1O5Z


Conserved Protein Domain Family
FolC

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COG0285: FolC 
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Statistics
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PSSM-Id: 440054
Aligned: 767 rows
Threshold Bit Score: 230.762
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1O5Z_A        13 Ma-----Y-LE---VLRYLYHKRPMGkVKPGLERISMLLSKLGNPHLEYKTIHIGGTNGKGSVANMVSNILVSQGYRVGS 83 
NP_924020      1 Mt------------AGGYLDHLQKFG-VHLGLERIQALLKRLGEPQVAFQAVHVAGTNGKGSVCAYLSHILQTAGYRTGR 67 
WP_015163477   1 Mgak-ntA-NS---ANDFLARFQRFG-IHLGLTRIKQLLDDLGNPQTQVPIVHVAGTNGKGSVCAYVASVLQAAGYKTGR 74 
WP_011242910   1 Ms-----L-AE---LDRLLGSFAQRG-VDLGLDRSLTVLERLGNPQNQIPIVHIAGTNGKGSTCAFVDTALRANGYRVGR 70 
NP_680981      3 La-----VaDP---LTAALRPYARFG-VRLGLEPIQALLSALGSPQFQVPLIHVAGTNGKGSVCAYLDSVLRAAGYRTGR 73 
NP_875767      1 Mnl--inY-KEnndFEELIPSFKSKG-MNLGLDRIQNALQKMGNPCHKVPAIQIAGTNGKGSITCFLESCLTKTHIKTGC 76 
WP_015108967   1 Mpspl-pppVD---LGDLLEPFARRG-VDLGLERLAGALAEGGHPERRFAAAQVAGTNGKGSICTFLHAILRAAGVHVGT 75 
WP_011129709   1 MskptspskED---LSDLIPRFDQRG-MDLDLERMQQALQAMGNPCASIPAIQVVGTNGKGSIASFIASSLKAAGIRVGL 76 
WP_012953653   1 ---------MS---IDSLLLPFQRFG-IHLGLERINNLLTKLENPCQNIPIIHVGGSNGKGSVCAYLSSILIEAGYKVGL 67 
WP_015227865   1 ---------MK---ITSYLQSFQRFG-VNLGLTRIKKLLAALGNPEKKVPLIHVAGTNGKGSASAYLSSVLTTAGYQVGR 67 
1O5Z_A        84 YYSPHLSTFRERIRLNEEYISEEDVVKIYETMEPILN---ELdkeeifSPSFFEVVTAMAFLYFAEKNVDIAVLEVGLGG 160
NP_924020     68 YTSPHLLDWNERIWIDGAFISDGALQACLAKVKASAE---HLpks-lgEPTQFEIVTAAAFLHFAQSAVEVAVVEVGLGG 143
WP_015163477  75 YTSPHLIDWHERICINDRWISNHDLIAALEVVQSKIK---PTtp--eqTPTQFEVFTAAAWWYFAQQQVDIAVIETGLGG 149
WP_011242910  71 YTSPHLISWCERLQLNGQQVSSDRLLEAVQTVLAAAD---GI------DLTPFELLTAAVWLVLADSDLDIVVIETGLGG 141
NP_680981     74 YTSPHLLSWCERICVDGEPIAPEVFLTLIQQIEAVLP---QVa----yPPSQFEVITAAAWLYFAQQGVDVAVMEVGLGG 146
NP_875767     77 TTSPHLVSWCERIRIDGQMISPEKLRKFVNEVKLITK---Se------QLTPFELVIASAFNYFFVNQVELILLEVGLGG 147
WP_015108967  76 YRSPHLVSWCERIQVDDAWIAPTTLRDGLARWQPLGR---Qr------RLTPFELITAAAFEHFARERVDLAVLEVGLGG 146
WP_011129709  77 TTSPHLVSWCERISSDGEPISIVELRQRLTALQPLAQ---Th------RLTPFELLIATAFDHFRSREVELLVLEVGLGG 147
WP_012953653  68 YTSPHLINWTERICLNNQPISELHLKEILINIQNLIF---NDq----dAPTQFEVITAAALAYFEQEKVDIIVMEVGLGG 140
WP_015227865  68 YTSPHLIDWTERLCLNEQPITETDFLAVLETVKNAINrnfSEe----kIPTLFEVVTAAAWLYFAEKKVNVAVMEVGLGG 143
1O5Z_A       161 RLDATNVV-FP--LCSTIVTVDRDHEKTLGYTIEQIAWEKSGIIKERVPLVTGERKREALKVMEDVARKKSSRMYVIDkD 237
NP_924020    144 RLDATNVFeQP--PASVITGIGLDHCDQLGSTLAAIAAEKAGILRSGCPLVCAPLAPEAMQVVTEKALALGVVITLAEpA 221
WP_015163477 150 RLDATNVCdRP--LVSVITSISMDHWQRLGNTLGQIAGEKAGIIKPNRPVVVGELPAEAAAVIAKQANDCQSPITWVEpA 227
WP_011242910 142 RLDATNVVaQP--LVTAITSIGHDHQAVLGPTLGAIAAEKAGIIKSRCPVVVGPLLPEARTVIRNRAEQLQALMIAIEpA 219
NP_680981    147 RLDATNVCqPP--LVSVITSIGWDHWQRLGNSLGAIAGEKAGILKQGVPAVIGPVPPEAKTVIAERLAALACPAVWPEpA 224
NP_875767    148 RLDATTAH--PwrPIIAMGKISFDHCEYLGESLAKITKEKAAVISYGSHVISADQEPEVKKILEDTVLKKNAKISWVSpl 225
WP_015108967 147 RLDATTVH--PrrPVIGFGAIGLDHREHLGDTLAAIAAEKAAVMGPGCRAFSCAQEAEARRVLEAEARRRGASLQWLEpl 224
WP_011129709 148 RLDATTAH--PyrPIIAMANIGLDHCEHLGYSLKEITAEKSAVISPGAAVISARQQTEVASILEDKAKHQQARLQWVSpl 225
WP_012953653 141 RLDATNICkSP--LVTVITSISLEHCQNLGPTLTDIAREKSGIFKFNCPVVIGEVPNEAKAIFISRIKALECPSVWVQpA 218
WP_015227865 144 RLDATNVKeEI--IASVITPISLEHWQVLGDTLTKIATEKAGILKLNCPAFIAPQHPEAAAVIQQKATILNCATTWVEpA 221
1O5Z_A       238 Fsvkvkslklhe---------------------------------------------nrfdycgentFEDLVLTMNGPHQ 272
NP_924020    222 Hevapge-------------------------------------------------------aqwqgF-RYRLPLAGGVQ 245
WP_015163477 228 RfinsavyisepssssslgdrtiepnnqtkqtnradlnqantisnsssqnqsnqssfaklpmatwqdI-TYPLSLLGDYQ 306
WP_011242910 220 Tviesgl-------------------------------------------------------wqsqgL-TYQSGLIGDVQ 243
NP_680981    225 Qrcverag-----------------------------------------------------watwggI-EYPLPLAGEMQ 250
NP_875767    226 -------------------------------------------------------------------sKQWELGIAGEIQ 238
WP_015108967 225 pav---------------------------------------------------------------adggPRLGLAGELQ 241
WP_011129709 226 -------------------------------------------------------------------pENWDLGLPGVLQ 238
WP_012953653 219 Iftknns-------------------------------------------------------aiydnI-EYSLALQGEVQ 242
WP_015227865 222 Trlteken-----------------------------------------------------wavsdgL-SYPLPLLGDVQ 247
1O5Z_A       273 IENAGVALKTLEAt--------GLpLSEKAIREGLKNAKNLGRFEILE-KnG-KMYILDGAHNPHGAESLVRSLKLYf-- 340
NP_924020    246 LQNSATALATCQVlr-----erGLpIDETAIRTGLENTVWPGRYQWLG-E----RLLLDGAHNEDSAVYLRRYLDTLh-- 313
WP_015163477 307 LINSAIALATIQAlq-----qqQWqIDEQAIQTGMAQTSWAGRLQWVDyQ-N-RRLLIDGAHNLAAAKQLRQFCDRTf-- 377
WP_011242910 244 RINSAIAIAILRQlq-----qqGWgLQDAAIAQGLADTDWPGRLQWLDyQ-G-RRLLIDGAHNPEAAIALRQAVDQLl-- 314
NP_680981    251 LVNSAIAIATLQClq-----aqGWqISLTAIQQGMAQTRWPGRLQWLHwQ-G-RQLLIDGAHNAPAAAYLRQYVDQL--- 320
NP_875767    239 RENAAVAKAVLESlp-----tfGWkINNNQIKKGLASANWPGRLQSTKwE-GlP-LILDGAHNPEAIRQLSKERALWv-- 309
WP_015108967 242 RHNGAVAVAMARAltapdgplaGTpLDAAAIRAGLESARWPGRLERHRwR-G-RELLIDGAHNPPAAATLRRELDRIdrl 319
WP_011129709 239 RQNAAVAKGALESla-----plGWrLNQDVIRTGLAHAYWPARLQTVHwQ-SqP-VLIDGAHNPPAAERLAHERQHW--- 308
WP_012953653 243 LSNSAISIEVIKIlk-----qrGWnIPISCIQDGIKKTLWRGRLEWLTwE-G-MNLLVDGAHNPDAAKMLRHHTDSL--- 312
WP_015227865 248 LTNSAVAVATLQSlq-----knGWhLPDAIIQQGMAKTRWLGRLQWVQwR-G-LSLLLDGAHNPAAAAALRQYVDTL--- 317
1O5Z_A       341 ------------NGEP--LSLVIGILDDKNREDILRKYTGIFeRVIVTRVPSPRMKDMNSLVDMAKKF--FK-NVEVIED 403
NP_924020    314 ------------PKES--IRWIVGILESKDARAVLKALLRPGdAFVAVPVPDARSHPPERLASMAQTM--GIhSIASASG 377
WP_015163477 378 ------------ANQD--RCWIMGILATKDYAGILKALVNKGdRLITLPIPGHQCVDPQELVAIGQPLl-NT-KPTLANN 441
WP_011242910 315 ------------PNQS--ITWLIGMLRAKDAQAVLATLLRSGdRCIAIPVPDHDCWSSEELQTWAAAQ--GA-IASTAAD 377
NP_680981    321 ------------GWTE--VTWVVGILANKDHEGILNHLLRAGdRLWLVPVPDHASANLEHLKDLAYTCcpRLgECRLFND 386
NP_875767    310 -------------NQSsiVHWIIGIQTNKNAPEMLRNLLKEKdIAWIVQIPNHQSWSKDQLLKACPEL--SH-QLRKAES 373
WP_015108967 320 drldgslhggleGARP--RRWLLGIQRHKEGAVMLEQLLRPGdRAAVVAVPEHASWTLEELVAACPGK--AD-QLEPAGS 394
WP_011129709 309 ------------SNQEfgVCWVLGLQAHKQAPAMLRHLLKPSdLAWIVPVPEHcSWTQHQLAAHCPDL--SS-QLQSADN 373
WP_012953653 313 -------------NKP--ITWIIGIINTKEHDKIFKELLKNNdTIYLVPISDHNNIKPKNLLRSIISCsvELeEIRVEKT 377
WP_015227865 318 ------------PQ-P--VTWIMGILSTKEQDKILNTLLRPGdTLYTVPVPDHRTTPPQELCEMQTQVe----ACFPCES 378
1O5Z_A       404 PLEAIE----------S-TERATVVTGSLFLVGYVR 428
NP_924020    378 FSEALQl--------sD-TEQLTVIAGSLYLAGAVL 404
WP_015163477 442 LEQALSiavnqsalamR-SSEPIIICGSLYLVGEFL 476
WP_011242910 378 WAEGLAia-------qT-YPEAIVFCGSLYLLGDFL 405
NP_680981    387 VAKALDr-----------aGDRCVVCGSLYLIARVL 411
NP_875767    374 ILKVLEllr----snnQwPTPPPIVTGSLYLIGDLI 405
WP_015108967 395 LAAGLDsl-------lP-PGPLPVVAGSLFLLGAVL 422
WP_011129709 374 VEQVFSill----kqnRwPNPPPVVAGSLYLLGDLL 405
WP_012953653 378 LNSALKkit----nrqS-NKNLVVLCGSLYLVGYLL 408
WP_015227865 379 LEAALErvv----sgeV-SHPTTILCGSLYLVGYFL 409
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