Conserved Protein Domain Family
PDHac_trf_mito

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TIGR01349: PDHac_trf_mito 
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
This model represents one of several closely related clades of the dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex. It includes sequences from mitochondria and from alpha and beta branches of the proteobacteria, as well as from some other bacteria. Sequences from Gram-positive bacteria are not included. The non-enzymatic homolog protein X, which serves as an E3 component binding protein, falls within the clade phylogenetically but is rejected by its low score. [Energy metabolism, Pyruvate dehydrogenase]
Statistics
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PSSM-Id: 273567
Aligned: 7 rows
Threshold Bit Score: 605.635
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P10515        93 KVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPED 172 human
Q9ZD20         4 KILMPALSPTMREGNLARWLKKEGDKVNPGEVIAEIETDKATMEVESVDEGILAKIIIPQNSQNVPVNSLIAVLSEEGED 83  Rickettsia prow...
P12695        36 IIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVEDKAD 115 Saccharomyces c...
O59816        55 VINMPALSPTMTTGNIGAFQKKIGDKIEPGDVLCEIETDKAQIDFEQQDEGYLAKILIETGTKDVPVGKPLAVTVENEGD 134 Schizosaccharom...
Q9R9N3         4 NITMPALSPTMEEGNLAKWLVKEGDKVKSGDVIAEIETDKATMEVEAVDEGTVAKIVVPAGTEGVKVNALIAVLAAEGED 83  Sinorhizobium m...
WP_010230671   4 LLKMPKLSPTMETGTLVKWHKQAGDEVHFGDVLLEISTDKAVLEHTASEDGWLLQILVKEGTK-IPIGTPIAVFSTEQNA 82  Chlamydia murid...
AAA16511      43 EITMPALSPSMTVGNIVQWKKKEGDQIKAGDVIREVETDKATMDSYEDGNGYLAKILIPEGTKGIEINKPIAIIVSKKED 122 Dictyostelium d...
P10515       173 IE-AFKnytldssaaptpqaapaptpaATASpptpsaqapgssypphmqvllpalsptmtmgtvqrwekkvgeklsegdl 251 human
Q9ZD20        84 KAdIDS---------------------FIAQ------------------------------------------------- 93  Rickettsia prow...
P12695       116 VP-AFKdfkleds-------gsdsktsTKAQ------------------------------------------------- 138 Saccharomyces c...
O59816       135 VA-AMAdfti-------------edssAKEP------------------------------------------------- 151 Schizosaccharom...
Q9R9N3        84 VAtAAKggngaaga------vpapkpkETAE------------------------------------------------- 108 Sinorhizobium m...
WP_010230671  83 EYdLKQllpleea-------sganeptEILPq------------------------------------------------ 107 Chlamydia murid...
AAA16511     123 IEsAVKnykpssqasstpvqeeapkpkQEAPkkstktypahkvvgmpalspsmetggiaswtkkegdqikagdaiaevet 202 Dictyostelium d...
P10515       252 laeietdkatigfevqeegylakilvpegtrdvplgtplciivekeadisafadyrptevtdlkpqVPPPTPPpvaAVPP 331 human
Q9ZD20        94 ------------------------------------------------------------------NNSVSLS---LKTD 104 Rickettsia prow...
P12695       139 ------------------------------------------------------------------PAEPQAE---KKQE 149 Saccharomyces c...
O59816       152 ------------------------------------------------------------------SAKSGEE---KSAP 162 Schizosaccharom...
Q9R9N3       109 ------------------------------------------------------------------TAPAAAP---APAA 119 Sinorhizobium m...
WP_010230671 108 ------------------------------------------------------------------TSPQNDShysGPSM 121 Chlamydia murid...
AAA16511     203 dkatmd-----fqyedgngylakilvpggtsgiqinqpvciivknkedcdkfadysveeqssssssSSQESTPs--SSSS 275 Dictyostelium d...
P10515       332 TPQPLAPTPSAPCPATPAGPKg-RVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPs-------KvAPAPa- 402 human
Q9ZD20       105 ATLKKSNDSITNVEGIKHDSN--KIFASPLAKRLAKIGDIRLENVQGSGPHGRIVKQDILSYDS--------S-TSSN-- 171 Rickettsia prow...
P12695       150 APAEETKTSAPEAKKSDVAAPqgRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEk------sSkQSSQts 223 Saccharomyces c...
O59816       163 SSEKQSKETSSPSNVSGEERGd-RVFASPLARKLAEEKDLDLSQIRGSGPNGRIIKVDIENFKPv------vApKPSNea 235 Schizosaccharom...
Q9R9N3       120 APAPQAAAPASPAP-ADGEGK--RIFSSPLARRLAKEAGIDLSAIAGSGPHGRVVKKDVETAVSggaakpagApAAAPap 196 Sinorhizobium m...
WP_010230671 122 AIVGFRPEPPLTTPLSVKYSGd-KVAASPLAKKLAKEQNLDLSGVAGSGPGGRIVKKDLEKAPPl---------RIAGfg 191 Chlamydia murid...
AAA16511     276 SSQESTPSQSSSQQTTRKSGE--RIFATPAARFEASSKGYDLSAINGTGPNNRILKADVLEFVPq-------KqEVAQqq 346 Dictyostelium d...
P10515       403 ---aVvppt-------gpgMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEG-- 470 human
Q9ZD20       172 ----K--------------IVYRDTEEYRSVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEd- 232 Rickettsia prow...
P12695       224 gaaaAtpaaatssttagsaPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATAND-- 301 Saccharomyces c...
O59816       236 aakaTtpaas-----aadaAAPG---DYEDLPLSNMRKIIASRLAESKNMNPHYYVTVSVNMEKIIRLRAALNAMADG-- 305 Schizosaccharom...
Q9R9N3       197 atlaKgmse-------davLKLFEPGSYELVPHDGMRKTIAKRLVESKQTIPHFYVSVDCELDALMALRAQLNAAAPEkd 269 Sinorhizobium m...
WP_010230671 192 y----------------peAPDVNPGSYVEESLSPIRESISKRLQAAKTFIPHFYVRQRIYASPLLALLKELQVQN---- 251 Chlamydia murid...
AAA16511     347 q-qqTtttt-------kkpTTPTSSGEFTDIPHSNIRKVTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMN---- 414 Dictyostelium d...
P10515       471 ---RSKISVNDFIIKASALACLKVPEANSSWM--D--TVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVS 543 human
Q9ZD20       233 --kVTKISVNDFIILAVAKALQEVPNANASWS--E--DAIRYYNNVDISVAVAIENGIVTPIVKDANKKNIIELSREMKT 306 Rickettsia prow...
P12695       302 ---KYKLSINDLLVKAITVAAKRVPDANAYWL--PneNVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKE 376 Saccharomyces c...
O59816       306 ---RYKLSVNDLVIKATTAALRQVPEVNAAWM--G--DFIRQYKNVDISMAVATPSGLITPVIRNTHALGLAEISTLAKD 378 Schizosaccharom...
Q9R9N3       270 gkpVYKLSVNDMVIKALALALRDVPDANVSWT--D--QNMVKHKHADVGVAVSIPGGLITPIVRQAELKSLSAISNEMKD 345 Sinorhizobium m...
WP_010230671 252 ----IKLSINDCIVRACALALKEFPEINSGFNsvD--NTIIRFSTIDISIAVAIPDGVITPIIRCADRKNVGTISAEIKG 325 Chlamydia murid...
AAA16511     415 ---TVKISVNDFIVKASLPALRDNPVVNSTWT--D--QFIRRYHNIDINVAVNTPQGLFTPIVRGVDMKGLNSISTSVKQ 487 Dictyostelium d...
P10515       544 LATKAREGKLQPHEFQGGTFTISNLGMF-GIKNFSAIINPPQACILAIGASEDK-LVPADNekgFDVASMMSVTLSCDHR 621 human
Q9ZD20       307 LIKKAKDNKLTPIEFQGGGFTISNLGMY-GIKNFNAIINTPQSCIMGVGASTKRaIVKNDQ---IIIATIMDVTLSADHR 382 Rickettsia prow...
P12695       377 LVKRARINKLAPEEFQGGTICISNMGMNnAVNMFTSIINPPQSTILAIATVERVaVEDAAAengFSFDNQVTITGTFDHR 456 Saccharomyces c...
O59816       379 YGQRARNNKLKPEEYQGGTFTISNLGMF-PVDQFTAIINPPQACILAVGTTVDTvVPDSTSekgFKVAPIMKCTLSSDHR 457 Schizosaccharom...
Q9R9N3       346 LGKRAKERKLKPEEYQGGTTAVSNMGMM-GVKDFAAVVNPPHATILAVGAGEDRvVVRNKE---MVIANVMTVTLSTDHR 421 Sinorhizobium m...
WP_010230671 326 LAARARQFSLKEEEYKGGSFCISNLGMT-GISDFTAILNPPQAAILAVGSVEEQpVVLNGE---LAVGSTCMLTLSVDHR 401 Chlamydia murid...
AAA16511     488 LAEKAQNGKLHPSEFESGTFTISNLGML-GIKQFAAVINPPQAAILALVPQKLVsFLSNKPdspYETATILSVTLSCDHR 566 Dictyostelium d...
P10515       622 VVDGAVGAQWLAEFRKYLEKPITMLL 647 human
Q9ZD20       383 VIDGAVSAEFLASFKRFIENPVLMLI 408 Rickettsia prowazekii str. Madrid E
P12695       457 TIDGAKGAEFMKELKTVIENPLEMLL 482 Saccharomyces cerevisiae S288c
O59816       458 VVDGAMAARFTTALKKILENPLEIML 483 Schizosaccharomyces pombe 972h-
Q9R9N3       422 CVDGALGAELLAAFKRYIENPMGMLV 447 Sinorhizobium meliloti 1021
WP_010230671 402 VIDGYPAAMFMKRLQKLLEAPSVLLL 427 Chlamydia muridarum
AAA16511     567 VIDGAVGAEWLKSFKDYVENPIKLIL 592 Dictyostelium discoideum
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