWSIVDDRLIEVMTcsRMTNWpyh--nsAFQIFNFSVTHESL---LENKFSYILA 1204
EFX89531     1149 PVSEetpleswVNAVGLLLTYLPESYWSVLYDRIVELLSgpQLSTYtyp--csPLHLFHFSTVVGQG---LDAPFVLLLA 1223
Q5EB59       1138 PRENit---awMNAIGLIITALPEPYWIVLHDRIVSVISssSLTSEtew-vgyPFRLFDFTACHQSY---SEMSCSYTLA 1210 Norway rat
Q60UZ5       1183 PFNV-------FNLIALLLTALPSTYADALHEEFIGVFKngETANL-------KFEEIVFDNYDSSLllhLPNRARSINM 1248 Caenorhabditi...
Q10669       1174 PFNI-------VNLTALLLTALPAAYSNALHDEFVAVFVngETANL-------KFEEIVFDNYEESLllnLPNRARTINV 1239 Caenorhabditi...
XP_015787237 1142 PRNTie---fwNNAIGVVLTALPEAYWSVINDRIISMMEspLLTYSph---pePFQMMNFSDSHKSM---SEMQPSYLIA 1212 two-spotted s...
XP_018667177 1171 EREQsl---pwLNAVALVLTALPEIYWKPLHQNILKMLQcpTLTADiepgssyPYHILSYSNQQLSF---TDMPCTRLLA 1244 vase tunicate
XP_001951332 1199 PSHEih---cwINSIGLIMSAMPEPFWVTLQDRIMQMMQspGLATWhya--htPFQLFNFDLAHGCM---LDNRFIYMLA 1270 pea aphid
6H02_A       1211 LAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRF----------QQer-trCMIEIGVAFYDMLL 1279
XP_970233    1172 LAHSVWHHAGPGQIASVPRWARECLPAVVRSEEQFLYVCHLVGPFLQRF----------NV-----AIVELTSALYELLA 1236
EEB17621     1205 LAHAMWYHAGVGQISTLPVFVKEKAKTVIKTEEQFLFLCHLVGPFLQRL----------NAer-prCVLELTIELYELLE 1273
EFX89531     1224 VSHAFFTHANIGQMGGLPQFVKDRLHPLIRTEEQYLWLCHLIGPTLQRF----------SVdk-pkCVFDLTVELYELLE 1292
Q5EB59       1211 LAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRF----------QQer-trCMIEIGVAFYDMLL 1279 Norway rat
Q60UZ5       1249 IAQIYWTQCNMALLNPFANDQVPKLLEHVKTEKDLWYTLRLVMPIIRRFwdswdfaktmRAlrerfGPLVIMKLIIEKLG 1328 Caenorhabditi...
Q10669       1240 ISQQYWLHCSLSLLNFFSHEYVPRILEHVKTEKDLWYTLRLVMPYLRRYyenwdtakqmRSqrenfGPLHIVKLVFQKLG 1319 Caenorhabditi...
XP_015787237 1213 LIHSFFHHASIGQITPIPQFLRERVKPIIKTEEQFLFIVHIVCPFLQRL----------YAer-trRAMEVTIELYSFLE 1281 two-spotted s...
XP_018667177 1245 LTHVVWHHMSIGQLSLVSQFLKEEAKPLIETELQLLYIFHLIGPYFPRF----------QLer-trCMMDVAQLLYNILL 1313 vase tunicate
XP_001951332 1271 LAHATWHHAGVGHIASIPLFVKEKLGPSVYSEEQFIFLCHLVAPFLSRY----------NLdkpspSIVDVTVELFNALE 1340 pea aphid
6H02_A       1280 NVDQCSTHLNYMDPICDFLYHMKYMFTG 1307
XP_970233    1237 QVDHAHSELKYMDPICDLLYHIKYMFVG 1264
EEB17621     1274 QVDKSVLQLKYMDPICDLLYHIKYMFVG 1301
EFX89531     1293 QVDKNVAEIRMIDPICDLLYHIKYMFTG 1320
Q5EB59       1280 NVDQCSTHLNYMDPICDFLYHMKYMFTG 1307 Norway rat
Q60UZ5       1329 SMAESGVEIVHEAPFCDLFYNCKYVFVG 1356 Caenorhabditis briggsae
Q10669       1320 SMAEEGVEIVYEQHLCDLFYNCKYFFAG 1347 Caenorhabditis elegans
XP_015787237 1282 VIDKNCTELRFMDTITDLLYHMKY-HIT 1308 two-spotted spider mite
XP_018667177 1314 RVSKHSSEIHFADEIADFLYHVKYMHIG 1341 vase tunicate
XP_001951332 1341 RMDKHVQTLHYMDPICDLLYHIKYQYVG 1368 pea aphid
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