6L7R,6L81


Conserved Protein Domain Family
MOZART1
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pfam12554: MOZART1 
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Mitotic-spindle organizing gamma-tubulin ring associated
The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes.
Links
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Statistics
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PSSM-Id: 432631
Aligned: 58 rows
Threshold Bit Score: 43.6085
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6L7R_B        20 VDILHEIATILNCHLDRRTLSICISMIENG-VNPEALANVIKEL 62 
EEC14245      31 FEVLQEMSQLLNTGLSPEALAVCVQLCERGaADPRSLANLVNGL 74 
XP_002026235  16 WDVLCGMLDCVNSGLAPESVRICMQLMGNG-VQPKQLAEIIRTL 58 
XP_002065642  30 MEILYGMSTLINTRLSKEALILCIELLEVG-VNAKVLAQVVLKI 72 
1_pfamImport   4 RTSIQGISQLLNTGLDSYSLELCMKLLEAG-IHPQALADVVNEI 46 
XP_002053764 186 RIAVHGMSELINTRLSTEALEICLELIEAG-VQPRALAEVVLHI 228
XP_001993707  45 RIAVHGMSSLINTRLSSEALQTCLALIEAG-VHSKALADIVMHI 87 
EDW50198      14 LTILQTISDVLNSGLSKESLKICIELVDNG-VSGGALAHVIQTI 56 
XP_001955889  37 LTVVHALSDLVNTGLSRESLKICTELLRAG-VDAKSLTKVIKTI 79 
XP_006957253  18 LENLFELSQTLNTGLSKETLSNSLELIDDG-LDPSTLADVILAL 60
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