Conserved Protein Domain Family
KAP
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pfam05804: KAP 
Kinesin-associated protein (KAP)
This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein, forming a heterotrimeric complex in vitro, called the Kinesin-II. It includes kinesin-associated protein 3 (KAP3, also known as SMAP). In human and mouse, KAP3 is involved in tethering the chromosomes to the spindle pole and in chromosome movement. It binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
Links
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Statistics
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PSSM-Id: 253396
Aligned: 3 rows
Threshold Bit Score: 1201.25
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q26626        13 VKGGSIDVHPTEKALVVNYELEATILGEMGDPMLGERKECQKIIRLRSLNSTTDIAALAREVVEKCKLIHPSKLPEVEQL 92   purple sea urchin
Q92845        13 VKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQL 92   human
NP_001138186  14 WKGGSIEPHPTDKALIVNYQLEATVFGEPNNPMIEEKKHCQKIIRLRSLNAKTDPAALAREVVEKCDLIHKSQLNDVEQI 93   fruit fly

Q26626        93 LYYLQNRKE---------------------TTqkAGAKKGELTGKLK-----------------DPPPYEGTELNEVANI 134  purple sea urchin
Q92845        93 LYYLQNRRD---------------------SL--SGKEKKEKSSKPK-----------------DPPPFEGMEIDEVANI 132  human
NP_001138186  94 IFYLKNRKDnasndipdnnthsrrsaalhtSHtrSSARSHSSVAAMTsstgsgggstgasngvsNALSAATPTAD--VSI 171  fruit fly

Q26626       135 NDIEDYIELLYEDNPEKVRGTALILQLARNPDNLEELQSNETVLGALARVLREEWKHSVELATNIVYIFFCFSSFSQFHS 214  purple sea urchin
Q92845       133 NDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHG 212  human
NP_001138186 172 NNIDEYVELLYEELGERIRGSAMILQMARNPDNLEELEKNEACLSALSRVLREDWRKSLDLSTNIIYIFFCFSTYTKFHP 251  fruit fly

Q26626       215 IVAHFKIGALVMGVVEHELKKHLSWNEELLKKKK---------------------------TAEENP------------- 254  purple sea urchin
Q92845       213 LITHYKIGALCMNIIDHELKRHELWQEELSKKKK---------------------------AVDEDP------------- 252  human
NP_001138186 252 LIVQYKIGSLCMDVIDYELRRYETMRNELDVRKQpngsstphsakaskeklnrstddfldiMNEEKPkemepprrripel 331  fruit fly

Q26626       255 ------------------------AS---KRDFEKST-----------------------------------------KK 266  purple sea urchin
Q92845       253 ------------------------ENqtlRKDYEKTF-----------------------------------------KK 267  human
NP_001138186 332 kqrpksgnwssfhgsmsssliksqIL---NSSYHESLcaggspggdtpavpaeqkaqsnesldrndpkvkkeeidrlnKQ 408  fruit fly

Q26626       267 YHGLLKKQEQLLRVSFYLLLNLSEDPKVELKMKNKNIIRLLIKTLERDNAELLILVVSFLKKLGIYVENKNEMAEQQIIE 346  purple sea urchin
Q92845       268 YQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVE 347  human
NP_001138186 409 LKIFAKKQEQLLRVAFYLLLNMAENVKLEEKMRRKHIVKMLVKALDRQNIDLLMLVSTFLKKLSIVGDNKDEMGALNIVA 488  fruit fly

Q26626       347 RLAKLVPCDHEDLLNITLRLLLNLSFDTDLRGKMIKLGMLPKFVELLANDNHRLVVLCVLYHVSQDDKAKSMFTYTDCIP 426  purple sea urchin
Q92845       348 KLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIP 427  human
NP_001138186 489 KLPRLFQSTHTDLVQVTLKLVFNLSFDGGLRRKMIAAGYLPMLVMFINDEKHHGIAVKILYHMSLDDKVKGMFTQTECVQ 568  fruit fly

Q26626       427 MIMKMMLESPTERLEIELVALGINLACNKHNAQLICEGNGLRLLMRRALKFRDPLLLKMIRNISQHDGPSKAQFIEYISD 506  purple sea urchin
Q92845       428 QLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGD 507  human
NP_001138186 569 MATDAIILNLNVKVDLDLIALCINLSLNRRNAQIMVEGQRLHSLMDRAFKYQDALLMKLLRNLSQHE-SLQLQFIDYVGD 647  fruit fly

Q26626       507 VARIIKESNDEELVVEALGIMANLTIPDLDYEMIINEFGLVPWIKEKLEPGAAEDDLVLEVVMLVGTVATDDSCAAMLAK 586  purple sea urchin
Q92845       508 LAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAK 587  human
NP_001138186 648 LARILTICDDEAFIVECLGILGNLALTDLDYSQILQNFQLIPWIRQILLPCARMDDLVLDTIVYLGTCACDELCALLFCR 727  fruit fly

Q26626       587 SGIIQSLIELLNAKQEDDEIVCQIVYVFYQMVFHEATREVIIKLTQAPAYLIDLMHDKNSEIRKVCDNTLDIISEFDEEW 666  purple sea urchin
Q92845       588 SGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEW 667  human
NP_001138186 728 AKVVISLIELLKAKQEDDEIVLQIIFVFQQILRHESTREYMIKETESAAYLIDLMHDKNEEIRKVCDYCLDIIAISDSEW 807  fruit fly

Q26626       667 ARKIKLEKFRWHNSQWLEMVESQQIDDGEGGLmYGDESYS-----PYIQESDILDRPDL 720  purple sea urchin
Q92845       668 AKKIQSEKFRWHNSQWLEMVESRQMDESEQYL-YGDDRIE-----PYIHEGDILERPDL 720  human
NP_001138186 808 AKRIKLEKFRNHNSQWLCMVESQQDQDNEQd--YADQEDEcdndlDTYLRSEYLDNCDL 864  fruit fly
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