1PF5


Conserved Protein Domain Family
YjgH_like
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cd02198: YjgH_like 
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YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Links
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Statistics
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PSSM-Id: 100005
Aligned: 20 rows
Threshold Bit Score: 129.689
Created: 8-Feb-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homotrimerputative active
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:homotrimer interaction site [polypeptide binding site]
Evidence:
  • Comment:based on similarity to other members of the superfamily
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ##  # #       # # ##                                            # ## # #      
1PF5_A       19 HRYSAAIRSGd-----LLFVSGQVGSredgtpepdFQQQVRLAFDNLHATLAAAGCTFD-------DIIDVTSFHtd-pE 85  Escherichia coli
NP_522905    32 FNYAPAVAAGg-----LLFIAGQIGIradgtvpasVEEQIDLAFQRLGAILQAAGLGFE-------DLVELVSYHvd-vD 98  Ralstonia solana...
ZP_01057914  18 LALSPGVLSGe-----HLFLTGMTGSeasgempddPEQQFRNAFAKIGAVLAEAGLDFS-------SIVEMTSYHvg-mS 84  Roseobacter sp. ...
NP_792289    19 AGYAPAVRVGd-----TLYCAGQVGRtrdmevilnPEAQFIACWENLRTVLAEGGCTFD-------DIVDMTTYHva-mS 85  Pseudomonas syri...
XP_568127    18 DNFAPAAAVIlpanakTLYISGVVGEnedg-sfgdFRTQVFLIFDRITEILLNASPSYKsagnawkHVFEITAYHvgplP 96  Cryptococcus neo...
ZP_01040314  56 FGFSEAVIHGd-----TVYLSGVILGppqe--getQEEAFDRTFQYIGGILERAGSSWG-------DVLDITTYHtd-iD 120 Erythrobacter sp...
YP_498359    10 FGYCAARAAGg-----LLFCSGQIGLeadgsvpeaASRQFDMAFAALAETLEQNGCATS-------DIVDLTSFHvg-yP 76  Novosphingobium ...
YP_509051    19 WHMSPGLMVGd-----FLFLTGMTGAgpdgivdpdPETQIRLAFQRADAVLQEAGLSFA-------HVVEMTSYHvg-iA 85  Jannaschia sp. CCS1
YP_511022    19 YHYAPGILVGd-----TLYCSGQVGRdadlnvvdgPEAQFTQAFENAGKVLAAAGASFD-------DVVELESWFag-sM 85  Jannaschia sp. CCS1
YP_778458    19 IGYAPAIKVGd-----TVYVSGQIGRdaamqlvedREAQIVQAFENLKRVLEAGGASLD-------DVVDLTTFHt--dM 84  Burkholderia amb...

Feature 1             #  #   #    #########           # # #   
1PF5_A       86 NQFEDIMTVKNEIFsapPYPNWTAVGVTWLa---GFDFEIKVIARI 128 Escherichia coli
NP_522905    99 RQLAAFRETKDRYIk-eGAPAWTILGVAALar-pTLLIEIKAVAAT 142 Ralstonia solanacearum GMI1000
ZP_01057914  85 DHFDLFTEVRRDYVc-ePFPAWTAHGVAELrr-pGAVVEIRVIAQK 128 Roseobacter sp. MED193
NP_792289    86 EHMPVFRDVKNRIFp-rGQCAWTCIGVAELah-pGLLLEIKCIAVR 129 Pseudomonas syringae pv. tomato str. DC3000
XP_568127    97 EHLPIELEAVDKYLk-gAHPTWTSAAVEKLfh-dEQLYEVHVKAIV 140 Cryptococcus neoformans var. neoformans JEC21
ZP_01040314 121 ASMPALAAVKNRYVk-aPFPAWTAIDVDRLya-pEGVVEIKITARR 164 Erythrobacter sp. NAP1
YP_498359    77 AHMEEFAKAKAAFLd-gATCCWTAIGVASLgy-pGSLVEIKAVATR 120 Novosphingobium aromaticivorans DSM 12444
YP_509051    86 SHIDAFRAIRSEYVa-aPHPAWTAIEVAGFvt-pGTVCELRIVAHR 129 Jannaschia sp. CCS1
YP_511022    86 DELKTFMAVKDRFFk-hRYPTWTGFSVNGFsm-pGILVEIKCKAIL 129 Jannaschia sp. CCS1
YP_778458    85 RDLPLFLQVRDRYFhahPRPAWTAVGAHMLggspGYIVEIKAVAVL 130 Burkholderia ambifaria AMMD

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