1RJ5


Conserved Protein Domain Family
alpha_CA_XII_XIV

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cd03126: alpha_CA_XII_XIV 
Click on image for an interactive view with Cn3D
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.
Statistics
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PSSM-Id: 239400
Aligned: 5 rows
Threshold Bit Score: 468.548
Created: 3-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitezinc binding
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:zinc binding histidines and other residues found to be important for enzymatic activity
  • Structure:1RJ5_A, extracellular domain of murine carbonic anhydrase Xiv, bound with zinc and acetate, contacts at 3.5 A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #                      # 
1RJ5_A        12 GQDHWPTSYPECGGDAQSPINIQTDSVIFDPDLPAVQPHGYDQLgTEPLDLHNNGHTVQLSLPPTLHLGGLPrKYTAAQL 91  Mus musculus
NP_001016431  30 GEKSWPKNYEFCGGVYQSPIDIHQDILQYDSSLQPVKLNGYNVSpAESFTLSNNGHTVQMSLVPTMQIKIAPfHYTASQL 109 western clawed ...
XP_413756     41 GENTWPKKYPFCGGVFQSPIDFHKDILQYDSNLSPLEFIGYNVSsTDQFTLTNNGHSVKMHLSPTMHIRNLPfEYTASQL 120 chicken
AAV38857      29 GQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPgTEPLDLHNNGHTVQLSLPSTLYLGGLPrKYVAAQL 108 human
NP_001209     39 GENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSaNKQFLLTNNGHSVKLNLPSDMHIQGLQsRYSATQL 118 human
Feature 1        # #          #            #                                                     
1RJ5_A        92 HLHWGQrgsleGSEHHINSEATAAELHVVHYDSqSYSSLSEAAQKPQGLAVLGILIEVGetENPAYDHILSRLHEIRYKD 171 Mus musculus
NP_001016431 110 HLHWGQrgtqkGSEHCIEGKRFAGEVHLVNYNSdKYSDITTAMKESDGLAVLGILLEVGp-FNPTFEKIISQLHSIGYKD 188 western clawed ...
XP_413756    121 HLHWGNrnkseGSEHTVSGKHFAAEVHIVHYNSeKYPDIAAAMDKANGLAVLAILLEIGp-FNPSYEKIFRHFRNVKYKD 199 chicken
AAV38857     109 HLHWGQkgspgGSEHQINSEATFAELHIVHYDSdSYDSLSEAAERPQGLAVLGILIEVGetKNIAYEHILSHLHEVRHKD 188 human
NP_001209    119 HLHWGNpndphGSEHTVSGQHFAAELHIVHYNSdLYPDASTASNKSEGLAVLAVLIEMGs-FNPSYDKIFSHLQHVKYKG 197 human
Feature 1                                    #                                                   
1RJ5_A       172 QKTSVPPFSVRELFPQQLEQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEKLQETLSsteed--psepLVQNYRVP 249 Mus musculus
NP_001016431 189 QSVQIAGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVTISEEQLITLETALYstdrn--esvqMTNNYRQL 266 western clawed ...
XP_413756    200 QMVHVPGFNVQELLPDRPDEYYRYEGSLTTPPCYPSVLWTVFRHPVKISQEQLLALETAMYctesddpepleMVNNFRNV 279 chicken
AAV38857     189 QKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFsteee--psklLVQNYRAL 266 human
NP_001209    198 QEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYcthmddpspreMINNFRQV 277 human
Feature 1                    
1RJ5_A       250 QPLNQRTIFASF 261 Mus musculus
NP_001016431 267 QPHGDRLVSVSF 278 western clawed frog
XP_413756    280 QEFRERLVFISF 291 chicken
AAV38857     267 QPLNQRMVFASF 278 human
NP_001209    278 QKFDERLVYTSF 289 human

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