4FDJ


Conserved Protein Domain Family
GALNS
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cd16157: GALNS 
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galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)
Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Links
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Statistics
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PSSM-Id: 293776
Aligned: 7 rows
Threshold Bit Score: 877.182
Created: 20-Mar-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4FDJ; human GALNS binds N-Acetyl-D-Galactosamine and Ca++ at active site, defined by 4A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ##                                      #                            # 
4FDJ_A         4 PPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLTGRLPIRNGFYTTNAHARNAYT 83  human
KFQ33069      15 PPNILLLLMDDMGWGDLGAFGEPSKETPNLDQMASEGMLFLDFYTANPLCSPSRAALLTGRLPVRNGFYTTNGHARNAYT 94  brown roatelo
EKC35816      19 KPNFILMLMDDMGWGDLGVFGEPNKETPYLDQMAAEGMLFPDFYSANPLCSPSRAALLTGRLPIRNGFYTTNGHARNAYT 98  Pacific oyster
ELT96000      26 KPNIIVMLMDDMGWGDLGSYGHPARETPNLDRMAAEGMLFTDFYSAAGICSPSRASVMTGRLPIRNGFYSTNQFAKNSYL 105 Capitella teleta
NP_001088386  27 RPNILLLLMDDMGWGDLGVFGEPSRETPNLDKMASEGMLFPNFYTANPLCSPSRAALLTGRLPIRNGFFTTNSHARNAYT 106 African clawed ...
XP_002736267  25 KPNVILMLMDDMGWGDLGVLGNPAKETPNLDRMASEGALMTDFYAPNPLCSPSRASLLTGRLPIRNGFYTTNDHARCSYT 104 Saccoglossus ko...
CBY11571      21 RPNIIYMLMDDLGWGDLGVNGNLHRETPNIDELARSGVVFTDFYSAAPLCSPSRASLLTGRLPIRNGFYTDNAKMRNGYT 100 Oikopleura dioica

Feature 1                                      # #                      #                        
4FDJ_A        84 PQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFgpYDNKARPNIPV--------- 154 human
KFQ33069      95 PQDIVGGIPDSELLLPELLKKAGYVNKIIGKWHLGHRPQFHPLKHGFDEWFGSPNCHFgpFDNTALPNIPV--------- 165 brown roatelo
EKC35816      99 PQNIVGGIPDEEILLPELLQKAGYKSKLVGKWHLGHQAKYLPLKHGFDEWFGAPNCHFgpYDNVHTPNIPV--------- 169 Pacific oyster
ELT96000     106 PQDVMGGISDSEVLFPELLKQNGYRNKIVGKWHLGHREQFLPLQHGFDEWFGAPDCHYk-YDDKVMPNIPV--------- 175 Capitella teleta
NP_001088386 107 PQEIVGGISDSEILFPELLKKAGYINKIIGKWHLGHRPSYHPLRHGFDEWFGSPNCHFgpYDNKQIPNIPL--------- 177 African clawed ...
XP_002736267 105 PQYIVGGIPDSEIVLPELLNKAGYRSKIIGKWHLGHQTQYHPLKHGFDEYFGAPNCHVgpYDNKKQPNIPV--------- 175 Saccoglossus ko...
CBY11571     101 PQNIVSGIADDEILLSELLQKSGYRTGLVGKWHLGHREQYMPLKHGFDFWFGAPNCHFg-PFDQDYPRLPArpglgrgra 179 Oikopleura dioica

Feature 1                                                                                  #     
4FDJ_A       155 ------------------YRDWEMVGRYYEEFPINlktGEANLTQIYLQEALDFIKRQa-rHHPFFLYWAVDATHAPVYA 215 human
KFQ33069     166 ------------------YRDWEMIGRYYEDFKIDlktGEANLTQIYLQEALDFISKQqtsQQPFFLYWAIDATHAPVYA 227 brown roatelo
EKC35816     170 ------------------YRNEEMAGRYYQDFKIEk-nGESNLTQLYTKEAVEFITRMhnkSKPFFLYWAVDATHEPLYA 230 Pacific oyster
ELT96000     176 ------------------YKDSLMQGRYYDHFKIDiktGLSNLTQLYIQEALDFLEKEr--DRPFFLYWAPDATHTPLYA 235 Capitella teleta
NP_001088386 178 ------------------YRDWNMVGRYYEEFNINhktGESNLTQIYLQEALEFIYSQavaQQPFFLYWSIDATHAPVYA 239 African clawed ...
XP_002736267 176 ------------------YRDADMIGRYYEEFKIDk-sGESNLTQMFIEEAIAFIEKQhqtGEQFFLYWTPDASHSPHYA 236 Saccoglossus ko...
CBY11571     180 gyfsipafddkhtpnipvFENDKMIGRYYEEISIDrnnARSNFTNTLRVRALEFVQNSvdaQKPFFLFFTPDSSHAPVYS 259 Oikopleura dioica

Feature 1                                                      ##                         ##     
4FDJ_A       216 SKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAAlisa-----peqGGSNGPFLCGKQTTFEG 290 human
KFQ33069     228 SKHFLGTSQRGLYGDAVQEIDDSVGKILKHLQKLGISENTFVFFTSDNGAAlisa-----pkqGGSNGPFLCGKQTTFEG 302 brown roatelo
EKC35816     231 SKPFLGTSNRGLYGDVVRELDSAVGKILASLRSLKIDNNTLVFFSSDNGGAtya------kqhGGSNGPFLCGKETTFEG 304 Pacific oyster
ELT96000     236 SEKFRGKSERGLYGDAVMELDSGVGKILNKLKELGIENNTFAFFSSDNGAAtyaftevsiiisGGSNGPFLCGKQTTFEG 315 Capitella teleta
NP_001088386 240 SRPFLGTSNRGLYGDAVREIDFSIGKILNLLNLTGIAKDTFVFFTSDNGAAlisa-----pmqGGSNGPFLCGKQTTFEG 314 African clawed ...
XP_002736267 237 SKSFLGTSQRELYGDAVMELDYGVGQILGKLKELQIENNTFVFFSSDNGAAlsg------gayVGSNGPFLCGKHTTFEG 310 Saccoglossus ko...
CBY11571     260 SPAFAGKSRRGKIGDAIMELDWAIGSIMESVKSLGIMEDTIIVFSSDNGAAcvgp-----veqCGSNGPLLCCKQTTFDG 334 Oikopleura dioica

Feature 1                                                                                        
4FDJ_A       291 GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRlm-------drPIFYYRGDT 363 human
KFQ33069     303 GMREPAIAWWPGHIPAGGVSHQLGNVMDLFSTSLSLAGLQPPGDRQIDGIDLLPAVLQGKli-------drPIFYYRGNE 375 brown roatelo
EKC35816     305 GMREPTIAWWPGHIKKGQVSHQVGSLMDLYTTFVDFAEVAMPTDRVIDGISLRASLLNNTnv-------qrPLFYYRGNQ 377 Pacific oyster
ELT96000     316 GMREPALAWWPTKIRPGSISKQVGNLMDIFSTVLKITSIPHPKGLYLDGVDLSSVLFNSKef-------drPVFYYRNDA 388 Capitella teleta
NP_001088386 315 GMRVPGIAWWPGHVAPGQVSYQLGSIMDLFTTSLSLAGLEIPRDRAIDGIDLSPVILESKet-------erPIFYYRGNE 387 African clawed ...
XP_002736267 311 GMREPSIAWWPGRIKPGKVSHQLGTIMDLFTTALDIAGVTLPTDRIIDGTSLLPALVNGKids------nkTIFFYRGDE 384 Saccoglossus ko...
CBY11571     335 GMRVPGILSWPGTVEPNQINNDVTGLMDLFTTGLALAEIPIPSDRFIDGKNLINLVKTKHtknsrksspsgTHFFYRGDT 414 Oikopleura dioica

Feature 1                                                                                        
4FDJ_A       364 LMAATLGqHKAHFWTWTNSWENfrqGIDFCPGQNVSGVTTHNLEDHTklPLIFHLGRDPGERFPLSFASAEYqealsrit 443 human
KFQ33069     376 MMAVRVGlYKAHYWTWSNSWEEyskGIDFCPGQNVSGVTTHTQEEHTtlPLLFHLGRDPGEKYPLSFASDEYqrameris 455 brown roatelo
EKC35816     378 IMAVRKGsYKAHLWTWTNSIEEfkkGTNFCPGQDIAGVTTHNQTDHTskPLLFHIGRDPGEKYPISPNTPEYkkempllm 457 Pacific oyster
ELT96000     389 LFKVRYGqYKAHFYTWDTPEDAqrlGYHYCPGQFVPKVTTALLTNYTdqPLLFHLGKDPGEKFIIDASSVEYsiamkqis 468 Capitella teleta
NP_001088386 388 LMAVRLGqHKAHYWTWSNSWEElsqGINFCPGQNITGVTTHMQVEHSinPLLFHLGRDPGEKYSISVLSTEYedavnris 467 African clawed ...
XP_002736267 385 LMAARHGlYKAHFWTWTNSEEEfkrGTNFCPGQEIDGVTTHNQTDYTaePLLFHIGRDPGEKYKINSKKAEYkaamqpis 464 Saccoglossus ko...
CBY11571     415 LGAVRRGdYKMHVYTWSGTKASs--IWHFCRGQNVPNVTTEVQTDHSkaPVIYNIGQDPSEKLPLPTKSAEYkqqrpile 492 Oikopleura dioica

Feature 1                                 
4FDJ_A       444 svVQQHQEALVPAQPQLNVCNWAVM 468 human
KFQ33069     456 avVQQHKATMVPGEPQLNVCDRAVM 480 brown roatelo
EKC35816     458 keIQNHMVLLVPATPQLNMCDEGVM 482 Pacific oyster
ELT96000     469 svVKEHLRTLVRGEPQFDWCDLAVQ 493 Capitella teleta
NP_001088386 468 yvVQQHRDSMVPGEPQLNVCDLAVM 492 African clawed frog
XP_002736267 465 qaVADHRKNLVPGEPQLNMCDTAVQ 489 Saccoglossus kowalevskii
CBY11571     493 kiIAEHQKTLVLGTPQLNYCDDSVM 517 Oikopleura dioica

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