2P22


Conserved Protein Domain Family
Mod_r
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pfam07200: Mod_r 
Modifier of rudimentary (Mod(r)) protein
This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.
Links
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Statistics
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PSSM-Id: 462117
Aligned: 146 rows
Threshold Bit Score: 54.1622
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2P22_C        36 NLLSSKEIIDLIQTHrHQLELYVTKF-NP--LTD-FAGKIHAFRDQFKQLEENFE-------------DLHEQKDKVQAL 98 
ESO04576     186 DKLSLEEIIDILSDD-EKLSRLT-TAcHRkqIDTyKHRLESMEQQIEHFAESNMKlk----------kEMELKKSSFIET 253
XP_013934365  44 NELSTAKLQELARSP-DLLQSYLYKT-SNf-dQIgTEIVESLEKQIEYTTKLLKNvk----------eDIVPQTDQINKQ 110
CAY68792      36 SSVPLSKLKELLDNQ-KLLKSYLL------------DSLQEFNQEIIHTLDENIRslqn------llqQYEDNSKDIDQL 96 
EEQ40127      21 KNLPAQFLADFSRSY-ELVQGFV---------EElPKYRETQ-AQIVDVANQQIElvnei---vqileEYEAKSAHISRQ 86 
CCE40239      32 ESLPTKTFEEFVNNE-ELIQGYI---------HQlEAYKSKL-KELQERAS-QASsllqseindtlipQYQDVSNKINQR 99 
XP_002548307  35 ETLPTSYLQDFSDNK-QLLQGYI---------RQlEAYSTKQ-QEVVRTLQ-QADdilenvvysqlikDYEKVIDKINQQ 102
EMG46218      35 EALPTANFQQFTENK-ELLQSYI---------KQlDTYQSKQ-QEIVNQLN-QLDdflenvvckklmnEYEELIEKINQQ 102
Q6BSN3        22 DSLPVSIIEQFIQLH-SLVRGYI---------KQlPAYQKWN-ETIIETLNWQITnlnei---ssilkTYNGTGTLIKEK 87  Debaryomyces ha...
EGV65816      41 SVLPAGIIDKLTQQH-SIFLGFI---------KSqPQLQEYN-SDTMAFLDSQIHtinqv---ielveEYTQTSERINEL 106

2P22_C        99 LE-N---ARILESKYVASWQDY--HsEFS-------------KKYGDIALKKKLEQNTKKLDEESSQLETTTrsI-D--- 155
ESO04576     254 HKaWlemKDHLSCAWDGYEQQLtsS-QLFssdgnsrqlgngcQQLSLLPLLDNVKVVAMEAEEEADAVAEEF--V----- 325
XP_013934365 111 LE-Q---FHEKLKKFDQLQVRM--Y-DLL-------------NKYSRESIIRAVERSVNDKDRDTKSLVDQ---IrSspa 167
CAY68792      97 NK-SldeLNVLFRRWKQTEIEM--Y-TIL-------------QRYQPNSLSKKLFELLEQSHLESQQLVSKL--EgS--- 154
EEQ40127      87 LK-T---MEELYREFLNLETYQ--Y-QSLs------------SNFNQNFLRTKFGRLAEASDKESVS----L--VrNkks 141
CCE40239     100 IK-T---LTQLHNEFLNLETIQ--Y-QTMs------------STFNEELLKHKFRKLIERNDEESRD----L--VkNins 154
XP_002548307 103 IK-S---INIIYQEFINLETYQ--Y-QLLs------------SNFNQDNLKAKFKKLIEENNQESLD----I--VkNfnd 157
EMG46218     103 IK-S---INIIYQEFINLETYQ--Y-QLLs------------SNYNQDNLKLKFKKLIEENNQESLN----I--VkKfhe 157
Q6BSN3        88 MA-K---LNSLYSEFINLETYQ--Y-QLLs------------SNFNQEFLKNKFHKVIVENDQESKK----L--VkEfkg 142 Debaryomyces ha...
EGV65816     107 IK-T---IKNVYTEFTDLEMIQ--Y-KLLa------------ENFNQDSLKAKFRKVIAAEDQESKA----F--IkEytn 161

2P22_C       156 -------SA-DDLDQFIKNYLDIRTQYHLRREKL 181
ESO04576     326 -------NDkMTVDAFVNTFLEKRKLFHTRKIKE 352
XP_013934365 168 -----eiDE-AQLASFMSTYTTERQEYYLKLEKL 195
CAY68792     155 -------VQeSDLQSFIREYRAKRKLYHLRKEKY 181
EEQ40127     142 ------laE-SDLASFLSEFKQKRKEYHLRKEKL 168
CCE40239     155 ----sevTD-EQLVDTLESFKQSRKTYHFKKEKL 183
XP_002548307 158 rshgseiSD-ESFGTMIENFKNSRKLYHFRKEKL 190
EMG46218     158 k--agenSD-ENFSTMIENFKNSRKLYHYRKEKL 188
Q6BSN3       143 s--ssddFE-NLFNNLIKDFRSSRKTYHLRKEKL 173 Debaryomyces hansenii
EGV65816     162 q--dtqvNS-SRLDEMLESFKKSRKKYHLRSEKM 192
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