Conserved Protein Domain Family
CobQ

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COG1492: CobQ 
Cobyric acid synthase [Coenzyme transport and metabolism]
Cobyric acid synthase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Statistics
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PSSM-Id: 441101
Aligned: 504 rows
Threshold Bit Score: 514.222
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_004214666   2 TRTLLVAGTASHVGKSTVVAGLCRLLADHGVSVAPFKAQNMSNNARVVVraA----Gvdgkegevkgqesrptgdgatmk 77 
NP_875650      8 HNALMVLGTSSGAGKSIITTAICRSLLRKGEVPIPFKGQNMSNNAWVDI--N----N----------------------- 58 
WP_014407147   1 MKAIMVVGTTSHAGKSFLTTGLCRLLRRRGDRVTPFKGQNMALNAFVTI--D----G----------------------- 51 
NP_682506      3 AKSLMVVGTTSHAGKSLLAAVICRWLAQQGYRVTPFKGQNMALNAYVTR--E----G----------------------- 53 
WP_011130554   2 STPLMVLGTSSGAGKSLMSAALCRLLLRQGETPIPFKGQNMSNNAWVDE--S----G----------------------- 52 
WP_011377496   1 MPALMVVGCTSHAGKSLITAAICRLLRRQGWRVAPFKGQNMALNAYVTA--S----G----------------------- 51 
WP_012164556   1 MGAIMVVGTTSHAGKSIMAAVICRMLKRKGYQVTPFKGQNMALNAYVTN--A----G----------------------- 51 
WP_041487753   1 MKTIMVVGTTSHAGKSFLTTALCRILVRQGWKVSPFKGQNMALNAYVTQ--D----G----------------------- 51 
WP_041698307   1 MRSIMVVGTASNAGKSLLCAAFCRLLKQKGYNVTPFKGQNMALNSYVVE--NnlngS----------------------- 55 
WP_015229971   2 KQALMVVGATSHAGKSLLCAAICRMLYRRGWRVTPFKGQNMALNAYVTD--N----G----------------------- 52 
WP_004214666  78 aadqwGEIGVSQFTQARAARLTPTTDVNPILLKPRGDGESQLIVQGEAREHVPAGSYYEeYWDDARDAAAQSYQRLAADH 157
NP_875650     59 -----GEMAYSQAVQAWAAGIEPICAMNPVLLKPQGDCTSEVIHLGKSVGVVQAANYYEdWFSSGWEAIQKGLNDIATSY 133
WP_014407147  52 -----GEMGHAQAVQAWAAGTVPRVAMNPILLKPQGDMTSQVIMLGQAVGTTRAQEYYQnYFDRGWQAIANSLETLAQDF 126
NP_682506     54 -----GEIGYAQAMQAWAAGIEPEVAMNPILLKPQGNMTSQVILRGQVVGVTRAADYYRdYFERGWQAITEALADLQQRF 128
WP_011130554  53 -----GEMAYSQALQAWAAGLKPQCAMNPVLLKPQGDSTSEVIHLGQSVGTARAETYYEqWFRPGWSVIREALKDLQCSY 127
WP_011377496  52 -----GEIGYAQAFQAWAAGVEPTIEMNPILLKPQGDMTSQVVLKGRAVGRTLAERYYQdYFEVGWEAICEALEQLQADY 126
WP_012164556  52 -----DEIGHAQAVQAWAAGLEPRVEMNPILLKPQGDMTSQVILNGKAVGRTQAADYYRdYFDRGWQAITTALVTLQQEF 126
WP_041487753  52 -----KEIGYAQAVQAWAAKIEPRVENNPILLKPQGNMTSQVILNGEVVGVTSAEDYYQnYFKVGWKAIKTSLRSLQSEF 126
WP_041698307  56 -----GEIGYAQAVQAWAAQVKPTVAMNPILLKPQGDMTSQVIHLGKPVGITKAANYYRnYFDSGWQCIQASLAKLAADF 130
WP_015229971  53 -----DEIGYAQAVQAWAAGIKPTVEMNPILLKPQGDMTSQVILNGKAVGRTQAQQYYEqYFDRGWQAITTALDTLSQTY 127
WP_004214666 158 --DVIVAEGAGSIAEINLHDQDLANVETARFADAEILLLVDIERGGAFASLYGTIELLPDDI--RERVVGAVITKFRGDP 233
NP_875650    134 kkHRLILEGAGSPVEINLQHRDLTNLKLAKHLNAKCVLVADIERGGVFAQIIGTLALLKPDE--KALIQGIIINRFRGDI 211
WP_014407147 127 --DVVVCEGAGSPAEINLKHRDLTNMRVATHLQAATILIADIDRGGVFAHVVGTLQLLEPEE--RKLIKGIVINKFRGQR 202
NP_682506    129 --DWIVCEGAGSPAEINLKHRDLTNMRVATYLGAPTILVADIDRGGVFAHIVGTLMLLEPAE--RALIQGIVINKFRGQR 204
WP_011130554 128 thGRLVLEGAGSPVEVNLQRRDLTNLRLAQFLRARCLLVADIERGGVFAQIMGTLSLLKPVE--KQLIRGLLINRFRGRR 205
WP_011377496 127 --DWIVCEGAGSPAEINLKHRDLTNLRVAKHLQAPTLLLVDIDRGGSFAHLIGTLELLDPDE--RSLIRGFVFNKFRGRR 202
WP_012164556 127 --DWIVCEGAGSPAEINLKHRDLTNMRVAKHLNAPTLLVADIDRGGVFAHIVGTLELLDPDE--RALIKGFVINKFRGQR 202
WP_041487753 127 --DFCVCEGAGSPAEINLKYRDLTNMRIAKYLHASTVLIVDIDRGGAFAHVVGTLQLLDKTE--RSLIKGIIINKFRGQR 202
WP_041698307 131 --EVVVCEGAGSPAEVNLRHRDLTNMRVALHLKAQTILVVNIDLGGAFAHVVGTLQLLPPEE--RALIKGIIINKFRGQR 206
WP_015229971 128 --DYIVCEGAGSPAEINLMHRDLTNMRVAQYLNASTLLVVDIERGGSFAHIIGTLEILKHANagHDLIKGIIINKFRGQE 205
WP_004214666 234 SLLESGIAEIESRTGVSILGVLPYD-DPGLPEEDSVGLPSadsrgvrggddGVPDEQRLRIAVPRLPRISNATDLEALAA 312
NP_875650    212 SLFEKGRQWIEEESKIPVLGIMPWLnEI-FPPEDSLDLLEr---------kHKKTKAEIQIAVIKLPSLSNFADLDPLEA 281
WP_014407147 203 SLLDSGITWLEEYTGIPVLGVIPYG-QNLFSAEDSLDILEr---------sGRPSKEDIRIVVLRLPRIANFTDFEPLEA 272
NP_682506    205 SLLDSGLQWLEETTGVPVLGVIPWL-ERHYAAEDSLDLWDp---------rPQRQGADLKITVIRLPRIANFTDIDPLLA 274
WP_011130554 206 ELFDEGRDWLEAETGIPVIGVMPWLeEL-FPPEDSLDLLEr---------rGKKNDAEIEIAVLKLPSLSNFSDLDPLEA 275
WP_011377496 203 ELLQSGLDWLEERTGIPVLGVIPWI-DRAFPSEDSLDLMEr---------rRRKTQAEVTIAVIRLPRIANFTDFDPLES 272
WP_012164556 203 SLLESGITWLEERTGIPVVGVIPWL-EHSLPAEDSLDLFEr---------rRTKPNAEVTIAVIRLPRISNFTDFDPLEA 272
WP_041487753 203 RLLNSGIKWLENYTKIPVLGVIPWK-DIMFPSEDSLDLLNr---------vPENSSKDISVTILKLPHIANFTDFEPLEY 272
WP_041698307 207 SLLDSGVEWLEKYTGISVLGVIPYL-DIAFPAEDSASLFEr---------rSRLNPAELQIVVIRLPRISNFTDFDPLLA 276
WP_015229971 206 SILQPGIEWVENYTGIPVIGVIPYL-QQVFPAEDSLDLLEr---------rGRKPNTDLTIAIIHLPKISNFTDFDPLEA 275
WP_004214666 313 EPGVTVVYLPVDDsgtnanaeavssgsfasaeieiDLdATADAVVIPGTKNTVDDCRALHAAGFADALRSFD---GPIVG 389
NP_875650    282 EPTIQLNWIQPGD----------------------YL-GNPNAVIIPGSKQTLKDLQSLQSSGLGNQIKEFAssgGTVFG 338
WP_014407147 273 ESGVYVDYLPLEK----------------------QL-GNPDAVIIPGSKTTIADLQALQNSGMAQQIMDYAqagGTVMG 329
NP_682506    275 EPSVAVEFLPPHR----------------------PL-GRPDAVILPGTKTTIADLQVLRETGMAEQLKTYAaqgGTILG 331
WP_011130554 276 EPTVQLRWVEPGT----------------------FL-GMPDAVIIPGSKQTLRDLNSLNRSGLGSQLQTYAqsgGHVFG 332
WP_011377496 273 EPSVQVRYVGLQD----------------------EL-GYPDAVILPGSKTTISDLLDLQRSGLAQAIRDYAaagGTVLG 329
WP_012164556 273 EPSVRLQFVGPNQ----------------------PL-GQPDAVIVPGSKTTISDLQQLQVSSMADQLRAYSqagGMVLG 329
WP_041487753 273 ERSVEVKYLDLNQ----------------------NI-GNPDVLIIPGSKTTISDLMALHESRMAIQIKEYLkrgGVILG 329
WP_041698307 277 EPSIDLKYILPGQ----------------------SL-GQPDAVILPGSKTTIADLEVLRSTGMIDQLRQFVnngGVIMG 333
WP_015229971 276 ETSVNVRYVRPED----------------------DL-GNPDVVILPGSKTTNTDLNHLHKTGMVMALKQYIeqgGTIFG 332
WP_004214666 390 ICGGYQLLGERLTNA-ALESt---dTSqcDTVPGLGLLPVETRFDETKHLERTTVPVDgaaspllagAAG--TASGYEIH 463
NP_875650    339 ICGGLQILGEKLEDPlGIEQsfletSI--SELEGLSLIPIKTIFHSKKSLTKKDVISKw--------pDEs-RIMGFELH 407
WP_014407147 330 ICGGYQMLGQTIADPeNIEG-----NV--SNCQGLGLLPLTTVINQEKITRQCQTITHa-------pPSGl-TVTGYEIH 394
NP_682506    332 ICGGWQMLGTAISDPlGLEG-----CP--GTYEGLGLMPLHTQLGPTKCTQQQQTQSLy-------fNCPe-PILGYEIH 396
WP_011130554 333 ICGGMQMLGRTLADPlGLEGvtttdPS--SSMAGLNLLPLDTVFKRNKALSQCQRITQw--------pDNa-KVKGFELH 401
WP_011377496 330 ICGGFQMMGQHILDLeGTEG-----IE--GQFEGLHLFPTQTWFTAEKTLRQRQTTARs-------pQAGl-PITGYEIH 394
WP_012164556 330 ICGGLQMLGQTISDPmGTEG-----PP--GEFAGLGLLPLQTTMSGDKITRQRQAQITlpsdcsalgEDAr-TIQGYEIH 401
WP_041487753 330 ICGGFQMLGEAIFDPnKIEG-----EY--KICSGLELLPMETEITSKKIVCKRETFSNy-------pYAGf-SAMGYEIH 394
WP_041698307 334 ICGGLQMLGKSIVDPeCLEG-----DL--NSAIGLNLLPIETVITPIKTAQQRSTTTNl-------aPPNl-PITGYEIH 398
WP_015229971 333 ICGGFQMLGETLSDPdGLEG-----EA--GDYSGVGLFPLKTTITSEKLTRQRDVNPIf-------pEDNqvSVTGYEIH 398
WP_004214666 464 AGRTRILDhes--vasPLg------ESSA--AH---G--LVLGTYLHGLFDNEGVRTAFLEAVARERGLEwppASptGaq 528
NP_875650    408 HGESTPTNsq----kvKVkdlcnetSLGWvnEEc--NpiKAAGTYLHGIFDNGTWRRLWINQIRKKANLYelpLLe-E-- 478
WP_014407147 395 QGLSRRSEhs-----qDFlpmfdqeELGMvnAQ---Q--NLWGCYLHGLFDNGAWRRCWLNNLRQRRGLDplpTSi-G-- 461
NP_682506    397 QGQSEYTGdr-----qGWhplfaapELGLvnRA---G--TLWGTYLHGLLENGPWRRHWLNGLRSRRQLPplpTAi-P-- 463
WP_011130554 402 HGNSQLIQgs----heSVlpmaddpSMGWvsKNescG--QVAGTYLHGIFENGRWRRLWLNLIRKQKGLAdlpTDi-S-- 472
WP_011377496 395 QGQTRLDSds-----eEFlpifddpKLGLcdRN---G--NLWGTYLHGIFDNGAWRRAWLNSLRHRRGLKalpTSi-G-- 461
WP_012164556 402 QGQTQVLQp------eAVqawfddpALGVvsCN---H--RILGTYLHGIFNNGPWRRVWLNQLRAQKNLLplpLAi-P-- 467
WP_041487753 395 QGVTSFSKdlettqdsQLyylfddsTLGVvnKN---L--TIWGCYLHGIFENGTWRRMWLNNLRRKKRLPplsTEv-V-- 466
WP_041698307 399 QGKSNFSPle----neQVmpwfadpNLGFvtSD---R--QVWATYLHGIFDNGKWRRSWLNLLREKKNLPpltIEv-P-- 466
WP_015229971 399 QGRTHFTGds-----kQLislfedtELGYvnAN---A--SVWGCYLHGLFENGTWRRQWLNLLREKKGLSplpTNv-P-- 465
WP_004214666 529 tarTGGQRGQSPFDRAASLLREnVDAEVVERL 560
NP_875650    479 ---NHDAKREKVINRLTDVFEEnINLEYLLKT 507
WP_014407147 462 ---NYQEQREGMLDSLADFVEThVNLEPILQS 490
NP_682506    464 ---HYGEQRTVALDELTKTVMAhLNLRGICKL 492
WP_011130554 473 ---NHEQQREQLLNRLADVFEEhVNINPLLGT 501
WP_011377496 462 ---HYQAQRDDLIDALADAVEPyLNLSPLLTA 490
WP_012164556 468 ---NYKVYRDHMLDQVTDAIAPyLNLQPFLGK 496
WP_041487753 467 ---NHLEQREKELDNIANLVEDfVDLTPLLK- 494
WP_041698307 467 ---DYNEQRDQLLDDLAKAIAEhVDLGRLGF- 494
WP_015229971 466 ---HHRQQREEVLDIATDIIEKhLDLNFFQ-- 492
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