5DZT


Conserved Protein Domain Family
DUF4135

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pfam13575: DUF4135 
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Domain of unknown function (DUF4135)
This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is approximately 380 amino acids in length. The family is found in association with pfam05147. This domain may be involved in synthesis of a lantibiotic compound.
Statistics
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PSSM-Id: 433321
Aligned: 82 rows
Threshold Bit Score: 191.718
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5DZT_A           201 PELMRITVVRMRYFLDNTKQMLIRVTEDLPSIQNCFNi--QS-SELNSISESQGDSHSRGKTVSTLTFSDGKKIVYKPK- 276 
Q62NU6           195 PVLGRLMAEKVLRVLEIHEEIIGRFLSDRSLIAKKFNia---sPELVGFEGDLGDSHKNGQSVKVLVLNN-GKLVYKPRs 270  Bacillus l...
Q9KFM7           148 PILGKLVVNETLRTINFVKKIIQHYMKDYLLLSDFFk---EKdLRLTNLQLGVGDTHVNGQCVTILTFASGQKVVYKPRs 224  Bacillus h...
jgi:Clocel_4225  125 PVLNRILLEKCKNQIRLINECLSNYIQDFEPMCETFEi--SAqSKIKQIIVTSGDSHNGGKKVILLELSE-NKILYKPHd 201 
WP_014215807     104 AYLDGLIKRRIPMIINFGGSVLEDFDSDRFQLGQKILnctGSqLRIEDFNYQRNDTRNGAQKVLVIITSF-GKIVYKPHr 182  Pediococcu...
CCZ10744         166 vfclsrLCRLSDNIVESSNMMLRRLNKDWPIIVTHFLpsvPDmGELEAVEFTGSDFHNGGQSVCIVSTTKGVRFVYKPRs 245 
WP_118192485     118 PKLLSILESYTVNIMLHIDRLLFALKADIESFa-------MKeSKIDEISLFEGDLHA-GNCVSSVLFLNGTKLYYKPRg 189  Prevotella...
jgi:Fluta_0264   133 PVLETLINHFIETQLLFCNTLLERITNDIKELQGFFQf----sGKLENIELYKGDLHCGNKSVCKLIFTD-RNIYYKPRn 207 
WP_014386878     165 SVMKTAIFSLIGGALKNLDFMIKHFLQDKELIMSQFGv-kENiKKINDLSVNLSDSHSNGKIVYKLTLDDNKEIIYKPRs 243  Pediococcus
CDD46587          99 PELEKSCEIVLRQQCDFAGQVMQRFWRDQKEIETALLggrRIrGKLT-LLLGEGDAHDKGMAVAQIRFEDGESIFYKPRs 177 
5DZT_A           277 INSENKLRDFFEFLNk--------eLEADIYIVKKVTR---------NTYFYEEYID--NIEINNIEEVKKYYERYGKLI 337 
Q62NU6           271 LSIDEHYRELLNWLNgr-------gMKYSLRAAEVLDR---------GNYGWQEFVK--HEGCSSEEELERFYFRQGGHL 332  Bacillus l...
Q9KFM7           225 LSIDKQFGEFIEWVNsk-------gFQPSLRIPIAIDR---------QTYGWYEFIP--HQEATSEDEIERYYSRIGGYL 286  Bacillus h...
jgi:Clocel_4225  202 FSSEKIFNEILESINke------qcIKYKLKTIKNITR---------DNYAWQDYIK--AIGCTKIQEVEEYYYKIGAYL 264 
WP_014215807     183 LNNDIFFEKMLGLLNkk------sgKKTKLVGVKSITV---------DLHGWQEYIN--QSEFKGSPS--EYYYEFGILA 243  Pediococcu...
CCZ10744         246 VIPDMLIFGQGDSCLkffad-kqlqTAPQFPGPGLMSYlpgddkrqgEEYGYMQFIE--HRTRISEQEERAYYFHLGQIT 322 
WP_118192485     190 AANEKFIMSIISALDkm-------gLSIQFGIPAFIDR---------ENYSWHFQVK--PCDMKNSDSINEYYYNLGKIQ 251  Prevotella...
jgi:Fluta_0264   208 FRNDQILMQLLENED------------LILKIPPFIEK---------GDYGYSKDIFnsQNDVPSHKKTEDYFYQLGKVI 266 
WP_014386878     244 VNTEIIYQKILSHFIkv------tpSSKKSLYYPIIDK---------KEYGWSVFVD--HKNCKTEQEVSSYYYNFGIIS 306  Pediococcus
CDD46587         178 LRGDRLFYKLQGKVEermkmertqeFPYPY-----LEC---------DGYCWTGKCQ--HELCLEEEEIAAFYKRLGIQL 241 
5DZT_A           338 GIAFLFNVTDLHYENI-IAHGEYPVIIDNETFFqQnIPIEFGNSatvdAKYK-YLDSIMVTGLVpy----lAMKDKSdsk 411 
Q62NU6           333 AILYGLRSVDFHNENI-IASGEHPILIDLETLFdNhVSIFAQNQnlhvTALE-LKHSVLSSMMLp-----vKFKHDEv-- 403  Bacillus l...
Q9KFM7           287 AIAYLFGATDLHLDNL-IACGEHPMLIDLETLFtN-DLDCYDSAfpfpALAReLTQSVFGTLMLp-----iTIASGKl-- 357  Bacillus h...
jgi:Clocel_4225  265 AVLYSLGCEDIHKENI-IASGNNPYLIDMETLSnCqAPLINDKAtmleHFFYeNSQSVFGTMLLpt---------nSa-- 332 
WP_014215807     244 AWAWLFKIGDLHNGNV-LQTAQGIRVIDLENLMtNqISDESSEKigdcYSNF-IRDSVLGSLLLplhikfyNET------ 315  Pediococcu...
CCZ10744         323 VYSKLLGILDLHQDNImVSDKGQAYPIDAEVAFwP---------------SFiLNPTVWAGSCMqkclklcCDTSEAi-- 385 
WP_118192485     252 ALLYLLGAQDIIPDNL-IVIGNCPYIIDCESIVsK-----KFKHldstKISAyLQSSVLETGILpdwmfngANDRSqiss 325  Prevotella...
jgi:Fluta_0264   267 KFITCNQLEDIIGENL-IYSNGNLFLIDSESIFmP---KIIDENnrfhQQSKlLELSVAGTSSIp-----------Sk-- 329 
WP_014386878     307 FVNMLLNTDDLHFENL-ISSDEYPVLVDVETIMsNdINRIDFSNagsiISHL-LNSTVLRSGLLpt----fVSFGGDn-- 378  Pediococcus
CDD46587         242 GVGYLLGTNDLHYENM-IAHGEEPVWIDLETLFgN-------------AGER--EPSVLTSGLLpsa------------- 292 
5DZT_A           412 dEG---VNLSALN-FKE-QSVPfkilk-----ikntFTDEMRFEyqthi----mdtaKNTPIMNNEK----ISFISYEKY 473 
Q62NU6           404 -LD---FDLSGIGgKGGqQSKKakgya-----vlnyGEDRMSLKetslt----teekLNAPKLNGRP----VSAVFYTDF 466  Bacillus l...
Q9KFM7           358 -LD---IDLSAVGgGKGvQSEKiktwv-----ivnqKTDEMKLVeqpyv----tessQNKPTVNGKE----ANIGNYIPH 420  Bacillus h...
jgi:Clocel_4225  333 -VSifdYDIGGISgDDNiETSKweafd-----iknqGTDNLQFVkeskf---itggcDNIVKLNGEA----TRARDYYKN 399 
WP_014215807     316 ------IDYSGFRgSKEqYikvnq--------lvdlGTDNLRFDftekriikndlelKNEPVV------------RYQKV 369  Pediococcu...
CCZ10744         386 -EDmtkIKATANFyLPSsQEQNpdillhdvymieerRRRNIACEkkepfy----------kyfkeGV----KSVIDILQK 450 
WP_118192485     326 v-------------------------------lfefDDSNFHLPkk---------egKSYPIT-----------AETLQD 354  Prevotella...
jgi:Fluta_0264   330 -IGlfeYDYSFILpSKRsKSRNin-----------nDQELFNFIf-------------------kKEvidtYLPDFYLIE 378 
WP_014386878     379 -EG---FDYSAINgEKD-VELPykvpr-----ienmYRSDMRIHyvhph----mhneNNQVRLKQTV----VNPHRYVKE 440  Pediococcus
CDD46587         293 ---lseRRFSAVMgGRKsCKAPwqvp------vvkkGKQGLCVEykipv----lkkgKNYP---GEE----LSIQNYEQE 352 
5DZT_A           474 IVTGMK----SI---L--MKAKDS--KKKILAYInNN-L-----QNLIV--RNVIRPTQRYADMLEFSYHPNCFSN-AIE 533 
Q62NU6           467 IVEGFK----NAyaiM--MKHKEE--LAGPSGFL-NL-F-----KHDEV--RHVFRPTHVYGKFLEASTHPDYLTA-GDK 528  Bacillus l...
Q9KFM7           421 VTDGFR----KMyrlF--LNEIDE--LMDHNGPI-FA-F-----ESCQI--RHVFRATHVYAKFLEASTHPDYLQE-PTR 482  Bacillus h...
jgi:Clocel_4225  400 IIEGFS----DCykiF--IKTPNK---------V-VDiL-----KESEViiRQVLRPTAVYSKFLEASTYPTYLTNeESF 458 
WP_014215807     370 INQGFI----IGvqfI--QEHLSE---------V-KRlL-----DGTYS--RQLVASSDFYKKLQGNMTHPKYATS---- 422  Pediococcu...
CCZ10744         451 NLAGYKveirKYyeqLqtV--------------------------------RIVPVATQAFNCYFNR-TTPRTQKQ---- 493 
WP_118192485     355 LEKGFT----DAcnfM--RAHKLD---------L-LSyIysydfNFMRS--RVLLHPTVIYSYILTEMVTPPYLHGgk-- 414  Prevotella...
jgi:Fluta_0264   379 NSEGYIa---CIyhlIsgYKDYQVetKTDTINQI-DQnMt-----------RIIVRDTARYAQLMDYLYHPEFLIDkEI- 442 
WP_014386878     441 IVKGFC----NAykkA--ISLKET--LISD---L-EF-F-----NGIQS--RILLKNTQQYSMVLRTSYHPIFLQN-AQE 499  Pediococcus
CDD46587         353 ILQGFC----GAyhyLseLSEEDLtaLLE---------------KEISS--RQLLGSTQLYQMILEASYHPSVLMK-NGG 410 
5DZT_A           534 REK--VLHNMWAY------PYKNKKVVHYE-------------FSDLIDGDIPIFY 568 
Q62NU6           529 REQ--LFDYMWMLak---qSEKANVFIPDE-------------IVDLLLHDIPYFT 566  Bacillus licheniformis DSM 13 = AT...
Q9KFM7           483 RNK--LFESFWNIts---lMAPFKKIVPHE-------------IAELENHDIPYFV 520  Bacillus halodurans
jgi:Clocel_4225  459 RGLfaKLDNLEEV--------KEKKKAQIE-------------IDSLYEFDIPYFY 493 
WP_014215807     423 -------------------MEQVNGLIGMQvefsnl--dnqkiLTDLKNYDIPYQe 457  Pediococcus claussenii
CCZ10744         494 -----ELDTLYSEfqvymnKQNCEETLDKDsfi-------rllLDDLNQGDIPLFY 537 
WP_118192485     415 -----------------niEELIEPIIRKEsygllsiplihsvASQIEKGDIPYYF 453  Prevotella copri
jgi:Fluta_0264   443 -----FLRQLAVLlp--mkEEKLADINRSE-------------VNQILKLDIPMFY 478 
WP_014386878     500 RIK--FLHSIGKNtd--tsSEQGKFILYSE-------------VQDLLNNDIPYFY 538  Pediococcus
CDD46587         411 RQE--FIQRVCKD----------HKRCQRE-------------QAVLLEGNVPSFY 441 
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