2VRY,2ZFO,1X9F,2D2M,1X9F,1ASH,2WTG,1YHU,1X9F,1KFR,2VYW,2D2M,1YHU,1X9F,2D2M,1JF3,1YHU,3MVC,2D2M,1YHU,1ITH,4G1B,3S1I,3AG0,2NRL,1FSL,3PT8,1B0B,2QFN,1UT0,1IT2,4HHB,1SI4,4B4Y,1HLB,1HLM,2C0K,1DM1,1ECA,1X3K,2G3H,4HRT,1GVH,3QQQ,1OJ6,3UBC,1TU9,1OUT,4HHB,1SI4,1X46,4U8U,3WCT,4BJA


Conserved Protein Domain Family
Mb-like
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cd01040: Mb-like 
Click on image for an interactive view with Cn3D
myoglobin-like; M family globin domain
This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.
Links
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Statistics
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PSSM-Id: 381254
Aligned: 383 rows
Threshold Bit Score: 40.1308
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heme binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:1UT0: Human cytoglobin binds heme; contacts at 4A
  • Structure:3UBC: Methylacidiphilum infernorum V4 Hell's Gate Globin I binds O2/heme; contacts at 4A
  • Structure:2NRL: Thunnus atlanticus myoglobin binds heme; contacts at 4A
  • Structure:1OJ6: Human brain neuroglobin binds heme; contacts at 4A
  • Structure:3QQQ: Trema tomentosa non-symbiotic hemoglobin binds heme; contacts at 4A
  • Structure:1GVH: ferric Escherichia coli Hmp binds heme; contacts at 4A.
  • Structure:1SI4: Human HbA2, delta subunit binds heme; contacts at 4A
  • Structure:4HHB: Human deoxyhemoglobin alpha subunit binds heme; contacts at 4A
  • Citation:PMID 5528692
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        ##                     #  ##  #                 
2VRY_A        12 IRQSWrvvsRSPLEHGTVLFARLFAlepsLLPLFQyngrqfsspedslsspeflDHIRKVMLVIDAAVTNVedlssleey 91  house mouse
1UT0_A        27 VQAMWarlyANSEDVGVAILVRFFVnfpsAKQYFSqfkhmedpl-emerspqlrKHASRVMGALNTVVENLhdpdkvssv 105 human
1IT2_A        19 INKIWpkiyKEYEQYSLNILLRFLKcfpqAQASFPkfstkksn---leqdpevkHQAVVIFNKVNEIINSMdnqeeiiks 95  inshore hagfish
1SI4_B        11 VNALWg--kVNVDAVGGEALGRLLVvypwTQRFFEsfgdlsspd-avmgnpkvkAHGKKVLGAFSDGLAHLdnl---kgt 84  human
AAD40480      17 VRASWavlmKDYEHAGVQILDKFFKanpaAKPFFTkmkdlhtle-dlassadarWHVERIIQAVNFAVINIedreklsnk 95  Atlantic hagfish
BAF47286      20 IKDSWsgvySEYESTSSEILIKFFVdnpsAQDFFPkfkdldsee-klkgstavrWHAERIINAVNDAIWLLdepeknakk 98  Lethenteron cam...
P02209        20 IRESWpqiyKNFEQNSLAVLLEFLKkfpkAQDSFPkfsakksh---leqdpavkLQAEVIINAVNHTIGLMdkeaamkky 96  Atlantic hagfish
EFN75768      33 VQNTWaivrKDDVSSGLAIMNAFFTrypeYQDQFKsfkgipfee--lsknkkfqAHCVSVIAGLSNVIDHIhnpelmeas 110 Harpegnathos sa...
NP_001071291  32 VQNTWavvrKDEVASGIAVMTAFFKkypeYQRYFTafmdtplne--lpankrfqAHCAGVITALNNVIDFLhdpglmeas 109 honey bee
EGI63772      29 VQKTWaivrKDEVSVGVVLLLAFFKqypeSQKEFKsfkdvplde--lpknkrfqAHCVNIIATLGKVIEQMhdpelmeas 106 Panamanian leaf...

Feature 1           #  ##      #   ##  #                                   
2VRY_A        92 LTSLGRKHRAv--gVRLSSFSTVGESLLYMLEkslgpdftpatRTAWSRLYGAVVQAM 147 house mouse
1UT0_A       106 LALVGKAHALkh-kVEPVYFKILSGVILEVVAeefasdfppetQRAWAKLRGLIYSHV 162 human
1IT2_A        96 LKDLSQKHKTvf-kVDSIWFKELSSIFVSTIDg----------GAEFEKLFSIICILL 142 inshore hagfish
1SI4_B        85 FSQLSELHCDkl-hVDPENFRLLGNVLVCVLArnfgkeftpqmQAAYQKVVAGVANAL 141 human
AAD40480      96 FVKLSQDHIEefhvTDPQYFMILSQTILDEVEkrngg-lsgegKSGWHKVMTIICKML 152 Atlantic hagfish
BAF47286      99 LKELSEKHAVql-nVDAKFFKVLAEVILDKVAekndgsfsdsaRSAWEKLLTYICISL 155 Lethenteron camtschaticum
P02209        97 LKDLSTKHSTef-qVNPDMFKELSAVFVSTMGg----------KAAYEKLFSIIATLL 143 Atlantic hagfish
EFN75768     111 LINLAERHKNr--gQTREHFQNLRYVLEDLIPsvfgkqytqevQEAWKKMFDYLFLIL 166 Harpegnathos saltator
NP_001071291 110 LIGLVERHKKr--gQTKEEFQNLKEVMLEVLRqalgkqytpevAEAWNKTLDMMFGKI 165 honey bee
EGI63772     107 LINFTEKHKVr--gQTPEQFENLKQVILDAFPslfgkqytlevQEAWKKTLDLIFSKI 162 Panamanian leafcutter ant

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