Conserved Protein Domain Family
MMADHC

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pfam10229: MMADHC 
Methylmalonic aciduria and homocystinuria type D protein
This entry represents methylmalonic aciduria and homocystinuria type D protein and homologs. These proteins are involved in cobalamin (vitamin B12) metabolism.
Statistics
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PSSM-Id: 431154
Aligned: 18 rows
Threshold Bit Score: 277.761
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OCA23858      24 RVSGTRAFSTAGSSGSDEPY-IAATPPDILPRTVWPDETMGPF--------------------------GPQDQRFQLPG 76 
XP_006003859  24 RIAGTKMFSTAGSSGSDEPH-VVFTPPDIGPRTVWPDEKMGPF--------------------------GPQDQRFQLPG 76 
XP_015213734  24 RIAGARCFSAAGSSGSDEPY-VAITPLDIGLRTVWPDEKMGPF--------------------------GPQDQRFQLPG 76 
NP_991157     24 RVVGARSFS--GASGSDEPH-LNTSTPDIAPRTVWPDESMGPF--------------------------GPQDKRFQLPG 74 
CAF95981      24 NMSAARSLCFAGDSGSNQPH-ETIVPLNLGLWAGGPDDRKGSF--------------------------GAQDR--QLPT 74 
Q9W375        22 TVHRGSNRLNDLLSTKVTNT-AIIPVARYSKRNGPPSDAGGYFktvksrdlddddelnslesepnweltAERGNRFYLPN 100 fruit fly
Q9XWC9         5 KGPQMRAFTQRVAAFSTQLQ-IDPIPIVFVGKGTTP-RQNSLL--------------------------GPNDSQYPFQG 56  Caenorhabditis ...
EFX90029      26 QQPHGKHFSSQGSGDKRHPHaIVLLDENADGTTVWPDPSLGLL--------------------------GPKDLRMPLPG 79 
XP_003456271  26 RVAGGRAFTAADSSGLKEPA-LASAPSAKGLQTLRPDEMMGPF--------------------------GPQDQRFLLPG 78 
1_pfamImport   1 RVTGTRNFSATGSSSSHELC-VAITPSEMA----WPDEIMGPF--------------------------GPQDHRFQLPG 49 
OCA23858      77 NVGFDAHVNGIDIKRRIEVNRNLPDLLTEPQPSERHEFVMAQFVTEFQGSEVSLEPQELNTMESYFENAK---------- 146
XP_006003859  77 NVGFGCHLNGTAAQQKNQVHKTVPDVLTEPAASERHEFIFAQFVNEYQGNEATPPTQQVNNADNYFENAN---------- 146
XP_015213734  77 NVGFGCHLEGTADQKQTPVHRPVPDVLSAPSSSERHEFILAQFVSEHQEKEVAPTSEQVNKAEKYFEMSN---------- 146
NP_991157     75 NVGFDCHLESPVEQRTTSVHSVMPDVLTAQSNNQRHDFILAQFINELHEDDKTSTAQNMDKAEQFFDHSS---------- 144
CAF95981      75 NL-LSCDLRGAAGQQRCLDSTVLP------IQARRSDLTMTEVLEEPLVTEELPR----SPPEAYFDGST---------- 133
Q9W375       101 GIG-------------------------PAWQGDSTTVGLLEPLGHLVNFHKGPNTDKSR-------------------- 135 fruit fly
Q9XWC9        57 DVSFAHKPLSIRQQVENSKIERVMDD-------TEHNLINLLSNTNIEVDRTHLAQLKEEAMEEIQANAAdv-------- 121 Caenorhabditis ...
EFX90029      80 NVGFS--------------HRISPSVLPATVQSTKKTWQDTELFSTLTNYERQYQVVKQSAQEDLDELNSteieellldl 145
XP_003456271  79 NVGFDCQLEGETEQQKSLTDKMLPDVLSAPSCYEKHEWLLAPSVGELSNKGDPASSDKVSTAEHYFDNSR---------- 148
1_pfamImport  50 NLGFDCDLQGIAEQMKSLAHSKVPDVLSSPPSSEQHELILAQVNRDSFEEDEPASSQDVHTADRYFDSSS---------- 119
OCA23858     147 ------VECAMQSCPDLLKKDFASMFP-EIPSN---NLMVLTVTQRTHNDMTIWSQEVENEREMLIEKFMNGAKEICYAL 216
XP_006003859 147 ------VECAIQTCPELLRKDFESLFP-EAPTN---SLTVLTVTQKTKNDMTVWSEEVEQERELLLEKFINGAKEICYAL 216
XP_015213734 147 ------VECAIQTCPVLLKKDVEAMFP-EAPAG---TQTVVTVTQKTQQDMTAWSEAVQVERETLLEKFVSGAKEICYAL 216
NP_991157    145 ------VECAIQSCPELLKRDFESMFP-EAPST---GMMVVTVTQRTQNDMTAWTEQVDQEREELLAKFIEGAKEICHAL 214
CAF95981     134 ------VECAVQFCPDQLRDDFRCIFP-EAPSS---GMTVVTVTQKTQNDMTSWSCAVEQEREQMLAKFIDGAKEICSVL 203
Q9W375       136 ------LEFTCCKCPLLIRVPLLEIFPvPVVAQqciNITMLVLSHEGDIEMGA-------------AKFVLAAREMCDRL 196 fruit fly
Q9XWC9       122 -----eIELSAIEAPKLLKKEMKYLFP-QMETQkmnNVTVFNLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTL 195 Caenorhabditis ...
EFX90029     146 pqpsdvLECVAQDCPKLVRKDFADLFP-SRDVTf-gPLTVVTLAQKTKSDMSSWSEVVEYEREELVACFVDAAKEICEQL 223
XP_003456271 149 ------VECATQACPELLKKDFQSMFP-EAPSC---GMMVVTVTQKTQNDMASWSAEVEDEREQMLDKFVAGARDICCAL 218
1_pfamImport 120 ------LECAVQCCPELLKKDFQSMFP-EAPST---GMMVVTVTQKTRNDMTSWCAEVEQERDQMLDKFCDGAQEICHAL 189
OCA23858     217 RTEGYWADFIDPLSGLAYFGPYTNNTLFETDERYRHLGFKVEDLGCCKVIRHNVWGTHVVVGSIFTNAPSDSPIMKKLG 295
XP_006003859 217 RSEGYWADFIDPSSGLAFFGSYTNNTLFETDERYRHLGFRIEDLGCCKVIRHNLWGAHVFVGSLFTNAPSDSLVMKKLQ 295
XP_015213734 217 QTAGYWADFIDPSSGLAYFGSYTNNVLFETDERYRHLGFQIEDLGCCKVIRHTLWGTHAFVGSLFTNAPPESLIMKKLQ 295
NP_991157    215 RNEGFWADFIDPSSGLAYFGSYTNNTLFETDDRYRHLGFQIEDLGCCKVIRHVMWGTHAFVGTLFTSAPPNSQIMKKLQ 293
CAF95981     204 QTEGFWADFIDPSSGLAFFGPYTNNTLFETDDRYRHLGFHIEDLGCCRVIQHSLWGTHVFVGTIFTSAAPDSHIMERLL 282
Q9W375       197 LSYGYWADFMNPFSGRPFFLPREGANLYRLDSRFRGLNMRLSEQNRCTVISAEKNDSTRFSGTIYSTAPNHYGQLMKLL 275 fruit fly
Q9XWC9       196 HRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKIEDLGCCKVLQHACWGSNAFVGTIFTDAPVDGDAVRDIL 274 Caenorhabditis e...
EFX90029     224 QHDGYWSDFIDPSSGRPYLGSYTNATLFETDERYRHLGFSIEDLGCCKIIRHGTWGTHAFVGCIFTNAPFDGDALQDVL 302
XP_003456271 219 QREGFWADFIDPSSGLAYFGPYTNNTLYETDDRYRHLGFQIEDLGCCKVIRHSLWGTHAFVGTIFTSAPPDTPAMKTLQ 297
1_pfamImport 190 QKEGFWADFVDPSSGLAFFGSYTNNTLFETDDRYRHLGFQIEDLGCCRVIRHSLWGTHVFVGTIFTSAPPSSLVMKNLQ 268
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