3EE6,1T1E


Conserved Protein Domain Family
Pro-peptidase_S53

?
cd11377: Pro-peptidase_S53 
Click on image for an interactive view with Cn3D
Activation domain of S53 peptidases
Members of this family are found in various subtilase propeptides, such as pro-kumamolysin and tripeptidyl peptidase I, and adopt a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptidase.
Statistics
?
PSSM-Id: 206778
Aligned: 69 rows
Threshold Bit Score: 69.5822
Created: 5-Apr-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
peptidase
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:peptidase domain interface [polypeptide binding site]
Evidence:
  • Structure:1T1E: The pro-domain of kumamolysin from Bacillus sp. MN-32 binds the catalytic domain, contacts at 4 A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                           # # # #     ##  #             ## #  #                        
3EE6_A        34 GWVSLGRADp---EEELSLTFA-LRQQNVERLSELVQAVSDPsspqygKYLTLENVadlvrPSPLTLHTVQKWLLAAGAq 109  human
1T1E_A        27 QAVDKGPVTg---DQRISVTVV-LRRQRGDELEAHVERQAALaph-arVHLEREAFaashgASLDDFAEIRKFAEAHGLt 101  Bacillus sp. M...
ZP_01911023  127 VYDDLGAADp---NDSFRALIG-LYLRDREELVDFTLEVSDPssdlygQYMSVDELldnhaPLEDDFELLQAWLEFEGLe 202  Plesiocystis p...
Q01UW2        42 HPQAQPQFDrglvDPAMRIPRAtLILKPAKSLAAFLAAQQIPgspeyrQFLSPEQFadrfgLTTDDLTKVVGWLESQGLk 121  Candidatus Sol...
Q82AV6        40 ATADKGATDn---GSQVSARVY-LAGKDAAGLAAYAKAVSDPnsasygKYLSAQQAqarfgATKAQVAEVTDWLKSAGLk 115  Streptomyces a...
YP_873421     63 HARDLGRAPa---TAAVQARIYlAPNGGLDALAARALAVSTPgsadygHFLSPAEYfaefgTTDATVRAVTRWLTSSGLt 139  Acidothermus c...
Q03TS3        42 HLYHVKKVAk---KKTVSLDIV-LKPRQTKTLSQLALAVNTTdsqsfkGYLTPQQFrakfgQSSATTSRLTRYFRACHLq 117  Lactobacillus ...
Q01ZH2        66 AANDIGAMDpattLPAMTLVLR-QSAAQQADLANLLAAQQDPaspeyhHWLTPEQYadrfgASADDVAKITAWLAQHNLq 144  Candidatus Sol...
Q97LD7        47 KASFLGDLDp---NTQVTIDIV-IKLQNKSELQQYINDTVTPkssnyrRYLSVAEFkksfaPKSKQINELTEYLKAFGIk 122  Clostridium ac...
Q1IVJ7        60 AARDAGAVDsnlsLDRILVLLQ-PSAKQSDALKLYLDDLQNTdsknyhQWLTPEQYaqkfgPTDADMQKVTDWLQSHGFk 138  Candidatus Kor...
Feature 1                                                                        ## ## 
3EE6_A       110 kCHSVitqdFLTCWLSIRQAELLLPgAEFHHYVGgpt-----etHVVRSp-hPYQLPQALAPHVDFVGGL 173  human
1T1E_A       102 lDRAHvaagTAVLSGPVDAVNQAFG-VELRHFDHpd-------gSYRSYv-gDVRVPASIAPLIEAVLGL 162  Bacillus sp. MN-32
ZP_01911023  203 vSYLAtnrmLIHFKGLVGQFNEAFD-TQLHVCMRknpqaggdpiPVYCTt-dSFTLPAFVADRSPGIVTA 270  Plesiocystis pacifica SIR-1
Q01UW2       122 aDRIArgrnAITFSGTAEQAARTLK-TEFHRYQVng-------kMHFAAa-aEPSIPEALGDVVAGFTGL 182  Candidatus Solibacter us...
Q82AV6       116 vTGSTq--hYVTVTGDVAAAEKAFG-TQLHNYVKg--------gKTYRApakTASAPAALDGAVLTVTGL 174  Streptomyces avermitilis
YP_873421    140 vTGVEahnrYLDITGSVAAAERAFG-VHIHAYSHd--------gQTVQApddTLTTPADLADDVLAVDGI 200  Acidothermus cellulolyti...
Q03TS3       118 aTAANng-lLIRVKGHVATINKAFA-VNLKTARYh--------gKKIQFskqAPRLPKQVAQPIRAVVGV 177  Lactobacillus brevis ATC...
Q01ZH2       145 vTAVGrgrmSVTFTGTAGDVEQAFQ-VSMHRYSVng-------rNHFANt-aEPSLPAAMEPAIRSIHGL 205  Candidatus Solibacter us...
Q97LD7       123 sEVYQdn-lIVTATGTADQINKAFN-VELKHASYk--------gKNFHAskkQPKLPKKIADNILCILGL 182  Clostridium acetobutylicum
Q1IVJ7       139 iSEVAagrqWIEVAGTAAQVRTAFN-TEIHKYHLng-------kDYFANa-sDVSLPRALSSVVRGVLSL 199  Candidatus Koribacter ve...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap