Conserved Protein Domain Family
Nup88

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pfam10168: Nup88 
Nuclear pore component
Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.
Statistics
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PSSM-Id: 462975
Aligned: 17 rows
Threshold Bit Score: 827.376
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN52725              8 SWRNVLNDHPLFLHLRRG-------ESDGKSNRT----------------EARGLVVVQDGDIYAWNGRNSTLVTANLKT 64 
1_pfamImport          1 SLRNVLDGHKIFEQDPVPl------GSPNEGGSE----------------KVKQLLHIDGGNLFVWNESRSCLMTTNLRS 58 
NP_001016790          6 HWQSSLSEHALFSRLKERtreveelREEGERRTRkd-------------kQLRNLLCVLDGDLLVWDSEECAFLTVRLRS 72 
Q3SZ56               13 LWQTWLPNHAVFLRLREGl------KNQSSTETEkpasslpsspplppqlLTRNLVLGLGGELFLWDPEESSFLVVRLRG 86  cattle
XP_006640886          8 RWRSELPGHDLFTKLRENl------DRDFRGSGRt---------------PAKNLAFCLNGDLFVWDEANSVFYTTNLRQ 66 
XP_003459163          8 QWLNDLPNHTIFKIIREKl------DLERTSSERg---------------IAKNLTFCLGADFFVWDDSDRVFYTTNLRQ 66 
A2CEI4                8 RWREALKNHDIFNNLQERl------HLEPQGTSKr---------------IAKNLTFCLNGDLFIWDSVESVFYTTNLRQ 66  zebrafish
XP_001949727          5 TDMLNLNKLEMFQTMRKVl------ETDGANTV-------------------RNLIAYKDQILYIWNPDECCLYSLLLNT 59 
WGS:AAPP:GF17877-PA   4 TDCFELNKAKLFEKIRHGl------P-IVQKT--------------------QNLLDCKDDLLFAWDAKDCCLLVRNWRT 56 
EKC41573              6 NWRTCLNELKIFKQLRENn------CTDSIQKRKl---------------HSKSLVQVLDSDVYVWDGYAAQLLNYNLKN 64 
EEN52725             65 llqdeaEVEKRPLKFQTLLCTDPPLSDVHHVKFSLTGNHVALWGPGGVSIMEVPRRWGKHAEFEGGKD---KVNCRSYPV 141
1_pfamImport         59 ------SLDGNKSNIQTLCCQNAPLFEVNKITFNCTSSHLALVGTRGVTVLALPRRWGKEAEYEGGKP---KIICRSSPV 129
NP_001016790         73 l----sVESTGSSGEQKLLCTNPPLFEVNEVLLSPTQHHVALVGSKGVMVLEIPKRWGKKSEFEGGEK---TVNCRAIPI 145
Q3SZ56               87 ps--gaGEEPSLSQYQRLLCINPPLFEIYQVLLSPTQHHVALIGIKGLMILELPKRWGKNSEFEGGKS---TVNCSTTPV 161 cattle
XP_006640886         67 ld--vsDG----ANYQTLMCINPPLFEVYQVLLSPTQYHVALIGRRGASVLELPQRWGKRSEFEGGRP---RINCKTIPV 137
XP_003459163         67 ln---tEESSSSGKYQTLLCINPPLFEVCQVLVSPTQHHVALVGQRGVSVLELPLRWGKRSEFEGGRS---KINCKTIPV 140
A2CEI4               67 ln---sDGEPDTSRYQTLLCINPPLFEVCQVLVSPSQYHVALIGQRGATVLELPQRWGKKSEFEGGRI---QINCKTIPV 140 zebrafish
XP_001949727         60 v-------HEEQPSYQKLFPGSPPLFDVDEILINEPGTLCALVGSKGVSVMRFPKRMGSKSLYDTSGSlgeGITCSTSLL 132
WGS:AAPP:GF17877-PA  57 plteaaGAKLAGVQFQTLIPSNTVSLDVDRVLVSNEGSLVALSGEHGVCVLELPRRWGQDGYYKDGKE---RITCRSFSL 133
EKC41573             65 f----sDSPDKKSRSQTLLCTDPPRFDVDGIDFNQSKSFLAIWGSSGVMVLEMPQRWGKYSEFEGGKP---AVTCKTTSV 137
EEN52725            142 AERLFATQSSLQLLQVDWHPGSPSD-THLVILTSD-NVLRIYD-IEKPDSPYQSFQLGEFAD--SFSLHSTSSATFNQA- 215
1_pfamImport        130 AERFFMSNISIQLIQASWYPSTSSQhPHLCLLTSD-NMLRIYSaTADTQTPIQTHKLNQVSDmnNTSLTASRASLLSISv 208
NP_001016790        146 AERIFTSSTSLVLKQALWYPSETQE-PHLILLTSD-NILRLYN-LHDPLTPEKVISLSSAEE--ETTLPHNGRS-YKAS- 218
Q3SZ56              162 AERFFTSSTSLTLKHAAWYPSEMLE-PHIVLLTSD-NVIRIYS-LREPQTPTKVIVLSEAEE--ESLILNKGRA-YTAS- 234 cattle
XP_006640886        138 AERFFTSSGSVILRDVAWYPSETEE-PHLVLLTSD-NTLRFYN-LKEPQSPARVLCLSQCEE--ENAVRTQGRS-YAAS- 210
XP_003459163        141 AERFFTSSPSVSLRQAAWYPSETDE-PHMVLLTSD-NTIRFYG-LKSPQTSAKILPVSQSED--ESSLHPPVRS-YAAS- 213
A2CEI4              141 AERFFTSSASVTLRQAVWYPSETEE-PHLVLLTSD-NTIRFYN-LKEPQSPARVLSVSQMDD--DSSVHTRSRS-YAAS- 213 zebrafish
XP_001949727        133 QDKFFITKHLTDVKRVRWYPGSPED-NHLVVLTNNkNCLRLF---KVDKGTGKLVSIWRLGPqtSRILAS---------- 198
WGS:AAPP:GF17877-PA 134 DSQLFLSSPQLEVRQVRWHPHSVSD-STLLVLLNN-NTIRVY-------NHSKLRHVWQVGP--SILRAGGNSSLTDF-- 200
EKC41573            138 AEHYFTSHKSVQLLQVAWHPGSETD-SHMTLLTSD-NLLSTYD-LREPDVPIHIVTLGDSLQ--DLTDSPSKTS-YRAA- 210
EEN52725            216 LGETAVSFTFAPPVD-MPVQekmkwKSDQTR--------------KTETM-Y-PVFVLRGNEDVYYLLTSLEQKSPKVS- 277
1_pfamImport        209 LGETVVAFDFAPVIEhTPST-----ISNLRK--------------KPEPIsLqPIYLLQGNGDVLLLLTSLTDNKFSRGi 269
NP_001016790        219 LGETAVACDFGPLTP-LPKG------FGQYN--------------KEDTVaY-PLYILYETGETYLMYIDLQKSNIKVGk 276
Q3SZ56              235 LGETAVAFDFGPLSA-VPKH-----IFGQKG--------------KEEVAaY-PLYILYENGETFLTYISLLHSPGSVGk 293 cattle
XP_006640886        211 LGEIAVAFDFGPLGC-APRQ-----LLGQRV--------------KEEVLaY-PLYILYENGETYLTYISLAHSGGSLGk 269
XP_003459163        214 LGEIAVAFDFGPISS-PPRQ-----LPGQVS--------------KDQLV-Y-PLYILYENGETYVSYTSQVNGI-SLSk 270
A2CEI4              214 LGETAVAFDFGPLAD-SP-H-----LSSLRM--------------KAELVvY-PLYILYGNGETFLNYISLSHSVGSLGk 271 zebrafish
XP_001949727        199 LGDTAVDFDFAPPVL----------LGSRIQ--------------SDPSImW-PILVLQGNGDVLCMNTTVDESM-NIKs 252
WGS:AAPP:GF17877-PA 201 -GEVAVDFDVAPAGKpKESEpledkNN--TLnqnnkslqnkkcnvNQEKIeW-PVIVLRENGNIYVLLTGLDSEMTR--- 273
EKC41573            211 LGDVAASFDFGP-----PVElkrknRFHSTL--------------TSPDVvW-PAYIVFGNGDVVIAYTDLSPDPSSIQk 270
EEN52725            278 --LQGPLTMHPPADDNYGIDACSILCLPCNPPLVVIATTTGRLYHCIVL---QGEEEDDDRRSEvswtgsDVSTrdtqdM 352
1_pfamImport        270 --FHGPLIMLPPAEDNYGVDSCSIIVMDTSPTTIAIATAAGKLHHCVALwvtDADDISVTSHHK------GDLT-----P 336
NP_001016790        277 --LLGPLPMYPAAEDNYGYDACAVLCLACVPNIIVIATESGLLYHCVVL---EGEDDDEQTSNKswn-ssCDLI-----P 345
Q3SZ56              294 --LLGPLPMHPAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVL---EGEEEDDQTSEKswd-srADLI-----P 362 cattle
XP_006640886        270 --PLGPLPMHPAAEDNYGYDACAVLCLPCVPNILVIATETGTLYHCVVL---EAEEDEEAGAGErwa-rgSEAV-----P 338
XP_003459163        271 --PVGPLPMYPAAEDNYGYDACAILCLPCVPSILVIATETGTLYHCVVL---ESEEEDDTGAVEkwi-rgTETV-----P 339
A2CEI4              272 --PMGPLPMYPAAEDNYGYDACAVLCLPCVPNILVIATESGMLYHCVVL---EAEEEEDGGAVErws-rgSETA-----P 340 zebrafish
XP_001949727        253 akITGPLTMYPPADDNYSEDACSILVMDTIPPSVVIASNFGELYNCLLLpdtQAKNEDEYESSEy--------------Q 318
WGS:AAPP:GF17877-PA 274 --LQGPITITPQVQDNYGLESCALMVIPSLPPTIVIAESNGKIHHALLM---EAEATE-----Hsfs-evDDFLli--eP 340
EKC41573            271 lsLQGPLVMLPPAEDNYGVDACSIAVLGTVPSVLVIGTRDGKLHHCLVM---QSSLEDTNLQSEtqsvisTDTSllyeaP 347
EEN52725            353 PepSLYVYESVELELSLGGTPDdIDSYpdyqpdncpIRLHPDPSSDGRYHCSHAMGVHSVALPWINKLHRFSQSDEEDKD 432
1_pfamImport        337 P--TLYVYETVELELDLLDEDVpENHH---------IILHKDSTLLTRYHCSTSVGVHSVALPWLNKMDAFIRAVEDDRD 405
NP_001016790        346 ---SLYVFECVELELALKLATE-EEESmeld-fscpIKLHRDPICPSRYHCTHVAGVHSVGLAWFNKLEKFLGSGEEDKD 420
Q3SZ56              363 ---SLYVFECVELELALKLASG--EDEpfdsdfscpIKLHRDPKCPSRYHCTHEAGVHSVGLTWIHKLHKFLGSDEEDKD 437 cattle
XP_006640886        339 ---SLYVFECVELELTLKVAAGrEEEEalesdftcpIRLHRDPLCQQRYHCTHEVGVHSVGLTWVNKLHKFLQSDEEDKD 415
XP_003459163        340 ---ALYVFECVELELILKVATG-EDEEpqefdftcpIKLHRDPLCQHRYHCTHEAGVHSVGLIWVNKLQRFLKSDEEDKD 415
A2CEI4              341 ---SLYVFECVELELTLKLPAG-EEEEitesdftcpIRLHRDPLCQHRYHCTHEAGVHSVGLTWFKKLHKFLESDEEDKD 416 zebrafish
XP_001949727        319 HeySLHIIETIELELGLNVEDNgEYDTsn------tIQLKRDAAVTSRYWCLHNTGVHSVTVPLSELLDEFSKT--NPDD 390
WGS:AAPP:GF17877-PA 341 SqyVIHVLETVKLELGLAAPS----RKgve----npIYLKRDLINELRYFAYHDAGLHVVSVSFIAELQRYLES-ESQED 411
EKC41573            348 DdvSLYVYESVELELSLTTTSL-KTEEfiedtftcpIKIIKDPMAPDRYHCIHSAGVHTIVLPWIQEYQKFFADSE---- 422
EEN52725            433 SLLELSRDQPCIVEHLVCTRPVPSSPPAPILGLTVVGdqlLGPT-LLCLTSDVTCIALPL---------LTHY-----AN 497
1_pfamImport        406 HLGDLAHDDPCVVEHVLCTKPTLSASPCPIIGITIATdaiFGPT-LLCLMADNHCTTVPL---------LNTF-----VP 470
NP_001016790        421 SLQELAAEQKCLVEHILCTKPLRCRLPSPIQGFWIISdlsLGTS-MICITCDFECIARPL---------LTTI-----RP 485
Q3SZ56              438 SLQELATEQKCFVEHILCTKPLPCRQPAPIRGFWIVPd-iLGPT-MICITSTYECLIRPL---------LSTV-----HP 501 cattle
XP_006640886        416 SLQELAAEQRCMVEHILCTRPLSSSSSAPVRGFWIVSdlsLGAT-MICITSTYECLTLPL---------LSSI-----RP 480
XP_003459163        416 SLQELAAEKRCIVEHILCTRPLLTSQSAPIRGFLIVSdlaLGAT-MICITSTYECILLPL---------LSSI-----RP 480
A2CEI4              417 SLQELAAEQRCIVEHILCTRPLANSLPAPVRGFWIVSdlsLGAT-MICITSTYECLLLPL---------LSSI-----RP 481 zebrafish
XP_001949727        391 FRGSPDIQGQSFVEYYICTG-LMNGETKPIKGFAILS---FPTDlLVTLLSNGEVVTQAIpdfhynklsIANMytnedNP 466
WGS:AAPP:GF17877-PA 412 RL-EMAASSS--AEYILCTKFESSDRVNPVFGIALLQ---MPAG-VVLLLGSGQVISLKL---------VIDAkl--lVT 473
EKC41573            423 ---NVPEQEDCIVEHLICTKPLPSSPVAPVLGLGLVRglsVEPS-LLTLTWDYELVSLPL---------CPSR-----YR 484
EEN52725            498 PPPPTLSSLPSQPVTS-PLRKLHS--KPFDQHIRDILRRD--ASNPILk-SIPKGSQPSDQECFQLLTRATQVFRDEYIK 571
1_pfamImport        471 TSPPLLSEKGDNTITApPPVPTQE--PSFTEHIKSILKRD--VSQPIIr-SGSSRESTSERECLQVVTRATQVLRDEYML 545
NP_001016790        486 PSPPLLCFKIDKSSTEiIPHVLEDvkGPFEEHIRGILRRN--SANPLLlnSSSKDSSPPPEECLQLLSRATQVFREEYLL 563
Q3SZ56              502 ASPPLLCTREDVEVAEsPLRILAEtpDSFEKHIRSILQRS--VANPAFlkSSEKDMAPPPEECLQLISRATQVFREQYIL 579 cattle
XP_006640886        481 HSPPLLCSRPGAGLGSsPLRGLAE--DSFEQHIRNILARS--STNPLLlrAGEKDSAPPPSECLQLLSRATQVFREEYIL 556
XP_003459163        481 PSPPLLCSHPGLGSASsPLRGLAE--DSFEQHIRNILARS--STNPLVlkAGDKDTSPPPPECLELLSRATQVFREEYIL 556
A2CEI4              482 ASPPLLCSHPGAGSDSsPLRGLAE--DSFEQHIRNILARS--STNPLMlrSGDKDSSPPPSECLQLLSRATQVFREEYIL 557 zebrafish
XP_001949727        467 ASEDQVDSSENVDKDD------------FSSFISALLQKEngTRNTIL-----KLGPDVPKEIVVQMVLQTINMRRGTLN 529
WGS:AAPP:GF17877-PA 474 PSES---KAINVDSDL------PDcgTTFVDTIKSLLQRS--VNQPIL---ADKLVAPSATESYELLNQAIEVLREQYLK 539
EKC41573            485 DSAGPLHTDEDPTTIEsPLRRLSR--EPFDLYIKKILQRN--VTNPKL--KFDKKTEISQQECFQLLTRATQVFREEYLQ 558
EEN52725            572 KQYQAREEVEKRVDLLKEQKAQQQTDLHTLREDRKSLTETAEKLAEKYEEANEKQQEYLRRVENVLKNLQARLPVLSDAE 651
1_pfamImport        546 KQKLARNAITKRVNLLSDLKLNQLDELHRLGDMKEVLTDNAEKIANDYEDCKERQESLMIRLEDVLKRTRDRDPVLSKSE 625
NP_001016790        564 KQDLAKEEIQRRVKLLIVQKEKQLEDLQYCKEERKSLTEMAERLAEKFEEAKEKQEDLINRLKRILRCFNTQLPVLSESE 643
Q3SZ56              580 KQDLAKEEIQRRVKLLCDQKKKQLEDLNYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKVLHSFHSQLPVLSDSE 659 cattle
XP_006640886        557 KQDLAREEMERRVKLLGEQKKKQLEDLALCREERKSLREMAERLAEKYEDARYRQEAIMNRMKQVLGSLRCQLPVLSDSE 636
XP_003459163        557 KQDMAREEMQRRVKLLTGQKNKQLEELSLCREERKSLREAAERLADKYEDAKYRQETIMNRVKKVLCSLQSQLPILSNSE 636
A2CEI4              558 KLGLAHEEMQRRVKLLSGQKNKQLEDLALCREDRKSLTEAAERLADKYEDAKYRQEAIMNRVKRVLGSLRSQLPVLSDSE 637 zebrafish
XP_001949727        530 NHKIVSEEIERRVRMLAKAKERQLQEMQRLEEARKKLQDDVENKAEKLDEISNKQEKLTQRASSMLLRLVSAAPDSISIK 609
WGS:AAPP:GF17877-PA 540 RHDLVRAAFARHINQIQLKRDQQLQEIQDLEQERELISERAHKLAERFEEISDNQEVLVRKCHALMQKANVALPSNVVAE 619
EKC41573            559 KQEHAQQEIQKRTRMLRSLRAQQEGDVRSLEVSRNHVRNMAESLATKYSDCQDKQEEILQRIEEVMRRLQEKMPMMSEAE 638
EEN52725            652 VSMKKELESLQEKLKHLKNSTQQVKTKWDYQKRQVT----QQARQSSSPALSQSQSKHMKELLKQEGDKIGELVKQVNSL 727
1_pfamImport        626 VAMNKELRAMKEKLWQLDNRIKQLKIKQEYQADKLT----SDHRKTGSVSSSSLHREKLKQILLEEGEKIHELIKKLNNL 701
NP_001016790        644 RDMKKELHATQEQLQQLGNAINQVNRKMSYQEKQMEk--gKSP-RKSSLTLSDYQKKNIKVVLKEHGENIQEMVKQINNV 720
Q3SZ56              660 RDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQRKMEk--vLSP-QKPTITLSAYQRKCIQSILKEEGEHIREMVKQINDI 736 cattle
XP_006640886        637 KDMRKELQTISDQLRHLGNGIKQVTMKMDYQKKQMEk--gMTT-PRTSLALNANQRKCVQSVLKEQSEHIADMMKQIKDI 713
XP_003459163        637 KEMKKELQTINDQLKHLDNCIRQVNMKMEYQKTQVDk--dMPG-TRARVSLNAPQKKVVQDVLKEQGQQIGDMMKQIKDI 713
A2CEI4              638 KDMRKELQTINDQLRHLDNGIKQVNMKKDYQKKQMNa--gASP-AHSSLTLNAHQRKCLQGVLKEQGEHIAGMMKQIKDI 714 zebrafish
XP_001949727        610 KK-RELLEGYKTKMDLMNKRIEEAREKWNIVQSESAaavyKQIYGSRSLKLTLEQELVIKGNLSEMGSTILDLEKKVRDL 688
WGS:AAPP:GF17877-PA 620 RDFIQEVNRLNSVTQILATGLQTAKNTINKQRYHIAk--sQDDLKRNAYELPEKQHRTITEILTQLASEIDRQITDVKRI 697
EKC41573            639 RGMKRELETMEEQLEIYKRSLDQLKIKQDYQRRQISq--tPNR-QLSSPSLKSSQLKQLREVLQQEGDDLGNLLKRVNSL 715
EEN52725            728 KLHCG 732
1_pfamImport        702 NAQAG 706
NP_001016790        721 RNHVN 725
Q3SZ56              737 RNHVN 741 cattle
XP_006640886        714 KNHFS 718
XP_003459163        714 KNHFS 718
A2CEI4              715 KNHFS 719 zebrafish
XP_001949727        689 RTVIN 693
WGS:AAPP:GF17877-PA 698 NKIVG 702
EKC41573            716 KLEAG 720
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