2GIA


Conserved Protein Domain Family
MRP

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pfam09387: MRP 
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Mitochondrial RNA binding protein MRP
MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.
Statistics
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PSSM-Id: 430576
Aligned: 9 rows
Threshold Bit Score: 182.07
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GIA_A         4 SSSDADGKEVGSsgegnratggkwrrpSLAQQRARR----AQLPPAFDVVHWNDEDISRG-------------------- 59 
XP_024840927  62 ARAAGDGPAGDG---------------AARLTKQRS----SAHRSAFSIHHSSRKVLSSAvshggsgtvqasaclrppvl 122
1_pfamImport   1 FTA-GDGPDTEGhayarnt--asvkdrASRTVKQHR----STSKPAFNINHMSRKATSSAvsqsschslqgnmalrppvl 73 
XP_005621272  62 ACATEDGQARDThscasst--aslkdrAARTVKQRR----SASKPAFSINHTSRKVVSCGvgqsgtstlssaaclrppvl 135
XP_003721918  18 SVRFQSSSALPAmnqnr-------------rsqnRRnfisTNSLPKFEI-HDVRDDPEHG-------------------- 63 
Q4QHR3        47 SSDAVaptsnnaq-------rnnsrnsSMQSQRGRR----DAMPPAFDIVHWNDEDIAAG-------------------- 95  Leishmania major
XP_829385     33 SSSDADGKEVGSsgegnratggkwrrpSLAQQRARR----AQLPPAFDVVHWNDEDISRG-------------------- 88 
Q4DWJ0        36 SEAPADSNAKHDtntsgsa--srwrrlSASQLRARR----PQLPPAFDVVHWNDDDMSSG-------------------- 89  Trypanosoma cruzi
XP_023510831  62 ACATEEGQAGDApscpssa--aslrdrAARTAKQRR----SASKLAFSVNHASGKAVSLAvgrrgsgglqgaaclqppvl 135
2GIA_A        60 --HLLR-VLHRDTFVVLDyhrqa---rmltEEG--------------NKAERVvs--vMLPAVYTARFLAVLEGR---SE 114
XP_024840927 123 deSLIReQTKVDHFWGLD------------DDGdlkggn---kaaiqGNGEVAae--aAGSNGYMCSECSLLAERkgaLT 185
1_pfamImport  74 deSLIReQTKVDHFWGLD------------DDSdlkeplggskaalqGNGDLAtvadtATVNGYTCSNCSLLSERkdvLT 141
XP_005621272 136 deSLIReQTKVDHFWGLD------------DDGdlkggn---kaatqGNGDLAae--aARSNGYTCSDCLLLSERkdtLT 198
XP_003721918  64 --SMTR--VSVDGKQLLvsq--------fpQLGprkadp--ndttpqFDRDRRis--mRFRHIDLAGFVSVVENR---IS 124
Q4QHR3        96 --HLLR-VVHRDGFIVLDyhrqrcataelrEDGsra--------anpNRAERVvt--vTLPPVYVARFLGVLEGR---MS 159 Leishmania major
XP_829385     89 --HLLR-VLHRDTFVVLDyhrqa---rmltEEG--------------NKAERVvs--vMLPAVYTARFLAVLEGR---SE 143
Q4DWJ0        90 --HLLR-VLHRDSFVVLDyhrqv---kklgEEG--------------NKAERVvs--vMLPAVYTARFLGVLEGR---LD 144 Trypanosoma cruzi
XP_023510831 136 deSLIReQTKVDHFWGLD------------DDGdlkggs---eaavqGNGDLA-----ARSNGFTCRDCSLLSGRedaLT 195
2GIA_A       115 KVEVHSRYTNATFTPNPAAP----------------------------------------YTFTLKCTSTRPAQQKQQV- 153
XP_024840927 186 ACSAAHGPVSRIYSRDRHQKrraagcgdgiwslavrtsascasflvqlfqvvlmklnyasENYKLKSCESKSYESESHEs 265
1_pfamImport 142 AHPTARGPTSRVYSRDRSQKr----------------------------------------------------------- 162
XP_005621272 199 AHSATHGPSPRLYSRDQGQKrnd-----------------------------------skGKELLEMHRAIRQQSSSPKr 243
XP_003721918 125 SHHVKNNAFDMAFEKTT-------------------------------------------NGYVLK--------GQVHRs 153
Q4QHR3       160 KLEVQSRFTNASFSPNAAKGk---------------------------------------HHYTLRCTSMKPTTGQIQTv 200 Leishmania major
XP_829385    144 KVEVHSRYTNATFTPNPAAP----------------------------------------YTFTLKCTSTRPAQQKQQVa 183
Q4DWJ0       145 KVEVQSRFTNAVFAPDPAVP----------------------------------------HTFILNCTSTRPPQQQQQQn 184 Trypanosoma cruzi
XP_023510831 196 TLPVAHGTSSRVYSRDRTQKrgasfcvdriwwlakytsssfssflvqlfqvvlmklnyesENYKLKSYESKDRESESYKs 275
2GIA_A       154 -A------------------------------------------------------------------------------ 154
XP_024840927 266 kAhsshcgrmdasmrlaedghlrangaslcdeckgrkhlethvstrsrpgglagtlglalsragqlsgqalhragaagwr 345
1_pfamImport     --------------------------------------------------------------------------------    
XP_005621272 244 vAgaiwhifsytghllvqmlqrig---------------------------------------------------asgws 272
XP_003721918 154 nS------------------------------------------------------------------------------ 155
Q4QHR3       201 dG------------------------------------------------------------------------------ 202 Leishmania major
XP_829385        --------------------------------------------------------------------------------    
Q4DWJ0       185 gG------------------------------------------------------------------------------ 186 Trypanosoma cruzi
XP_023510831 276 kSrestahssycgrvnvtelfredgrlgvhgeslc-----------------------------rllmqtlrrigaagwf 326
2GIA_A       155 ----------------GEEGDETFEWT----VEFDVAESLMLQRFLTQALHYNTG 189
XP_024840927 346 vsrtllsvlclataapGKAASEVFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 400
1_pfamImport 163 ----------------RKAASGVFWWLgfgwYQFVTLMSWLNVFLLTRCLRNICK 201
XP_005621272 273 vsktllcvlwlamvapGKAASGIFWWLgigwYQFVTLISWLNVFLLTRCLRNICK 327
XP_003721918 156 --------------------QANEEWA----VRFENQFAVTMEHFLESALTESFG 186
Q4QHR3       203 ----------------ADVHEETVEWT----VEFDAAESLMLHRFLTQALHYNTG 237 Leishmania major
XP_829385    184 ----------------gEEGDETFEWT----VEFDVAESLMLQRFLTQALHYNTG 218
Q4DWJ0       187 -----------------NGEEEKFDWT----VKFDVAESLMLHRFLTQALHYNTG 220 Trypanosoma cruzi
XP_023510831 327 vlkavlsvvwlavvapGKAASGVLWWLgigwYQLVTLISWLNVFLLTRCLRNICK 381
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