4EJS,4A8J


Conserved Protein Domain Family
Elp6
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cd19495: Elp6 
Elongator subcomplex subunit Elp6
Elongator is a highly conserved multiprotein complex involved in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification. It is composed of two subcomplexes, Elp1-3 and Elp4-6. Elp4-6 forms a heterohexameric RecA-like ring structure, although they lack the key sequence signatures of ATPases.
Links
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Statistics
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PSSM-Id: 410903
Aligned: 48 rows
Threshold Bit Score: 111.232
Created: 16-Jul-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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hexamer
Conserved site includes 54 residues -Click on image for an interactive view with Cn3D
Feature 1:hexamer interface [polypeptide binding site]
Evidence:
  • Structure:4A8J; Saccharomyces cerevisiae Elongator subcomplex Elp456 hexamer interface, contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # # ##   # ##                                     ###  ##                    
4EJS_C        34 NLFFITHQSc-tQPLWMINALVETHvlgspsslnessssmlpsstrsHAVLASFIHeqNYFTNSLNKLkip-------sn 105 Saccharomyces c...
4A8J_C        37 NLFFITHQSc-tQPLWXINALVETHvlgspsslnessssxlpsstrsHAVLASFIHeqNYFTNSLNKLkip-------sn 108 Saccharomyces c...
NP_001026873  20 KLTLLCDAKt--DGSFLVHHFLSFYlkanc-------------kvcfVALIQSFSHy-SIVGQKLGVSltma----rerg 79  human
NP_567351     27 KVILIEDCVe-tSGSFVLHQLMKRVlssnss-----------dalifLAFARPFSHy-DRILRKLGCNlath----ksnn 89  thale cress
EFA80411      27 KLILIADTLg-aEGSFVIHDVLQSVskrdd------------mgvclVGLNQSLFHy-HSVGRKLGYNltte----nqkg 88  Polysphondylium...
XP_002683282  26 QLIYVRDGTtscDGGFLVHHFLNSFinhgk-------------kvtlCSFNQSFFHy-NTVELKLNINleke----sqeg 87  Naegleria grube...
EFX89633      19 KSLIIVQHN---DGSPFLHSLLTQSarq-----------------grKICLVSFNHs-VGYYHNVGTRlgwnlnnllskn 77  common water flea
XP_002737485  20 QFILLSDNLt--DGTFILHHYISLFlkggh-------------kvclVSLSQSFSHy-NAVGQKLGVNlsla----kekn 79  Saccoglossus ko...
Q0IHA2        20 KFTLLCDSNt--DGSFLVHHFLSYYlragc-------------rvcfVALVQSFSHy-NIVAQKLGVNlssa----kdeg 79  African clawed ...
NP_001096612  20 DFILLSDRQa--DASFLIHHYLSFYlragc-------------kvcfLGLVQSFSHy-SAVGQRLGVSltqa----rekg 79  zebrafish

Feature 1              ####                                                                      
4EJS_C       106 NYNVLDFLSDFivnnihn-------------------------------------------kprdkiLSDVLAKFSAAiq 142 Saccharomyces c...
4A8J_C       109 NYNVLDFLSDFivnnihn-------------------------------------------kprdkiLSDVLAKFSAAiq 145 Saccharomyces c...
NP_001026873  80 QLVFLEGLKSAvdvvfqaqkeph--------------------------------plqflreanagnLKPLFEFVREAlk 127 human
NP_567351     90 RLVFFDMLMVKcsdgdqm-------------------------------------------ednvsaVAKLFREIQETvr 126 thale cress
EFA80411      89 HFSFINGLGSSyswieqlaaaareeagieeeppldpiskgfqpfpiqplpansssnnntnksdksqfFKQLFELLVKDhq 168 Polysphondylium...
XP_002683282  88 KFTFIDAQQSFvdssvetgddlllfsspllitk------------ttpatrptcivnlkhnnsldeyLANLFEILTCEkq 155 Naegleria grube...
EFX89633      78 QAVFIGGLQTLkdssrlqncsnp---------------------------------fdflfnpstcpIQTLLLSIQEVis 124 common water flea
XP_002737485  80 QLVFIDGLQCSlqlfassddsmqn-------------------------------nplvcirdskttLQPLYEMVRNAvc 128 Saccoglossus ko...
Q0IHA2        80 QLVFLEGLKSYtdllfgdkseaee-------------------------------tnplcflragsdLRPLYSFVSAAla 128 African clawed ...
NP_001096612  80 QLVFLEGLKDSigailkedtsegt-------------------------------qalsylrspragLEGLFRFVESSlc 128 zebrafish

Feature 1                         #  # ### #       ###  ## ##                #  #               #
4EJS_C       143 nn------ptdTIVIIEQPELLLSLVSgltcselNNKFITPLLRqc-------kVLIIVSNSDIfnideydasvhssnLQ 209 Saccharomyces c...
4A8J_C       146 nn------ptdTIVIIEQPELLLSLVSgltcselNNKFITPLLRqc-------kVLIIVSNSDIfnideydasvhssnLQ 212 Saccharomyces c...
NP_001026873 128 pvdsgearwtyPVLLVDDLSVLLSLGMga---vaVLDFIHYCRAtvcw---elkGNMVVLVHDSgdae-------deeND 194 human
NP_567351    127 klqs--vtsgnITVMVDDMSLLEIATTgsn-sdhVLDFLHYCHTlsse---sncSLVILNHEDIyas---------meRP 191 thale cress
EFA80411     169 qrmk-klqnshTLFVIDNLNLLSSFGAsd---idVLHFIQFCQSyvke--qancSLLLLYHSDCt------------dDE 230 Polysphondylium...
XP_002683282 156 ---------qsSCIILDHVNPLLQYYFdqdvnrkLLKFITKLKKfys----nniSIIVLMHNHPad----------deNT 212 Naegleria grube...
EFX89633     125 nw-----veqpFSLVIDELDCLLSLGVqp---nrIVKFFQHCHSlvqt--nskgSLIISMGVTPsd----------keVI 184 common water flea
XP_002737485 129 nsdg--kvetpVLLLIDDLSILLSLGIsl---isVYDFMHYCVVmlcgsiqsvgCLVTLIHSDKde-----------eNS 192 Saccoglossus ko...
Q0IHA2       129 psag--qpwkcPVLILDDLSVLLSLGVts---lqVLDFMHYCRAtvct--qykgNVLCLVHGAEesg--------deeNE 193 African clawed ...
NP_001096612 129 qsg----ddgpPVLIIDDLSVLLSLGVsa---gaILDFTLYCRAtvcs--elqgNMVILVRCEEedadd-----deegLN 194 zebrafish

Feature 1        # ### ###   # # ## #       #     ###              ###    ## #       
4EJS_C       210 NFYKSSFIKSMINLNLNPLKTGFAKDVTGSLHVCRGgapiatsntslhvVENEYLYLNEkESTKLFYR 277 Saccharomyces cerevisiae S288c
4A8J_C       213 NFYKSSFIKSXINLNLNPLKTGFAKDVTGSLHVCRGgapiatsntslhvVENEYLYLNEkESTKLFYR 280 Saccharomyces cerevisiae S288c
NP_001026873 195 ILLNGLSHQSHLILRAEGLATGFCRDVHGQLRILWRrpsqp---avhrdQSFTYQYKIQdKSVSFFAK 259 human
NP_567351    192 AFLLQMVCLADVVIKAEPLASGLANDVHGQLTVLNKgisnsg-rgssrnKLQNFQFRIKeNGIDYFYP 258 thale cress
EFA80411     231 TFLRLLQYESDLTLMVDGLKTGYSRDIDGQIDFLQKredn------tlqRLSAIHYQVLdNSIRYFSM 292 Polysphondylium pallidum PN500
XP_002683282 213 QLTNMFEHMSDIVYRVGPLPTGYSKDVHGKVECISYindgt----lassKKASLHFKTFeSKVSLFAP 276 Naegleria gruberi strain NEG-M
EFX89633     185 QCSQLLAHWCDLVITEKGLQTGKSKDLTGSLTVNWNih---------pfTEQLFHFKCYdRGIKMFAP 243 common water flea
XP_002737485 193 LLLRHLLYSSHLHLHMNGLSSGFCKDVHGELSIHWNdpwqi---lpsrqRRKIYQYKIQdKHVSFFAP 257 Saccoglossus kowalevskii
Q0IHA2       194 LVLRSLSHQSHLILQAEGLSTGFCKDVHGQLKIIRGavssg---krgknQPEIYQYKIQdKHVAFFAR 258 African clawed frog
NP_001096612 195 LLQRGLVHQCHLALHVEGLPTGYCRDIHGQMEVWWRqgen-----daynQRKIFQFKVHdKGASFFTR 257 zebrafish

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